Abstract Purpose The outcome of XEN implantation in Chinese eyes has not been previously reported. The purpose of our study is to evaluate the efficacy and safety of combined cataract surgery and XEN implantation in Chinese eyes with glaucoma. Methods We conducted a prospective study of 31 consecutive Chinese patients who underwent combined...
00:53
Abstract Introduction Rheumatoid arthritis (RA) is a chronic systemic auto-immune disease associated with a prothrombotic state. Tocilizumab, an interleukin-6 receptor inhibitor, is highly effective in controlling disease activity and thrombotic risk. Factor XIII (FXIII), involved in thrombotic complications, has been reported to be reduced in RA patients during maintenance treatment with tocilizumab, but no data are available before...
00:53
Abstract Introduction To compare the impact of non-mechanical excimer-assisted (EXCIMER) and femtosecond laser-assisted (FEMTO) trephination on outcomes after penetrating keratoplasty (PK). Methods In this retrospective study, 68 eyes from 23 females and 45 males (mean age at time of surgery, 53.3 ± 19.8 years) were included. Inclusion criteria...
00:53
Abstract The current recommendations for the treatment of chronic obstructive pulmonary disease (COPD) are pushing towards triple combination therapy based on the combination of an inhaled corticosteroid (ICS) associated with two bronchodilator agents. However, dual bronchodilation remains the cornerstone for the treatment of most COPD patients. Combining a long-acting β2 adrenoceptor agonist (LABA) with a long-acting muscarinic antagonist (LAMA) induces appreciable synergistic...
00:53
Abstract Introduction Oral semaglutide is the first orally administered glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes, and has been evaluated in the PIONEER clinical trial program. These trials assessed the proportions of patients achieving single and composite endpoints, encompassing glycemic control [defined in terms of glycated hemoglobin (HbA1c)], weight loss, and hypoglycemia. The present study...
00:53
Abstract Introduction Despite the fact that perianal fistulas are associated with significant morbidity and impaired quality of life, their prevalence in Europe is unknown. The aim of this study was to estimate the prevalence of perianal fistulas in Europe, overall and according to etiology. Methods Two independent literature reviews were performed...
00:53
Abstract The microvasculature and immune cells are major components of the tumor microenvironment (TME). Hypoxia plays a pivotal role in the TME through hypoxia-inducible factor 1-alpha (HIF-1α) which upregulates vascular endothelial growth factor (VEGF). VEGF, an angiogenesis stimulator, suppresses tumor immunity by inhibiting the maturation of dendritic cells, and induces immunosuppressive cells such as regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor...
Mon Nov 11, 2019 02:00
The upregulated expression of the JAK/STAT pathway promotes tumor growth in Hodgkin lymphoma (HL) and primary mediastinal large B-cell lymphoma (PMBCL). Based on the hypothesis that JAK2 is a therapeutic targe... (Source: BMC Cancer)
Sun Nov 10, 2019 01:00
High perioperative morbidity, mortality, and uncertain outcome of surgery in octogenarians with proximal gastric carcinoma (PGC) pose a dilemma for both patients and physicians. We aim to evaluate the risks an... (Source: BMC Cancer)
Sat Nov 09, 2019 01:00
BRCA1 associated-protein 1 (BAP1) tumor predisposition syndrome is associated with an increased risk for malignant mesotheliomas, uveal and cutaneous melanomas, renal cell carcinomas, and singular cutaneous lesio... (Source: BMC Cancer)
Sat Nov 09, 2019 01:00
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune... (Source: BMC Cancer)
Sat Nov 09, 2019 01:00
The present standard of surgical treatment for esophageal cancer is country dependent. The aim of the present study was to investigate the basic aspects of surgical procedures performed for esophageal cancer, ... (Source: BMC Cancer)
Fri Nov 08, 2019 01:00
In past decades, circular RNAs (circRNAs) have achieved increasing attention because of its regulatory role in different kinds of cancers. However, how circAGFG1 regulates cervical cancer (CC) is still largely... (Source: BMC Cancer)
Fri Nov 08, 2019 01:00
A psychiatrist whose “touchy-feely” advances led five female colleagues to complain about him has been suspended from the UK medical register for six months.James Ugbo’s “unwelcome, flirtatious...
Mon Nov 11, 2019 18:31
In final appraisal documents the UK National Institute for Health and Care Excellence has recommended the use of cannabidiol with clobazam for treating seizures associated with two rare and severe...
Mon Nov 11, 2019 18:30
What you need to know Official guidance advises consistency in brand prescribing of anti-epileptic drugsSleep disorders are very common, can trigger seizures, affect the whole family, and can often...
Mon Nov 11, 2019 17:06
bmj;367/nov11_7/l6454/FAF1faMaurice Wilson Fowles was born in St Helens, Lancashire. He met his wife of over 60 years, Claudine Louise-Marie, when she was undertaking nurse training on the Isle of...
Mon Nov 11, 2019 16:51
A 50% drop in the number of 18-25 year olds presenting for specialist drug treatment over the past decade may be due more to cuts to services than to reduced drug use by young people, an expert on...
Mon Nov 11, 2019 15:31
What’s the claim?The media have reported that the health and social care secretary, Matt Hancock, and Genomics England are looking to launch a pilot next year in which parents will be asked whether...
Mon Nov 11, 2019 14:26
bmj;367/nov11_4/l6450/FAF1faAfter house jobs in Bristol Alan George Blandford joined his brother in law, Michael Bourke, in a semirural practice in Shepton Mallet, where he spent the rest of his...
Mon Nov 11, 2019 14:11
bmj;367/nov11_3/l6445/FAF1faPhoto credit: American University of BeirutNabil Nassar, who has died at the age of 80, enjoyed a dual career as a physician and teacher at the American University of...
Mon Nov 11, 2019 13:46
Advocate for their wellbeingChristian Harkensee, consultant paediatrician, coach, and mentor, says, “Being formally investigated will cause shock and stress. There may be feelings of shame and guilt...
Mon Nov 11, 2019 12:56
The studyLyttle MD, Rainford NEA, Gamble C, et al. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label,...
Mon Nov 11, 2019 12:55
Background To the authors' knowledge, little is known regarding the impact of the Patient Protection and Affordable Care Act (ACA) on people living with HIV and cancer (PLWHC), who have lower cancer treatment rates and worse cancer outcomes. To investigate this research gap, the authors examined the effects of the ACA on insurance coverage and receipt of cancer treatment among PLWHC in the United States. Methods HIV‐infected individuals aged 18 to 64 years old with cancer diagnosed between...
Mon Nov 11, 2019 10:14
Both cell adhesion and matrix metalloproteinase (MMP) activity depend on pH at the cell surface. By regulating extracellular juxtamembrane pH, the Na+/H+ exchanger NHE1 plays a significant part in human melanoma ... (Source: Cancer Cell International)
Sat Nov 09, 2019 01:00
Tripartite motif ‑containing 27 (TRIM27) belongs to the TRIM protein family, which is closely related to the progression of some certain human cancers. Nevertheless, the biological function of TRIM27 in esophag... (Source: Cancer Cell International)
Fri Nov 08, 2019 01:00
Tripartite motif-containing protein 11 (TRIM11), a member of RING family of E3 ubiquitin ligases, is identified as an oncogene in certain human tumors. However, the detailed biological function of TRIM11 in ch... (Source: Cancer Cell International)
Fri Nov 08, 2019 01:00
Value‐based pricing allows for more accurate estimates of the generated value for a novel therapeutic. However, the impact of drug funding at value‐based prices, as compared to manufacturer‐submitted prices, for contemporary cancer therapeutics remains under‐characterized. By quantifying the incremental net health benefit and incremental net monetary benefit, this study revealed overall population‐level net gains with drug funding at value‐based pricing to various reference cost‐effectiveness thresholds....
Mon Nov 11, 2019 14:13
Nanostructured Substrates (NS) could be used to enrich exfoliated nucleate cells from urine samples. The assay based on NS enrichment and immunocytology could be a novel non‐invasive diagnostic tool for urothelial carcinoma (UC). Abstract Background Early detection of urothelial carcinoma (UC) by noninvasive diagnostic methods with high accuracy is still underscored. This study aimed to develop a noninvasive assay incorporating both enrichment of urine exfoliated cells and immunoassays for UC...
Sun Nov 10, 2019 21:39
Background Non–small cell lung cancer is the most common type of lung cancer. Lung resection is proven to be the most effective curative treatment for early-stage non–small cell lung cancer (stages I-IIIA). Studies show evidence-based pulmonary rehabilitation is critical for improving exercise capacity and pulmonary function, reducing burden of cancer-related symptoms, and facilitating quality of life following a lung resection. Objective To explore the effectiveness of an animation education...
Fri Nov 08, 2019 02:00
Abstract Breast cancer is the most prevalent malignancy among women. Although endocrine therapy is effective, development of endocrine resistance is a major clinical challenge. The tumor microenvironment (TME) promotes tumor malignancy, and tumor‐associated macrophages (TAMs) within the TME play a crucial role in endocrine resistance. Here, we aimed to elucidate the relationship between TAMs and the endocrine‐resistant phenotype of breast cancer. Macrophages were cultured with conditioned medium...
Mon Nov 11, 2019 14:53
Recently, immune checkpoint therapy was shown to be very effective in the treatment of several cancers by reactivating the immune system. This was also shown for hard to treat cancers such as melanoma and lung cancer. At the forefront of immune checkpoint therapy are antibodies targeting cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and the programmed cell death-1 (PD-1). However, clinical success of immune checkpoint inhibitors greatly varies between different cancer types, ranging from objective...
Mon Nov 11, 2019 02:00
Pancreatic adenocarcinoma (PDAC) is the most common type of pancreatic cancer (PC) [1–3]. PDAC incidence is rising; it is expected to become the second cause of cancer-related death by 2030 and has a very poor prognosis[4]. More than 80% of patients have an advanced disease at diagnosis, and the 5-year overall survival rate is approximately 7% [5]. Poor survival is attributed to high aggressiveness, intrinsic chemotherapeutics resistance and lack of effectively targetable oncogenic drivers. Systemic...
Mon Nov 11, 2019 02:00
Rectal cancers account for 39% of colorectal tumours, and represent the 8th most common malignancy and the 9th leading cause of cancer-related deaths [1]. In 2018, 704,376 new diagnoses and 310,394 deaths for this disease were registered worldwide [1]. The global distribution of rectal cancer is characterised by some geographic variation with incidence rates being higher in Eastern Europe, Australia/New Zealand and Eastern Asia while lower in most African regions and Southern Asia [1]. Rectal cancers...
Mon Nov 11, 2019 02:00
Prostate cancer (PCa) is the most prevalent cancer in men and one of the predominant causes of death among men in European countries [1]. While most PCa remain localized, a subset will be aggressive, leading to metastasis formation associated with significant morbidity and mortality. Thus, one major issue in PCa research is to early detect those patients who are likely to harbor an aggressive variant of PCa at young age importantly needing an active anti-cancer treatment.
Mon Nov 11, 2019 02:00
Multiple myeloma (MM) is an incurable plasma cell dyscrasia characterized by the uncontrollable proliferation of clonal plasma cells resulting in myeloma-defining events (end-organ damage and/or biomarkers of malignancy) [1]. MM constitutes a significant contributor to the global burden of hematological malignancy causing 2.1 million disability-adjusted life-years (DALYs) worldwide according to the Global Burden of Disease 2016 study [2]. During the last decades, an increase in the disease incidence...
Mon Nov 11, 2019 02:00
Urothelial carcinomas (UC) are immunogenic tumors against which immunotherapeutic approaches have shown substantial clinical benefit [1]. Despite their immunogenicity, tumors can evade the immune system by a variety of means, including altered expression of proteins that act within the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway to suppress T-cell antitumor activity [1–3]. PD-L1 is highly expressed on the surface of activated T cells in response to inflammation or...
Mon Nov 11, 2019 02:00
Atezolizumab monotherapy improved overall survival compared with platinum-based chemotherapy as a first-line treatment in patients with wild-type non –small cell lung cancer with PD-L1 expression ≥50%. (Source: CancerNetwork)
Mon Nov 11, 2019 18:15
PRS-343, a HER2/4-1BB targeting bispecific construct, is well-tolerated and demonstrated anti-tumor activity in heavily pre-treated patient population across multiple tumor types. (Source: CancerNetwork)
Mon Nov 11, 2019 06:00
The FDA has accepted the supplemental biologics license application and granted breakthrough therapy designation to nivolumab plus ipilimumab for the treatment of patients with advanced hepatocellular carcinoma previously treated with sorafenib. (Source: CancerNetwork)
Mon Nov 11, 2019 06:00
Why are geriatric patients less likely to get treated for their non-melanoma skin cancers? Researchers investigate and report. (Source: CancerNetwork)
Sun Oct 20, 2019 06:00
After conflicting opinions over the years, a study published in the journal Hematology explores the association between diabetes mellitus non-hodgkin lymphoma. (Source: CancerNetwork)
Fri Oct 18, 2019 06:00
Cancers, Vol. 11, Pages 1773: Serum miRNA Are Promising Biomarkers for the Detection of Early Hepatocellular Carcinoma after Treatment with Direct-Acting Antivirals Cancers doi: 10.3390/cancers11111773 Authors: Devis Pascut Luisa Cavalletto Muhammad Yogi Pratama Silvia Bresolin Luca Trentin Giuseppe Basso Giorgio Bedogni Claudio Tiribelli Liliana Chemello Direct antiviral agents (DAAs) have excellent efficacy against chronic hepatitis C virus (HCV) infection....
Mon Nov 11, 2019 02:00
Cancers, Vol. 11, Pages 1777: Health Status in Long-Term Survivors of Hepatoblastoma Cancers doi: 10.3390/cancers11111777 Authors: Bożenna Dembowska-Bagińska Jolanta Więckowska Agnieszka Brożyna Ewa Święszkowska Hor Ismail Dorota Broniszczak-Czyszek Marek Stefanowicz Wiesława Grajkowska Piotr Kaliciński The aim of this study was to evaluate the health status of children cured from hepatoblastoma. Forty-five patients with hepatoblastoma treated between 1996–2014...
Mon Nov 11, 2019 02:00
Cancers, Vol. 11, Pages 1776: Deficiency of 15-LOX-1 Induces Radioresistance through Downregulation of MacroH2A2 in Colorectal Cancer Cancers doi: 10.3390/cancers11111776 Authors: Yoo Jin Na Bo Ram Kim Jung Lim Kim Sanghee Kang Yoon A. Jeong Seong Hye Park Min Jee Jo Jeong-Yub Kim Hong Jun Kim Sang Cheul Oh Dae-Hee Lee Despite the importance of radiation therapy, there are few radiation-related markers available for use in clinical practice. A larger catalog...
Mon Nov 11, 2019 02:00
Cancers, Vol. 11, Pages 1775: Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer Cancers doi: 10.3390/cancers11111775 Authors: Cally J. Ho Sharon M. Gorski Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have found evidence that autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes for degradation and recycling, contributes to treatment...
Mon Nov 11, 2019 02:00
Cancers, Vol. 11, Pages 1778: A Role for the Biological Clock in Liver Cancer Cancers doi: 10.3390/cancers11111778 Authors: Mazzoccoli Miele Marrone Mazza Vinciguerra Grieco The biological clock controls at the molecular level several aspects of mammalian physiology, by regulating daily oscillations of crucial biological processes such as nutrient metabolism in the liver. Disruption of the circadian clock circuitry has recently been identified as an independent risk...
Mon Nov 11, 2019 02:00
Cancers, Vol. 11, Pages 1774: Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia Cancers doi: 10.3390/cancers11111774 Authors: Eleonora Mäkelä Eliisa Löyttyniemi Urpu Salmenniemi Otto Kauko Taru Varila Veli Kairisto Maija Itälä-Remes Jukka Westermarck Disease relapse from standard chemotherapy in acute myeloid leukemia (AML) is poorly understood. The importance of protein phosphatase 2A (PP2A) as an AML tumor suppressor...
Mon Nov 11, 2019 02:00
Cancers, Vol. 11, Pages 1772: Brain Tumors in NF1 Children: Influence on Neurocognitive and Behavioral Outcome Cancers doi: 10.3390/cancers11111772 Authors: Matilde Taddei Alessandra Erbetta Silvia Esposito Veronica Saletti Sara Bulgheroni Daria Riva Neurofibromatosis type-1 (NF1) is a monogenic tumor-predisposition syndrome creating a wide variety of cognitive and behavioral abnormalities, such as decrease in cognitive functioning, deficits in visuospatial processing,...
Mon Nov 11, 2019 02:00
Purpose: To characterize immune cell expression among patients with Non-Muscle Invasive Bladder Cancer (NMIBC) treated with BCG. Experimental Design: Patients with NMIBC treated with intravesical BCG (2008-2015) were identified, and a TMA was constructed using paired pre and post-BCG bladder samples. Immunohistochemistry was performed for CD8, CD4, FoxP3, PD-L1 (SP-142 and 22C3) and PD-1. A full slide review of PD-L1+ staining tumors was performed to characterize PD-L1 and CD8 co-localization. RNAseq...
Mon Nov 11, 2019 16:23
Females differ from males in incidence and clinical characteristics of colorectal cancer. Understanding the differences can lead to development of preventive approaches. To identify reproductive factors currently associated with the risk of colorectal cancer. Consecutively diagnosed female colorectal cancer cases and randomly chosen colorectal cancer-free controls matched on age/ethnicity/primary care clinic within the molecular epidemiology of colorectal cancer study, a population-based case-control...
Thu Nov 07, 2019 02:00
Future Oncology, Ahead of Print.
Mon Nov 11, 2019 14:38
Future Oncology, Ahead of Print.
Mon Nov 11, 2019 13:24
Future Oncology, Ahead of Print.
Mon Nov 11, 2019 12:02
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Mon Nov 11, 2019 10:00
Abstract Incidence of cancer is increasing in the developing countries such as Turkey. Screenings are important part of preventive medicine practices which can reduce deaths due to cancer. Our aim was to identify patient’s awareness and knowledge level of cancers and screenings and to create a road map of what we need to do to increase screening rates. This study was a descriptive type, and the research population was the patients between the age of 30 and 75, who went to 18 different...
Mon Nov 11, 2019 02:00
Abstract Breast cancer is the most commonly diagnosed cancer among women in the USA. Despite the availability of screening mammograms, significant disparities still exist in breast cancer outcomes of racial/ethnic and sexual/gender minorities. To address these disparities, the Mount Sinai Mobile Breast Health Program in New York City collaborated with local organizations to develop culturally and linguistically appropriate breast cancer education programs aimed at increasing screening...
Mon Nov 11, 2019 02:00
(Source: Karmanos Cancer Institute)
Mon Nov 11, 2019 14:45
(Source: Karmanos Cancer Institute)
Tue Oct 15, 2019 17:28
Abstract Purpose Cognitive functions are differentially represented in brain hemispheres. Aphasia is an “easy to recognize” symptom of diseases affecting the left side. In contrast, lesions in the right hemisphere cause subtle neuropsychological deficits such as neglect and anosognosia. We evaluated whether right-sided malignant brain tumors are on average larger at the time of first diagnosis as compared to left-sided tumors, and extrapolated...
Mon Nov 11, 2019 02:00
Abstract Purpose For meningiomas, the 2016 revision of the WHO classification introduced brain invasion per se as a sufficient condition to classify as grade II. We analyzed whether meningiomas previously graded as WHO grade I differ in prognosis depending on the presence of microscopic brain invasion. Methods A consecutive series of patients with intracranial...
Mon Nov 11, 2019 02:00
Abstract Reproducible patient positioning is essential for precision in radiation therapy (RT) delivery. We tested the hypothesis that a structured daily pre-treatment stretching regimen is both feasible and effective for minimizing variability in positioning, as measured by sacral slope angles (SSA). Eight female subjects undergoing pelvic radiotherapy performed a structured daily hip exercise regimen (extension and external rotation) immediately prior to both simulation imaging...
02:00
Abstract Patients with advanced stage ovarian clear cell carcinoma (OCCC) have a poor prognosis due to resistance to conventional platinum chemotherapy. Recent studies have demonstrated that PI3K/AKT/mTOR and ERK1/2 signaling pathways are involved in this chemoresistance. Progranulin (PGRN) overexpression contributes to cisplatin resistance of epithelial ovarian cancer cell lines. Also, PGRN expression is regulated by AKT/mTOR and ERK1/2 signaling pathways in different cell types....
02:00
We set out to investigate whether transcriptome-based molecular subtypes in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are predictive of response to PD-1 blockade. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Mon Nov 11, 2019 00:00
Contributors : Zintis Inde ; Giovanni C Forcina ; Kyle Denton ; Scott J DixonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnti-cancer drugs and other lethal agents can induce heterogeneous cell death responses in a population of cancer cells, a phenomenon referred to as fractional killing (FK). FK is often studied on a cell-by-cell basis in response to one or a limited number of stimuli. Here, we develop and validate methods to quantify FK in a high-throughput...
02:09
Contributors : K Bedi ; M T Paulsen ; T E Wilson ; M LjungmanSeries Type : OtherOrganism : Homo sapiensMicroRNAs (miRNAs) are key contributors to gene regulatory networks. Because miRNAs are processed from RNA polymerase II transcripts, insight into miRNA regulation requires a comprehensive understanding of the regulation of primary miRNA transcripts. We used Bru-seq nascent RNA sequencing and hidden Markov model segmentation to map primary miRNA transcription units (TUs) across 32 human cell lines,...
Mon Nov 11, 2019 05:00
Contributors : Anita Sveen ; Ina A Eilertsen ; Ragnhild A LotheSeries Type : Expression profiling by array ; Third-party reanalysisOrganism : Homo sapiensWe have compared gene expression profiling by RNA sequencing and exon-resolution microarrays to determine the impact of analysis platform on clinically relevant transcriptomic subtyping frameworks. These samples represent a subset of the total series analyzed. (Source: GEO: Gene Expression Omnibus)
Mon Nov 11, 2019 05:00
Contributors : Pakavarin Louphrasitthiphol ; Colin R GodingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe MITF and SOX10 transcription factors regulate the expression of genes important for melanoma proliferation, invasion and metastasis. Despite growing evidence of the contribution of long non-coding RNAs (lncRNAs) in melanoma and other cancers, their functions within MITF-SOX10 transcriptional programmes is poorly investigated. Here, we identify 245 candidate...
Mon Nov 11, 2019 05:00
Contributor : Y SuarezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goal of this study is to compare transcriptome profiling of different populations of CD45 immune cells of isolated from LLC tumors from miR-21 conditionally deleted on LysM expressing cells (mir-21 flox/flox; lysmCre) mice vs. control (mir-21flox/flox) mice. (Source: GEO: Gene Expression Omnibus)
Mon Nov 11, 2019 05:00
We report herein the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 potently induces the degradation of STAT3 protein in vitro and in vivo and demonstrates high selectivity over other STAT members. Induced degradation of STAT3 results in a strong suppression of its transcription network in leukemia and lymphoma cells. SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large cell lymphoma cell lines by inducing cell cycle arrest and/or apoptosis. SD-36 achieves...
Mon Nov 11, 2019 05:00
Contributors : Ya Gao ; Yifan Zhang ; Qingfeng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLeucine-rich-alpha-2-glycoprotein1 (LRG1), a highly conserved member of the leucine-rich repeat family of proteins, has been reported to be involved in several tumors. Previous studies showed that it has great importance in epithelial –mesenchymal transition in colorectal cancer and could promote glioma cell lines invasion and migration. Despite the intimate relationships...
Mon Nov 11, 2019 05:00
Contributors : Ileana C Cuevas ; Diego H CastrillonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFbxw7 is a tumor supressor frequently mutated in endometrial cancer. To analyze the signaling pathways that can be altered by Fbxw7 we compared RNA expression in the presence or absence of Fbxw7 in mouse endometrial cancer cells deficient for Fbxw7 and Pten. (Source: GEO: Gene Expression Omnibus)
Mon Nov 11, 2019 05:00
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA greater understanding of the hypersensitivity and curability of testicular germ cell tumors (TGCTs) has the potential to inform strategies to sensitize other solid tumors to conventional chemotherapies. More than 80% of metastatic TGCT patients are cured with cisplatin-based chemotherapy. However, resistance can occur, which results in poor outcomes. The mechanisms of cisplatin hypersensitivity and resistance...
Mon Nov 11, 2019 05:00
Molecules, Vol. 24, Pages 4077: Synthesis, Structure and In Vitro Cytotoxic Activity of Novel Cinchona—Chalcone Hybrids with 1,4-Disubstituted- and 1,5-Disubstituted 1,2,3-Triazole Linkers Molecules doi: 10.3390/molecules24224077 Authors: Jernei Duró Dembo Lajkó Takács Kőhidai Schlosser Csámpai By means of copper(I)-and ruthenium(II)-catalyzed click reactions of quinine- and quinidine-derived alkynes with azide-substituted chalcones a systematic series of...
Mon Nov 11, 2019 00:00
Authors: Kinoshita T Abstract This chapter focuses on protein kinases that transfer the phosphate group of ATP to the hydroxyl group of a substrate protein. Five hundred eighteen human protein kinases are classified into serine/threonine kinases and tyrosine kinases and individually or synergistically transduce physiologic stimuli into cell to promote cell proliferation or apoptosis, etc. Protein kinases are identified as drug targets because dysfunction of kinases leads to severe diseases...
01:57
Authors: Panicker RC, Chattopadhaya S, Coyne AG, Srinivasan R Abstract Deregulation of protein kinase activity has been linked to many diseases ranging from cancer to AIDS and neurodegenerative diseases. Not surprisingly, drugging the human kinome - the complete set of kinases encoded by the human genome - has been one of the major drug discovery pipelines. Majority of the approved clinical kinase inhibitors target the ATP binding site of kinases. However, the remarkable sequence and structural...
01:57
In this study, we analyzed the function of miR-21 in noncancer cells of the tumor microenvironment to further evaluate its contribution to tumor progression. We report that the expression of miR-21 in cells of the tumor immune infiltrate, and in particular in macrophages, was responsible for promoting tumor growth. Absence of miR-21 expression in tumor- associated macrophages (TAMs), caused a global rewiring of their transcriptional regulatory network that was skewed toward a proinflammatory angiostatic...
01:35
Immune checkpoint inhibitors (ICIs), although promising, have variable benefit in head and neck cancer (HNC). We noted that tumor galectin-1 (Gal1) levels were inversely correlated with treatment response and survival in patients with HNC who were treated with ICIs. Using multiple HNC mouse models, we show that tumor-secreted Gal1 mediates immune evasion by preventing T cell migration into the tumor. Mechanistically, Gal1 reprograms the tumor endothelium to upregulate cell-surface programmed death...
01:35
Catecholamines released by sympathetic nerves can activate adrenergic receptors present on nearly every cell type, including myeloid-derived suppressor cells (MDSCs). Using in vitro systems, murine tumor models in wild-type and genetically modified (β2-AR–/–) mice, and adoptive transfer approaches, we found that the degree of β2-AR signaling significantly influences MDSC frequency and survival in tumors and other tissues. It also modulates their expression of immunosuppressive molecules such as arginase-I...
01:35
Tumor-induced immunosuppression is a common obstacle for cancer treatment. Adrenergic signaling triggered by chronic stress participates in the creation of an immunosuppressive microenvironment by promoting myeloid-derived suppressor cell (MDSC) proliferation and activation. In this issue of the JCI, Mohammadpour et al. elegantly delve into the mechanisms underlying MDSC contribution to tumor development. They used in vitro and in vivo mouse models to demonstrate that chronic stress results in MDSC...
01:35
Cancer immunotherapy and its budding effectiveness at improving patient outcomes has revitalized our hope to fight cancer in a logical and safe manner. Immunotherapeutic approaches to reengage the immune system have largely focused on reversing immune checkpoint inhibitor pathways, which suppress the antitumor response. Although these approaches have generated much excitement, they still lack absolute success. Interestingly, newly described host-tumor sugar chains (glycosylations) and glycosylation-binding...
01:35
Publication date: Available online 10 November 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Zhizhong Zhang, Tianyang Zheng, Rong ZhuAbstractCharacterization of single-cell biophysical properties and cell type classification are significant to study cytopathology, cell sorting, drug screening, etc. Existing methods usually suffer from unsatisfied measurement accuracy and low efficiency. We propose a new dielectrophoresis (DEP) model reduction method to characterize biophysical properties...
01:13
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC07538K, CommunicationLifo Ruan, Mengxue Zhou, Jun Chen, Hui Huang, Jiayu Zhang, Hongyan Sun, Zhifang Chai, Yi Hu Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC -...
01:11
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03731 (Source: Analytical Chemistry)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Nov 11, 2019 06:00
ConclusionsErroneous provider interpretation of UDT results, infrequent documentation of interpretation, lack of communication of results to patients, and prescription refills despite inaccurate interpretations are common. Expert assistance with urine toxicology interpretations may be needed to improve provider accuracy when interpreting toxicology results. (Source: Journal of General Internal Medicine)
Mon Nov 11, 2019 00:00
Nature Reviews Urology, Published online: 11 November 2019; doi:10.1038/s41585-019-0251-xIn this Review, Morris et al. summarize the mechanisms through which 223Ra exerts its biological effects in metastatic castration-resistant prostate cancer, discuss potential 223Ra combination therapies and provide future perspectives for targeted alpha-particle therapy. (Source: Nature Reviews Urology)
Mon Nov 11, 2019 00:00
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