Our meta-analysis of several ethnic groups (Japanese, Korean, Indian, Brazilian) revealed a significant genome-wide association between cold medicine-related SJS/TEN (CM-SJS/TEN) with severe ocular complicatio...
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Background Wide variations in revision endoscopic sinus surgery (ESS) rates for chronic rhinosinusitis with nasal polyposis (CRSwNP) have been reported. It is important to understand expected revision rates and factors that impact the need for revision. Methods A literature search was conducted on PubMed, Scopus, and the Cochrane Database of Systematic Reviews. Following PRISMA guidelines, a systematic review and meta‐analysis was performed on studies that reported revision surgery data for...
Thu Nov 21, 2019 12:49
Background Olfactory dysfunction is one of the common symptoms of eosinophilic chronic rhinosinusitis (ECRS), for which endoscopic sinus surgery (ESS) is the standard treatment. Although the success rates of ESS for restoring olfaction in CRS have been reported, those for ECRS, as defined by new Japanese diagnostic criteria, remain unclear and the parameters affecting improvement rates have not yet been identified. Methods Eighty‐four patients with ECRS who underwent full‐house ESS were retrospectively...
Thu Nov 21, 2019 12:48
A long-term goal of clinical care has always been to fit the specific treatment to the individual patient—what we would now call personalized medicine. However, the ability to predict which patient will best respond to which treatment has historically been nearly impossible. Accordingly, personalized medicine has typically involved significant trial and error with different therapies until desired clinical results are achieved. Fortunately for both patients and physicians, this paradigm has begun...
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Environmental nonallergenic exposures, such as microbes and air pollutants, are thought to influence the clinical manifestations of allergic and atopic disease. However, as patterns of urbanization, climate change, and socioeconomic health disparities persist, the health effects of the envirome are increasingly relevant to practitioners and policymakers. In this issue of Annals, Peden1 outlines the influence of pollutant, infectious, and psychosocial conditions on the incidence and severity of allergic...
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The goal of personalized medicine is arguably as old as medicine itself,1 and the promise of using simultaneously broad (all genes and all exposures), precise (single molecules or cells), and unbiased (not dependent on prior knowledge) data sets to tailor clinical care is the compelling objective of systems biology as applied to medicine. In this issue, Virkud et al2 present a useful and informative overview of the “big data” domains, including genomics, epigenomics, transcriptomics, and proteomics...
04:37
Urticaria is characterized by the appearance of hives or angioedema.1 Chronic urticaria is defined by urticarial episodes that last more than 6 weeks, occurring daily or several times per week.2 Although acute urticaria is commonly associated with infections,3 most cases of chronic urticaria have no identifiable cause. Nevertheless, several reports documented chronic urticaria from infectious causes including Helicobacter pylori.4 Studies show association of upper respiratory infections, including...
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Omalizumab improves clinical outcomes in patients with asthma. Several studies have shown lung function improvements with omalizumab; however, this has not been examined exclusively in adolescents.
Thu Nov 21, 2019 02:00
For this month’s Annals the three recent reviews for ‘From pages of Allergy Watch’ focused on articles about anaphylaxis. The first article reviews a prospective cohort study evaluating potential predictors of severe reactions after Hymenoptera stings. The next article cites data from a large US claims database to predict patients at risk for recurrent ED visits for anaphylaxis. The last review analyzed data from the European Anaphylaxis Registry finding that only 27% of patients received epinephrine...
Thu Nov 21, 2019 02:00
Publication date: Available online 20 November 2019Source: Allergology InternationalAuthor(s): Antonella Muraro, David Alejandro Mendoza HernandezAbstractThere is an increasing public concern on food allergy and related anaphylactic reactions that occur mainly at the community level. The perception of the disease is huge among parents who believe that 1 out of 20 children suffers from severe food allergy. The discrepancy between this self-reported prevalence and the real one when a food challenge...
Thu Nov 21, 2019 17:52
Publication date: Available online 20 November 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Seema Aceves, Margaret H. Collins, Marc E. Rothenberg, Glenn T. Furuta, Nirmala Gonsalves, Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)AbstractRecent advances in rare diseases research are accelerated by the work of consortia that have been supported by the National Institutes for Health. Development of such consortia rely on multi-disciplinary relationships and...
Thu Nov 21, 2019 17:30
Publication date: Available online 21 November 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Leonard Bielory, Luis Delgado, Constance H. Katelaris, Andrea Leonardi, Nelson Rosario, Pakit VichyanoudAbstract: 19-09-0439R1Ocular allergy (OA), interchangeably known as allergic conjunctivitis, is a common immunological hypersensitivity disorder affecting up to 40% of the population. OA has been increasing in frequency with symptoms of itching, redness, and swelling that significantly...
Thu Nov 21, 2019 16:47
Thu Nov 21, 2019 14:41
Thu Nov 21, 2019 11:53
Abstract A recent survey of the European Academy of Allergy and Clinical Immunology (EAACI) Drug Allergy Interest Group (DAIG) on how European allergy specialists deal with beta‐lactam (BL) hypersensitivity demonstrated a significant heterogeneity in current practice, suggesting the need to review and update existing EAACI guidelines in order to make the diagnostic procedures as safe and accurate, but also as cost‐effective, as possible. For this purpose, a bibliographic search on large studies...
Thu Nov 21, 2019 11:24
Abstract Background Transforming growth factor β1 (TGFβ1) is a cytokine that exerts immunosuppressive functions, as reflected by its ability to induce regulatory T (Treg) cell differentiation and inhibit Th1 and Th2 responses. Hence, peptides that mimic the active core domain of TGFβ1 may be promising candidates for modulation of the allergic response. This study aimed to investigate a synthetic TGFβ1 mimetic peptide (TGFβ1‐mim) for its ability to modulate the immune response during allergic...
Wed Nov 20, 2019 18:39
Abstract Background The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Cell‐free eosinophil granules are found in tissues in eosinophilic diseases, including asthma. This suggests that eosinophils have lysed and released cellular content, likely harming tissues. Objective The present study explores the mechanism of CD32‐ and αMß2 integrin‐dependent eosinophil cytolysis of IL3‐primed blood eosinophils seeded on heat‐aggregated immunoglobulin...
Thu Nov 21, 2019 12:06
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