Electrospinning is a maturing manufacturing technology that is already being used in medicine to produce unusual materials with novel properties. It involves melting a polymer and extruding it through a narrow nozzle, while an electric field is used to pull and spin the polymer into a very fine mesh. When a biocompatible polymer is used, the printed materials may be applicable for medical applications, as the resulting mesh has an extremely large surface area. The fibers can also have drugs...
Thu Nov 14, 2019 20:49
Butterfly Network, the digital health unicorn democratizing medical imaging, is continuing to add new applications for its handheld, single probe, smartphone-connected ultrasound technology. The Butterfly iQ, the multi-purpose pocket-sized ultrasound, won FDA clearance a couple years ago and earlier this year received the CE Mark, clearing it for distribution in Europe. The innovation found within Butterfly iQ centers around the device’s matrix array of microelectromechanical (MEMS)...
Thu Nov 14, 2019 19:58
Publication date: Available online 13 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Sagus Sampath, Paul Frankel, Bianca del Vecchio, Nora Ruel, Bertram Yuh, An Liu, Tsung Tsai, Jeffrey WongPurposeThe primary objectives of this study were to evaluate toxicity of escalating doses of prostate bed SBRT and provide dose recommendations for phase II study.Methods and MaterialsPatients with organ-confined, node-negative prostate cancer who had biochemical failure...
Thu Nov 14, 2019 19:53
Abstract Marker‐based motion capture techniques are commonly used to measure human body kinematics. These techniques require an accurate mapping from physical marker position to model marker position. Traditional methods utilize a manual process to achieve marker positions that result in accurate tracking. In this work, we present an optimization algorithm for model marker placement to minimize marker tracking error during inverse kinematics analysis of dynamic human motion. The algorithm sequentially...
Wed Nov 13, 2019 18:09
Abstract Most biological tissues grow by the synthesis of new material close to the tissue's interface, where spatial interactions can exert strong geometric influences on the local rate of growth. These geometric influences may be mechanistic, or cell behavioural in nature. The control of geometry on tissue growth has been evidenced in many in‐vivo and in‐vitro experiments, including bone remodelling, wound healing, and tissue engineering scaffolds. In this paper, we propose a generalisation of...
Wed Nov 13, 2019 18:00
Cisplatin- (CDDP) induced acute kidney injury (AKI) limits the clinical use of cisplatin. Several sirtuin (SIRT) family proteins are involved in AKI, while the roles of Sirt5 in cisplatin-induced AKI remain unknown. In the present study, we characterized the role and mechanism of Sirt5 in cisplatin-induced apoptosis using the human kidney 2 (HK-2) cell line. CDDP treatment decreased Sirt5 expression of HK-2 cells in a dose-dependent manner. In addition, Sirt5 overexpression enhanced the metabolic...
Thu Nov 14, 2019 18:05
Neurological diseases particularly Alzheimer’s disease (AD), Parkinson’s disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour. Striatum, which is a component of the basal ganglia, is involved in facilitating voluntary movement while the cerebellum is involved in the maintenance of balance and coordination of voluntary movements. Dopamine, serotonin, gamma-aminobutyric...
Thu Nov 14, 2019 18:05
Background. The aim of this study was to assess the retinal and choroidal microvasculature features using optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP). Methods. This study was a meta-analysis of relevant published studies that were included after a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. Mean difference (MD) with a 95% confidence interval was used to assess continuous variable outcomes. Heterogeneity was...
Thu Nov 14, 2019 17:05
Scientists at Harvard’s Wyss Institute have developed a technique to deliver chemotherapy to the lungs using red blood cells. The method involves binding chemotherapy-loaded nanoparticles to red blood cells, which are then injected into the bloodstream. Once the red blood cells reach the lungs they have to squeeze through the small capillaries and the resulting shear force removes the nanoparticles, which can then enter cells within the lungs. The researchers hope that the technique could help treat...
Thu Nov 14, 2019 16:54
Drug-releasing implants may have significant benefits for treating a variety of diseases. They’re already used in a few limited applications, but wider implementation has proven to be challenging because it is difficult to know how a drug moves through the implant and into the surrounding tissues. Now, researchers at Purdue University have developed a way to use an MRI machine to view the movement of a drug through and out of a drug eluting implant. The capability will allow drug implant developers...
Thu Nov 14, 2019 16:35
In the process of bone tissue engineering, the osteoimmunomodulatory property of biomaterials is very important for osteogenic differentiation of stem cells, which determines the outcome of bone regeneration. Magnesium (Mg) is a biodegradable, biocompatible metal that has osteoconductive properties and has been regarded as a promising bone biomaterial. However, the high degradation rate of Mg leads to excessive inflammation, thereby restricting its application in bone tissue engineering. Importantly,...
Thu Nov 14, 2019 16:05
Objective. This study investigates the effects of using a twin inclined plane device (TIPD) on the remolding and ultrastructure variation of mandibular condyle in growing rats. Materials and Methods. Forty-eight male Wistar rats (six weeks old, body weight of approximately 190–210 g) were divided into experimental group (wearing appliance, n = 32) and control group (no appliance, n = 16). Samples were collected on days 3, 14, 30, and 60. The immunohistochemical analysis for vascular endothelial growth...
Thu Nov 14, 2019 16:05
Land use is the main driver of soil organic carbon spatial distribution in a high mountain ecosystem
Background Terrestrial ecosystems play a significant role in carbon (C) storage. Human activities, such as urbanization, infrastructure, and land use change, can reduce significantly the C stored in the soil. The aim of this research was to measure the spatial variability of soil organic C (SOC) in the national park La Malinche (NPLM) in the central highlands of Mexico as an example of highland ecosystems and to determine the impact of land use change on the SOC stocks through deterministic and...
Thu Nov 14, 2019 02:00
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme that plays important roles in multiple cellular processes including phytohormone signaling, plant development, and transcriptional regulation. Although GAPDH genes have been well characterized in various plant species such as Arabidopsis, tobacco, wheat, rice, and watermelon, comprehensive analysis has yet to be completed at the whole genome level in sweet orange (Citrus sinensis). In this study, six GAPDH genes distributed...
Thu Nov 14, 2019 02:00
Background Dysregulated long non-coding RNAs (lncRNAs) may serve as potential biomarkers of cancers including breast cancer (BRCA). This study aimed to identify lncRNAs with strong prognostic value for BRCA. Methods LncRNA expression profiles of 929 tissue samples were downloaded from TANRIC database. We performed differential expression analysis between paired BRCA and adjacent normal tissues. Survival analysis was used to identify lncRNAs with prognostic value. Univariate and multivariate...
Thu Nov 14, 2019 02:00
Background Sacbrood virus (SBV) is one of the most pathogenic honeybee viruses that exhibits host specificity and regional variations. The SBV strains that infect the Chinese honeybee Apis cerana are called Chinese SBVs (CSBVs). Methods In this study, a CSBV strain named AmCSBV-SDLY-2016 (GenBank accession No. MG733283) infecting A. mellifera was identified by electron microscopy, its protein composition was analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis and agar...
Thu Nov 14, 2019 02:00
Background The neuromuscular decline impact in the functional independence of older women is determining the necessity of implementing new strategies focused on core strength training and postural stability maintenance to promote healthy aging. Objectives To define whether Pilates or resistance training is better at improving (a) core isometric and isokinetic muscular strength, and (b) static and dynamic balance, in older women. Methods This was a cluster randomized controlled...
Thu Nov 14, 2019 02:00
miR-221 is regarded as an oncogene in many malignancies, and miR-221-mediated resistance towards TRAIL was one of the first oncogenic roles shown for this small noncoding RNA. In contrast, miR-221 is downregulated in prostate cancer (PCa), thereby implying a tumour suppressive function. By using proliferation and apoptosis assays, we show a novel feature of miR-221 in PCa cells: instead of inducing TRAIL resistance, miR-221 sensitized cells towards TRAIL-induced proliferation inhibition and apoptosis...
Thu Nov 14, 2019 12:05
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