Abstract Myeloid-derived suppressor cells (MDSC) are present in most cancer patients where they are significant contributors to the immune suppressive tumor microenvironment (TME). The TME is a hostile locale due to deficiencies in oxygen (hypoxia) and nutrients, and the presence of reactive oxygen species (ROS). The survival of tumor cells within the TME is partially governed by two mechanisms: (1) Activation of the transcription factor Nuclear Factor Erythroid-derived 2-like...
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Abstract Purpose Children with unresectable brainstem-infiltrated ganglioglioma have poor progression-free survival when treated with conventional chemotherapy and radiation regimens. The BRAFV600E mutation occurs in a large number of gangliogliomas, making them amenable for targeted therapy using mutation-specific kinase inhibitors. However, limited data exists on the effectiveness and best treatment duration of these inhibitors in this...
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Cancers, Vol. 11, Pages 1333: Radiation Tolerance in Tardigrades: Current Knowledge and Potential Applications in Medicine Cancers doi: 10.3390/cancers11091333 Authors: K. Ingemar Jönsson Tardigrades represent a phylum of very small aquatic animals in which many species have evolved adaptations to survive under extreme environmental conditions, such as desiccation and freezing. Studies on several species have documented that tardigrades also belong to the most radiation-tolerant animals...
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Cancers, Vol. 11, Pages 1330: Transport-Mediated Oxaliplatin Resistance Associated with Endogenous Overexpression of MRP2 in Caco-2 and PANC-1 Cells Cancers doi: 10.3390/cancers11091330 Authors: Riya Biswas Piyush Bugde Ji He Fabrice Merien Jun Lu Dong-Xu Liu Khine Myint Johnson Liu Mark McKeage Yan Li Our recent publications showed that multidrug resistance protein 2 (MRP2, encoded by the ABCC2 gene) conferred oxaliplatin resistance in human liver cancer HepG2...
Sun Sep 08, 2019 03:00
Cancers, Vol. 11, Pages 1331: Elimination of SOX2/OCT4-Associated Prostate Cancer Stem Cells Blocks Tumor Development and Enhances Therapeutic Response Cancers doi: 10.3390/cancers11091331 Authors: Prasanna Kumar Vaddi Mark A. Stamnes Huojun Cao Songhai Chen SOX2 and OCT4 are key regulators of embryonic stem cell pluripotency. They are overexpressed in prostate cancers and have been associated with cancer stem cell (CSC) properties. However, reliable tools for detecting and...
Sun Sep 08, 2019 03:00
Cancers, Vol. 11, Pages 1332: Bone Metastases in Neuroendocrine Neoplasms: From Pathogenesis to Clinical Management Cancers doi: 10.3390/cancers11091332 Authors: Barbara Altieri Carla Di Dato Chiara Martini Concetta Sciammarella Antonella Di Sarno Annamaria Colao Antongiulio Faggiano on behalf of NIKE Group on behalf of NIKE Group Bone represents a common site of metastases for several solid tumors. However, the ability of neuroendocrine neoplasms (NENs) to localize...
Sun Sep 08, 2019 03:00
Publication date: Available online 8 September 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Sonia How Ming Wong, Wei Yang Kong, Chee Mun Fang, Hwei-San Loh, Lay-Hong Chuah, Syahril Abdullah, Siew Ching NgaiAbstractApoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. Resistance to apoptosis is a hallmark of virtually all malignancies. Despite being a cause of pathological conditions, apoptosis could be a promising target...
Sun Sep 08, 2019 13:04
Publication date: Available online 7 September 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Khurum Khan, Nicola Valeri, Charles Dearman, Sheela Rao, David Watkins, Naureen Starling, Ian Chau, David CunninghamAbstractDespite significant progress in management of metastatic colorectal cancer (mCRC) pertaining to better screening procedures and amelioration of the therapeutic armamentarium with targeted therapies, prognosis remains poor. Targeting endothelial receptor growth factor...
Sun Sep 08, 2019 13:04
Abstract Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis via blood and lymphatic vessels. We performed a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We conducted a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results...
Sun Sep 08, 2019 12:46
Abstract Gastric cancer (GC) remains the fifth most prevalent cancer worldwide and third leading cause of global cancer mortality. Comprehensive ‐omic studies have unveiled a heterogeneous GC landscape, with considerable molecular diversity both between and within tumours. Given the complex nature of GC, a long‐sought goal includes the effective identification of distinct patient subsets with prognostic and/or predictive outcomes, to enable tailoring of specific treatments (“precision oncology”)....
Sun Sep 08, 2019 12:46
Liver cancer is the second most common cause of cancer death worldwide, with hepatocellular carcinoma (HCC) the most prevalent primary liver cancer [1–3]. More than half of HCC patients are diagnosed at an advanced stage, often with macroscopic vascular invasion (MVI) which has limited treatment options and poor prognosis [4–6]. According to the updated Barcelona Clinic Liver Cancer (BCLC) staging, systemic therapy including sorafenib and lenvatinib is the only recommended first-line treatment option...
Sat Sep 07, 2019 03:00
Radical chemoradiation is the standard treatment in loco-regional anal cancer, achieving a 3 year disease free survival of 73% [1–3]. Intensity modulated radiotherapy (IMRT) is now used as standard in the UK [1]. IMRT enables the delivery of varying dose levels to multiple targets while decreasing dose to organs at risk resulting in reduced adverse events [4]. Additionally, IMRT offers the ability to spare pelvic bone marrow (PBM) but this is not routinely done for anal cancer. Irradiation of PBM...
Sat Sep 07, 2019 03:00
Abstract The majority of pancreatic cancers are diagnosed at an advanced stage, when surgical options are limited and treatment relies on systemic chemotherapy. In the NAPOLI-1 trial, liposomal irinotecan in combination with fluorouracil (nal-iri/5FU) was shown to improve overall survival when compared to fluorouracil alone for metastatic pancreatic cancer. Other retrospective studies have shown the combination of fluorouracil and conventional irinotecan (FOLFIRI) to be a viable...
Sat Sep 07, 2019 03:00
Abstract Preclinical and clinical studies have suggested that cancer treatment with antitumor antibodies induces a specific adaptive T cell response. A central role in this process has been attributed to CD4+ T cells, but the relevant T cell epitopes, mostly derived from non-mutated self-antigens, are largely unknown. In this study, we have characterized human CD20-derived epitopes restricted by HLA-DR1, HLA-DR3, HLA-DR4, and HLA-DR7, and investigated whether T cell responses directed...
Sat Sep 07, 2019 03:00
Abstract Circular RNAs (circRNAs) play a critical role during hepatocellular carcinoma (HCC) development. CircRNA PTPRM (circPTPRM) has not been reported to cause disease and its role in HCC is unclear. This study explored circRNA expression and the function of circPTPRM in HCC. RNA sequencing (RNA-seq) was performed on 3 randomly selected pairs of HCC tissues and their corresponding adjacent non-tumor tissues. Three differentially expressed circRNAs, circPTPRM, circSMAD2 and...
Sat Sep 07, 2019 03:00
Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Ardashel Latsuzbaia, Marc Arbyn, Jessica Tapp, Marc Fischer, Steven Weyers, Pascale Pesch, Joël MossongAbstractBackgroundIn Luxembourg, the human papillomavirus (HPV) vaccination program introduced in 2008, provided either bivalent (BV) or quadrivalent (QV) vaccines to girls aged 12–17 years. Here, we estimate the effectiveness of BV and QV vaccines combined and separately in reducing type-specific HPV prevalence eight...
Sat Sep 07, 2019 15:55
Long non-coding RNA plays a crucial role in the occurrence and progression of glioma. We aimed to explore the function of LINC00174 in cell proliferation, apoptosis, migration, invasion and glycolysis of gliom...
Fri Sep 06, 2019 03:00
FAM92A1–289(abbreviated FAM289) is recognized as one of the newly-discovered putative oncogenes. However, its role and molecular mechanisms in promoting cancer progression has not yet been elucidated. This stu...
Fri Sep 06, 2019 03:00
m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process has been found to be upregulated in many cancers, including...
Fri Sep 06, 2019 03:00
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Caroline Truntzer, Nicolas Isambert, Laurent Arnould, Sylvain Ladoire, Francois GhiringhelliAbstractPurposeTumour-infiltrating lymphocyte (TIL) detection by histology is associated with outcomes in breast cancer; nevertheless, analysis standardisation is difficult. We determined whether transcriptomic data could generate a genomic signature that estimated TIL infiltrates and determined patient prognosis in localised...
Sat Sep 07, 2019 15:23
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Siow Ming Lee, Sunil Upadhyay, Conrad Lewanski, Stephen Falk, Geraldine Skailes, Penella J. Woll, Matthew Hatton, Rohit Lal, Richard Jones, Elizabeth Toy, Robin Rudd, Yenting Ngai, Alex Edwards, Allan HackshawAbstractPurposeWe previously demonstrated that the median survival of patients with poor prognosis non–small cell lung cancer (NSCLC) considered unfit for first-line platinum chemotherapy was <4 months....
Sat Sep 07, 2019 15:23
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Rosanna K. Jackson, Martina Liebich, Philip Berry, Julie Errington, Jizhong Liu, Catriona Parker, John Moppett, Sujith Samarasinghe, Rachael Hough, Clare Rowntree, Nick J. Goulden, Ajay Vora, Pamela R. Kearns, Vaskar Saha, Georg Hempel, Julie A.E. Irving, Gareth J. VealAbstractIntroductionThe use of dexamethasone in acute lymphoblastic leukaemia therapy contributes to short- and long-term toxicities. The UKALL...
Sat Sep 07, 2019 15:23
Publication date: Available online 6 September 2019Source: Cancer/RadiothérapieAuthor(s): I. Latorzeff, C. Bourgier, B. Pinel, C. Hennequin, G. Jimenez, O. Chapet, X. ZasadnyRésuméLe fondement du traitement de la maladie primitive en cas de cancer d’emblée métastatique au moment du diagnostic repose sur la connaissance de l’histoire naturelle de la maladie, de la biologie de la tumeur primaire et de ses métastases, des progrès des techniques de radiothérapie moderne (modulation d’intensité, stéréotaxie)...
Sat Sep 07, 2019 15:13
Publication date: Available online 6 September 2019Source: Cancer/RadiothérapieAuthor(s): M. Laurans, A. Botticella, Y. Moukasse, A. Lévy, C. Le PéchouxRésuméAu cours des vingt dernières années, plusieurs évolutions ont révolutionné la prise en charge des cancers du poumon, composés à plus de 85 % de carcinomes bronchiques non à petites cellules et de près de 15 % de carcinomes bronchiques à petites cellules. La question des volumes cibles ganglionnaires s’est posée lorsqu’est apparue la possibilité...
Sat Sep 07, 2019 15:13
Abstract Purpose Histology samples are important for the appropriate administration of tumor type-specific cytotoxic and molecular-targeted therapies for the treatment of non-small cell lung cancer (NSCLC). When biopsy samples lack a definite morphology, a diagnosis can be selected from three subtypes based on immunohistochemistry (IHC) results, as follows: favor adenocarcinoma (ADC), favor squamous cell carcinoma (SQC), or not otherwise...
Sat Sep 07, 2019 03:00
Cancers, Vol. 11, Pages 1329: Morpho-Molecular Assessment Indicates New Prognostic Aspects and Personalized Therapeutic Options in Sinonasal Melanoma Cancers doi: 10.3390/cancers11091329 Authors: Sandra N. Freiberger Grégoire B. Morand Patrick Turko Ulrich Wager Reinhard Dummer Martin Hüllner David Holzmann Niels J. Rupp Mitchell P. Levesque Sinonasal melanoma is a rare subtype of melanoma and little is known about its molecular fingerprint. Systemic treatment...
Sat Sep 07, 2019 03:00
Cancers, Vol. 11, Pages 1327: Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy Cancers doi: 10.3390/cancers11091327 Authors: Richard S. Laschanzky Lisa E. Humphrey Jihyun Ma Lynette M. Smith Thomas J. Enke Surendra K. Shukla Aneesha Dasgupta Pankaj K. Singh Gillian M. Howell Michael G. Brattain Quan P. Ly Adrian R. Black Jennifer D. Black Pancreatic ductal adenocarcinoma...
Sat Sep 07, 2019 03:00
Cancers, Vol. 11, Pages 1328: Anthracyclines Suppress Both NADPH Oxidase- Dependent and -Independent NETosis in Human Neutrophils Cancers doi: 10.3390/cancers11091328 Authors: Meraj A. Khan Adam D’Ovidio Harvard Tran Nades Palaniyar Neutrophil extracellular traps (NETs) are cytotoxic DNA-protein complexes that play positive and negative roles in combating infection, inflammation, organ damage, autoimmunity, sepsis and cancer. However, NETosis regulatory effects of most of the...
Sat Sep 07, 2019 03:00
Cancers, Vol. 11, Pages 1326: Survival Benefits of Chemotherapy for Patients with Advanced Pancreatic Cancer in A Clinical Real-World Cohort Cancers doi: 10.3390/cancers11091326 Authors: Maximilian Kordes Jingru Yu Oscar Malgerud Maria Gustafsson Liljefors J. -Matthias Löhr Clinical outcomes of chemotherapy for patients with advanced pancreatic adenocarcinoma in a real-world setting might differ from outcomes in randomized clinical trials (RCTs). Here we show in a single-institution...
Sat Sep 07, 2019 03:00
Cancers, Vol. 11, Pages 1325: Panoptic View of Prognostic Models for Personalized Breast Cancer Management Cancers doi: 10.3390/cancers11091325 Authors: Geetanjali Saini Karuna Mittal Padmashree Rida Emiel A. M. Janssen Keerthi Gogineni Ritu Aneja The efforts to personalize treatment for patients with breast cancer have led to a focus on the deeper characterization of genotypic and phenotypic heterogeneity among breast cancers. Traditional pathology utilizes microscopy...
Sat Sep 07, 2019 03:00
Purpose: KRAS is mutated in the majority of pancreatic ductal adenocarcinoma. MAPK and PI3K-AKT are primary KRAS effector pathways, but combined MAPK and PI3K inhibition has not been demonstrated to be clinically effective to date. We explore the resistance mechanisms uniquely employed by malignant cells. Experimental Design: We evaluated the expression and activation of receptor tyrosine kinases in response to combined MEK and AKT inhibition in KPC mice and pancreatic ductal organoids. Additionally,...
Fri Sep 06, 2019 15:54
Radiation-induced gastrointestinal toxicity is a significant comorbidity affecting many cancer patients. Intestinal microbial changes are observed in patients suffering from radiation enteropathy, although a causal relationship with disease activity has yet to be proven. Implementation of bacterial profiling in clinical care could improve recognition and management of this debilitating disease.
Fri Sep 06, 2019 15:54
Purpose: Long noncoding RNAs (lncRNAs) have essential roles in diverse cellular processes, both in normal and diseased cell types, and thus have emerged as potential therapeutic targets. A specific member of this family, the SWI/SNF complex antagonist associated with prostate cancer 1 (SChLAP1), has been shown to promote aggressive prostate cancer growth by antagonizing the SWI/SNF complex and therefore serves as a biomarker for poor prognosis. Here, we investigated whether SChLAP1 plays a potential...
Fri Sep 06, 2019 15:54
Purpose: Whether endometrial cancer (EC) should be considered part of the gBRCA1/2-associated Hereditary Breast and Ovarian Cancer (HBOC)-syndrome is topic of debate. We sought to assess whether ECs occurring in gBRCA carriers are enriched for clinicopathologic and molecular characteristics, thereby supporting a causal relationship. Experimental Design: Thirty-eight gBRCA carriers that developed EC were selected from the nationwide cohort study on Hereditary Breast and Ovarian Cancer in the Netherlands...
Fri Sep 06, 2019 15:54
Gastric carcinomas (GC) are heterogeneous tumours, composed of a subpopulation of CD44+ tumorigenic and chemo‐resistant cancer stem cells (CSC). YAP1 and TAZ oncoproteins (Y/T) interact with TEAD transcription factors to promote cell survival and proliferation in multiple tissues. Their activity and role in GC remain unclear. This work aimed to analyse Y/T‐TEAD activity and molecular signature in gastric CSC, and to assess the effect of Verteporfin, an FDA‐approved drug preventing Y/T‐TEAD interaction,...
Fri Sep 06, 2019 22:54
The objective of this study was to assess the performance of different triage strategies for high‐risk HPV (hrHPV)‐positive results utilizing either extended genotyping or a p16/Ki‐67 dual‐stained cytology (DS) approach, with or without partial genotyping. A subset of women with hrHPV infections participating in the ATHENA study were analyzed to determine the number of cervical intraepithelial neoplasia grade 3 or worse (≥CIN3) cases detected, and the absolute risk for ≥CIN3 of each genotype. A clinical...
Fri Sep 06, 2019 17:43
Preclinical studies indicate that activated IGF‐1R can drive endocrine resistance in ER‐positive (ER+) breast cancer, but its clinical relevance is unknown. We studied the effect of IGF‐1R signaling on tamoxifen benefit in patients and we searched for approaches to overcome IGF‐1R‐mediated tamoxifen failure in cell lines. Primary tumor blocks from postmenopausal ER+ breast cancer patients randomized between adjuvant tamoxifen versus nil were recollected. Immunohistochemistry for IGF‐1R, p‐IGF‐1R/InsR,...
Fri Sep 06, 2019 17:37
Abstract Human papillomavirus (HPV) vaccination uptake varies by geographic regions with rural, often medically underserved areas, lagging behind more urban regions in terms of vaccine initiation and completion. In these regions, pharmacies may serve as an additional location for HPV vaccine administration. Little is known about rural caregivers’ willingness to have their HPV vaccine age-eligible children obtain this vaccine from their local pharmacist. First and second authors...
Sat Sep 07, 2019 03:00
Background The role of chemotherapy in extremity/trunk soft‐tissue sarcoma (ET‐STS) is controversial, even for patients at high risk for distant recurrence and death (those with high‐grade tumors ≥5 cm in size). This study examines the impact of integrating chemotherapy with neoadjuvant radiotherapy (RT) on overall survival (OS) for patients with high‐risk ET‐STS. Methods The National Cancer Data Base was queried for adult patients with high‐risk ET‐STS who received neoadjuvant RT and limb...
Fri Sep 06, 2019 16:20
Background Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. Methods Data were harmonized across 13 studies in the International Barrett's and Esophageal Adenocarcinoma Consortium, comprising 2309 esophageal adenocarcinoma (EA) cases, 1938 esophagogastric junction adenocarcinoma (EGJA) cases, 1728 Barrett's esophagus (BE) cases, and 16,354 controls. Logistic regression was used to estimate study‐specific...
Fri Sep 06, 2019 16:20
Patient satisfaction with treatment outcomes after surgery and/or radiotherapy for spinal metastases
Background Patient satisfaction is infrequently investigated despite its importance in assessing efficacy and patient comprehension. The purpose of this study was to investigate patient satisfaction with treatment outcomes after surgery and/or radiotherapy for spinal metastases and to evaluate how health‐related quality of life (HRQOL) is related to patient satisfaction. Methods Patients with spinal metastases treated with surgery and/or radiotherapy were enrolled in a prospective, international,...
Fri Sep 06, 2019 16:19
In prostate cancer patients, imaging of bone metastases is enhanced through the use of sodium fluoride positron emission tomography (18F-NaF PET/CT). This imaging technique shows areas of enhanced osteoblastic ac...
Thu Sep 05, 2019 03:00
Abstract Purpose We aim to investigate the impacts of extent of resection and adjuvant radiotherapy on survival of high-grade meningiomas (WHO grade II–III) according to modern diagnosis and management. Methods Patients with high-grade meningiomas were identified in the Surveillance Epidemiology and End Results (SEER) database between 2000 and 2015 and used...
Fri Sep 06, 2019 03:00
Abstract Older patients are underrepresented in oncological clinical trials. The incidence of hepatopancreaticobiliary (HPB) malignancies is higher in older patients, but data on outcomes are lacking. This study assessed patient outcomes in those < 80 and ≥ 80 years with a HPB malignancy seen at a tertiary referral centre, The Christie NHS Foundation Trust. Data on patients with a HPB malignancy were collected retrospectively between 2012 and 2017 via on-line case-note review....
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1324: Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients Cancers doi: 10.3390/cancers11091324 Authors: Balázs Kis Badie Bogdándi Candéias Garcia Dominczyk Frey Gaipl Jurányi Kocsis Rutten Sáfrány Widlak Lumniczky Though radiotherapy is a local therapy, it has systemic effects mainly influencing immune and inflammation processes. This has important...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1319: Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma Cancers doi: 10.3390/cancers11091319 Authors: Hendriksma Ruler Verbist Jong Langeveld Benthem Sjögren Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1322: A Tunable Nanoplatform of Nanogold Functionalised with Angiogenin Peptides for Anti-Angiogenic Therapy of Brain Tumours Cancers doi: 10.3390/cancers11091322 Authors: Naletova Cucci D’Angeli Anfuso Magrì La Mendola Lupo Satriano Angiogenin (ANG), an endogenous protein that plays a key role in cell growth and survival, has been scrutinised here as promising nanomedicine tool for the modulation of pro-/anti-angiogenic processes...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1321: Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research Cancers doi: 10.3390/cancers11091321 Authors: Inoue Deem Kopetz Heffernan Draetta Carugo Our poor understanding of the intricate biology of cancer and the limited availability of preclinical models that faithfully recapitulate the complexity of tumors are primary contributors to the high failure rate of novel therapeutics in oncology...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1320: Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer Cancers doi: 10.3390/cancers11091320 Authors: Nazareth Jones Gabrielli The poor selectivity of standard cytotoxic chemotherapy regimens causes severe side-effects in patients and reduces the quality of life during treatment. Targeting cancer-specific vulnerabilities can improve response rates, increase overall survival and limit toxic side effects in patients....
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1323: Clinical Significance of ABCB1 in Acute Myeloid Leukemia: A Comprehensive Study Cancers doi: 10.3390/cancers11091323 Authors: Boyer Gonzales Barthélémy Marceau-Renaut Peyrouze Guihard Lepelley Plesa Nibourel Delattre Wetterwald Pottier Plantier Botton Dombret Berthon Preudhomme Roumier Cheok ABCB1 is a member of the ATP binding cassette transporter family and high ABCB1 activity is...
Fri Sep 06, 2019 03:00
Abstract Background Stereotactic body radiotherapy (SBRT) can achieve high tumour control with limited toxicity for inoperable early stage non-small-cell lung cancer (NSCLC) patients. Patients and methods The German Epidemiologic Cancer Registries from the Robert-Koch Institute were assessed. Periods according to the availability of SBRT were: (1) 2000–2003...
Fri Sep 06, 2019 03:00
Publication date: Available online 5 September 2019Source: Cancer/RadiothérapieAuthor(s): C. Bourgier, I. Latorzeff, P. Fenoglietto, P. Boisselier, M. Charissoux, C. Llacer, C. Lemanski, O. Riou, M.-P. Farcy-Jacquet, D. AzriaRésuméNous proposons dans cette revue de rapporter l’impact de la radiothérapie stéréotaxique chez les patients ayant un cancer oligométastatique ou en oligoprogression en termes de survie sans progression métastatique et globale, et d’identifier quelle est la place de cette...
Fri Sep 06, 2019 17:06
Cancers, Vol. 11, Pages 1318: PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition Cancers doi: 10.3390/cancers11091318 Authors: Cretella Digiacomo Giovannetti Cavazzoni The recent approval of immune checkpoint inhibitors drastically changed the standard treatments in many advanced cancer patients, but molecular changes within the tumor can prevent the activity of immunotherapy drugs. Thus, the introduction of the inhibitors of the immune...
Fri Sep 06, 2019 03:00
Abstract Purpose Immune checkpoint inhibitors (ICIs) are effective against a wide variety of cancers. However, they also induce a plethora of unique immune-related adverse events (irAEs). Since for many organ systems symptoms can be unspecific, differential diagnosis with progression of disease or infection may be difficult. C-reactive protein (CRP) has been suggested as a marker for infection. The purpose of this study was to evaluate...
Fri Sep 06, 2019 03:00
Publication date: Available online 5 September 2019Source: European Journal of Surgical OncologyAuthor(s): Belinda C.S. Pearce, Roanne N. Fiddes, Nirmala Paramanathan, Natalie Chand, Siobhan A.M. Laws, Richard M. RainsburyAbstractObjectivesExtreme oncoplastic breast conserving surgery (eOPBCS) allows breast conservation for tumours ≥ 50 mm, but long-term outcomes are unclear. We investigated early complications and the longer-term clinical and oncological outcomes following eOPBCS to assess the clinical...
Fri Sep 06, 2019 15:56
Abstract Purpose Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates centriole duplication. PLK4 deregulation causes centrosome number abnormalities, mitotic defects, chromosomal instability and, consequently, tumorigenesis. Therefore, PLK4 has emerged as a therapeutic target for the treatment of multiple cancers. In this review, we summarize the critical role of centrosome amplification and PLK4 in cancer. We...
Fri Sep 06, 2019 03:00
Hypoxia is a key feature of breast cancer, which affects cancer development, metastasis and metabolism. Previous studies suggested that circular RNAs (circRNAs) could participate in cancer progression and hypo...
Thu Sep 05, 2019 03:00
Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple c...
Thu Sep 05, 2019 03:00
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