Nature Communications, Published online: 20 November 2019; doi:10.1038/s41467-019-13379-9Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
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Nature Communications, Published online: 20 November 2019; doi:10.1038/s41467-019-13097-2Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
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Nature Communications, Published online: 20 November 2019; doi:10.1038/s41467-019-13370-4Author Correction: Competitive endogenous RNA is an intrinsic component of EMT regulatory circuits and modulates EMT
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Nature Communications, Published online: 20 November 2019; doi:10.1038/s41467-019-13390-0Author Correction: The importance of Antarctic krill in biogeochemical cycles
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Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-12424-xFrom observational studies, alcohol consumption behaviours are known to be correlated in spouses. Here, Howe et al. use partners’ genotypic information in a Mendelian randomization framework and show that a SNP in the ADH1B gene associates with partner’s alcohol consumption, suggesting that alcohol consumption affects mate choice.
Tue Nov 19, 2019 02:00
Tue Nov 19, 2019 02:00
Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-13007-6Multiplexed genome engineering with Cas9 can increase efficiency but also the risk of unintended alterations. Here the authors demonstrate the use of multiplexed base editors on primary T cells with reduced translocation frequency.
Tue Nov 19, 2019 02:00
Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-13155-9Determining the structure-property relationship responsible for charge transport in organic semiconductors remains a challenge. Here, the authors, through spectroscopic & microscopic studies on organic transistors, report the intrinsic factors that affect charge transport in polymer semiconductors.
Tue Nov 19, 2019 02:00
Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-13089-2Cervicovaginal inflammation and human papillomavirus (HPV) are separately associated with increased risk of HIV acquisition. Here the authors longitudinally profile 48 cervicovaginal cytokines and HPV status in a large observational HIV high-risk cohort, and show the same cytokines associate with HPV infection and HIV risk.
Tue Nov 19, 2019 02:00
Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-12996-8The ERK signalling pathway is activated in many cancers, however ERK1 and ERK2 are difficult to target pharmacologically. Here, the authors identify a small molecule inhibitor that binds covalently to the D-recruitment site of ERK and induces cell death and reduces tumour growth in mice.
Tue Nov 19, 2019 02:00
Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-12928-6Drug target identification is a crucial step in drug development. Here, the authors introduce a Bayesian machine learning framework that integrates multiple data types to predict the targets of small molecules, enabling identification of a new set of microtubule inhibitors and the target of the anti-cancer molecule ONC201.
Tue Nov 19, 2019 02:00
Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-12997-7While single-atom catalysis offers an efficient materials usage, the ambiguous interactions with supports poses a difficulty in understanding catalytic performances. Here, authors show an ensemble effect via synergy of Co adatoms and the S of MoS2 supports to boost hydrogen evolution activities.
Tue Nov 19, 2019 02:00
Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-13035-2Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.
Tue Nov 19, 2019 02:00
Nature Communications, Published online: 19 November 2019; doi:10.1038/s41467-019-13045-0Perception of red and far-red light by photosensory phytochromes regulates plant development and adaptive responses to light. Here, Legris et al. review current models of phytochrome function connecting light-induced conformational changes to physiological outputs and highlight open questions for future research.
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