The 3'X domain of hepatitis C virus has been reported to control viral replication and translation by modulating the exposure of a nucleotide segment involved in a distal base-pairing interaction with an upstream 5BSL3.2 domain. To study the mechanism of this molecular switch, we have analysed the structure of 3'X mutants that favour one of the two previously proposed conformations comprising either two or three stem-loops. Only the two-stem conformation was found to be stable and to allow the establishment...
Wed Nov 06, 2019 20:48
Increasing evidence shows that stimulated by retinoic acid 6 (STRA6) participates in regulating multiple cancers. However, the biological roles of STRA6 in gastric cancer (GC) remain unknown. This study aimed ...
Wed Nov 06, 2019 02:00
Limited effective intervention for advanced hepatocellular carcinoma (HCC) is available. This study aimed to investigate the potential clinical utility of apatinib, a highly selective inhibitor of the vascular...
Wed Nov 06, 2019 02:00
The regulatory non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), emerge as pivotal markers during tumor progression. Abnormal sialylated glycoprotein often leads to the malignan...
Wed Nov 06, 2019 02:00
The first line therapy for patients with diffuse large B cell (DLBCL) is R-CHOP. About half of DLBCL patients are either refractory to, or will relapse, after the treatment. Therefore, identifying novel drug t...
Wed Nov 06, 2019 02:00
Abstract The major cellular antioxidant glutathione (GSH) protects cancer cells from oxidative damage that can lead to the induction of ferroptosis, an iron‐dependent form of cell death triggered by the aberrant accumulation of lipid peroxides. Inhibitors of the cystine‐glutamate antiporter subunit xCT, which mediates the uptake of extracellular cystine and thereby promotes GSH synthesis, are thus potential anticancer agents. On the other hand, the efficacy of xCT‐targeted therapy has been found...
Wed Nov 06, 2019 12:50
Abstract Capn4, also known as CapnS1, is a member of the Calpain family, which plays a crucial role in maintaining the activity and function of calpain. We have previously reported that Capn4 also plays an essential role in the migration of nasopharyngeal carcinoma (NPC) cells through the regulation of matrix metalloproteinase 2 (MMP2) via nuclear factor‐κB (NF‐κB) activation. EBV latent membrane protein 1 (LMP1) is closely related to the malignant behaviors of NPC; however, the relationship between...
Tue Nov 05, 2019 19:57
Cover of this issue. Immunofluorescence of ASCT2 (green) and CD44v (red) in tumors formed in athymic mice injected with HSC‐2 cells. See also Okazaki et al. (pp. https://doi.org/10.1111/cas.141823453–3463 of this issue).
Fri Nov 01, 2019 21:00
We know very well what causes climate change, and in general terms, what the dangers are. This is a new kind of environmental problem, and it is important to understand why responding to climate change is so challenging. But that is no reason to give up: in fact there are many opportunities to intervene, including actions that can be taken by surgeons and other health professionals. Abstract We know very well what causes climate change, and in general terms, what the dangers are. This is a...
Wed Nov 06, 2019 15:24
Three dry lab models were developed including the anastomosis of a transected silicon pancreatic stent (model 1), a rough model (model 2) simulating pancreaticojejunostomy (PJ), and an advanced three‐dimensional printed model (model 3) more vividly simulating PJ. The specifically designed series of dry lab training models may be a potential training tool for advancing the robotic PJ through quality improvement exercise in dry lab. Abstract Background This pioneering study is aimed to design...
Wed Nov 06, 2019 13:48
Computed tomography (CT) is an essential diagnostic tool for severe multi‐trauma patients. Our median time to CT scanning of 43 min is well within the timeframe recommended by international guidelines. Our study shows that early CT scanning may improve outcomes in severely injured trauma patients. Background Computed tomography (CT) is an essential diagnostic tool for severe multi‐trauma patients. International guidelines recommend an optimal time of 1 h from arrival. The aim of this study...
Tue Nov 05, 2019 14:10
Abstract This network meta‐analysis was conducted to compare the efficacy of six interventions including anti‐blocking agents, intrauterine contraceptive devices (IUDs), estrogens, intrauterine balloon, Foley catheter and amnion graft for the prevention of intrauterine adhesions (IUAs). We searched PubMed, Embase and Cochrane Library from inception to December 2016. Cohort studies meeting these six interventions in the prevention of IUAs were included. The combination of direct and indirect evidence...
Wed Nov 06, 2019 14:14
Abstract There have been literature reports that some recommended meropenem dosage regimens may fail to meet therapeutic targets in some high‐risk children and adults. We evaluated this observation in children using literature studies conducted in infants and children. Observed and, as necessary, simulated data from the literature were combined, yielding a dataset of 288 subjects (1 day to ~17 yr). A population pharmacokinetic model was fit to the data and then used to simulate the recommended dosing...
Wed Nov 06, 2019 12:50
Objectives To determine recurrence rates for benign phonotraumatic vocal fold lesions after microlaryngoscopic surgery. Study Design Retrospective review. Methods Records of adults who underwent microlaryngoscopy between 2006 and 2017 for vocal fold cysts, midfold masses, polyps, pseudocysts, sulcus vocalis (Ford type 3), and varices were reviewed for demographics, medical history, treatment, and lesion recurrence. Patients operated for nonphonotraumatic lesions (e.g., granuloma, keratosis/leukoplakia,...
Wed Nov 06, 2019 17:21
Objectives To develop and validate a clinical prediction model (CPM) for survival in hypopharynx cancer, thereby aiming to improve individualized estimations of survival. Methods Retrospective cohort study of hypopharynx cancer patients. We randomly split the cohort into a derivation and validation dataset. The model was fitted on the derivation dataset and validated on the validation dataset. We used a Cox's proportional hazard model and least absolute shrinkage and selection operator (LASSO)...
Wed Nov 06, 2019 17:16
Objectives/Hypothesis Voice outcomes of cordectomy for early glottic cancer are often poor due to vocal fold scarring and tissue defects. Improvements in this aspect could make cordectomy a more acceptable treatment option than radiotherapy. We hypothesized that a polyglycolic acid (PGA) sheet could be used to cover vocal fold defects. The present study aimed to prevent vocal fold scarring after cordectomy using the PGA sheet. Study Design Animal experiment. Methods Nine male beagles...
Wed Nov 06, 2019 17:04
Wed Nov 06, 2019 16:53
Introduction Although attic retractions have previously been classified into Grades 0 through IV, it is often not possible to assign attic retraction pockets into a single specific category. The present study describes an improved classification system based on otoscopic and endoscopic visualization of the retraction pocket fundus, the ossicular status in the attic, degree of scutal erosion, and the presence or absence of cholesteatoma. Materials and Methods One hundred and fifty‐four patients...
Wed Nov 06, 2019 16:35
Objectives/Hypothesis To suggest a strategy for transoral removal of hilar and intraparenchymal submandibular stones. Study Design Retrospective case series. Methods Retrospective evaluation was performed for 514 consecutive patients with hilar and intraparenchymal submandibular stones treated via endoscopy‐assisted surgery from January 2006 to June 2018. Three patients had bilateral stones. The stones were classified as: hilar (type I), posthilar (type II), intraparenchymal (type III),...
Wed Nov 06, 2019 14:31
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07976
Wed Nov 06, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07225
Wed Nov 06, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09385
Wed Nov 06, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09932
Wed Nov 06, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11320
Wed Nov 06, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07723
Wed Nov 06, 2019 07:00
Abstract Human skin melanin pigmentation is regulated by systemic and local factors. According to the type of melanin produced by melanocytes, the transfer and degradation of melanosomes differ, thus accounting for most variations between ethnicities. We made the surprising observation that in a drastically changed environment, white and black phenotypes are reversible since Caucasian skin grafted onto nude mice can become black with all black phenotypic characteristics. Black xenografts differed...
Wed Nov 06, 2019 12:53
Abstract There are virtually no data regarding appropriate oral intake in infants with dwarfing disorders such as achondroplasia, nor is there clear information regarding appropriate weight gain velocity in this population. Yet, these individuals are at increased risk for both early failure to thrive and, later in life, for obesity. Having appropriate expectations regarding weight gain and reasonable goals in management is imperative. We sought to clarify the rate of weight gain in infants with...
Wed Nov 06, 2019 14:14
Abstract Individuals with PWS require marked caloric restriction and daily exercise to prevent morbid obesity. Lower energy expenditure, hypotonia, decreased muscle mass, and cognitive impairment make exercise challenging for this population. Exercise guidelines include resistance training as an important component. Myokine responses to resistance exercise may mediate beneficial metabolic effects. We aimed to determine if young PWS adults can perform a resistance exercise program and to measure...
Wed Nov 06, 2019 14:10
Abstract The aim is to study adults with vascular Ehlers–Danlos syndrome (vEDS) and Loeys–Dietz syndrome (LDS) with regard to sociodemographic characteristics, perceived vascular‐ and multi‐organ symptom burdens, and health services utilization. This is a cross‐sectional study. In 2018, a postal questionnaire was sent to 71 individuals with genetically verified LDS types 1–4 or vEDS, age ≥ 18 years, recruited through a National Resource Centre for Rare Disorders in Norway. Eighteen patients with...
Wed Nov 06, 2019 14:04
Abstract Bohring‐Opitz syndrome (BOS) has been described as a clinically recognizable genetic syndrome since 1999. Clinical diagnostic criteria were established in 2011 and include microcephaly, trigonocephaly, distinctive craniofacial dysmorphic features, facial nevus flammeus, failure to thrive, and severe developmental delays. The same year, different de novo heterozygous nonsense mutations in the ASXL1 were found in affected individuals. Since then, several cases have been reported confirming...
Wed Nov 06, 2019 14:00
As molecular methods continue to elucidate genetic structure at increasingly finer resolutions, delimiting species in the grey zone of the speciation continuum is becoming more relevant in biodiversity research, especially in under-studied biodiversity hotspots such as Southeast Asia where new species are being described at an unprecedented rate. Obvious species at both ends of the speciation continuum have mostly been described and attention is now turning towards the grey zone: an intermediate...
Wed Nov 06, 2019 02:00
Background: Drosanthemum, the only genus of the tribe Drosanthemeae, is widespread over the Greater Cape Floristic Region in southern Africa. With 114 recognized species, Drosanthemum together with the highly succulent and species-rich tribe Ruschieae constitute the 'core ruschioids' in Aizoaceae. Within Drosanthemum, nine subgenera have been described based on flower and fruit morphology. Their phylogenetic relationships, however, have not yet been investigated, hampering understanding of monophyletic...
Wed Nov 06, 2019 02:00
Classical r- vs. K-selection theory describes the trade-offs between high reproductive output and competitiveness and guides research in evolutionary ecology1-5. While its impact has waned in the recent past, cancer evolution may rekindle it6-10. Indeed, solid tumors are an ideal theater for r- and K-selection and, hence, a good testing ground for ideas on life-history strategy evolution11,12. In this study, we impose r- or K-selection on HeLa cells to obtain strongly proliferative r cells and highly...
Wed Nov 06, 2019 02:00
Most model-based molecular phylogenetic methods assume that the sequences diverged on a tree under homogeneous conditions. If evolution occurred under these conditions, then it is unlikely that the sequences would become compositionally heterogeneous. Conversely, if the sequences are compositionally heterogeneous, then it is unlikely that they have evolved under homogeneous conditions. We present methods to detect and analyse heterogeneous evolution in aligned sequence data and to examine--visually...
Wed Nov 06, 2019 02:00
In the absence of effective antiviral therapy, HIV-1 evolves in response to the within-host environment, of which the immune system is an important aspect. During the earliest stages of infection, this process of evolution is very rapid, driven by a small number of CTL escape mechanisms. As the infection progresses, immune escape variants evolve under reduced magnitudes of selection, while competition between an increasing number of polymorphic alleles (i.e., clonal interference) makes it difficult...
Wed Nov 06, 2019 02:00
Since its inception in 1973 the slightly deleterious model of molecular evolution, aka the Nearly Neutral Theory of molecular evolution, remains a central model to explain the main patterns of DNA polymorphism in natural populations. This is not to say that the quantitative fit to data is perfect. In a recent study CASTELLANO et al. (2018) used polymorphism data from D. melanogaster to test whether, as predicted by the Nearly Neutral Theory, the proportion of effectively neutral mutations depends...
Wed Nov 06, 2019 02:00
Sexual interactions play an important role in the evolution of reproductive isolation, with important consequences for speciation. Theoretical studies have focused on the evolution of mate preferences in each sex separately. However, mounting empirical evidence suggests that premating isolation often involves mutual mate choice. Here, using a population genetic model, we investigate how female and male mate choice coevolve under a phenotype matching rule and how this affects reproductive isolation....
Wed Nov 06, 2019 02:00
The cover image is based on the Original Article Quantitative Clinical Adjustment Analysis of Posterior Single Implant Crown in A Chairside Digital Workflow: A Randomized Controlled Trial by Ye Lin et al., https://doi.org/10.1111/clr.13519.
Wed Nov 06, 2019 19:01
Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease characterized by persistent inflammation and bacterial infection. Ciprofloxacin and azithromycin are commonly prescribed antibiotics for CRS, but the ability to provide targeted release in the sinuses could mitigate side effects and improve drug concentrations at the infected site. This study was aimed to evaluate the efficacy of the novel ciprofloxacin‐azithromycin sinus stent (CASS) in vitro. Methods The CASS was created...
Wed Nov 06, 2019 22:00
Background Aspirin‐exacerbated respiratory disease (AERD) is the triad of asthma, nasal polyposis, and sensitivity to cyclooxygenase‐1 inhibitors. Treatment options include medical management, surgical intervention, and aspirin desensitization (AsaD). Methods AERD patients were identified using the MarketScan Database from 2009 to 2015. Patients were included using International Classification of Diseases, 9th edition (ICD‐9) codes for asthma, nasal polyposis, and drug allergy. Treatments...
Wed Nov 06, 2019 22:00
Background Fibroblast migration plays a significant role in wound healing after endoscopic sinonasal surgery. Cigarette smoke extract (CSE) is a potent inhibitor of fibroblast functions including cell proliferation and migration. The purpose of the study was to determine the influence of CSE on migration and collagen gel contraction in nasal fibroblasts and investigate its underlying mechanisms. Methods Fibroblast migration was evaluated using wound healing assay and transwell migration assay....
Wed Nov 06, 2019 20:10
Background Excess opioid use after surgery contributes to opiate misuse and diversion. Understanding opioid prescribing and utilization patterns after sinonasal surgery is critical in designing effective practice protocols. In this study we aim to identify factors associated with variable opioid usage and further delineate optimal prescription patterns for sinonasal surgery. Methods All patients undergoing sinonasal surgery within a single health‐care system from March 2017 to August 2018...
Wed Nov 06, 2019 18:09
Receptor activator of nuclear factor κB ligand is a biomarker for osteitis of chronic rhinosinusitis
Background Evidence of osteitis is frequently observed in patients with chronic rhinosinusitis (CRS), especially in recalcitrant cases. However, studies focusing on biological markers of osteitis are limited and it remains unclear whether osteitis is associated with different phenotypes of CRS. This study aimed to analyze the expression and assess the roles of receptor activator of nuclear factor κB ligand (RANKL) in patients with CRS and osteitis. Methods CRS patients with nasal polyps (CRSwNP,...
Wed Nov 06, 2019 17:55
Background Nasal saline irrigation has become standard of care in various sinonasal conditions, including allergic and nonallergic rhinitis, chronic rhinosinusitis, and in the postoperative patient. Evidence regarding the mechanisms and dynamics of liquid flow through the sinonasal cavity remains limited due to inadequate experimental models (cadaveric, 3‐dimensional [3D] printed, imaging of labeled dyes and radioisotopes). We aimed to develop a computational fluid dynamics (CFD) model of nasal...
Wed Nov 06, 2019 14:40
Background The objective of this study is to characterize changes in hemodynamics, pain, and anxiety during office‐based endoscopic sinus procedures performed under local anesthesia. Methods We conducted a prospective study of adults undergoing in‐office endoscopic sinus procedures under local anesthesia. Patients with American Society of Anesthesiologists (ASA) Physical Status Classification System class 1 or 2 were included. Anesthesia was administered by topical 4% lidocaine/oxymetazoline...
Tue Nov 05, 2019 19:17
Summary Sleep problems in adolescence are increasingly common, and associated with adverse health and psychological outcomes. Adolescents’ sleep problems may be related to the family’s socioeconomic status, but studies are few and no study has examined whether social inequality in sleep problems changes as sleep problems become increasingly common. This study examined trends in difficulties falling asleep among adolescents in Denmark, whether this sleep problem was associated with socioeconomic...
Wed Nov 06, 2019 14:37
Abstract Adolescents are at risk of sleep deficit, which has serious consequences for their daytime functioning. However, school‐based interventions to improve sleep have shown limited success. This might be due to the content of the programmes (e.g., not targeting central factors such as daytime stress and technology use) or because changes have not been captured due to a lack of long‐term follow‐ups. Hence, the aim of this study was to evaluate the long‐term effects of a school‐based sleep education...
Tue Nov 05, 2019 19:03
J Neurol Surg BDOI: 10.1055/s-0039-3399553 Objectives This study was aimed to propose an expanded endoscopic-assisted lateral approach to the infratemporal fossa (ITF) and compare its area of exposure and surgical freedom with the endoscopic endonasal transptergyoid approach (EETA). Methods Anatomical dissections were performed in five cadaver heads (10 sides). The ITF was first examined through the endoscopically assisted lateral corridor, herein referred to as the endoscopic-assisted...
Wed Nov 06, 2019 01:00
J Neurol Surg BDOI: 10.1055/s-0039-1697976 Objectives The main purpose of this article is to investigate the prevalence and features of posterior fossa defects (PFD) in spontaneous cerebrospinal fluid leaks (sCSFL). Design Retrospective case series. Setting Tertiary skull base center. Participants Consecutive adults undergoing lateral skull base repair of sCSFL between 2003 and 2018. Main Outcome Measures The following data were collected:...
Wed Nov 06, 2019 01:00
Horm Metab ResDOI: 10.1055/a-1038-7478© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Wed Nov 06, 2019 01:00
ABSTRACT Objective Symptomatic head trauma associated with American‐style football (ASF) has been linked to brain pathology, along with physical and mental distress in later life. Still, the longer‐term effects of such trauma on objective metrics of cognitive‐motor function remain poorly understood. We hypothesized that ASF‐related symptomatic head trauma would predict worse gait performance, particularly during dual task conditions (i.e., walking while performing an additional cognitive task),...
Wed Nov 06, 2019 17:54
Abstract Objective Clinical outcomes in multiple sclerosis (MS) are highly variable. We aim to determine the long‐term clinical outcomes in MS, and to identify early prognostic features of these outcomes. Methods 132 people presenting with a clinically isolated syndrome (CIS) were prospectively recruited between 1984‐87, and followed up clinically and radiologically 1, 5, 10, 14, 20 and now 30 years later. All available notes and magnetic resonance imaging (MRI) scans were reviewed, and...
Wed Nov 06, 2019 17:08
Abstract Itch, also known as pruritus, is an unpleasant sensation that results in an urge to scratch. We can feel itch at any location where itch occurs from the top of the head to the toes. However, there are topographical differences in itch intensity. Itch is mainly conducted by C nerve fibers from the skin where itch emanates to the central nervous system. However, the abundancy of C fibers does not necessarily lead to higher itch intensity.Interestingly reduction and/or structural changes of...
Wed Nov 06, 2019 14:05
Abstract Objectives The primary objectives were to: 1) identify current published research in electronic health (eHealth) and mobile health (mHealth) interventions for youth undergoing cancer treatment and childhood, adolescent, and young adult survivors of childhood cancer and 2) critically appraise the current scientific evidence on their effectiveness and efficacy. As an exploratory aim, we identified pediatric cancer patients' and survivors' perceptions, attitudes, and concerns related to...
Wed Nov 06, 2019 14:35
Abstract Objective Latina breast cancer survivors (BCS) report more symptom burden and poorer health‐related quality of life than non‐Latina BCS. However, there are few evidence‐based and culturally informed resources that are easily accessible to this population. This study aimed to establish the feasibility and preliminary efficacy of the My Guide and My Health smartphone applications among Latina BCS. Both applications are culturally informed and contain evidence‐based information for reducing...
Wed Nov 06, 2019 13:10
Journal Name: Journal of Pediatric Endocrinology and MetabolismIssue: Ahead of print
01:38
Abstract Purpose To develop a deep convolutional neural network (CNN) model to categorize multiphase CT and MRI liver observations using the liver imaging reporting and data system (LI-RADS) (version 2014). Methods A pre-existing dataset comprising 314 hepatic observations (163 CT, 151 MRI) with corresponding diameters and LI-RADS categories (LR-1–5) assigned...
Wed Nov 06, 2019 02:00
Initial experience with 3D CT cinematic rendering of acute pancreatitis and associated complications
Abstract Inflammation of the pancreas can present with a wide range of imaging findings from mild enlargement of the gland and surrounding infiltrative fat stranding through extensive glandular necrosis. Complications of pancreatitis are varied and include infected fluid collections, pseudocysts, and vascular findings such as pseudoaneurysms and thromboses. Cross-sectional imaging with computed tomography (CT) is one of the mainstays of evaluating patients with pancreatitis. New...
Wed Nov 06, 2019 02:00
Abstract Patients with early stage hepatocellular carcinoma (HCC) can be cured by liver transplantation. HCC imaging features on CT or MRI are specific enough to allow for definitive diagnosis and treatment without the need of confirmatory biopsy. When applied to the appropriate at-risk population the Liver Imaging Reporting and Data System (LI-RADS) imaging criteria achieve high specificity and positive predictive value for the diagnosis of HCC. The Organ Procurement and Transplantation...
Wed Nov 06, 2019 02:00
Abstract Purpose To assess the agreement of one-dimensional transient elastography (1D-TE), two-dimensional shear wave elastography (2D-SWE), and magnetic resonance elastography (MRE) in a consecutive cohort of patients affected by hepatitis C virus (HCV) and to understand which patient-related factors are associated with disagreement. Methods Ninety-one...
Wed Nov 06, 2019 02:00
Abstract Extension of tumor tissue within a vein is a recognized prognostic factor in abdominal malignancy because of its influence on tumor staging and selection of therapeutic management. With the advent of newer surgical techniques, and variable treatment strategies, imaging plays a crucial role in categorizing patients according to the tumor resectability and vascular reconstruction techniques during surgery. Understanding the clinical impact of tumor thrombus increases the...
Wed Nov 06, 2019 02:00
The cover image is based on the Original Article Histopathological changes in tumor budding between biopsy and resected specimens from patients treated with preoperative S‐1 chemotherapy for oral cancer by Mai Seki‐Soda et al., https://doi.org/10.1111/jop.12923
Wed Nov 06, 2019 22:00
Abstract Visfatin acts as a significant regulator of inflammatory cytokines. However, the immunological response and therapeutic effects of visfatin under bacterial stress in murine lung tissue are still not clear. To investigate the role of visfatin on lipopolysaccharide (LPS)-induced acute lung injury (ALI), thirty Kunming mice were divided into Saline, LPS, and LPS + visfatin groups. After routine blood examination, the effects of visfatin...
Wed Nov 06, 2019 02:00
Oncogenesis, Published online: 06 November 2019; doi:10.1038/s41389-019-0174-7Epigenetic regulation of lung cancer cell proliferation and migration by the chromatin remodeling protein BRG1
Wed Nov 06, 2019 02:00
Wed Nov 06, 2019 02:00
Methomyl is the most common cause of suicidal death but heroin is the most common cause of accidental death. The problem is to determine the exact cause and manner of death between methomyl or heroin toxicity....
Tue Nov 05, 2019 02:00
Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the...
Wed Nov 06, 2019 02:00
Paul Leslie Gordon Townsend
Wed Nov 06, 2019 02:00
To identify the progression of voice disorders and their risk factors in teachers.
Wed Nov 06, 2019 02:00
Abstract Masseteric-facial anastomosis has gained popularity in recent days compared to the facial–hypoglossal anastomosis. Masseteric nerve has numerous advantages like its proximity to the facial nerve, stronger motor impulse, its reliability, low morbidity in harvesting and sacrificing the nerve and faster re-innervation that is achievable in most patients. The present case series demonstrate the surgical technique and the effectiveness of the masseteric nerve as donor for early...
Wed Nov 06, 2019 02:00
Abstract Aims to evaluate quality of life in paediatric SDB due to adenotonsillar hypertrophy and efficacy of treatment modalities (medical and surgical) by using OSA-18 questionnaire. Prospective study, conducted from April 2019 to June 2019, including 42 patients with clinical features suggestive of SDB due to adenotonsillar hypertrophy, in age group of 3–15 years. Nasopharyngoscopy was done to grade adenoid hypertrophy. OSA-18 QOL questionnaire was recorded in all patients and...
Wed Nov 06, 2019 02:00
Abstract Purpose Cutaneous T cell lymphomas (CTCL) are rare and histologically diverse lymphoproliferative neoplasms, with mycosis fungoides (MF) representing the most common disease subset. Given the emerging role of myeloid-derived suppressor cells (MDSC) as a clinically applicable biomarker in solid tumors, we sought to investigate the presence of tumor-infiltrating and circulating MDSC in early- and advanced-stage MF patients and evaluate...
Wed Nov 06, 2019 02:00
Abstract Introduction Next-generation sequencing (NGS)-based assays to understand various mutations and co-occurrence of genomic alterations in non-small cell lung cancer (NSCLC) have enabled understanding of treatment impact on clinical outcomes. Methods This retrospective study was conducted in 1353 formalin-fixed paraffin-embedded (FFPE) tissues from surgically...
Wed Nov 06, 2019 02:00
Abstract Purpose Anlotinib is a novel multi-target tyrosine kinase inhibitor (TKI) for tumor angiogenesis and tumor cell proliferation. The efficacy of anlotinib as a third-line or beyond therapy for SCLC was confirmed in the ALTER1202 trial. For lung cancer patients treated with antiangiogenesis agents, the phenomenon of cavitation is commonly seen in the lung target lesions. The impact of tumor cavitation on survival in lung cancer patients...
Wed Nov 06, 2019 02:00
Abstract Purpose In metastatic colorectal cancer (MCRC), mucinous histology has been associated with poor response rate and prognosis. We investigated whether bevacizumab combined with different chemotherapy regimens may have an impact on clinical outcomes of MCRC patients with mucinous histology. Methods 685 MCRC patients were classified in mucinous adenocarcinoma...
Wed Nov 06, 2019 02:00
This article presents a modified cochlear surface preparation method that requires decalcification and use of a cell and tissue adhesive to adhere the pieces of cochlear epithelia to 10 mm round cover slips for immunohistochemistry in adult mouse cochleae.
Wed Nov 06, 2019 23:00
Orthotopic human liver metastatic uveal melanoma xenograft mouse models were created using surgical orthotopic implantation techniques with patient-derived tumor chunk and needle injection techniques with cultured human uveal melanoma cell lines.
Wed Nov 06, 2019 20:00
This protocol outlines the establishment of a mouse model for studying Malassezia-host interactions in the skin. It describes the cultivation of Malassezia in vitro, the infection of the murine skin with Malassezia, and the subsequent analysis of the inflammation and the fungal burden in the skin tissue.
Wed Nov 06, 2019 20:00
The purpose of this study is to establish and validate an animal model for research in the recovery and sequela stages of brain ischemia by testing brain infarction and sensorimotor function after middle cerebral artery occlusion/reperfusion (MCAO/R) after 1-90 days in rats.
Wed Nov 06, 2019 20:00
This method describes the culture of iPSC-derived endothelial cells as 40 perfused 3D microvessels in a standardized microfluidic platform. This platform enables the study of gradient-driven angiogenic sprouting in 3D, including anastomosis and stabilization of the angiogenic sprouts in a scalable and high-throughput manner.
Wed Nov 06, 2019 20:00
CO2-lasertonsillotomy under local anesthesia is an interesting alternative treatment method for tonsillectomy under general anesthesia for tonsil-related complaints in adults. This report presents a step-by-step protocol detailing the execution of CO2-lasertonsillotomy under local anesthesia.
Wed Nov 06, 2019 20:00
We describe an imaging approach for the determination of the average oligomeric state of mEGFP-tagged-receptor oligomers induced by ligand binding in the plasma membrane of living cells. The protocol is based on Total Internal Reflection Fluorescence (TIRF) microscopy combined with Number and Brightness (N&B) analysis.
Wed Nov 06, 2019 20:00
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