The Neck Imaging Reporting and Data System (NI‐RADS) was conceived in 2016 with the objective of standardizing assessment and reporting in surveillance imaging for patients with head and neck squamous cell carcinomas and their subsequent management. The goals are to simplify radiology reports while increasing the consistency and accuracy of the interpretation of cancer surveillance imaging; enable better communication among clinicians and between clinicians and patients; facilitate outcomes research;...
Thu Nov 21, 2019 16:29
Background Hürthle cell metaplasia is common in hyperplastic nodules, particularly within the setting of lymphocytic thyroiditis (LT). The Bethesda System for Reporting Thyroid Cytopathology indicates that it is acceptable to classify Hürthle cell–predominant fine‐needle aspiration (HC FNA) specimens as atypia of undetermined significance (AUS) rather than suspicious for a Hürthle cell neoplasm (HUR) within the setting of multiple nodules or known LT. The goal of the current study was to address...
Thu Nov 21, 2019 16:28
Thu Nov 21, 2019 16:26
Background Liquid biopsy using cell‐free DNA (cfDNA) presents new opportunities for solid tumor genotyping. While studies have demonstrated the utility of cfDNA from plasma, cfDNA from other body fluids remains underexplored. Methods We evaluated the molecular features and clinicopathologic correlates of cfDNA from serous body cavity fluids by performing hybrid capture‐based next‐generation sequencing (NGS) on cfDNA isolated from residual effusion supernatants. Twenty‐one serous effusions...
Thu Nov 21, 2019 16:24
Abstract To evaluate the diagnostic performance and clinical significance of 4 systems of substaging cases with non-muscle invasive urothelial bladder carcinoma. In addition 4 cutoff measures were evaluated for prediction of muscularis-mucosa invasion. Four substaging systems were applied to 57 NMIBC cases to assess which of these reported methods correlates best with recurrence and progression. On univariate regression analysis patients having tumor size more than 3 cm, solid...
Thu Nov 21, 2019 02:00
Heart failure with preserved ejection fraction is a relatively new entity in cardiac research. Here, we used a large animal model to analyze differential morphological changes across the left ventricular wall. Our data support the concept that the subendocardial interstitium plays a pivotal role in the pathophysiology of heart failure with preserved ejection fraction. Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction. This study aimed to analyze...
Thu Nov 21, 2019 18:23
Zusammenfassung Mutierte Gene der RAS(Rattensarkomvirus Protein)-Familie gehören zu den am häufigsten mutierten Genen, die als sog. Treiber Pathogenese und Therapieansprechen von Tumoren beeinflussen. Aufgrund der Entdeckung des malignen Potenzials zellulärer, mutierter RAS-Gene vor mehr als 3 Jahrzehnten und der intensiven Grundlagenforschung zur Biologie und Funktion ihrer Genprodukte gehören sie zu den am besten untersuchten Krebsgenen. Trotz der hohen klinischen Relevanz sind...
Thu Nov 21, 2019 02:00
Zusammenfassung Michael Mihatsch, 1943 in Gleiwitz geboren, studierte Medizin in Bonn und Freiburg und ging danach nach Basel, um eine Pathologieausbildung zu beginnen. An der Universität Basel wurde er 1978 Assistenzprofessor und leitete von 1988 bis 2007 das dortige Institut. Mihatsch machte Basel zu einem Zentrum für angehende Nierenpathologen. Seine bedeutendste Leistung ist die Beschreibung des Zusammenhangs zwischen Phenacetin-Einnahme und Nephropathie...
Thu Nov 21, 2019 02:00
Zusammenfassung Die Sertoli-Zellen (SZ) spielen bereits in der embryonalen Phase eine zentrale Rolle in der Genese männlicher Geschlechtsorgane und postpubertär in der Erhaltung der normalen Spermatogenese. Für letztere ist vor allem die von den SZ gebildete Blut-Hoden-Schranke wichtig. Sie trennt die an der Basis der Hodenkanälchen gelegenen Spermatogonien von denen im adluminalen Bereich gelegenen meiotischen Keimzellen. Zwei benachbarten SZ werden von Tight Junctions dicht aneinandergebunden...
Thu Nov 21, 2019 02:00
Although microRNAs (miRNAs) play an important role in invasive tumor lesions, which involve cancer tissues mixed with stromal tissues, the differences in miRNA expression between cancer and stromal cells remain unclear. We selected 13 miRNAs and examined their differential expression patterns in cancer gland cells and surrounding stromal cells isolated from 24 colorectal cancer (CRC) specimens using a crypt isolation method. Although six miRNAs were upregulated in gland cells, only three were upregulated...
Thu Nov 21, 2019 13:19
SUMMARY It was Sunao Tawara who, in 1906, established the foundations for knowledge of the arrangement of the atrioventricular conduction axis in man and other mammals. Study of the hearts of ungulates was a central part in his investigation, which assessed other species, including man. He described several subtle differences between the mammals. We have now ourselves studied the cardiac conduction tissue of the ox heart, comparing our findings with our knowledge of the arrangement in man, and providing...
Thu Nov 21, 2019 12:39
Introduction The superior frontal gyrus (SFG) is an important region implicated in a variety of tasks including motor movement, working memory, resting‐state and cognitive control. A detailed understanding of the subcortical white matter of the SFG could improve post‐operative morbidity related to surgery around this gyrus. Through DSI‐based fiber tractography validated by gross anatomical dissection, we characterized the fiber tracts of the SFG based on their relationships to other well‐known neuroanatomic...
Thu Nov 21, 2019 12:39
Discussion is on‐going concerning the need to ensure the clinical relevance of the biomedical sciences. However, clinical relevance within health care courses presupposes that there is internationally agreed core material to be taught and learned. For anatomy, by the initial use of Delphi Panels that comprise anatomists, scientists and clinicians, the International Federation of Associations of Anatomists (IFAA) is developing internationally accepted core syllabuses for all anatomical sciences disciplines...
Thu Nov 21, 2019 12:39
Few neuroimaging anatomic studies to date have investigated in detail the point of entry of cortical bridging veins (CBVs) into the superior sagittal sinus (SSS). Although we know that most CBVs join the SSS at an acute angle opposite to the direction of SSS blood flow, the three‐dimensional (3‐D) spatial configuration of these venous confluences has not been studied previously. This anatomical information would be pertinent to several clinically applicable scenarios, such as in planning intracranial...
Thu Nov 21, 2019 12:39
The direct insertion of an enthesis is composed of uncalcified fibrocartilage (FC) and calcified FC, believed to function as buffers for multi‐directional forces applied to the ligament. This study was performed to investigate the relationship between the fibrocartilage thickness and bony trabecular orientation of the anterior cruciate ligament (ACL) on both the femoral and tibial sides. Six cadavers were examined (age at death: 73‐92 y). Both femoral and tibial insertions of the ACL were harvested...
Thu Nov 21, 2019 12:39
Introduction The aim of this study was to investigate the intersection point of the radial artery with Henry's approach. Material/Methods Ninety forearms from adult human cadavers which had been embalmed using Thiel's method underwent dissection. Henry's approach was performed alongside the whole length of the forearm and the radial artery's course was investigated. Its crossing point with the approach was identified and the distance from this point to the radial styloid process was determined....
Thu Nov 21, 2019 12:39
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