ConclusionsPRDR radiation therapy with capecitabine was a well-tolerated and effective method for treating patients with recurrent breast cancer. Prospective studies are necessary to compare side effects and efficacy with conventional dose rate reirradiation and to evaluate the potential role for capecitabine in the recurrent setting. (Source: Practical Radiation Oncology)
Thu Oct 31, 2019 22:44
Publication date: Available online 11 October 2019Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Jennifer C. Zhao, Justin R. Arnall, Allison L. Martin, Saad Usmani, Shebli Atrash (Source: Hematology Oncology and Stem Cell Therapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 22:44
ConclusionThalidomide-based regimens are potential salvage treatment options for patients with RRMM, even with prior resistance to IMiDs. (Source: Clinical Lymphoma Myeloma and Leukemia)
Thu Oct 31, 2019 22:44
ConclusionOutpatient ASCT is a safe and feasible treatment strategy with low transplant-related mortality. Overall resource utilization is significantly lower than inpatient ASCT: however, this requires a multidisciplinary approach with close follow-up. (Source: Clinical Lymphoma Myeloma and Leukemia)
Thu Oct 31, 2019 22:44
Publication date: November 2019Source: Cancer Genetics, Volume 239Author(s): (Source: Cancer Genetics)
Thu Oct 31, 2019 22:44
Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s)
Publication date: Available online 30 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Joseph Carmicheal, Asish Patel, Vipin Dalal, Pranita Atri, Amaninder S. Dhaliwal, Uwe A. Wittel, Mokenge P. Malafa, Geoffrey Talmon, Benjamin J. Swanson, Shailender Singh, Maneesh Jain, Sukhwinder Kaur, Surinder K. BatraAbstractPancreatic ductal adenocarcinoma (PDAC) is an incredibly deadly disease with a 5-year survival rate of 6%. The presence of pancreatic cystic lesions...
Thu Oct 31, 2019 22:44
Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Urvi H. Gala, Dave A. Miller, Robert O. WilliamsAbstractThe treatment of cancer is still a major challenge. But tremendous progress in anticancer drug discovery and development has occurred in the last few decades. However, this progress has resulted in few effective oncology products due to challenges associated with anticancer drug delivery. Oral administration is the most...
Thu Oct 31, 2019 22:44
This study combines metabolomics and gut microbiota diversity analysis to explore metabolic changes using a rat model as well as the changes in intestinal flora composition. The results showed that amino acid metabolism was disturbed with serine, glutamate and glutamine being downregulated whilst glycine, hydroxyproline and alanine being upregulated. The combined glycine, serine and glutamate could predict hyperuricemia nephropathy with an area under the curve of 1.00. Imbalanced intestinal flora...
Thu Oct 31, 2019 22:44
In this study, to explore the active constituents of S. chinensis, we compared pharmacodynamics and chemical profiles in vitro/in vivo of EES/WES for the first time using multiple chemical analysis, pharmacological and data processing approaches. It was proved that there was no significant difference in the anti-depressive effects between WES and EES. However, the contents of most components in vitro and in plasma were higher in EES than those in WES, which was unconvincing for their similar efficacy....
Thu Oct 31, 2019 22:44
Conclusions: The rate of LR for patients with myxofibrosarcoma was high. The impact of RT on local tumor control was unclear. The surgical margin was important for both local and distant tumor control. Large tumor size was a risk factor for distant metastasis. PMID: 31662702 [PubMed] (Source: Sarcoma)
Thu Oct 31, 2019 22:05
Authors: Rampado R, Crotti S, Caliceti P, Pucciarelli S, Agostini M Abstract Colorectal cancer (CRC) is a diffused disease with limited therapeutic options, none of which are often curative. Based on the molecular markers and targets expressed by the affected tissues, numerous novel approaches have been developed to study and treat this disease. In particular, the field of nanotechnology offers an astonishingly wide array of innovative nanovectors with high versatility and adaptability...
Thu Oct 31, 2019 22:04
Conclusion: Since stage-specific survival is similar in Kuwait and the US, late stage at diagnosis is likely to be a major contributing factor to the overall lower survival in Kuwait than in the US. Increasing public awareness of cancer risk factors and symptoms and investment in early detection will be vital to reduce the proportion of patients diagnosed at a late stage and to improve survival. PMID: 31662756 [PubMed] (Source: Journal of Oncology)
Thu Oct 31, 2019 22:04
We report that IL-2R is expressed in cervical cancer cells. IL-2 decreases cervical cancer cell proliferation via transient arrest of the G1 phase, which does not result in apoptosis or senescence. IL-2 upregulates the expression of p53 and p21 and downregulates cyclin D. In addition, we report the resistance of cervical cancer cells to treatments that induce apoptosis in HeLa and INBL cells. When arrested cells were treated with cisplatin, the cytokine protected cells from apoptosis induced by cisplatin....
Thu Oct 31, 2019 22:04
Authors: Guo FF, Cui JW Abstract Earlier studies on elucidating the role of lymphocytes in tumor immunity predominantly focused on T cells. However, the role of B cells in tumor immunity has increasingly received better attention in recent studies. The B cells that infiltrate tumor tissues are called tumor-infiltrating B cells (TIBs). It is found that TIBs play a multifaceted dual role in regulating tumor immunity rather than just tumor inhibition or promotion. In this article, latest research...
Thu Oct 31, 2019 22:04
Conclusions: IOUS improves staging in patients undergoing resection for CRLMs even in the era of liver-specific MRI. Intraoperative detection of new CRLMs negatively affects oncologic outcomes. PMID: 31662749 [PubMed] (Source: Journal of Oncology)
Thu Oct 31, 2019 22:04
Conclusion: Anti-PD-1 antibody-containing regimen was safe and effective in Chinese patients with advanced melanoma, and elevated CRP and ECOG score were independent factors predicting the efficacy of anti-PD-1 therapy. PMID: 31662753 [PubMed] (Source: Journal of Oncology)
Thu Oct 31, 2019 22:04
Authors: Hernández-Luna MA, López-Briones S, Luria-Pérez R Abstract Worldwide, neoplasms of the gastrointestinal tract have a very high incidence and mortality. Among these, colorectal cancer, which includes colon and rectum malignancies, representing both highest incidence and mortality. While gallbladder cancer, another neoplasm associated to gastrointestinal tract occurs less frequently. Genetic factors, inflammation and nutrition are important risk factors associated with colorectal...
Thu Oct 31, 2019 22:04
Authors: Zhu D, Fang C, He W, Wu C, Li X, Wu J Abstract We investigated the role of miR-181a in diffuse large B-cell lymphoma (DLBCL) and its potential target genes. miR-181a levels were lower in activated B-cell- (ABC-) like DLBCL cells than that in germinal center B-cell- (GCB-) like DLBCL cells. Overexpression of miR-181a in ABC-like DLBCL cell lines (OCI-LY10 and U2932) resulted in G0/G1 cell cycle arrest, increased apoptosis, and decreased invasiveness. miRNA target prediction programs...
Thu Oct 31, 2019 22:04
Authors: Tax G, Lia A, Santino A, Roversi P Abstract Endoplasmic reticulum glycoprotein folding quality control (ERQC) and ER-associated degradation (ERAD) preside over cellular glycoprotein secretion and maintain steady glycoproteostasis. When cells turn malignant, cancer cell plasticity is affected and supported either by point mutations, preferential isoform selection, altered expression levels, or shifts to conformational equilibria of a secreted glycoprotein. Such changes are crucial...
Thu Oct 31, 2019 22:04
Authors: Figueroa-Protti L, Soto-Molinari R, Calderón-Osorno M, Mora J, Alpízar-Alpízar W Abstract Gastric cancer (GC) is one of the most important malignancies worldwide because of its high incidence and mortality. The very low survival rates are mainly related to late diagnosis and limited treatment options. GC is the final clinical outcome of a stepwise process that starts with a chronic and sustained inflammatory reaction mounted in response to Helicobacter pylori infection. The bacterium...
Thu Oct 31, 2019 22:04
BOSTON (CBS)- Think you’re allergic to penicillin? Chances are…you’re not. In fact, more than 30 million people in the United States wrongly believe they’re allergic to penicillin. Many people report that they’re allergic to penicillin, or amoxicillin, or one of the other penicillin’s, often saying they’re mom told them they had some type of reaction when they were little. So many doctors turn to other types of antibiotics to treat common ailments like strep throat or ear infections, which may...
Wed Oct 30, 2019 22:57
Authors: El Alami Laaroussi A, Hia ME, Rachik M, Ghazzali R Abstract Despite advanced discoveries in cancerology, conventional treatments by surgery, chemotherapy, or radiotherapy remain ineffective in some situations. Oncolytic virotherapy, i.e., the involvement of replicative viruses targeting specific tumor cells, opens new perspectives for better management of this disease. Certain viruses naturally have a preferential tropism for the tumor cells; others are genetically modifiable to...
Thu Oct 31, 2019 21:37
Authors: Elgin Christo VR, Khanna Nehemiah H, Minu B, Kannan A Abstract A framework for clinical diagnosis which uses bioinspired algorithms for feature selection and gradient descendant backpropagation neural network for classification has been designed and implemented. The clinical data are subjected to data preprocessing, feature selection, and classification. Hot deck imputation has been used for handling missing values and min-max normalization is used for data transformation. Wrapper...
Thu Oct 31, 2019 21:37
Publication date: Available online 30 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): María Victoria Cano-Cortés, Saúl Abenhamar Navarro-Marchal, María Paz Ruiz-Blas, Juan José Díaz-Mochón, Juan Antonio Marchal, Rosario M. Sánchez-MartínAbstractA novel chemical-based orthogonal bioconjugation strategy to produce tri-functionalised nanoparticles (NPs) carrying doxorubicin (DOX), near-infrared cyanine dye (Cy7) and a homing peptide CRGDK, a peptide specifically binds...
Thu Oct 31, 2019 21:14
Publication date: Available online 31 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Ramin Khademi, Abolhassan RazminiaAbstractIn this research, an experimental validated predictive finite element model of a cancerous human eye is developed to investigate how the tumor cells in retinoblastoma can be selectively damaged in the course of laser irradiation. In the computational modeling, the tumor is assumed to be in the initial growth stages and located in the macular...
Thu Oct 31, 2019 21:14
Publication date: February 2020Source: Materials Science and Engineering: C, Volume 107Author(s): GU Preethi, J Sreekutty, BS Unnikrishnan, MG Archana, HP Syama, Mohan Deepa, R Shiji, KS Anusree, TT SreelekhaAbstractA variety of naturally derived and synthetic biomaterial scaffolds have been investigated as 3D environments for supporting cell growth and can be used to achieve drug delivery with high loading efficiency. Polysaccharides which enhance the tumour-specific drug release are ideal candidates...
Thu Oct 31, 2019 21:11
Publication date: February 2020Source: Materials Science and Engineering: C, Volume 107Author(s): Julia C. Fontoura, Christian Viezzer, Fabiana G. dos Santos, Rosane A. Ligabue, Ricardo Weinlich, Renato D. Puga, Dyeison Antonow, Patricia Severino, Cristina BonorinoAbstractIn vitro drug screening is widely used in the development of new drugs, because they constitute a cost-effective approach to select compounds with more potential for therapy. They are also an attractive alternative to in vivo testing....
Thu Oct 31, 2019 21:11
Previous research showed that family caregiver's perception of burden can influence patient's report on their quality of life (QoL). The present study investigated the relationship between the two variables by considering the role of patient's anxiety and depression. A total of 382 dyads of Chinese breast cancer patients and their family caregivers participated in this study. The results showed that the mediation model fitted the data well (χ2 = 49.859; df = 16; χ2/df = 3.116; RMSEA = 0.05; TLI =...
Thu Oct 31, 2019 21:09
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Linda Schadt, Colin Sparano, Nicole Angelika Schweiger, Karina Silina, Virginia Cecconi, Giulia Lucchiari, Hideo Yagita, Emilien Guggisberg, Sascha Saba, Zuzana Nascakova, Winfried Barchet, Maries van den BroekSummarySensing of cytoplasmic DNA by cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) results in production of the dinucleotide cGAMP and consecutive activation of stimulator of...
Thu Oct 31, 2019 21:05
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Qingqing Yan, Emily J. Shields, Roberto Bonasio, Kavitha SarmaSummaryR-loops are three-stranded DNA:RNA hybrids that are implicated in many nuclear processes. While R-loops may have physiological roles, the formation of stable, aberrant R-loops has been observed in neurological disorders and cancers. Current methods to assess their genome-wide distribution rely on affinity purification, which is plagued by large input...
Thu Oct 31, 2019 21:05
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Sander Tuit, Camilla Salvagno, Theodore S. Kapellos, Cheei-Sing Hau, Lea Seep, Marie Oestreich, Kathrin Klee, Karin E. de Visser, Thomas Ulas, Joachim L. SchultzeSummaryTumor-associated macrophages (TAMs) are frequently the most abundant immune cells in cancers and are associated with poor survival. Here, we generated TAM molecular signatures from K14cre;Cdh1flox/flox;Trp53flox/flox (KEP) and MMTV-NeuT (NeuT) transgenic...
Thu Oct 31, 2019 21:05
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Aishwarya Pawar, Paradesi Naidu Gollavilli, Shaomeng Wang, Irfan A. Asangani (Source: Cell Reports)
Thu Oct 31, 2019 21:05
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. MurphySummaryGlutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate...
Thu Oct 31, 2019 21:05
In conclusion, our findings indicate that miR‑486 may serve as a novel prognostic biomarker but may also be applied as a new therapeutic approach for the treatment of RCC. PMID: 31661131 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 20:52
Cannabinoid receptor 2‑selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord. Mol Med Rep. 2019 Oct 25;: Authors: Mao Y, Huang Y, Zhang Y, Wang C, Wu H, Tian X, Liu Y, Hou B, Liang Y, Rong H, Gu X, Ma Z Abstract Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although cannabinoid receptor 2 (CB2) agonists may have an analgesic effect, the underlying...
Thu Oct 31, 2019 20:52
In conclusion, these results indicated that miR‑593 may act as a tumor suppressor in NSCLC to decelerate cancer aggressiveness by inhibiting SLUG expression. PMID: 31661137 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Thu Oct 31, 2019 20:52
In conclusion, a prognostic risk model for HCC is proposed based on the bioinformatic analysis of methylation‑driven genes. The findings of the present study may improve understanding of the pathogenesis and prognosis of HCC. PMID: 31661127 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Thu Oct 31, 2019 20:52
In conclusion, serum miR‑508‑3p and miR‑885‑5p are novel potential biomarkers for the diagnosis of ccRCC. PMID: 31661117 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Thu Oct 31, 2019 20:52
Authors: Hu L, Li H, Lee ED, Grandis JR, Bauman JE, Johnson DE Abstract Patients who have undergone curative‑intent therapy for head and neck squamous cell carcinoma (HNSCC) exhibit a high rate of development of second primary tumors (SPTs), which are frequently lethal. A chemoprevention strategy that prevents SPTs would have a major impact on patient outcomes. Sulforaphane, a naturally‑occurring compound derived from cruciferous vegetables exhibits chemopreventive activity against HNSCC...
Thu Oct 31, 2019 20:52
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