Analytical ChemistryDOI: 10.1021/acs.analchem.9b03731 (Source: Analytical Chemistry)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Nov 11, 2019 06:00
ConclusionsErroneous provider interpretation of UDT results, infrequent documentation of interpretation, lack of communication of results to patients, and prescription refills despite inaccurate interpretations are common. Expert assistance with urine toxicology interpretations may be needed to improve provider accuracy when interpreting toxicology results. (Source: Journal of General Internal Medicine)
Mon Nov 11, 2019 00:00
Nature Reviews Urology, Published online: 11 November 2019; doi:10.1038/s41585-019-0251-xIn this Review, Morris et al. summarize the mechanisms through which 223Ra exerts its biological effects in metastatic castration-resistant prostate cancer, discuss potential 223Ra combination therapies and provide future perspectives for targeted alpha-particle therapy. (Source: Nature Reviews Urology)
Mon Nov 11, 2019 00:00
To assess which patients respond best following cytoreductive nephrectomy for renal cell carcinoma (RCC) with sarcomatoid dedifferentiation (sRCC) and whether outcomes are improving over time. (Source: Urology)
Mon Nov 11, 2019 00:00
ConclusionIn renal cell carcinoma, rapid and successful drug development has resulted in multiple treatment options, requiring careful decision making for individual patients and have emphasized how newly developed therapies work. (Source: International Urology and Nephrology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Mon Nov 11, 2019 23:41
ConclusionsUnmarried men are at higher risk of not benefiting of cytoreductive nephrectomy, metastasectomy, or systemic therapy than their married counterparts. Unmarried women are at higher risk of not benefiting of cytoreductive nephrectomy or systemic therapy. These gender-related differences cumulate in higher CSM in unmarried men, but not in unmarried women. (Source: International Urology and Nephrology)
Mon Nov 11, 2019 23:41
This study aimed to establish a new selection criterion for liver resection in HCC. (Source: Surgery)
Mon Nov 11, 2019 00:00
ConclusionsPatients with a low PMI experienced an increased incidence of hematological and non-hematological toxicities during preoperative chemotherapy for gastric cancer. Clinicians should be aware of these risks in this population. (Source: Surgery Today)
Mon Nov 11, 2019 00:00
ConclusionsAlthough postoperative pneumonia is associated with many clinical variables, active medical intervention for the prevention of pneumonia in patients with multiple risk factors can improve the postoperative course. In particular, perioperative nutritional care may prevent postoperative pneumonia in patients with malnutrition and a poor PS. (Source: Surgery Today)
Mon Nov 11, 2019 00:00
AbstractArsenic (As) is a potentially toxic and carcinogenic metalloid. It has gained considerable attention owing to its high ecotoxic nature. High As contamination of groundwater in scattered areas is the current status of Pakistan. A number of assessments exist for the As contamination of the drinking water in District Vehari, Pakistan. However, there is scarcity of data about As contents in drinking water of health facilities and healthcare centers in District Vehari. The current study, therefore,...
Mon Nov 11, 2019 00:00
ConclusionQOL scores in Indian women did not differ significantly between MRM and BCT in the long term. Both options are acceptable in the study setting. (Source: Quality of Life Research)
Mon Nov 11, 2019 00:00
Authors: Dart Arisan Owen Hao Jiang Uysal-Onganer Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer, proving difficult to manage clinically. Wnt-11, a developmentally regulated gene producing a secreted protein, has been associated with various carcinomas but has not previously been studied in PDAC. The present study aimed to elucidate these aspects first in vitro and then in a clinical setting in vivo. Molecular analyses of Wnt-11 expression...
Mon Nov 11, 2019 00:00
Gene Therapy, Published online: 11 November 2019; doi:10.1038/s41434-019-0108-1Long noncoding RNA RBMS3-AS3 acts as a microRNA-4534 sponge to inhibit the progression of prostate cancer by upregulating VASH1 (Source: Gene Therapy)
Mon Nov 11, 2019 00:00
Cell Death & Disease, Published online: 11 November 2019; doi:10.1038/s41419-019-2090-3Long noncoding RNA LINC00518 acts as a competing endogenous RNA to promote the metastasis of malignant melanoma via miR-204-5p/AP1S2 axis (Source: Cell death and disease)
Mon Nov 11, 2019 00:00
ConclusionPET/CT-guided molecular biopsy using Ga-68 labelled radiotracers is feasible and can be performed safely and accurately with a high-diagnostic yield. It is helpful in accurately staging the disease when tracer-avid isolated distant lesion evident on imaging and highly practical in patients with previous inconclusive sampling. (Source: Diagnostic and Interventional Imaging)
Mon Nov 11, 2019 22:37
ConclusionsMRI may offer more superior diagnostic performance than CT for detecting T3-4 disease and EMVI, thereby supporting its alternative application to CT in local staging of colon cancer. (Source: European Journal of Radiology)
Mon Nov 11, 2019 22:36
Authors: de Azevedo JTC, Mizukami A, Moço PD, Malmegrim KCR Abstract CAR-T cell immunotherapy is a promising therapeutic modality for cancer patients. The success of CAR-T cell therapy has been associated with the phenotype, activation and functional profiling of infused CAR-T cells. Therefore, immunophenotypic characterization of CAR-T cells during bioprocess is crucial for cell quality control and ultimately for improved antitumor efficacy. In this chapter, we propose a flow cytometry...
Mon Nov 11, 2019 22:23
Authors: Chicaybam L, Abdo L, Bonamino MH Abstract Adoptive immunotherapy of cancer using T cells expressing chimeric antigen receptors (CARs) is now an approved treatment for non-Hodgkin lymphoma (NHL) and B cell acute lymphoblastic leukemia (B-ALL), inducing high response rates in patients. The infusion products are generated by using retro- or lentiviral transduction to induce CAR expression in T cells followed by an in vitro expansion protocol. However, use of viral vectors is cumbersome...
Mon Nov 11, 2019 22:23
Authors: Schwab RD, Bedoya DM, King TR, Levine BL, Posey AD Abstract Chimeric antigen receptor (CAR) T cell therapies are ex vivo manufactured cellular products that have been useful in the treatment of blood cancers and solid tumors. The quality of the final cellular product is influenced by several amenable factors during the manufacturing process. This review discusses several of the influences on cell product phenotype, including the raw starting material, methods of activation and...
Mon Nov 11, 2019 22:23
Authors: Nacasaki Silvestre R, Moço PD, Picanço-Castro V Abstract Immunotherapy using T cells modified with chimeric antigen receptor (CAR) has been proven effective in the treatment of leukemia and lymphomas resistant to chemotherapy. Recent clinical studies have shown excellent responses of CAR-T cells in a variety of B cell tumors. However, it is important to validate in vitro activity of these cells, though different sorts of assays, which are capable of measuring the cytotoxic potential...
Mon Nov 11, 2019 22:23
Authors: Cornetta K, Koop S, Nance E, House K, Duffy L Abstract Lentiviral vectors are being used in a growing number of clinical applications, including T cell immunotherapy for cancer. As this new technology moves forward, a safety concern is the inadvertent recombination and subsequent development of a replication-competent lentivirus (RCL) during the manufacture of the vector material. To assess this risk, regulators have required screening of T cell products infused into patients for...
Mon Nov 11, 2019 22:23
Authors: Picanço-Castro V, Swiech K, Malmegrim KCR, Covas DT Abstract Immunotherapy has been growing in the past decade as a therapeutic alternative for cancer treatment. In this chapter, we deal with CAR-T cells, genetically engineered autologous T cells to express a chimeric receptor specific for an antigen expressed on tumor cell surface. While this type of personalized therapy is revolutionizing cancer treatment, especially B cell malignancies, it has some challenging limitations. Here,...
Mon Nov 11, 2019 22:23
Authors: Androulla MN, Lefkothea PC Abstract Chimeric antigen receptor (CAR) cancer immunotherapy uses autologous immune system's cells, genetically modified, to reinforce the immune system against cancer cells. Genetic modification is usually mediated via viral transfection, despite the risk of insertional oncogenesis and off target side effects. In vitro-transcribed (IVT)-mRNA-mediated transfection could contribute to a much safer CAR therapy, since IVT-mRNA leaves no ultimate genetic...
Mon Nov 11, 2019 22:23
Authors: de Souza Fernandes Pereira M, Fantacini DMC, Picanço-Castro V Abstract Immunotherapy has been showed as a promisor treatment, in special for hematological diseases. Chimeric antigen receptor T cells (CARs) which are showing satisfactory results in early-phase cancer clinical trials can be highlighted. However, preclinical models are critical steps prior to clinical trial. In this way, a well-established preclinical model is an important key in order to confirm the proof of principle....
Mon Nov 11, 2019 22:23
Authors: Leyton-Castro NF, Brigido MM, Maranhão AQ Abstract CAR-T cell therapy emerged in the last years as a great promise to cancer treatment. Nowadays, there is a run to improve the breadth of its use, and thus, new chimeric antigen receptors (CAR) are being proposed. The antigen-binding counterpart of CAR is an antibody fragment, scFv (single chain variable fragment), that recognizes a membrane protein associated to a cancer cell. In this chapter, the use of human scFv phage display...
Mon Nov 11, 2019 22:23
ABSTRACT An unusual case of intraosseous mucoepidermoid carcinoma is reported in a 22-year-old female, located in the posterior maxilla region. The article summarizes the main characteristics of the disease, including clinical-pathologic characteristics, treatment and prognosis.RESUMEN Reportamos un caso raro de carcinoma epidermoide intra óseo ubicado en región posterior de la maxila en una paciente de 22 años de edad. El artículo resume las principales características del proceso neoplásico, incluyendo...
Mon Nov 11, 2019 22:02
We report a clinical case of BCC, with a bibliographical review, highlighting the clinical similarity of such malignant tumor with other benign and malignant tumors of the skin, besides the importance of dermoscopy for the diagnostic aid.RESUMEN El carcinoma basocelular (CBC) polipoide es un tumor raro, considerado como una variante cl ínica e histopatológica del CBC nodular. Presenta amplia base exofítica o pedunculada que se une a la superficie de la piel y exhibe, histopatológicamente, las agregaciones...
Mon Nov 11, 2019 22:02
ABSTRACT A 52-year-old male patient complained of loss of sensitivity and pain in the maxilla. After examination, root canal treatment of tooth 12 was requested. Subsequently, there was a purplish increased volume of softened consistency in the area of vestibular attached gingiva of tooth 12. The anterior upper dental segment presented mobility. Incisional biopsy revealed malignant neoplasm of glandular epithelial origin, suggestive of solid adenoid cystic carcinoma (ACC). An immunohistochemical...
Mon Nov 11, 2019 22:02
ABSTRACT Ameloblastic carcinoma (AC) is a rare odontogenic tumor that represents the malignant counterpart of an ameloblastoma. There are few cases of AC in the English-language literature, with only 16 cases arising from preexisting ameloblastomas reported in the last 10 years. Multiple local recurrences of ameloblastomas precede this transformation. In the current report, we describe a case of AC at the posterior maxilla in a 42-year-old female submitted to surgical resection, with three recurrences...
Mon Nov 11, 2019 22:02
ABSTRACT Carcinoma cuniculatum (CC), a rare variant of oral squamous cell carcinoma, presents well-differentiated neoplastic epithelial cells infiltrating the underlying submucosal or bone tissues, forming the so-called "rabbit burrows" filled with keratin. A 67-year-old female patient was referred complaining of a painless tumoral mass in the left mandibular body, with several months of evolution. Previous history indicated extraction of the teeth #37 and #38 and diagnosis of chronic suppurative...
Mon Nov 11, 2019 22:02
ABSTRACT Squamous cell carcinoma is a malignant neoplasm that affects the structures and tissues of the oral cavity. Interleukins (IL) synthesized from a tumor modulate a cascade reaction that may influence the prognosis of the disease. We aim to investigate in the literature whether interleukins are mediators that negatively or positively influence the prognosis of patients with oral squamous cell carcinoma. A systematic review study was performed according to the Preferred Reporting Items for Systematic...
Mon Nov 11, 2019 22:02
AbstractPurpose of ReviewThe purpose of this review is to explore the role of monocyte chemoattractant protein-1 (MCP-1 or CCL2) in the processes that underpin bone remodelling, particularly the action of osteoblasts and osteoclasts, and its role in the development and metastasis of cancers that target the bone.Recent FindingsMCP-1 is a key mediator of osteoclastogenesis, being the highest induced gene during intermittent treatment with parathyroid hormone (iPTH), but also regulates catabolic effects...
Mon Nov 11, 2019 00:00
Gynecologic Care for Women With Physical Disabilities: A Qualitative Study of Patients and Providers
Women with physical disabilities have unmet gynecologic care needs, including disparities in cancer screening and contraceptive care, when compared with women without physical disabilities. Our objective was to qualitatively assess provider and patient perspectives regarding barriers to gynecologic health care for women with physical disabilities. (Source: Womens Health Issues)
Mon Nov 11, 2019 00:00
European Journal of Clinical Nutrition, Published online: 11 November 2019; doi:10.1038/s41430-019-0527-5Effects of enteral nutritional rich in n-3 polyunsaturated fatty acids on the nutritional status of gastrointestinal cancer patients: a systematic review and meta-analysis (Source: European Journal of Clinical Nutrition)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Mon Nov 11, 2019 00:00
This review describes the germ cell neoplasms that are malignant and most commonly associated with several types of gonadal dysgenesis. The most common neoplasm is gonadoblastoma, while others including dysgerminomas, yolk-sac tumors and teratomas are rare but can occur. The purpose of this review is to evaluate the incidences of these abnormalities and the circumstances surrounding these specific tumors. According to well-established methods, a PubMed systematic review was performed, to obtain relevant...
Mon Nov 11, 2019 20:35
(Source: Clinics)
Mon Nov 11, 2019 20:35
Blood Cancer Journal, Published online: 11 November 2019; doi:10.1038/s41408-019-0247-zEASIX for prediction of survival in lower-risk myelodysplastic syndromes (Source: Blood Cancer Journal)
Mon Nov 11, 2019 00:00
Mon Nov 11, 2019 00:00
AbstractPurpose of ReviewTo offer a “toolbox” for geriatric nurses consisting of a general understanding of geriatric oncology, use of a comprehensive geriatric assessment (CGA), role in the multidisciplinary team (MDT), and additional roles as leader, clinician, educator, advocate, and exemplar.Recent FindingsGeriatric oncology incorporates the use of the Ambulatory Geriatric Oncology Program (AGOC), CGA, and an MDT to determine functional status, comorbid conditions, social support, and emotional...
Mon Nov 11, 2019 00:00
ConclusionsIn patients with RA, the relative increase in etanercept-associated risk of experiencing congestive heart failure, serious infection, non-melanoma skin cancer, or interstitial lung disease was similar between elderly and non-elderly. (Source: Drugs and Aging)
Mon Nov 11, 2019 00:00
ConclusionR-TME for rectal cancer can achieve better oncological outcomes compared with L-TME, especially in stage III rectal cancers. However, a longer follow-up period is needed to confirm these findings. (Source: International Journal of Colorectal Disease)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Nov 11, 2019 00:00
This article [1] is retracted at the request of Editor-in-Chief. (Source: Digestive Diseases and Sciences)
Mon Nov 11, 2019 00:00
AbstractProstate cancer is the most common cancer among men in the USA. Interestingly, recent studies suggest that patients with inflammatory bowel disease (IBD) are at increased risk of developing prostate cancer. Importantly, patients with IBD who develop prostate cancer require thoughtful care when using immunosuppressants to treat the IBD in the setting of malignancy. Further, consideration must be given to the proximity of the prostate to the gastrointestinal tract when treating with radiation...
Mon Nov 11, 2019 00:00
ConclusionsERCC1 gene expression is significantly related to tumor stage and prognosis in resected ESCC patients from Asian countries. More prospective studies with larger samples are needed to testify our findings. (Source: Digestive Diseases and Sciences)
Mon Nov 11, 2019 00:00
First of all, we greatly appreciate the letter from Yu et al.,1 which addressed several concerns regarding our study2 where we concluded that the risk of hepatocellular carcinoma (HCC) was not statistically different between patients treated with entecavir (ETV) vs. tenofovir disoproxil fumarate (TDF) for chronic hepatitis B virus (HBV) infection. Actually, the controversy concerning which antiviral agent is better in improving prognosis among patients with chronic HBV infection remains, however,...
Mon Nov 11, 2019 00:00
Nature Reviews Gastroenterology & Hepatology, Published online: 11 November 2019; doi:10.1038/s41575-019-0238-3In 2019, powerful single-cell analyses were applied to liver cancer biology at an unprecedented level. In parallel with this achievement was the identification of serum α-fetoprotein as a biomarker for patient selection in the use of ramucirumab for liver cancer and that β-catenin activation can distinguish between liver cancer immunotherapy responders and non-responders. (Source: Nature...
Mon Nov 11, 2019 00:00
In conclusion, the developed UHPLC-Q-TOF-MS method with high sensitivity and resolution is suitable for identifying and characterizing the chemical constituents of XAJDD in vitro and characterizing the primary components and their metabolites in vivo; moreover, the results will provide essential data for further studying the relationship between the chemical components and pharmacological activity of XAJDD. (Source: Journal of Pharmaceutical and Biomedical Analysis)MedWorm Message: Have you tried...
Mon Nov 11, 2019 19:16
ConclusionKnowledge about population health, built on new awareness and topical health knowledge, and using new skills to identify relevant information and library resources, could open minds and enhance community support for preventive and medical interventions. (Source: Health Information and Libraries Journal)
Mon Nov 11, 2019 00:00
Nitric oxide (NO) is an important signaling molecule that plays a key role in maintaining vascular homeostasis. Dinitrosyl iron complexes (DNICs) generating NO are widely used to treat cardiovascular diseases. However, the involvement of DNICs in the metabolic processes of the cell, their protective properties in doxorubicin-induced toxicity remain to be clarified. Here, we found that novel class of mononuclear DNICs with functional sulfur-containing ligands enhanced the cell viability of human lung...
Mon Nov 11, 2019 00:00
ConclusionEthyl acetate & Water extracts have represented potent activity against Salmonella typhi, Escherichia coli, & Staphylococcus aureus bacteria as well, provided cytotoxicity against tested cancer cell lines. These results can be explored to identify individual phyto-molecules from the extracts for anticancer & antimicrobial potentials to identify new phytomedicines. (Source: European Journal of Integrative Medicine)MedWorm Message: Have you tried our new medical search engine?...
Mon Nov 11, 2019 18:41
Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy ... (Source: Molecular Cancer)
Mon Nov 11, 2019 01:00
AbstractInterferon-stimulated gene 15 (ISG15) is a 15 kDa protein induced by type I interferons (IFN-α and IFN-β) and is a member of the ubiquitin-like superfamily of proteins. The ISG15 pathway is highly expressed in various malignancies, including pancreatic ductal adenocarcinoma (PDAC), suggesting a potential role of the ISG15 pathway (free ISG1 5 and ISG15 conjugates) in pancreatic carcinogenesis. However, very little is known about how the ISG15 pathway may contribute to pancreatic tumorigenesis....
Mon Nov 11, 2019 00:00
Authors: Eleonora Mäkelä Eliisa Löyttyniemi Urpu Salmenniemi Otto Kauko Taru Varila Veli Kairisto Maija Itälä-Remes Jukka Westermarck Disease relapse from standard chemotherapy in acute myeloid leukemia (AML) is poorly understood. The importance of protein phosphatase 2A (PP2A) as an AML tumor suppressor is emerging. Therefore, here, we examined the potential role of endogenous PP2A inhibitor proteins as biomarkers predicting AML relapse in a standard patient population...
Mon Nov 11, 2019 00:00
Nature Reviews Clinical Oncology, Published online: 11 November 2019; doi:10.1038/s41571-019-0284-3Systemic hormone therapies and chemotherapy are the cornerstones of treatment for patients with de novo metastatic prostate cancer, with a currently limited role for local treatments. Herein, the authors outline the pathobiological and immunological rationale for local cytoreductive treatment of the primary tumour and/or metastases in patients with this disease. They also review the preclinical and...
Mon Nov 11, 2019 00:00
Oncogene, Published online: 11 November 2019; doi:10.1038/s41388-019-1096-8Correction: VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (Source: Oncogene)
Mon Nov 11, 2019 00:00
ConclusionRight-hemispheric symptoms appear to be less clinically conspicuous resulting in a delayed diagnosis of GBM, which might be improved by raising awareness for the corresponding neuropsychological deficits. Whether our findings have prognostic implications needs to be evaluated in future studies. (Source: Journal of Neuro-Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any...
Mon Nov 11, 2019 00:00
Authors: Mazzoccoli Miele Marrone Mazza Vinciguerra Grieco The biological clock controls at the molecular level several aspects of mammalian physiology, by regulating daily oscillations of crucial biological processes such as nutrient metabolism in the liver. Disruption of the circadian clock circuitry has recently been identified as an independent risk factor for cancer and classified as a potential group 2A carcinogen to humans. Hepatocellular carcinoma (HCC) is the...
Mon Nov 11, 2019 00:00
ConclusionOur findings suggest that tumor progression accompanied by a high stage, long operative time, and insufficient bowel preparation and early postoperative diarrhea due to a large tumor circumference may be risk factors of AL after LALAR for rectal cancer. (Source: Journal of Gastrointestinal Cancer)
Mon Nov 11, 2019 00:00
AbstractBreast cancer is the most commonly diagnosed cancer among women in the USA. Despite the availability of screening mammograms, significant disparities still exist in breast cancer outcomes of racial/ethnic and sexual/gender minorities. To address these disparities, the Mount Sinai Mobile Breast Health Program in New York City collaborated with local organizations to develop culturally and linguistically appropriate breast cancer education programs aimed at increasing screening mammogram utilization....
Mon Nov 11, 2019 00:00
Authors: Liqiu Ma Ryosuke Kambe Tomoko Tsuchiya Shiro Kanegasaki Akihisa Takahashi Significant numbers of malignant tumor cells that have spread to surrounding tissues and other distant organs are often too small to be picked up in a diagnostic test, and prevention of even such small metastases should improve patient outcomes. Using a mouse model, we show in this article that intravenous administration of a human CCL3 variant carrying a single amino acid substitution after mild...
Mon Nov 11, 2019 00:00
Authors: Devis Pascut Luisa Cavalletto Muhammad Yogi Pratama Silvia Bresolin Luca Trentin Giuseppe Basso Giorgio Bedogni Claudio Tiribelli Liliana Chemello Direct antiviral agents (DAAs) have excellent efficacy against chronic hepatitis C virus (HCV) infection. Despite this strength, recent studies raised concerns about an unexpected hepatocellular carcinoma (HCC) occurrence rate after DAA therapy. In this exploratory case-control study, we evaluated the potential...
Mon Nov 11, 2019 00:00
ConclusionGIST patients under our care experienced a 17.9% overall risk of developing SPTs with different histology. When comparing patients with isolated GIST and patients with GIST and SPT, age was the only variable significantly related to the development of other neoplasms. However, the potential non-random association and causal relationship between GISTs and SPTs remain to be investigated. (Source: Journal of Gastrointestinal Cancer)
Mon Nov 11, 2019 00:00
ConclusionsIn this bi-institutional series, brain invasion was frequent among meningiomas WHO grade I when brain/meningioma interface was available for histology (16.5%). However, brain invasion did not impact early recurrence. (Source: Journal of Neuro-Oncology)
Mon Nov 11, 2019 00:00
. (Source: Nutrition and Cancer)
Mon Nov 11, 2019 00:00
This study was a descriptive type, and the research population was the patients between the age of 30 and 75, who went to 18 different Family Health Centres in dif ferent places in Turkey for any reason in July–September 2016. The survey was completed by face-to-face interview and consisted of 20 questions about the socio-demographic attributes, level of cancer and cancer screenings knowledge, causes of screening, and reasons for not doing. Screening rates w as self-reported by patients. A total...
Mon Nov 11, 2019 00:00
Authors: Cally J. Ho Sharon M. Gorski Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have found evidence that autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes for degradation and recycling, contributes to treatment resistance in different cancer types. A role for autophagy in resistance to chemotherapies and targeted therapies has been described based largely...
Mon Nov 11, 2019 00:00
AbstractDisparities in cancer incidence and mortality rates among racial and ethnic minorities (African Americans, Asian Americans, Pacific Islanders, American Indians, and Latinos/Hispanic Americans) in the USA are well documented. Enrollment of underrepresented populations in cancer therapeutic clinical trials, however, is very low. This is true despite federal mandates to ensure accrual rates adequate for analyses and the evidence that the effectiveness of specific therapies and medications varies...
Mon Nov 11, 2019 00:00
Conclusion: Survivors of hepatoblastoma are at risk for long-term complications. They require long-term monitoring for late effects. (Source: Cancers)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Mon Nov 11, 2019 00:00
Authors: Matilde Taddei Alessandra Erbetta Silvia Esposito Veronica Saletti Sara Bulgheroni Daria Riva Neurofibromatosis type-1 (NF1) is a monogenic tumor-predisposition syndrome creating a wide variety of cognitive and behavioral abnormalities, such as decrease in cognitive functioning, deficits in visuospatial processing, attention, and social functioning. NF1 patients are at risk to develop neurofibromas and other tumors, such as optic pathway gliomas and other tumors of...
Mon Nov 11, 2019 00:00
Authors: Yoo Jin Na Bo Ram Kim Jung Lim Kim Sanghee Kang Yoon A. Jeong Seong Hye Park Min Jee Jo Jeong-Yub Kim Hong Jun Kim Sang Cheul Oh Dae-Hee Lee Despite the importance of radiation therapy, there are few radiation-related markers available for use in clinical practice. A larger catalog of such biomarkers is required to help clinicians decide when radiotherapy should be replaced with a patient-specific treatment. Arachidonate 15-lipoxygenase (15-LOX-1) enzyme...
Mon Nov 11, 2019 00:00
SummaryThe optimal surveillance strategy in renal cell carcinoma after curative resection or ablation is a field of ongoing research. This review discusses the evidence behind routine follow up, duration of follow up, imaging modality and intervals as well as surveillance after local ablative therapy. The recommendations and differences of major guidelines are outlined as well. A risk based approach is advocated taking into account both tumor and patient specific characteristics. (Source: Memo -...
Mon Nov 11, 2019 00:00
Conclusions: IPMT is potentially feasible for high-risk USM patients. Future trials adequately powered for relevant endpoints are thus recommended. (Source: Cancers)
Mon Nov 11, 2019 00:00
AbstractDNA damage repair deficiency leads to the increased risk of genome instability and oncogenic transformation. In the meanwhile, this deficiency could be exploited for cancer treatment by inducing excessive genome instability and catastrophic DNA damage. Continuous DNA replication in cancer cells leads to higher demand of DNA repair components. Due to the oncogenic loss of some DNA repair effectors (e.g. BRCA) and incomplete DNA repair repertoire, some cancer cells are addicted to certain DNA...
Mon Nov 11, 2019 00:00
AbstractPurpose of ReviewImmune checkpoint blockade (ICB) has changed the clinical course of multiple cancer types and durable responses have now been observed in breast cancer (BC) patients. Most data suggest that, compared to other subtypes, triple-negative BC (TNBC) patients are more responsive to ICB, and anti-PD-L1 therapy is now approved in PD-L1+ metastatic TNBC, in combination with chemotherapy.Recent FindingsNearly 40% of PD-L1+ TNBC patients did not respond to this combination. Thus, additional...
Mon Nov 11, 2019 00:00
AbstractThe microvasculature and immune cells are major components of the tumor microenvironment (TME). Hypoxia plays a pivotal role in the TME through hypoxia-inducible factor 1-alpha (HIF-1 α) which upregulates vascular endothelial growth factor (VEGF). VEGF, an angiogenesis stimulator, suppresses tumor immunity by inhibiting the maturation of dendritic cells, and induces immunosuppressive cells such as regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor c ells. HIF-1α...
Mon Nov 11, 2019 00:00
ConclusionsStrengths include an innovative model of referral and funding, through a life insurance provider, the involvement of a multidisciplinary collaborative team to design, develop and implement the pilot, and considerable consumer involvement.Implications for Cancer SurvivorsThe refined intervention will address a critical gap to improve reintegration into work and society, contributing to improved quality of life for cancer survivors in Australia. Models of referral through insurers to rehabilitation...
Mon Nov 11, 2019 00:00
Breast cancer is the most common female malignancy worldwide, however its molecular pathogenesis still needs in-depth investigation. Here we first revealed that the olfactory receptor family 2, subfamily T, member 6 (OR2T6) was significantly over-expressed in breast cancer tissues compared with normal breast tissues. OR2T6 expression was tightly correlated with higher TNM staging, positive lymph node metastasis, and associated with poorer patients' overall and disease-free survival. And OR2T6 enhanced...
Mon Nov 11, 2019 00:00
We report a case of a 47-year-old female known with metastatic papillary thyroid cancer. Her treatment history included total thyroidectomy and 3 previous radio ablations with a cumulative dose of 950 mCi of131I. On follow-up, her thyroglobulin levels had demonstrated a rising trend (from 3789.0 to 4240.0 ug/L) despite a123I whole-body scan demonstrating a reduction in tracer avid lesions. She was suspected of having radio-resistant disease. The patient underwent both18F-FDG and68Ga-PSMA PET/CT imaging...
Mon Nov 11, 2019 00:00
Collectively, successful delivery of miR and chemotherapy by pH ‐responsive targeting nanoparticles modulates β‐catenin/multiple drug resistance/apoptosis/metastasis pathways and induces cancer cell death, mainly via apoptosis. These pH‐sensitive targeting nanoparticles carrying chemotherapy and gene therapeutics remarkably enhance anticancer efficacy in tumor‐bearing mice. Thus, these nanoparticles may provide a potential regimen for effective treatment of colorectal cancer. AbstractIrinotecan is...
Mon Nov 11, 2019 00:00
ConclusionsWe suggest SPECT/CT as the primary modality of choice for the assessment of the ratio of diseased lung area. Both perfusion scan and SPECT/CT can be used for the prediction of postoperative lung function. (Source: Nuclear Medicine and Molecular Imaging)
Mon Nov 11, 2019 00:00
In this study, we measured the analgesic effects of different intrathecal doses of SRT1720 on BCP in a murine model and further examined whether SRT1720 attenuated BCP by suppressing CREB/CREB-regulated transcription coactivator 1 (CRTC1) signalling pathway. Our results demonstrated that the BCP mice developed significant mechanical allodynia and spontaneous flinching, which were accompanied by the upregulation of phospho-Ser133 CREB (p-CREB) and CRTC1 expression in the spinal cord. SRT1720 treatment...
Mon Nov 11, 2019 16:12
AbstractPatient-reported outcome and experience measures are increasingly important in health care and health research. The use of these measures is growing in the US and overseas, and performance measures that incorporate patient-reported outcomes are being considered, particularly in cancer. A major challenge for the use of these measures is patient non-response, especially for diseases such as cancer and dementia. A commonly used approach is to ask a proxy such as the patient ’s spouse or child...
Mon Nov 11, 2019 00:00
Using chemoproteomics to find new cancer drug targets (Source: Chemical and Engineering News)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Nov 11, 2019 07:01
A 24-year-old male presented to the emergency department with a purpuric rash that started a week prior on the arms, trunk, and legs, along with acute onset testicular pain radiating to the lower abdomen. Ultrasound performed during that ED visit showed bilateral testicular solid masses, hypovascular or avascular, a nd a hypervascular left testicle and epididymis (Figure 1). Differential based on ultrasound findings included: testicular carcinoma, granulomatous epididymoorchitis such as sarcoidosis...
Sun Nov 10, 2019 00:00
Conclusion In our study, the hypoxic environment induced by CO2 exposure does not affect the expression of critical biomarkers of NB aggressiveness, such as N-Myc, VEGF, and MMP-2, in human SH-SY5Y NB cells without N-Myc amplification. These data suggest that CO2 pneumoperitoneum might not adversely impact NB cell invasiveness; however, it is necessary to evaluate these effects in others in vitro and in vivo models. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table...
Sun Nov 10, 2019 00:00
ConclusionsDEB ‐TACE with 70–150 μm particles demonstrates improved 1‐month objective tumour response compared to 100–300 μm, whilst having a similar safety profile. Elevated ALP, lower albumin and higher BCLC stage were significantly associated with poorer survival outcomes. (Source: Journal of Medical Imaging and Radiation Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income...
Sun Nov 10, 2019 00:00
Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1)-encoded multidrug resistance protein 1 (MDR1) constitutes a major mechanism of cancer drug resistance including docetaxel (DTX) and cabazitaxel (CTX) resistance in castration-resistant prostate cancer (CRPC). However, no therapeutics that targets MDR1 is available at clinic for taxane sensitization. We report here that ROR, a nuclear receptor family member, unexpectedly mediates MDR1/ABCB1 overexpression. ROR plays an important...
Mon Nov 11, 2019 17:21
Genetic alterations in tumor cells provide promising targets for anti-tumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibition of the protein arginine methyltransferase 5 (PRMT5). MTAP deficiency leads to accumulation of methylthioadenosine (MTA), which reduces PRMT5 activity, and thus, sensitizes the tumor cells to selective PRMT5 inhibitors (PRMT5i). PRMT5i are investigated as a...
Mon Nov 11, 2019 17:21
Abstract Background Extraskeletal osteosarcoma is an extremely rare disease, comprising less than 0.1% of all cancers diagnosed in the United States, of which less than 5% occur in the upper extremities. The management of two cases of pediatric upper extremity extraskeletal osteosarcoma is discussed. Case description Two children initially noticed painless left upper extremity masses at the ages of 16 and 13, respectively. Following a period of several months, both lesions became symptomatic,...
Mon Nov 11, 2019 13:43
Abstract Objective Parents with cancer want information about maintaining family functioning despite cancer. This scoping review assesses what online information resources are available to help parents with cancer maintain family functioning, the quality of the available information, and whether resources provide specific advice for parents of adolescent and young adult (AYA) children. Methods To identify available relevant English‐language online information resources, we imitated a parental...
Mon Nov 11, 2019 11:40
The appropriate timing of radiotherapy (RT) for patients after radical prostatectomy (RP) with adverse pathological features (APFs) remains controversial. This systematic review was conducted to compare the ef...
Sat Nov 09, 2019 02:00
Publication date: Available online 11 November 2019Source: Seminars in OncologyAuthor(s): Massimo Breccia, Joseph R. Carver, Sebastian Szmit, Wojciech Jurczak, Emanuela Salvatorelli, Giorgio MinottiAbstractSession II of the Second International Colloquium on Cardio-Oncology (Kraków, May 2–4 2018), chaired by Dr Breccia (Rome, Italy) and Dr Jurczak (Krakòw, Poland), focused on mechanisms and clinical course of cardiovascular toxicity of cancer treatment. Whereas the venerable anthracyclines keep challenging...
Mon Nov 11, 2019 17:49
Publication date: Available online 11 November 2019Source: Seminars in OncologyAuthor(s): Edward TH Yeh, Michael S. Ewer, Javid Moslehi, Monika Dlugosz-Danecka, Jose Banchs, Hui-Ming Chang, Giorgio MinottiAbstractThe opening session of Second International Colloquium on Cardio-Oncology addressed two areas of vital interest. The first reviewed new thoughts related to established agents. While anthracycline cardiotoxicity has been studied and reviewed extensively, ongoing research attempting to understand...
Mon Nov 11, 2019 17:49
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