Abstract Inadequate palliative care training in medical education is associated with many physicians feeling unprepared to care for dying patients and their families. Therefore, an opportunity exists to offer physicians continuing medical education that increases their understanding of and comfort with complex palliative care issues. The goal of the current study was to evaluate The Confessions of a Reluctant Caregiver Palliative Educational Program as an educational tool for physicians....
02:00
Purpose: DNA mismatch repair defects (MMRd) and tumor hypermutation are rare and under-characterized in metastatic prostate cancer. Furthermore, since hypermutated MMRd prostate cancers can respond to immune checkpoint inhibitors, there is an urgent need for practical detection tools. Experimental design: We analyzed plasma cell-free DNA targeted sequencing data from 433 metastatic prostate cancer patients with circulating tumor DNA (ctDNA) purity ≥2%. Samples with somatic hypermutation were subjected...
Tue Nov 19, 2019 17:09
Purpose: Though pituitary adenoma is classified as benign, CD is associated with significant morbidity due to the numerous sequelae of elevated cortisol levels. Successful therapy for CD remains elusive due to high rates of treatment-refractory recurrence. The frequent emergence of lymphocytic hypophysitis following checkpoint blockade for other cancers, as well as the expression of PD-L1 on pituitary adenomas, suggest a role for immunotherapy. Experimental Design: This study confirms PD-L1 expression...
Tue Nov 19, 2019 17:09
Radiotherapy (RT) is along with surgery the mainstay of treatment in head and neck squamous cell carcinoma (HNSCC). Radioresistance represents a major source of treatment failure, underlining the urgent necessity to explore and implement effective radiosensitization strategies. The MET receptor widely participates in acquisition and maintenance of an aggressive phenotype in HNSCC and modulates the DNA damage response following ionizing radiation (IR). Here we assessed MET expression and mutation...
Tue Nov 19, 2019 17:17
Investigations into the human 8-oxodGTPase, MutT Homolog 1 (MTH1), have risen sharply since the first-in-class MTH1 inhibitors were reported to be highly tumoricidal. However, MTH1 as a cancer therapeutic target is currently controversial because subsequently-developed inhibitors did not exhibit similar cytotoxic effects. Here, we provide the first direct evidence for MTH1-independent 8-oxodGTPase function in human cancer cells and human tumors, using a novel ATP-releasing guanine-oxidized (ARGO)...
Tue Nov 19, 2019 17:17
Mutation of the oncogene BRAF is among the most common genetic alterations in melanoma. BRAF inhibitors alone or in combination with MEK inhibitors fail to eradicate the tumor in most patients due to combinations of intrinsic or acquired resistance. Therefore, novel strategies are needed to improve the therapeutic efficacy of BRAF inhibition. We demonstrated that dinaciclib has potent anti-melanoma effects by inducing BAK-dependent apoptosis through MCL1 reduction. Contrary to dinaciclib, the inhibitors...
Tue Nov 19, 2019 17:17
Testicular cancer (TC) is the most common cancer type among young men. Despite highly effective cisplatin-based chemotherapy, around 20% of patients with metastatic disease will still die from the disease. The aim of this study was to explore the use of kinase inhibitors to sensitize testicular cancer cells to cisplatin treatment. Activation of kinases, including receptor tyrosine kinases, and downstream substrates was studied in five cisplatin-sensitive or resistant TC cell lines using phospho-kinase...
Tue Nov 19, 2019 17:17
The goal was to develop and characterize a companion diagnostic for the releasable PEG40kDa~SN-38 oncology drug, PLX038, that would identify tumors susceptible to high accumulation of PLX038. PEG conjugates of the zirconium ligand desferroxamine B (DFB) of similar size and charge to PLX038 were prepared that contained one or four DFB as well as one that contained three SN-38 moieties and one DFB. Uptake and associated kinetic parameters of the 89Zr-labeled nanocarriers was determined in tumor and...
Tue Nov 19, 2019 17:17
The ERK pathway is critical in oncogenesis; aberrations in components of this pathway are common in approximately 30% of human cancers. ERK1/2 (ERK) regulates cell proliferation, differentiation and survival and is the terminal node of the pathway. BRAF- and MEK-targeted therapies are effective in BRAF V600E/K metastatic melanoma and lung cancers; however, responses are short-lived due to emergence of resistance. Reactivation of ERK signaling is central to the mechanisms of acquired resistance. Therefore,...
Tue Nov 19, 2019 17:17
Abstract The safety of anti-programmed cell death 1 (PD-1) antibody for patients with preexisting interstitial lung disease (ILD) remains unknown. The aim of this study was to evaluate the dependence of preexisting ILD on anti-PD-1 antibody-induced pneumonitis in non-small cell lung cancer (NSCLC) patients. We retrospectively reviewed the association of preexisting ILD with the incidence, radiographic pattern, and outcome of pneumonitis in NSCLC patients receiving anti-PD-1 antibody....
Tue Nov 19, 2019 02:00
Cancers, Vol. 11, Pages 1820: Endometrial Cancer Stem Cells: Role, Characterization and Therapeutic Implications Cancers doi: 10.3390/cancers11111820 Authors: Giannone Attademo Scotto Genta Ghisoni Tuninetti Aglietta Pignata Valabrega Endometrial cancer (EC) is the most frequent gynecological cancer. In patients with relapsed and advanced disease, prognosis is still dismal and development of resistance is common. In this context, endometrial Cancer Stem...
Tue Nov 19, 2019 02:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue Nov 19, 2019 19:08
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue Nov 19, 2019 19:08
Publication date: January–February 2020Source: Reports of Practical Oncology & Radiotherapy, Volume 25, Issue 1Author(s): Hayley B. Stowe, Brandon T. Mullins, Bhishamjit S. CheraAbstractAimTo report a case of radiation-induced brachial plexopathy (RIBP) with significant radiographic and clinical improvement after a course of hyperbaric oxygen (HBO).BackgroundRIBP is a rare complication after radiotherapy to the neck and axilla. There are no standard treatment options, with empirical use pharmacotherapy...
Tue Nov 19, 2019 18:45
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Nov 19, 2019 18:43
Abstract Purpose To evaluate surgical resection with brachytherapy placement as a salvage treatment in patients with recurrent high-grade meningioma who exhausted prior external beam treatment options. Methods Single-center retrospective review of our institutional experience of brachytherapy implantation from 2012 to 2018. The primary outcome of the study...
Tue Nov 19, 2019 02:00
Cancers, Vol. 11, Pages 1818: WWOX Possesses N-Terminal Cell Surface-Exposed Epitopes WWOX7-21 and WWOX7-11 for Signaling Cancer Growth Suppression and Prevention In Vivo Cancers doi: 10.3390/cancers11111818 Authors: Wan-Jen Wang Pei-Chuan Ho Ganesan Nagarajan Yu-An Chen Hsiang-Ling Kuo Dudekula Subhan Wan-Pei Su Jean-Yun Chang Chen-Yu Lu Katarina T. Chang Sing-Ru Lin Ming-Hui Lee Nan-Shan Chang Membrane hyaluronidase Hyal-2 supports cancer cell growth....
Tue Nov 19, 2019 02:00
Cancers, Vol. 11, Pages 1819: Reactivation of Hepatitis B Virus in Patients with Multiple Myeloma Cancers doi: 10.3390/cancers11111819 Authors: Yutaka Tsukune Makoto Sasaki Norio Komatsu Reactivation of hepatitis B virus (HBV) is a well-known complication in patients with hematological malignancies during or after cytotoxic chemotherapy. If the initiation of antiviral therapy is delayed in patients with HBV reactivation, these patients can develop severe hepatitis and may die of...
Tue Nov 19, 2019 02:00
Publication date: Available online 19 November 2019Source: Seminars in OncologyAuthor(s): Emily Howard, Richard M. Steingart, Gregory T. Armstrong, Alexander R. Lyon, Saro H. Armenian, Laura Cicconi, Francesco Lo CocoAbstractMalignant disease and its treatment carry huge burdens for patients. Some are immediate, in that the disease itself presents as a life threatening event, or the treatment may result in immediate and devastating toxicity. More often the treatment of cancer is associated with more...
Tue Nov 19, 2019 11:50
Publication date: Available online 19 November 2019Source: Seminars in OncologyAuthor(s): Daniela M. Cardinale, Ana Barac, Adam Torbicki, Bijoy K. Khandheria, Daniel Lenihan, Giorgio MinottiABSTRACTSession III of the Second International Colloquium on Cardio-Oncology focused on the diagnosis, management, and prevention of cardiovascular toxicity of cancer drugs. With a large menu of biomarker and imaging modalities available to the cardio oncologist, there continues to be no consensus regarding the...
Tue Nov 19, 2019 11:50
Publication date: Available online 19 November 2019Source: Seminars in OncologyAuthor(s): Chris Plummer, Richard M. Steingart, Wojcech Jurczak, Zaza Iakobishvili, Alex R. Lyon, John P. Plastaras, Giorgio MinottiABSTRACTSession IV of the Second International Colloquium on Cardio-Oncology held in Kraków, focused on the cardiovascular risks of using hormone replacement therapy in breast cancer and androgen deprivation therapy in prostate cancer and continued the theme from Session 3 with a discussion...
Tue Nov 19, 2019 11:50
Publication date: Available online 18 November 2019Source: Seminars in OncologyAuthor(s): Michael S. Ewer, Joseph R. Carver, Giorgio Minotti
Tue Nov 19, 2019 11:50
Publication date: Available online 18 November 2019Source: Seminars in OncologyAuthor(s): Susan F. Dent, Thomas M. Suter, Teresa López-Fernández, Grzegorz Opolski, Pierantonio Menna, Giorgio MinottiABSTRACTSession V of the Colloquium was chaired by Professors Teresa López-Fernández of Spain and Grzegorz Opolski of Poland. The 3 speakers addressed cardio-oncology issues as they relate to both clinical studies and real life situations. Professor Susan Dent discussed cardio-oncology network for patients,...
Tue Nov 19, 2019 11:50
Cancers, Vol. 11, Pages 1817: Biological Functions of the ING Proteins Cancers doi: 10.3390/cancers11111817 Authors: Arthur Dantas Buthaina Al Shueili Yang Yang Arash Nabbi Dieter Fink Karl Riabowol The proteins belonging to the inhibitor of growth (ING) family of proteins serve as epigenetic readers of the H3K4Me3 histone mark of active gene transcription and target histone acetyltransferase (HAT) or histone deacetylase (HDAC) protein complexes, in order to alter local...
Tue Nov 19, 2019 02:00
Cancers, Vol. 11, Pages 1816: Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle Cancers doi: 10.3390/cancers11111816 Authors: Guanmin Meng Melinda Wuest Xiaoyun Tang Jennifer Dufour YuanYuan Zhao Jonathan M. Curtis Todd P. W. McMullen David Murray Frank Wuest David N. Brindley Breast cancer patients are usually treated with multiple fractions of radiotherapy (RT) to the...
Tue Nov 19, 2019 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου