Background: Patients with 1p/19q co-deleted low grade glioma (LGG) have longer overall survival and better treatment response than patients with 1p/19q intact tumors. Therefore, it is relevant to know the 1p/19q status. To investigate whether the 1p/19q status can be assessed prior to tumor resection, we developed a machine learning algorithm to predict the 1p/19q status of presumed LGG based on preoperative magnetic resonance imaging (MRI). Methods: Preoperative brain MRI scans from 284 patients...
Mon Sep 23, 2019 16:07
Purpose: The outgrowth of antigen negative variants is a significant challenge for adoptive therapy with T cells that target a single specificity. Chimeric antigen receptors (CARs) are typically designed with one or two scFvs that impart antigen specificity fused to activation and costimulation domains of T cell signaling molecules. We designed and evaluated the function of CARs with up to three specificities for overcoming tumor escape using Designed Ankyrin Repeat Proteins (DARPins) rather than...
Mon Sep 23, 2019 16:07
PURPOSE: While patients with advanced-stage non-small cell lung cancers (NSCLCs) harboring MET exon 14 skipping mutations (METex14) often benefit from MET tyrosine kinase inhibitor (TKI) treatment, clinical benefit is limited by primary and acquired drug resistance. The molecular basis for this resistance remains incompletely understood. METHODS: Targeted sequencing analysis was performed on cell-free circulating tumor DNA obtained from 289 patients with advanced-stage METex14-mutated NSCLC. RESULTS:...
Mon Sep 23, 2019 16:07
Purpose: Activation of NFE2L2 has been linked to chemoresistance in cell line models. Recently, somatic mutations which activate NFE2L2, including mutations in NFE2L2,KEAP1, or CUL3,have been found to be associated with poor outcomes in patients with non-small cell lung cancer (NSCLC). However, the impact of these mutations on chemoresistance remains incompletely explored. Experimental Design: We investigated the effect of Keap1 deletion on chemoresistance in cell lines from Trp53-based mouse models...
Mon Sep 23, 2019 16:07
Purpose: Previous studies have suggested that higher circulating 25-hydroxyvitamin D [25(OH)D] levels are associated with decreased colorectal cancer (CRC) risk and improved survival. However, the influence of vitamin D status on disease progression and patient survival remains largely unknown for patients with advanced or metastatic CRC. Experimental design: We prospectively collected blood samples in 1,041 patients with previously untreated advanced or metastatic CRC participating in a randomized...
Mon Sep 23, 2019 16:07
Purpose: To determine if FDG PET can expand eligibility in biomarker selected clinical trials by providing a means to quantitate response in patients with non-assessable disease by RECIST. Experimental Design: SUMMIT (NCT01953926) is a multicenter phase II "basket" trial of neratinib. Patients had advanced ERBB2 (HER2)-mutant solid tumors, ≥1 measurable lesion, preferably defined unidimensionally by RECIST v1.1, or alternatively metabolically by PET Response Criteria (PRC). The primary aim was to...
Mon Sep 23, 2019 16:07
Purpose: To investigate the presence of ESR1 mutation in primary oestrogen-receptor positive breast cancer (ER+BC) treated with extended (>4 weeks) neoadjuvant (pre-surgical) aromatase inhibitor (NAI) therapy and to identify patients who may gain less benefit from aromatase inhibition (AI) alone based upon on-treatment changes in gene expression. Experimental Design: We evaluated ER, progesterone receptor and Ki67 by immunostaining, ESR1 mutations by droplet-digital-PCR and expression of over...
Mon Sep 23, 2019 16:07
Summary Advances in interventional radiology have seen the adaptation of urological endoscopic laser techniques to treat biliary tract calculi. Percutaneous transhepatic biliary laser lithotripsy provides an effective alternative procedure for the management of intrahepatic or conventionally refractory choledocholithiasis which would otherwise require invasive and high‐risk surgical intervention. Several small studies have validated the procedure for management in this subset of patients, with most...
Mon Sep 23, 2019 12:56
Autotaxin catalyzes the formation of lysophosphatidic acid, which stimulates tumor growth and metastasis and decreases the effectiveness of cancer therapies. In breast cancer, autotaxin is secreted mainly by breast adipocytes, especially when stimulated by inflammatory cytokines produced by tumors. In this work, we studied the effects of an ATX inhibitor, GLPG1690, which is in Phase 3 clinical trials for idiopathic pulmonary fibrosis, on responses to radiotherapy and chemotherapy in a syngeneic...
Mon Sep 23, 2019 22:11
The second-generation anti-androgen, enzalutamide (ENZ), is approved for castrate-resistant (CR) PC and targets androgen receptor (AR) activity in CRPC. Despite initial clinical activity, acquired resistance to ENZ arises rapidly and most patients develop terminal disease. Previous work has established Stat5 as a potent inducer of PC growth. Here, we investigated the significance of Jak2-Stat5 signaling in resistance of PC to ENZ. The levels of Jak2 and Stat5 mRNA, proteins and activation were evaluated...
Mon Sep 23, 2019 22:11
Mutations in genes encoding isocitrate dehydrogenases (IDHs) 1 and 2 are common cancer-related genetic abnormalities. Malignancies with mutated IDHs exhibit similar pathogenesis, metabolic pattern, and resistance signature. However, an effective therapy against IDH1-mutated solid tumor remains unavailable. In the present study, we showed that acquisition of IDH1 mutation results in the disruption of NADP+/NADPH balance and an increased demand for glutathione metabolism. Moreover, the nuclear factor...
Mon Sep 23, 2019 22:11
Rejuvenation Research, Ahead of Print.
Mon Sep 23, 2019 10:00
Rejuvenation Research, Ahead of Print.
Mon Sep 23, 2019 10:00
Rejuvenation Research, Ahead of Print.
Mon Sep 23, 2019 10:00
Nikhil Seniaray, Ritu Verma, Rajeev Ranjan, Ethel Belho, Dharmender Malik, Vanshika Gupta, Abhinav Jaimini, Harsh MahajanIndian Journal of Nuclear Medicine 2019 34(4):321-323 Early diagnosis is imperative for adequate management of patients with osmotic demyelination syndrome (ODS), which is usually a result of rapid shifts of osmolality secondary to rapid correction of hyponatremia. Magnetic resonance imaging (MRI) with its special sequences is the investigation of choice for early detection...
Mon Sep 23, 2019 00:00
Vishnukumar Rajaraman, Madhusudhanan PonnusamyIndian Journal of Nuclear Medicine 2019 34(4):351-352 Abnormal Pertechnetate distribution can occur due to many reasons such as retrosternal extension of eutopic thyroid gland, ectopic functioning thyroid gland, physiological uptake in esophagus, teratoma having functioning thyroid tissue component, metastatic lymph nodes and sequestered thyroid nodule. We present a case of thyrotoxicosis with hyper functioning thyroid gland and two abnormal foci...
Mon Sep 23, 2019 00:00
Nitin Gupta, Ritu Verma, Ethel Shangne Belho, Anisha ManochaIndian Journal of Nuclear Medicine 2019 34(4):319-320 Rosai–Dorfman disease (RDD) is an uncommon proliferative histiocytic disorder. Patients usually present with painless massive cervical lymphadenopathy with fever and leukocytosis. Isolated extranodal disease is rare and more severe fibrosis, fewer histiocytosis in lesions make diagnosis more difficult as compared to nodal disease. Here, we report a case of isolated extranodal RDD...
Mon Sep 23, 2019 00:00
Jose Rafael Infante, Manuel Moreno, Andrés Martínez, Juan Ignacio Rayo, Justo Serrano, Amparo Cobo, Pedro JimenezIndian Journal of Nuclear Medicine 2019 34(4):347-348 Syringomyelia is a rare degenerative disease affecting the spinal cord and brain stem causing progressive neurological dysfunction. The presence of gastrointestinal symptoms in these patients is common, although references related to nuclear medicine imaging procedures in this pathology are limited, focusing on the study of gastric...
Mon Sep 23, 2019 00:00
Madhur Kumar Srivastava, Kavitha Nallapareddy, Ram Manohar Pagala, Vinodh Kumar KendarlaIndian Journal of Nuclear Medicine 2019 34(4):317-318 Pelvic insufficiency fractures (IFs) are frequently diagnosed on technetium-99m methylene diphosphonate bone scan (BS), where it remains an important diagnostic imaging modality. Involvement of iliac bone in pelvic IFs is very rare. Differentiation from metastases is crucial where BS shows characteristic appearance obviating the need for further investigations...
Mon Sep 23, 2019 00:00
Nestor Martinez-Amador, Remedios Quirce, Isabel MartÍnez-RodrÍguez, Blanca Lucas-Velázquez, Cristina Fernández-MartÍnez, Ignacio BanzoIndian Journal of Nuclear Medicine 2019 34(4):341-343 Extramedullary plasmacytoma is an unusual manifestation in multiple myeloma (MM). It can present as a solitary bone lesion and/or soft-tissue mass. Plasmacytoma can be presented at any location, but it is more common in the head and neck, usually without systemic involvement. The presence of plasmacytoma in...
Mon Sep 23, 2019 00:00
Ravishankar Pillenahalli Maheshwarappa, Islam Ahmed Shehata Elhelf, Parren McNeelyIndian Journal of Nuclear Medicine 2019 34(4):313-316 Bone scans are the most commonly used imaging technique to rule out local recurrence or metastasis during surveillance of malignant bone tumors after treatment. Although bone scans are very sensitive in detecting recurrence or metastasis, they are less specific. There are many nonmalignant conditions which can mimic either recurrence or metastasis on a Tc-99m...
Mon Sep 23, 2019 00:00
Piyush Chandra, Satish Nath, Deepti JainIndian Journal of Nuclear Medicine 2019 34(4):335-337 Immunoglobulin G4-related disease (IgG4) is an immune-mediated fibro-inflammatory entity which affects multiple organs, most frequently the pancreas. Although extrapancreatic inflammations are commonly seen in 18F-fluorodeoxyglucose positron emission tomography/computed tomography of majority of these patients at follow-up, simultaneous involvement of the gastric/biliary tract at presentation is rare....
Mon Sep 23, 2019 00:00
S Chandra Teja Reddy, V Venkatrami Reddy, D Bhargavi, B Deepthi, Suma Tammineni, Ranadheer Manthri, Tekchand KalawatIndian Journal of Nuclear Medicine 2019 34(4):309-312 Solid pseudopapillary neoplasm (SPN) is a rare histopathologic variant of pancreatic tumors. Franz first described this tumor as a “papillary tumor of the pancreas, benign or malignant.” In 1996, the World Health Organization named this tumor as SPN of the pancreas. It has a female preponderance with a male-to-female ratio of...
Mon Sep 23, 2019 00:00
Luca Filippi, Barbara Sardella, Orazio Schillaci, Oreste BagniIndian Journal of Nuclear Medicine 2019 34(4):329-331 Lymphadenitis, due to typical or atypical Mycobacterium, is a clinical condition frequently associated with human immunodeficiency virus (HIV) infection. Differential diagnosis between benign and malignant causes may be a challenge for clinicians. In this regard, the role of positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) has still not been fully explored....
Mon Sep 23, 2019 00:00
Rashmi Ranjan Mohanty, Kanhaiyalal Agrawal, Bikash Ranjan MeherIndian Journal of Nuclear Medicine 2019 34(4):307-308 Thyroiditis is a very rare cause of fever of unknown origin (FUO). Thyroiditis presenting as only fever and weight loss is very rare. We present a case of FUO, which was later on confirmed as thyroiditis on thyroid scintigraphy.
Mon Sep 23, 2019 00:00
Varvara Valotassiou, George Angelidis, Sotiria Alexiou, Dimitrios Psimadas, Ioannis Tsougos, Panagiotis GeorgouliasIndian Journal of Nuclear Medicine 2019 34(4):324-325 A 50-year-old man with beta-thalassemia major underwent Tc-99m sestamibi parathyroid scintigraphy due to elevated parathyroid hormone and calcium serum levels. Single-photon emission computed tomography imaging of neck and thorax revealed a parathyroid adenoma, as well as increased tracer uptake in a paraspinal region in the right...
Mon Sep 23, 2019 00:00
Kasturi Rangan, Manish Ora, Amrin Israrahmed, Sanjay GambhirIndian Journal of Nuclear Medicine 2019 34(4):302-306 Krukenberg tumors described by Friedrich Ernst Krukenberg are still fascinating for their mysterious origin. It is known to be a rare entity and commonly originates from adenocarcinoma of stomach. We present three interestingly rare cases of this entity, revealed by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (F-18 FDG-PET/CT) scan and discuss how F-18...
Mon Sep 23, 2019 00:00
VNSSVAMS D Mahalakshmi, Sapana Bothra, Aromal Chekavar, Mallika Dhanda, Sabaretnam MayilvagananIndian Journal of Nuclear Medicine 2019 34(4):353-353
Mon Sep 23, 2019 00:00
Boon Mathew, Nilendu C Purandare, Sneha Shah, Ameya Puranik, Archi Agrawal, Venkatesh RangarajanIndian Journal of Nuclear Medicine 2019 34(4):295-301 18F flurodeoxyglucose positron emission tomography-computed tomography (18F FDG PET-CT) is widely used in the evaluation of patients with lung mass suspicious for malignancy. In addition to malignancy, a variety of benign neoplasms and inflammatory lesions can arise in the lungs, many of which show increased FDG concentration, thereby mimicking...
Mon Sep 23, 2019 00:00
Nikhil Seniaray, Anuj JainIndian Journal of Nuclear Medicine 2019 34(4):344-346 A 41-year-old lady presented with headache and ophthalmoplegia of the left eye for 1 week and underwent magnetic resonance imaging (MRI) of the brain, which showed homogeneously enhancing nodular thickening of meninges in the left anterior and middle cranial fossa with perilesional white matter edema of the left fronto-temporal lobes which appeared suspicious for neurosarcoidosis. She subsequently underwent 18F-fluorodeoxyglucose...
Mon Sep 23, 2019 00:00
Arvind Krishnamurthy, Saket Mittal, Krishna Kumar RamachandranIndian Journal of Nuclear Medicine 2019 34(4):290-294 Background: The present study aims to explore the role of sentinel lymph node biopsy (SLNB) with intraoperative frozen section in the management of early-staged oral tongue cancers. Materials and Methods: Fifty-two patients with clinical stages cT1/2N0 oral tongue cancers were included in the present study. The curative surgery was preceded by the performance of an SLNB using a...
Mon Sep 23, 2019 00:00
Anuja Anand, Amish Choudhary, Pankaj Dougall, Bhavna Bansal, Madhavi ChawlaIndian Journal of Nuclear Medicine 2019 34(4):332-334 This case is a very good example of how a multimodality approach was taken in diagnosis and management of patient with suspected uterine sarcoma, which turned out to be uterine leiomyoma with parasitic leiomyoma mimicking the pararenal deposit. There has been an increased use of fluorodeoxyglucose avid positron emission tomography-computed tomography in pelvic malignancies,...
Mon Sep 23, 2019 00:00
Ranadheer Gupta Manthri, Sai Moulika Jeepalem, VS Krishna Mohan, D Bhargavi, Narendra Hulikal, Tekchand KalawatIndian Journal of Nuclear Medicine 2019 34(4):284-289 Introduction: Breast cancer is the most common malignancy among women all over the world, which accounts to 25% of all cancers. In known cases of breast cancer, the risk of developing another denovo malignancy is more when compared to low risk groups, which might be due to common environmental risk factors, treatment induced risk...
Mon Sep 23, 2019 00:00
Manish Ora, Sanjay GambhirIndian Journal of Nuclear Medicine 2019 34(4):263-270 Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Invasive coronary angiography (ICA) is the gold standard for the evaluation of epicardial CAD. In the pathogenesis of the CAD, myocardial perfusion abnormalities are the first changes that appear followed by wall motion abnormalities, electrocardiogram changes, and angina. Myocardial perfusion imaging (MPI) demonstrates the cumulative...
Mon Sep 23, 2019 00:00
Maciej J Pelak, Andrea d'AmicoIndian Journal of Nuclear Medicine 2019 34(4):278-283 Purpose of the study: The purpose of this study was to evaluate the potential value of gallium-68 (Ga-68)-DOTATATE positron emission tomography/computed tomography (PET/CT) in predicting the risk of progression in nonbenign meningioma after definite irradiation. We retrospectively reviewed our patients with meningiomas who had the highest risk of progression: WHO histological Grade II and III tumors and with macroscopic...
Mon Sep 23, 2019 00:00
Saurabh Arora, Nishikant Avinash Damle, Rachna Meel, Kanak Lata, Nikhil Tandon, Sanjay Sharma, Chandrasekhar BalIndian Journal of Nuclear Medicine 2019 34(4):338-340 Graves' ophthalmopathy (GO) involves autoimmune activation of fibroblasts, resulting in chronic inflammatory reaction. Somatostatin receptors are expressed in the cells associated with chronic inflammation. We hereby present patients with active GO, with delayed response to the standard treatment regimen, in whom68Ga-DOTANOC positron...
Mon Sep 23, 2019 00:00
Esraa El-Kholy, Lobna KhaledIndian Journal of Nuclear Medicine 2019 34(4):271-277 Purpose: The aim of this study was to evaluate the accuracy of dual-time point in differentiating benign from malignant local recurrent lesions in pancreatic cancer. Patients and Methods: Thirty-four patients with pancreatic cancer (22 males and 12 females, mean age: 58.3 ± 10.3) who presented with soft-tissue lesions at the operative bed. Early whole-body positron emission tomography/computed tomography (PET/CT)...
Mon Sep 23, 2019 00:00
Nitin Gupta, Ritu Verma, Ethel Shangne BelhoIndian Journal of Nuclear Medicine 2019 34(4):349-350 Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare clinical entity involving musculoskeletal and dermatologic systems. Its main features are prominent inflammatory cutaneous and articular manifestations. Anterior chest wall pain, more commonly at sternoclavicular and sternocostal joints, along with palmoplantar pustulosis and acne can point to this uncommon syndrome....
Mon Sep 23, 2019 00:00
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