Παρασκευή 1 Νοεμβρίου 2019


Fear in dreams and in wakefulness: Evidence for day/night affective homeostasis.
Related ArticlesFear in dreams and in wakefulness: Evidence for day/night affective homeostasis. Hum Brain Mapp. 2019 Oct 30;: Authors: Sterpenich V, Perogamvros L, Tononi G, Schwartz S Abstract Recent neuroscientific theories have proposed that emotions experienced in dreams contribute to the resolution of emotional distress and preparation for future affective reactions. We addressed one emerging prediction, namely that experiencing fear in dreams...
pubmed: sleep
Thu Oct 31, 2019 12:28
Soft and persistent-The influence of sand-flooring and calves on the resting behavior of a zoo-kept African elephant (Loxodonta africana) group.
Related ArticlesSoft and persistent-The influence of sand-flooring and calves on the resting behavior of a zoo-kept African elephant (Loxodonta africana) group. Zoo Biol. 2019 Oct 29;: Authors: Schiffmann C, Hård T, Hjelm M, Clauss M Abstract Caring for all aspects of zoo elephants' well-being is considered a major challenge. Providing an appropriate flooring substrate to facilitate lying rest presents a meaningful part of a holistic management concept....
pubmed: sleep
Thu Oct 31, 2019 12:28
Wellbuilt for Wellbeing: Controlling Relative Humidity in the Workplace Matters for Our Health.
Related ArticlesWellbuilt for Wellbeing: Controlling Relative Humidity in the Workplace Matters for Our Health. Indoor Air. 2019 Oct 30;: Authors: Razjouyan J, Lee H, Gilligan B, Lindberg C, Nguyen H, Canada K, Burton A, Sharafkhaneh A, Srinivasan K, Currim F, Ram S, Mehl MR, Goebel N, Lunden M, Bhangar S, Heerwagen J, Kampschroer K, Sternberg EM, Najafi B Abstract This study offers a new perspective on the role of relative humidity in strategies to...
pubmed: sleep
Thu Oct 31, 2019 12:28
Behavioral states modulate sensory processing in early development.
Related ArticlesBehavioral states modulate sensory processing in early development. Curr Sleep Med Rep. 2019 Sep;5(3):112-117 Authors: Dooley JC, Sokoloff G, Blumberg MS Abstract Purpose of Review: Sleep-wake states modulate cortical activity in adults. In infants, however, such modulation is less clear; indeed, early cortical activity comprises bursts of neural activity driven predominantly by peripheral sensory input. Consequently, in many studies...
pubmed: sleep
Thu Oct 31, 2019 12:28
Cognitive-Behavioral Therapy for Insomnia: An Effective and Underutilized Treatment for Insomnia.
Related ArticlesCognitive-Behavioral Therapy for Insomnia: An Effective and Underutilized Treatment for Insomnia. Am J Lifestyle Med. 2019 Nov-Dec;13(6):544-547 Authors: Rossman J Abstract Sleep difficulties are an extremely prevalent health problem, with about 33% to 50% of adults reporting regular difficulty falling asleep or staying asleep. About 7% to 18% of adults meet the criteria for an insomnia disorder.1,2 Sleep disruptions contribute to a variety...
pubmed: sleep
Thu Oct 31, 2019 12:28
Medical Treatment and Dose Estimation of a Person Exposed to Tritium.
Related ArticlesMedical Treatment and Dose Estimation of a Person Exposed to Tritium. Dose Response. 2019 Oct-Dec;17(4):1559325819880670 Authors: Chen W, Li H, Wang K, Bian H, Wang Y, Cui F, Liu Y, Chen Q Abstract In this study, we aimed to investigate the damaging effects and clinical therapy of internal contamination with tritium to provide information and gain experience for medical treatments in case of an emergency due to a nuclear accident. Histories...
pubmed: sleep
Thu Oct 31, 2019 12:28
Frequency of Signs and Symptoms in Persons With Asthma.
Related ArticlesFrequency of Signs and Symptoms in Persons With Asthma. Respir Care. 2019 Oct 29;: Authors: He Z, Feng J, Xia J, Wu Q, Yang H, Ma Q Abstract BACKGROUND: Signs and symptoms of asthma are well established; however, no study has been performed to rank them. Therefore, we performed this systematic review and meta-analysis to determine the pooled frequencies of different signs and symptoms of asthma in subjects age ≥ 14 y to develop a patient-specific...
pubmed: sleep
Thu Oct 31, 2019 12:28
Cross-sectional study of the health of southern African truck drivers.
Related ArticlesCross-sectional study of the health of southern African truck drivers. BMJ Open. 2019 Oct 28;9(10):e032025 Authors: Lalla-Edward ST, Fischer AE, Venter WDF, Scheuermaier K, Meel R, Hankins C, Gomez G, Klipstein-Grobusch K, Draaijer M, Vos AG Abstract OBJECTIVES: Lifestyle and working conditions of truck drivers predisposes them to risk-factors associated with communicable and non-communicable diseases, but little is known about the health...
pubmed: sleep
Thu Oct 31, 2019 12:28
Long-term outcomes in patients with acute pulmonary embolism after in-hospital treatment: study protocol of the prospective Lungenembolie Augsburg Studie (LEA study).
Related ArticlesLong-term outcomes in patients with acute pulmonary embolism after in-hospital treatment: study protocol of the prospective Lungenembolie Augsburg Studie (LEA study). BMJ Open. 2019 Oct 28;9(10):e031411 Authors: Meisinger C, Linseisen J, Kirchberger I, von Scheidt W, Berghaus TM Abstract INTRODUCTION: Acute pulmonary embolism (PE) is a frequent life-threatening event and an important cause of hospitalisation, morbidity and mortality worldwide....
pubmed: sleep
Thu Oct 31, 2019 12:28
Evaluating the efficacy of Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis (iBEAT-OA) in the community: a study protocol for a randomised controlled trial.
Related ArticlesEvaluating the efficacy of Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis (iBEAT-OA) in the community: a study protocol for a randomised controlled trial. BMJ Open. 2019 Oct 28;9(10):e030564 Authors: Gohir SA, Greenhaff P, Abhishek A, Valdes AM Abstract INTRODUCTION: Knee osteoarthritis (OA) is the most common joint disease worldwide. As of today, there are no disease-modifying drugs, but there is evidence that...
pubmed: sleep
Thu Oct 31, 2019 12:28
Determining factors related to poor quality of life in patients with axial spondyloarthritis: results from the British Society for Rheumatology Biologics Register (BSRBR-AS).
Related ArticlesDetermining factors related to poor quality of life in patients with axial spondyloarthritis: results from the British Society for Rheumatology Biologics Register (BSRBR-AS). Ann Rheum Dis. 2019 Oct 29;: Authors: Macfarlane GJ, Rotariu O, Jones GT, Pathan E, Dean LE Abstract OBJECTIVE: To determine modifiable factors associated with poor quality of life (QoL) in patients with axial spondyloarthritis (axSpA). METHODS: Analysis...
pubmed: sleep
Thu Oct 31, 2019 12:28
Comparison of land use regression and random forests models on estimating noise levels in five Canadian cities.
Related ArticlesComparison of land use regression and random forests models on estimating noise levels in five Canadian cities. Environ Pollut. 2019 Oct 10;:113367 Authors: Liu Y, Goudreau S, Oiamo T, Rainham D, Hatzopoulou M, Chen H, Davies H, Tremblay M, Johnson J, Bockstael A, Leroux T, Smargiassi A Abstract Chronic exposure to environment noise is associated with sleep disturbance and cardiovascular diseases. Assessment of population exposed to environmental...
pubmed: sleep
Thu Oct 31, 2019 12:28
Comparing acupressure with aromatherapy using Citrus aurantium in terms of their effectiveness in sleep quality in patients undergoing percutaneous coronary interventions: A randomized clinical trial.
Related ArticlesComparing acupressure with aromatherapy using Citrus aurantium in terms of their effectiveness in sleep quality in patients undergoing percutaneous coronary interventions: A randomized clinical trial. Complement Ther Clin Pract. 2019 Oct 23;:101066 Authors: Asgari MR, Vafaei-Moghadam A, Babamohamadi H, Ghorbani R, Esmaeili R Abstract INTRODUCTION: Poor sleep quality is prevalent in candidates for percutaneous coronary interventions (PCIs)....
pubmed: sleep
Thu Oct 31, 2019 12:28
Measurement Invariance and Sleep Quality Differences Between Men and Women in the Pittsburgh Sleep Quality Index.
Related ArticlesMeasurement Invariance and Sleep Quality Differences Between Men and Women in the Pittsburgh Sleep Quality Index. J Clin Sleep Med. 2019 Oct 30;: Authors: Li L, Sheehan CM, Thompson MS Abstract STUDY OBJECTIVES: Previous research has reported mixed results in terms of sex differences in sleep quality. We conducted an analysis of measurement invariance of the Pittsburgh Sleep Quality Index (PSQI) between men and women to provide a necessary...
pubmed: sleep
Thu Oct 31, 2019 12:28
Prematurity as a Risk Factor of Sleep-Disordered Breathing in Children Younger Than Two Years: A Retrospective Case-Control Study.
Related ArticlesPrematurity as a Risk Factor of Sleep-Disordered Breathing in Children Younger Than Two Years: A Retrospective Case-Control Study. J Clin Sleep Med. 2019 Oct 30;: Authors: Sadras I, Reiter J, Fuchs N, Erlichman I, Gozal D, Gileles-Hillel A Abstract STUDY OBJECTIVES: Sleep-disordered breathing (SDB) is a highly prevalent condition affecting 2% to 4% of children. However, the prevalence and characteristics of SDB in children younger than...
pubmed: sleep
Thu Oct 31, 2019 12:28
Effect of Treatment of Central Sleep Apnea/Cheyne-Stokes Respiration on Left Ventricular Ejection Fraction in Heart Failure: A Network Meta-Analysis.
Related ArticlesEffect of Treatment of Central Sleep Apnea/Cheyne-Stokes Respiration on Left Ventricular Ejection Fraction in Heart Failure: A Network Meta-Analysis. J Clin Sleep Med. 2019 Oct 30;: Authors: Schwarz EI, Scherff F, Haile SR, Steier J, Kohler M Abstract STUDY OBJECTIVES: Patients who have experienced heart failure with central sleep apnea/Cheyne-Stokes respiration (CSA/CSR) have an impaired prognosis. Continuous positive airway pressure...
pubmed: sleep
Thu Oct 31, 2019 12:28
Predictors of Insomnia Severity Index Profiles in United States Veterans With Obstructive Sleep Apnea.
Related ArticlesPredictors of Insomnia Severity Index Profiles in United States Veterans With Obstructive Sleep Apnea. J Clin Sleep Med. 2019 Oct 30;: Authors: Wallace DM, Wohlgemuth WK Abstract STUDY OBJECTIVES: The Insomnia Severity Index (ISI) has been used to define insomnia symptoms in individuals with obstructive sleep apnea (OSA). However, whether distinct ISI profiles exist in individuals with OSA is unclear. The aims of this study were to determine...
pubmed: sleep
Thu Oct 31, 2019 12:28
Effects of Pharmacotherapy Treatment on Patient-Reported Outcomes in a Narcolepsy and Idiopathic Hypersomnia Cohort.
Related ArticlesEffects of Pharmacotherapy Treatment on Patient-Reported Outcomes in a Narcolepsy and Idiopathic Hypersomnia Cohort. J Clin Sleep Med. 2019 Oct 30;: Authors: Pascoe M, Bena J, Foldvary-Schaefer N Abstract STUDY OBJECTIVE: We aimed to evaluate the association between patient-reported outcomes (PROs) and treatment regimen/standardized dose (STD), a measure of drug burden, in patients with narcolepsy type 1 (NT1)/type 2 (NT2) and idiopathic...
pubmed: sleep
Thu Oct 31, 2019 12:28
Semistructured Motivational Interviews of Patients and Caregivers to Improve CPAP Adherence: A Qualitative Analysis.
Related ArticlesSemistructured Motivational Interviews of Patients and Caregivers to Improve CPAP Adherence: A Qualitative Analysis. J Clin Sleep Med. 2019 Oct 30;: Authors: Khan NNS, Olomu AB, Bottu S, Roller MR, Smith RC Abstract STUDY OBJECTIVES: The aim of this qualitative analysis was to identify obstructive sleep apnea (OSA) patients' preferences, partner experiences, barriers and facilitators to positive airway pressure (PAP) adherence, and to...
pubmed: sleep
Thu Oct 31, 2019 12:28
Cumulative Health Risk Behaviors and Adolescent Suicide: The Moderating Role of Future Orientation.
Related ArticlesCumulative Health Risk Behaviors and Adolescent Suicide: The Moderating Role of Future Orientation. Am J Health Behav. 2019 Nov 01;43(6):1086-1102 Authors: Xiao Y, Lu W Abstract Objectives: In this study, we investigated the association between cumulative health risk behaviors (HRBs) and adolescent suicidal behaviors and the moderating effect of future orientation. Methods: We used data were from 4255 adolescents in grades 9th-12th participating...
pubmed: sleep
Thu Oct 31, 2019 12:28
Factors of Physical Activity and Sedentary Behavior in Elderly Koreans.
Related ArticlesFactors of Physical Activity and Sedentary Behavior in Elderly Koreans. Am J Health Behav. 2019 Nov 01;43(6):1040-1049 Authors: Park S, Castaneda-Gameros D, Park SY, Oh IH Abstract Objectives: In this study, we examined factors of moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB) in elderly Koreans. Methods: We used 2015 data from the Sixth National Health and Nutrition Examination Survey. To analyze physical activity...
pubmed: sleep
Thu Oct 31, 2019 12:28
Phenotyping 1488 patients with painful temporomandibular disorders and its relevance to subjective sleep quality: A key step for stratified medicine.
Related ArticlesPhenotyping 1488 patients with painful temporomandibular disorders and its relevance to subjective sleep quality: A key step for stratified medicine. Cranio. 2019 Oct 29;:1-11 Authors: Kim HK, Kim ME Abstract Objective: To investigate biopsychosocial characteristics and sleep quality among three TMD phenotypes and to identify the influential factors on sleep quality among those patients.Methods: Retrospective data from chart review and...
pubmed: sleep
Thu Oct 31, 2019 12:28
A Multifactorial Approach to Sleep and Its Association with Health-Related Quality of Life in a Multiethnic Asian Working Population: A Cross-Sectional Analysis.
Related ArticlesA Multifactorial Approach to Sleep and Its Association with Health-Related Quality of Life in a Multiethnic Asian Working Population: A Cross-Sectional Analysis. Int J Environ Res Public Health. 2019 Oct 28;16(21): Authors: Dunleavy G, Tonon AC, Chua AP, Zhang Y, Cheung KL, Thach TQ, Rykov Y, Soh CK, Christopoulos G, de Vries H, Car J Abstract This study aims to explore if objectively and subjectively measured sleep parameters are associated...
pubmed: sleep
Thu Oct 31, 2019 12:28
Low white-matter integrity between the left thalamus and inferior frontal gyrus in patients with insomnia disorder
Related ArticlesLow white-matter integrity between the left thalamus and inferior frontal gyrus in patients with insomnia disorder J Psychiatry Neurosci. 2018 11 01;43(6):366-374 Authors: Kang JMK, Joo SWJ, Son YDS, Kim HK, Ko KPK, Lee JSL, Kang SGK Abstract Background: Previous studies have reported functional and structural abnormalities in the thalamus and the pars triangularis of the inferior frontal gyrus in patients with insomnia disorder. However,...
pubmed: sleep
Thu Oct 31, 2019 12:28
health technology; +270 new citations
270 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: health technology These pubmed results were generated on 2019/10/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
pubmed: health technology
Thu Oct 31, 2019 12:06
Enchantment in psychiatric medicine.
Related ArticlesEnchantment in psychiatric medicine. Asian J Psychiatr. 2019 Oct 09;47:101823 Authors: Redinger M Abstract Max Weber's 1918 essay "Science as a Vocation" posits that increasing scientific knowledge has contributed to a disenchantment of the natural world. His argument has implications for medicine, an applied science aimed at the improvement of health, including psychiatric medicine. Using Weber's argument, this paper discusses the ambivalent...
pubmed: philosophy for medic...
Thu Oct 31, 2019 13:34
Artificial wombs, birth and 'birth': a response to Romanis.
Related ArticlesArtificial wombs, birth and 'birth': a response to Romanis. J Med Ethics. 2019 Oct 29;: Authors: Colgrove N Abstract Recently, I argued that human subjects in artificial wombs (AWs) 'share the same moral status as newborns' and so, deserve the same treatment and protections as newborns. This thesis rests on two claims: (A) subjects of partial ectogenesis-those that develop in utero for at time before being transferred to AWs-are newborns...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Longer-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL): extension study of a randomised trial of 20 757 blood donors.
Related ArticlesLonger-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL): extension study of a randomised trial of 20 757 blood donors. Lancet Haematol. 2019 Oct;6(10):e510-e520 Authors: Kaptoge S, Di Angelantonio E, Moore C, Walker M, Armitage J, Ouwehand WH, Roberts DJ, Danesh J, Thompson SG, INTERVAL Trial Group Abstract BACKGROUND: The INTERVAL trial showed that, over a 2-year period, inter-donation intervals...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Transcatheter closure of atrial septal communication: Impact on quality of life in mid-term follow-up.
Related ArticlesTranscatheter closure of atrial septal communication: Impact on quality of life in mid-term follow-up. Adv Clin Exp Med. 2019 Aug;28(8):1079-1085 Authors: Lelakowska M, Matusik PT, Podolec PS, Olszowska M, Nessler JM, Podolec N, Przewłocki T, Komar M Abstract BACKGROUND: Atrial septal defect (ASD) and patent foramen ovale (PFO) are specific types of atrial septal communications (ASC). OBJECTIVES: We aimed to assess quality of...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Patenting Foundational Technologies: Lessons From CRISPR and Other Core Biotechnologies.
Related ArticlesPatenting Foundational Technologies: Lessons From CRISPR and Other Core Biotechnologies. Am J Bioeth. 2018 12;18(12):36-48 Authors: Feeney O, Cockbain J, Morrison M, Diependaele L, Van Assche K, Sterckx S Abstract In 2012, a new and promising gene manipulation technique, CRISPR-Cas9, was announced that seems likely to be a foundational technique in health care and agriculture. However, patents have been granted. As with other technological...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Facial Feminization Surgery: The Ethics of Gatekeeping in Transgender Health.
Related ArticlesFacial Feminization Surgery: The Ethics of Gatekeeping in Transgender Health. Am J Bioeth. 2018 12;18(12):3-9 Authors: Dubov A, Fraenkel L Abstract The lack of access to gender-affirming surgery represents a significant unmet health care need within the transgender community, frequently resulting in depression and self-destructive behavior. While some transgender people may have access to gender reassignment surgery (GRS), an overwhelming...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Response to Comment on Johnson et al. Cost-effectiveness Analysis of Routine Screening Using Massively Parallel Sequencing for Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Cohort: Reduced Health System Costs and Improved Patient Quality of Life. Diabetes Care 2019;42:69-76.
Related ArticlesResponse to Comment on Johnson et al. Cost-effectiveness Analysis of Routine Screening Using Massively Parallel Sequencing for Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Cohort: Reduced Health System Costs and Improved Patient Quality of Life. Diabetes Care 2019;42:69-76. Diabetes Care. 2019 05;42(5):e79-e80 Authors: Johnson SR, Carter HE, Leo P, Hollingworth SA, Davis EA, Jones TW, Conwell LS, Harris M, Brown MA, Graves N, Duncan EL...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Comment on Johnson et al. Cost-effectiveness Analysis of Routine Screening Using Massively Parallel Sequencing for Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Cohort: Reduced Health System Costs and Improved Patient Quality of Life. Diabetes Care 2019;42:69-76.
Related ArticlesComment on Johnson et al. Cost-effectiveness Analysis of Routine Screening Using Massively Parallel Sequencing for Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Cohort: Reduced Health System Costs and Improved Patient Quality of Life. Diabetes Care 2019;42:69-76. Diabetes Care. 2019 05;42(5):e78 Authors: Estrella JFGL, Simmons D PMID: 31010947 [PubMed - indexed for MEDLINE]
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Histopathologic analysis in chronic rhinosinusitis: Impact on quality of life outcomes.
Related ArticlesHistopathologic analysis in chronic rhinosinusitis: Impact on quality of life outcomes. Am J Otolaryngol. 2019 May - Jun;40(3):423-426 Authors: Wang F, Yang Y, Wu Q, Chen H Abstract OBJECTIVE: This study investigates the impact of histopathologic parameters on quality of life outcomes in patients with chronic rhinosinusitis. SETTING: Hospital of Zhejiang University. STUDY DESIGN: Retrospective analysis of collected...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Advanced heart failure: A review.
Related ArticlesAdvanced heart failure: A review. Adv Clin Exp Med. 2019 Aug;28(8):1143-1148 Authors: Kępińska K, Adamczak DM, Kałużna-Oleksy M Abstract Heart failure (HF) has been recognized as a pandemic and is a serious clinical and health problem associated with significant mortality, morbidity and expenditure on healthcare, especially among older people. Progress in medicine has made it possible for an increasing number of people with HF to live...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
New perspectives about the role of robot-assisted surgery for the treatment of endometriosis.
Related ArticlesNew perspectives about the role of robot-assisted surgery for the treatment of endometriosis. J Robot Surg. 2019 08;13(4):609-610 Authors: Furbetta N, Bianchini M, Palmeri M, Morelli L PMID: 30830570 [PubMed - indexed for MEDLINE]
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Negative body image in breast cancer patients.
Related ArticlesNegative body image in breast cancer patients. Adv Clin Exp Med. 2019 Aug;28(8):1137-1142 Authors: Kołodziejczyk A, Pawłowski T Abstract The aim of this overview study is to familiarize readers with the impact of changes to body image (BI) among patients treated for breast cancer. Body image is subjected to many changes during oncological treatment and every method of treatment (surgery, chemotherapy, radiotherapy, and hormone therapy)...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
Patient-reported outcome and muscle-tendon pain after periacetabular osteotomy are related: 1-year follow-up in 82 patients with hip dysplasia.
Related ArticlesPatient-reported outcome and muscle-tendon pain after periacetabular osteotomy are related: 1-year follow-up in 82 patients with hip dysplasia. Acta Orthop. 2019 02;90(1):40-45 Authors: Jacobsen JS, Søballe K, Thorborg K, Bolvig L, Storgaard Jakobsen S, Hölmich P, Mechlenburg I Abstract Background and purpose - Larger prospective studies investigating periacetabular osteotomy (PAO) with patient-reported outcome measures developed for...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06
The Influence of University Students' Stress Mindsets on Health and Performance Outcomes.
Related ArticlesThe Influence of University Students' Stress Mindsets on Health and Performance Outcomes. Ann Behav Med. 2018 11 12;52(12):1046-1059 Authors: Keech JJ, Hagger MS, O'Callaghan FV, Hamilton K Abstract Background: Emerging evidence indicates that holding particular stress mindsets has favorable implications for peoples' health and performance under stress. Purpose: The aim of the current study was to examine the processes by which...
pubmed: philosophy for medic...
Thu Oct 31, 2019 12:06

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