ConclusionsMycobacterial infections of the anus and perineum are rare. The most common clinical presentations are the presence of ulceration and fistulization. The diagnosis involves more than one procedure for identifying the bacilli and should consider the presence of manifestations in more than one organ. The treatment is based on pharmacological intervention. Surgery is recommended for acute complications or chronic sequelae of the disease.ResumoIntroduçãoInfecções micobacterianas constituem...
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Publication date: Available online 31 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Q. Jiang, A. Tang, S. Long, Q. Qi, C. Song, Y. Xin, C. Zhang, Z. Cao, J. ZhangAbstractWe have explored the relations between clinicopathological features and cervical lymph node metastases (LNM) in patients with cN0 squamous cell carcinoma (SCC) of the tongue, and developed and validated a nomogram for predicting the risk of their development. Clinical data on 230 patients with cN0...
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Response to: Comment on "circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer". Dis Markers. 2019;2019:9356804 Authors: Cai J, Chen Z, Zuo X PMID: 31662805 [PubMed - in process] (Source: Disease Markers)
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ConclusionInhibition of LncRNA FOXD3-AS1 suppresses the aggressive biological behaviors of thyroid cancer via elevating miR-296-5p and inactivating TGF-β1/Smads signaling pathway. (Source: Molecular and Cellular Endocrinology)
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Publication date: Available online 30 October 2019Source: International Journal of PharmaceuticsAuthor(s): Edi Simoni, Filippo Valente, Lukas Boge, Mimmi Eriksson, Erica Gentilin, Mariarita Candito, Diego Cazzador, Laura AstolfiAbstractSensorineural hearing loss due to aging, noise exposure, trauma or drug ototoxicity is irreversible because cochlear hair cells and neurons cannot regenerate. Recently, therapeutic strategies involving nanoparticles have been developed as innovative drug delivery systems....
Thu Oct 31, 2019 23:39
The The FDA and the American Society of Clinical Oncology (ASCO) intend to leverage their combined strengths for the joint development of the substantive actions of this workshop to provide current hematology and oncology fellows with a solid foundation in the process of oncology drug development and regulatory science. (Source: FDA Center for Drug Evaluation and Research - What's New)
Thu Oct 31, 2019 18:15
Publication date: Available online 31 October 2019Source: SteroidsAuthor(s): Rami Masamrekh, Tatiana Filippova, Yaraslau Haurychenka, Kirill Shcherbakov, Alexander Veselovsky, Natallia Strushkevich, Tatsiana Shkel, Andrei Gilep, Sergey Usanov, Victoria Shumyantseva, Alexey KuzikovAbstractAbiraterone D4A metabolite, the product of 3β-hydroxysteroid dehydrogenase activity toward abiraterone, may serve as a potential antitumor agent for the treatment of prostate cancer. The main adverse effect of abiraterone...
Thu Oct 31, 2019 23:39
In this study, a novel class of hetero-steroids were synthesized, analytical and spectral data proved the validity of the novel synthesized steroid derivatives. The cytotoxicity of the synthesized compounds 2, 5, 6, 7, 10, 11, 12, 14, 15, 17 were evaluated using human hepatocellular carcinoma cell lines (HepG2 and Huh-7) and non-small cell lung cancer (A549) cell lines. The synthesized compounds reported a remarkable gradual decrease in the cell viability of the three tested cancer cell lines. It...
Thu Oct 31, 2019 23:39
Publication date: Available online 31 October 2019Source: SteroidsAuthor(s): Alexandra S. Latysheva, Vladimir A. Zolottsev, Alexander V. Veselovsky, Kirill A. Scherbakov, Galina E. Morozevich, Vadim S. Pokrovsky, Roman A. Novikov, Vladimir P. Timofeev, Yaroslav V. Tkachev, Alexander Y. MisharinAbstractSeven new oxazoline, benzoxazole and benzimidazole derivatives were synthesized from 3β-acetoxyandrosta-5,16-dien-17-carboxylic, 3β-acetoxyandrost-5-en-17β-carboxylic and 3β-acetoxypregn-5-en-21-oic...
Thu Oct 31, 2019 23:39
Publication date: Available online 31 October 2019Source: Pharmacological ResearchAuthor(s): Ali F. Abdel-Wahab, Waheed Mahmoud, Randa M. Al-HarizyAbstractMost solid tumor cells adapt to their heterogeneous microenvironment by depending largely on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which is a hallmark of cancer. The altered energy metabolism not only provides cancer cell with ATP for cellular energy, but also generate essential metabolic intermediates...
Thu Oct 31, 2019 23:39
Publication date: Available online 31 October 2019Source: Pharmacological ResearchAuthor(s): Jong Hyun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Gautam Sethi, Kwang Seok AhnAbstractEpithelial mesenchymal transition (EMT) refers to a phenomenon through which epithelial cells develop the metastatic and invasive potential, which are closely related to carcinogenesis. Farnesol (FOH) obtained from the oils of diverse plants can exhibit significant therapeutic actions against...
Thu Oct 31, 2019 23:39
Publication date: Available online 31 October 2019Source: Pharmacological ResearchAuthor(s): Francesca Marino, Valeria Nucera, Elisabetta Gerratana, Alessia Fiorenza, Donatella Sangari, Gianfranco Miceli, Ignazio Francesco Masala, Fabiola Atzeni (Source: Pharmacological Research)
Thu Oct 31, 2019 23:39
Publication date: Available online 30 October 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Hsiao-Wei Liao, Ching-Hua Kuo, Hsi-Chun Chao, Guan-Yuan ChenAbstractVarious lipidomics studies have revealed the potential of using phospholipids as disease biomarkers for conditions such as Alzheimer’s disease, cancer, and sepsis. Establishing accurate quantification methods for targeted phospholipid analysis is important for making these potential markers more clinically relevant....
Thu Oct 31, 2019 23:39
Publication date: Available online 31 October 2019Source: International Journal of PharmaceuticsAuthor(s): Mohammadjavad Jahanshahi, Elaheh Kowsari, Vahid Haddadi-Asl, Mehdi Khoobi, Jong Hyun Lee, Firoz Babu Kadumudi, Sepehr Talebian, Nazila Kamaly, Mehdi MehraliAbstractFluorinated graphene has recently gained much attention for cancer drug delivery, owing to its peculiar properties including high electronegativity difference, magnetic resonance imaging contrast agent, and the photothermal effect....
Thu Oct 31, 2019 23:39
Publication date: Available online 31 October 2019Source: International Journal of PharmaceuticsAuthor(s): Hongxia Tang, Danfei Chen, Chaoqun Li, Caihong Zheng, Xiaodong Wu, Yue Zhang, Qianqian Song, Weidong FeiAbstractHepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths. Unfortunately, there is still no completely effective treatment. Ferroptosis could affect the development of HCC by regulating the level of glutathione (GSH), intracellular lipid peroxidation, and...
Thu Oct 31, 2019 23:39
We report the self-assembly of anti-cancer drug-loaded solid lipid nanoparticles (SLNs) from spray dried microparticles comprising poly(vinylpyrrolidone) (PVP) loaded with glyceryl tristearate (GTS) and either indomethacin (IMC) or 5-fluorouracil (5-FU). When the spray dried microparticles are added to water, the PVP matrix dissolves and the GTS and drug self-assemble into SLNs. The SLNs provide a non-toxic delivery platform for both hydrophobic (indomethacin) and hydrophilic (5-fluorouracil) drugs....
Thu Oct 31, 2019 23:39
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Yanqi Wen, Silin Zhang, Jing Yang, Duanying GuoAbstractCervical cancer (CC) is one of the most common cancers in women. However, copy number alteration (CNA)-driven dysregulated genes and their functions in CC are still rarely investigated. In the present study, we conducted integrative analysis of CNA and gene expression data from The Cancer Genome Atlas (TCGA) cervical cancer to identify dysregulated...
Thu Oct 31, 2019 23:39
Communication and resolution programs emphasize transparency, patient-centeredness, and learning when a harm event has occurred.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Thu Oct 31, 2019 22:29
(Source: The Doctors Lounge - Oncology)
Thu Oct 31, 2019 18:00
Overall survival significantly longer, percentage of remission higher than with salvage chemotherapy (Source: The Doctors Lounge - Oncology)
Thu Oct 31, 2019 18:00
Long - term outcomes similar with, without sentinel lymph node biopsy in breast - conserving surgery (Source: The Doctors Lounge - Oncology)
Thu Oct 31, 2019 18:00
A new study shows that almost all postmenopausal women taking endocrine therapy to prevent breast cancer relapses report adverse effects on sexual function.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Thu Oct 31, 2019 15:39
Dr Mark Kris shares his disappointment that the recent FLAURA results did not evaluate progression-free survival, a parameter that means so much to patients.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Thu Oct 31, 2019 15:19
Treatment with SY-1425 in combination with azacitidine induced a 62% complete response rate with incomplete blood count recovery rate among unfit patients with RARA-positive AML. (Source: CancerNetwork)
Thu Oct 31, 2019 05:00
Using RNA sequencing for individual pediatric cancer cases could more effectively target gene expression in tumors. (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 05:00
A relatively enormous ‘protein scaffolding’ network that stabilizes and then fixes DNA damage was found to be a potential cause of cancer by a team of scientists in Denmark if the mechanism utilizing the proteins 53BP1 and RIF1 malfunctions. The resulting pathway could be the culprit behind some diseases, according t o the results reported in the journal Nature. (Source: CancerNetwork)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a...
Thu Oct 31, 2019 05:00
ConclusionsGKRS for BM from ovarian cancer is a safe and effective modality. Our findings are in agreement with the recent literature indicating that women with brain metastases from ovarian cancer will benefit with radiosurgery and may achieve long term survival with brain control. (Source: Reports of Practical Oncology and Radiotherapy)
Thu Oct 31, 2019 22:44
ConclusionsResults for 230 MeV protons show that with proposed BSA, proton beam current about 5.75 μA is required for this purpose. (Source: Reports of Practical Oncology and Radiotherapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Oct 31, 2019 22:44
Publication date: Available online 28 September 2019Source: Practical Radiation OncologyAuthor(s): Alexandra D. Dreyfuss, Michael Lariviere, Leslie K. Ballas, John P. PlastarasAbstractCell-based immunotherapies have the potential to redefine modern oncologic care, providing promising new treatments for patients with otherwise poor prognoses. Chimeric antigen receptor (CAR) T cell therapy has produced remarkable remission rates in patients with even the most treatment-refractory hematologic malignancies....
Thu Oct 31, 2019 22:44
Breast radiotherapy using a breast cup: moving the target, not the patient.: Breast cup radiotherapy
ConclusionUse of the breast cup in breast radiotherapy decreases dose to underlying organs at risk, and is cost effective. It can be easily integrated with DIBH, IMRT and VMAT techniques. With use of the device a supine patient position can be maintained, meaning nodal regions can be treated mono-isocentrically. (Source: Practical Radiation Oncology)
Thu Oct 31, 2019 22:44
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