Radioresistance remains a challenge to the successful treatment of various tumors. Intrinsic factors like alterations in signaling pathways regulate response to radiation. RhoC, which has been shown to modulat...
Thu Sep 05, 2019 03:00
Dysregulation of microRNAs (miRNAs) play critical roles in cancerous processes. Although miR-3064 was reported to be an important tumor suppressor in ovarian cancer, the cellular impact of miR-3064 on pancreat...
Thu Sep 05, 2019 03:00
In the original publication of this article [1], the Fig. 7 is wrong, but does not affect discussions and conclusions drawn in the article.
Thu Sep 05, 2019 03:00
Abstract Our objective was to build a mock pharmacogenomic (PGx) patient portal and assess its ability to disseminate test results and information to patients. The YourPGx Portal delivered four sample PGx results (omeprazole, simvastatin, clopidogrel, and codeine). We hosted two study groups to assess patient knowledge and perceptions of PGx before and after accessing the portal. Ten PGx‐tested and 10 traditional care (TC) participants were included (average 61 years, 60% women, 50% African‐American,...
Fri Sep 06, 2019 13:30
Abstract As the prognosis of colorectal cancer (CRC) does not always coincide with the pathology and/or surgical findings, a reliable noninvasive prediction tool for the prognosis of CRC is needed. Patients admitted for initial treatment of CRC between January 1, 2015 and December 31, 2015 were retrieved and reviewed. Records of circulating CD16+ CD56+ natural killer (NK) cells were analyzed before and after the initial chemotherapy of FOLFOX plan. Patients were followed up until...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1317: Real-World Outcomes and Prognostic Factors in Patients Receiving Nivolumab Therapy for Recurrent or Metastatic Head and Neck Carcinoma Cancers doi: 10.3390/cancers11091317 Authors: Ryusuke Hori Shogo Shinohara Tsuyoshi Kojima Hiroki Kagoshima Morimasa Kitamura Ichiro Tateya Hisanobu Tamaki Yohei Kumabe Ryo Asato Hiroyuki Harada Yoshiharu Kitani Takashi Tsujimura Keigo Honda Kazuyuki Ichimaru Koichi Omori Recently,...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1316: Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors
Cancers, Vol. 11, Pages 1316: Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors Cancers doi: 10.3390/cancers11091316 Authors: Violeta Bakardjieva-Mihaylova Karolina Skvarova Kramarzova Martina Slamova Michael Svaton Katerina Rejlova Marketa Zaliova Alena Dobiasova Karel Fiser Jan Stuchly Marek Grega Blanka Rosova Roman Zachoval Petr Klezl Vaclav Eis Eva Kindlova Tomas Buchler Jan Trka Ludmila Boublikova The emergence...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1314: Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy Cancers doi: 10.3390/cancers11091314 Authors: Yingxuan Zhang Zheyan Fang Ruizhen Li Xiaotian Huang Qiong Liu Cancer vaccines have been extensively studied in recent years and have contributed to exceptional achievements in cancer treatment. They are some of the most newly developed vaccines, although only two are currently approved for use, Provenge and Talimogene...
Fri Sep 06, 2019 03:00
Publication date: Available online 5 September 2019Source: Practical Radiation OncologyAuthor(s): Justin Oh
Fri Sep 06, 2019 14:23
Publication date: Available online 5 September 2019Source: Practical Radiation OncologyAuthor(s): Robert W. Mutter, Krishan R. Jethwa, Hok Seum Wan Chan Tseung, Stephanie M. Wick, Mohamed MH. Kahila, Jason K. Viehman, Dean A. Shumway, Kimberly S. Corbin, Sean S. Park, Nicholas B. Remmes, Thomas J. Whitaker, Chris J. BeltranPurposeThe relative biological effectiveness (RBE) rises with increasing linear energy transfer towards the end of proton tracks. Presently, there is no consensus on how RBE heterogeneity...
Fri Sep 06, 2019 14:23
Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Hyun-Soo Zhang, Eun-Kyung Lee, Yuh-Seog Jung, Byung-Ho Nam, Boyoung ParkAbstractBackgroundThe characteristics of diagnosed papillary thyroid cancer (PTC) have changed over time with the increasing trend of early diagnosis, and the survival impact of conventional prognostic factors such as lymph node metastasis (LNM) and extrathyroidal extension (ETE) is controversial. We investigated PTC prognostic factors for overall...
Fri Sep 06, 2019 13:46
Abstract Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors in the urinary system. Surgical intervention is the preferred treatment for ccRCC, but targeted biological therapy is required for the postoperative recurrent or metastatic ccRCC. Autophagy is an intracellular degradation system for misfolded/aggregated proteins and dysfunctional organelles. Defective autophagy is associated with many diseases. MuL1 is a mitochondrion‐associated E3 ubiquitin ligase and involved...
Thu Sep 05, 2019 21:43
Abstract NOP2/Sun domain family, member 2 (NSUN2) is a nucleolar RNA methyl‐transferase catalyzing 5‐methylcytosine formation. Evidence shows that NSUN2 is correlated with cell unlimited proliferation. However, its functional role in gallbladder carcinoma (GBC), the most common biliary tract malignancy with poor prognosis, remains to be determined. Here we found that NSUN2 was highly expressed in GBC tissues as well as cell lines. NSUN2 silencing repressed GBC cell proliferation and tumorigenesis...
Thu Sep 05, 2019 19:53
Cancers, Vol. 11, Pages 1315: TREM2 Acts as a Tumor Suppressor in Colorectal Carcinoma through Wnt1/β-catenin and Erk Signaling Cancers doi: 10.3390/cancers11091315 Authors: Su-Man Kim Eun-Mi Kim Kon-Young Ji Hwa-Youn Lee Su-Min Yee Su-Min Woo Ja-Woon Yi Chul-Ho Yun Harim Choi Hyung-Sik Kang TREM2 (triggering receptor expressed on myeloid cells) is involved in the development of malignancies. However, the function of TREM2 in colorectal cancer has not been...
Fri Sep 06, 2019 03:00
Thu Sep 05, 2019 19:23
Abstract Long noncoding RNA (lncRNA) polymorphisms are reportedly in connection with tumor susceptibility and prognosis. Glioma is one of the most aggressive and common cancers of the central nervous system. This study aimed to investigate the relationship between four lncRNA variants and glioma susceptibility and prognosis in a Chinese Han population. Sequenom Mass‐ARRAY was used to genotype 605 patients with glioma and 1300 cancer‐free individuals. Odds ratios or hazard ratios and related 95%...
Thu Sep 05, 2019 18:58
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