Cancers, Vol. 11, Pages 1834: Overcoming Ibrutinib Resistance in Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers11121834 Authors: Puła Gołos Górniak Jamroziak Ibrutinib is the first Bruton’s tyrosine kinase (BTK) inhibitor, which showed significant clinical activity in chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) patients regardless of cytogenetic risk factors. Recent results of phase III clinical trials in treatment-naïve...
Thu Nov 21, 2019 02:00
Cancers, Vol. 11, Pages 1836: Cancer Cell Membrane-Coated Nanoparticles for Cancer Management Cancers doi: 10.3390/cancers11121836 Authors: Harris Scully Day Cancer is a global health problem in need of transformative treatment solutions for improved patient outcomes. Many conventional treatments prove ineffective and produce undesirable side effects because they are incapable of targeting only cancer cells within tumors and metastases post administration. There is a desperate...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1488: pMHC Structural Comparisons as a Pivotal Element to Detect and Validate T-Cell Targets for Vaccine Development and Immunotherapy—A New Methodological Proposal Cells doi: 10.3390/cells8121488 Authors: Priscila Vianna Marcus F.A. Mendes Marcelo A. Bragatte Priscila S. Ferreira Francisco M. Salzano Martin H. Bonamino Gustavo F. Vieira The search for epitopes that will effectively trigger an immune response remains the “El Dorado”...
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Cells, Vol. 8, Pages 1489: TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism Cells doi: 10.3390/cells8121489 Authors: Marianna Boia-Ferreira Kamila G. Moreno Alana B. C. Basílio Lucas P. da Silva Larissa Vuitika Bruna Soley Ana Carolina M. Wille Lucélia Donatti Katia C. Barbaro Olga M. Chaim Luiza Helena Gremski Silvio S. Veiga Andrea Senff-Ribeiro LiTCTP is a toxin from...
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Cells, Vol. 8, Pages 1486: Molecular Insights into the Mechanism of Necroptosis: The Necrosome As a Potential Therapeutic Target Cells doi: 10.3390/cells8121486 Authors: Chen Kos Garssen Redegeld Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and vascularization. It plays important roles in various pathological processes, including neurodegeneration,...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1487: Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo Cells doi: 10.3390/cells8121487 Authors: Gammon Pisaneschi Bandi Smith Sun Rao Muller Wong De Groot Ackroyd Mawlawi Davies Gopal Di Francesco Marszalek Dewhirst Piwnica-Worms Tumors lack a well-regulated vascular supply of O2 and often fail to balance...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1482: MicroRNA—A Tumor Trojan Horse for Tumor-Associated Macrophages Cells doi: 10.3390/cells8121482 Authors: Syed Frank Raue Brüne MicroRNAs (miRs) significantly contribute to the regulation of gene expression, by virtue of their ability to interact with a broad, yet specific set of target genes. MiRs are produced and released by almost every cell type and play an important role in horizontal gene regulation in the tumor microenvironment (TME). In the...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1485: Isolation and Culture of Human Stem Cells from Apical Papilla under Low Oxygen Concentration Highlight Original Properties Cells doi: 10.3390/cells8121485 Authors: Rémy Ferraro Le Salver Rey Genot Djavaheri-Mergny Thébaud Boiziau Boeuf : Stem cells isolated from the apical papilla of wisdom teeth (SCAPs) are an attractive model for tissue repair due to their availability, high proliferation rate and potential to differentiate...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1483: The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling Cells doi: 10.3390/cells8121483 Authors: Rodríguez Martínez-González Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1–4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1484: RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta Cells doi: 10.3390/cells8121484 Authors: Wildner Friemel Jennewein Roth Ritter Schüttler Chen Louwen Yuan Kreis Preeclampsia (PE) remains a leading cause of maternal and perinatal mortality and morbidity worldwide. Its pathogenesis has not been fully elucidated and no causal therapy is currently available. It is of clinical...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1480: Adjuvant Epigenetic Therapy of Decitabine and Suberoylanilide Hydroxamic Acid Exerts Anti-Neoplastic Effects in Acute Myeloid Leukemia Cells Cells doi: 10.3390/cells8121480 Authors: Abou Najem Khawaja Hodroj Babikian Rizk Atypical epigenetic processes including histone acetylation and DNA methylation have been identified as a fundamental theme in hematologic malignancies. Such mechanisms modify gene expression and prompt, in part at least,...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1481: JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses Cells doi: 10.3390/cells8121481 Authors: Sundqvist Voytyuk Hamdi Popeijus van der Burgt Janssen Martens Moustakas Heldin ten Dijke van Dam Transforming growth factor-β (TGFβ) has both tumor-suppressive and tumor-promoting effects in breast...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1477: The Brain Entangled: The Contribution of Neutrophil Extracellular Traps to the Diseases of the Central Nervous System Cells doi: 10.3390/cells8121477 Authors: Manda-Handzlik Demkow Under normal conditions, neutrophils are restricted from trafficking into the brain parenchyma and cerebrospinal fluid by the presence of the brain–blood barrier (BBB). Yet, infiltration of the central nervous system (CNS) by neutrophils is a well-known phenomenon...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1478: Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases Cells doi: 10.3390/cells8121478 Authors: Olayioye Noll Hausser As membrane-associated master regulators of cytoskeletal remodeling, Rho GTPases coordinate a wide range of biological processes such as cell adhesion, motility, and polarity. In the last years, Rho GTPases have also been recognized to control intracellular membrane sorting and trafficking steps directly; however,...
Thu Nov 21, 2019 02:00
Cells, Vol. 8, Pages 1479: Comparison of the Effect of Two Hyaluronic Acid Preparations on Fibroblast and Endothelial Cell Functions Related to Angiogenesis Cells doi: 10.3390/cells8121479 Authors: Ciccone Zazzetta Morbidelli Hyaluronic acid (HA) is used in substitutive and aesthetic medicine with various applications. Ultrapure absorbable HA (Bioregen®) and a mix of reticulated and free low molecular weight HA (Regenyal Idea Bioexpander®) (both provided by Regenyal...
Thu Nov 21, 2019 02:00
Diagnostics, Vol. 9, Pages 200: Overall Survival and Adjuvant Therapy in Women with Ovarian Carcinosarcoma: A Single-Institution Experience Diagnostics doi: 10.3390/diagnostics9040200 Authors: Aaron Nizam Bethany Bustamante Weiwei Shan Karin K. Shih Jill S. Whyte Antoinette Sakaris Lisa dos Santos Marina Frimer Andrew W. Menzin Alexander Truskinovsky Gary L. Goldberg Background: Carcinosarcoma of the ovary (CSO) is a rare and aggressive variant of ovarian...
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Diagnostics, Vol. 9, Pages 199: Diagnostic Approach to Traumatic Axonal Injury of the Spinothalamic Tract in Individual Patients with Mild Traumatic Brain Injury Diagnostics doi: 10.3390/diagnostics9040199 Authors: Jang Lee Objectives: We investigated an approach for the diagnosis of traumatic axonal injury (TAI) of the spinothalamic tract (STT) that was based on diffusion tensor tractography (DTT) results and a statistical comparison of individual patients who showed central pain...
Thu Nov 21, 2019 02:00
Foods, Vol. 8, Pages 605: Characterization of Fulvic Acid Beverages by Mineral Profile and Antioxidant Capacity Foods doi: 10.3390/foods8120605 Authors: Monika Swat Iga Rybicka Anna Gliszczyńska-Świgło The main purpose of the study was to investigate the quality of fulvic acid-based food products. The concentrations of Ca, K, Mg, Na, Cu, Fe, Mn, and Zn, and antioxidant capacities of fulvic acid concentrates and ready-to drink beverages available on the global market were determined....
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Foods, Vol. 8, Pages 604: Use of Fermented Hemp, Chickpea and Milling By-Products to Improve the Nutritional Value of Semolina Pasta Foods doi: 10.3390/foods8120604 Authors: Rosa Schettino Erica Pontonio Carlo Giuseppe Rizzello A biotechnological approach including enzymatic treatment (protease and xylanase) and lactic acid bacteria fermentation has been evaluated to enhance the nutritional value of semolina pasta enriched with hemp, chickpea and milling by-products. The intense...
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Foods, Vol. 8, Pages 603: Prior Exposure to Dry-Cured Meat Promotes Resistance to Simulated Gastric Fluid in Salmonella Typhimurium Foods doi: 10.3390/foods8120603 Authors: Yhan S. Mutz Denes K. A. Rosario Vinicius S. Castro Patricia C. Bernardes Vania M. F. Paschoalin Carlos A. Conte-Junior This study assessed if exposure of foodborne Salmonella enterica in Brazilian dry-cured loin (BDL) affects pathogen inactivation in simulated gastric fluid (SGF). The acid tolerance...
Thu Nov 21, 2019 02:00
Foods, Vol. 8, Pages 602: Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors Foods doi: 10.3390/foods8120602 Authors: Quan Thien Khanh Tran Xuan We previously reported the inhibitory potentials of momilactones A (MA) and B (MB) against key enzymes related to type 2 diabetes and obesity. In this study, antioxidant and anti-skin-aging activities of MA and MB were investigated and compared with tricin, a well-known antioxidant...
Thu Nov 21, 2019 02:00
Foods, Vol. 8, Pages 601: A High-Throughput In Vitro Assay for Screening Rice Starch Digestibility Foods doi: 10.3390/foods8120601 Authors: Toutounji Butardo Zou Farahnaky Pallas Oli Blanchard The development of rice that can produce slow and steady postprandial glucose in the bloodstream is a response to alarmingly high global rates of obesity and related chronic diseases. However, rice grain quality programs from all over the world currently do not have access...
Thu Nov 21, 2019 02:00
Fractal Fract, Vol. 3, Pages 53: A Fractional Measles Model Having Monotonic Real Statistical Data for Constant Transmission Rate of the Disease Fractal and Fractional doi: 10.3390/fractalfract3040053 Authors: Ricardo Almeida Sania Qureshi Non-Markovian effects have a vital role in modeling the processes related with natural phenomena such as epidemiology. Various infectious diseases have long-range memory characteristics and, thus, non-local operators are one of the best choices...
Thu Nov 21, 2019 02:00
Healthcare, Vol. 7, Pages 151: Nurse Prescribing-Readiness of Polish Nurses to Take on New Competencies—A Cross-Sectional Study Healthcare doi: 10.3390/healthcare7040151 Authors: Bartosiewicz Różański From January 2016, nurses in Poland received new competencies for prescribing. The work is the first in Poland to elaborate on the subject of nurses’ readiness to learn and develop in the context of new nursing rights regarding autonomous prescription of medication and continuation...
Thu Nov 21, 2019 02:00
IJERPH, Vol. 16, Pages 4649: Impact of Birth Weight and Length on Primary Hypertension in Children International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234649 Authors: Aneta Weres Joanna Baran Ewelina Czenczek-Lewandowska Justyna Leszczak Artur Mazur Background: A child’s birth parameters not only enable assessment of intrauterine growth but are also helpful in identifying children at risk of developmental defects or diseases occurring...
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IJERPH, Vol. 16, Pages 4645: The Adjustment Disorder Diagnosis, Its Importance to Liaison Psychiatry, and its Psychobiology International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234645 Authors: James J. Strain Adjustment Disorder (AD) is one of the most common psychiatric diagnoses employed. In fact, it is the most frequent diagnosis utilized for psychiatric disorders in the military and in children, and is often utilized in the consultation-liaison medical...
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IJERPH, Vol. 16, Pages 4647: Relationship of Cardiorespiratory Fitness and Body Mass Index with the Incidence of Dyslipidemia among Japanese Women: A Cohort Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234647 Authors: Takahisa Ohta Junzo Nagashima Hiroyuki Sasai Naokata Ishii Low cardiorespiratory fitness (CRF) and obesity are independent risk factors for dyslipidemia. We investigated the synergistic effects of CRF and obesity...
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IJERPH, Vol. 16, Pages 4646: Perceptions about the Self-Learning Methodology in Simulated Environments in Nursing Students: A Mixed Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234646 Authors: José Luis Díaz Agea Antonio Jesús Ramos-Morcillo Francisco José Amo Setien María Ruzafa-Martínez César Hueso-Montoro César Leal-Costa The self-learning methodology in simulated environments (MAES©) is an active method of education....
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IJERPH, Vol. 16, Pages 4644: The Role of Health Literacy in Explaining the Relation between Educational Level and Decision Making about Colorectal Cancer Screening International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234644 Authors: Anke J. Woudstra Ellen M. A. Smets Mathilde G. E. Verdam Mirjam P. Fransen Little is known about why educational inequalities exist in informed decision making in colorectal cancer (CRC) screening. Insight into the...
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IJERPH, Vol. 16, Pages 4643: ‘It Shouldn’t Be This Hard’: Exploring the Challenges of Rural Health Research International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234643 Authors: Heath Greville Emma Haynes Robin Kagie Sandra C Thompson Health research is important for innovation and assessment of health status and health interventions, and maintaining a strong, engaged cohort of rural health researchers is essential for the ongoing improvement...
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IJERPH, Vol. 16, Pages 4641: Mechanism Underlying Flow Velocity and Its Corresponding Influence on the Growth of Euglena gracilis, a Dominant Bloom Species in Reservoirs International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234641 Authors: Yi Tan Jia Li Linglei Zhang Min Chen Yaowen Zhang Ruidong An The effects of hydrodynamics on algae growth have received considerable attention, and flow velocity is one of the most frequently discussed...
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IJERPH, Vol. 16, Pages 4642: Social Inequalities in Use of Preventive Dental and Medical Services among Adults in European Countries International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234642 Authors: Shiho Kino Eduardo Bernabé Wael Sabbah This study examined inequalities in dental check-ups and medical screenings using subjective and objective socioeconomic indicators. Data from 23,464 adults, aged 20 years old and over, who participated in a...
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IJERPH, Vol. 16, Pages 4640: Spatiotemporal Analysis and Control of Landscape Eco-Security at the Urban Fringe in Shrinking Resource Cities: A Case Study in Daqing, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234640 Authors: Chen Xu Fadelelseed Li As the main bearing area of the ecological crisis in resource-rich cities, it is essential for the urban fringe to enhance regional ecological security during a city’s...
Thu Nov 21, 2019 02:00
IJERPH, Vol. 16, Pages 4639: Effects of Nanoplastics on Freshwater Biofilm Microbial Metabolic Functions as Determined by BIOLOG ECO Microplates International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234639 Authors: Miao Guo Liu Liu You Qu Hou Nanoplastic (NP) contamination is becoming a pervasive issue as NPs, originating from microplastic particles, pose potentially harmful environmental impacts on aquatic ecosystems. The environmental...
Thu Nov 21, 2019 02:00
IJERPH, Vol. 16, Pages 4638: Exit and Entry Screening Practices for Infectious Diseases among Travelers at Points of Entry: Looking for Evidence on Public Health Impact International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234638 Authors: Mouchtouri Christoforidou an der Heiden Lemos Fanos Rexroth Grote Belfroid Swaan Hadjichristodoulou A scoping search and a systematic literature review were conducted to give an insight...
Thu Nov 21, 2019 02:00
IJERPH, Vol. 16, Pages 4637: Effects of a Risk-Based Licensing Scheme on the Incidence of Alcohol-Related Assault in Queensland, Australia: A Quasi-Experimental Evaluation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234637 Authors: Nepal Kypri Attia Evans Chikritzhs Miller : Amid concerns about increasing alcohol-related violence in licensed premises, Queensland introduced a system of risk-based licensing (RBL) in 2009,...
Thu Nov 21, 2019 02:00
IJERPH, Vol. 16, Pages 4635: Personal Factors, Internet Characteristics, and Environmental Factors Contributing to Adolescent Internet Addiction: A Public Health Perspective International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234635 Authors: Chung Lee Lee Individual characteristics, family- and school-related variables, and environmental variables have equal importance in understanding Internet addiction. Most previous studies on Internet addiction...
Thu Nov 21, 2019 02:00
IJERPH, Vol. 16, Pages 4636: Are the Levels of Lipid Parameters Associated with Biometeorological Conditions? International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234636 Authors: Skutecki Cymes Dragańska Glińska-Lewczuk Buciński Drozdowski Romaszko Lipid disorders, especially hypercholesterolemia, are one of the most thoroughly investigated cardiovascular risk factors. Their correlation with biometeorological conditions has been...
Thu Nov 21, 2019 02:00
IJERPH, Vol. 16, Pages 4634: Victimization of Traditional and Cyber Bullying During Childhood and Their Correlates Among Adult Gay and Bisexual Men in Taiwan: A Retrospective Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16234634 Authors: Wang Hsiao Yen This study examined the associations of timing of sexual orientation developmental milestones, gender role nonconformity, and family-related factors with victimization of traditional...
Thu Nov 21, 2019 02:00
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