The purpose of this study was to evaluate feeding impairment following non-operative or operative management of airway obstruction in a large series of infants with Robin sequence (RS) by rate of G-tube placement. A retrospective study was conducted at Boston Children’s Hospital including 225 patients (47.1% female) with RS treated between 1976 and 2018. Subjects were grouped by intervention required for successful management of airway obstruction: non-operative only (n = 120), tongue–lip adhesion...
Wed Nov 06, 2019 02:00
The primary goal of this study was to identify and quantify indications for retaining third molars. This retrospective cohort study included 1682 patients (818 male, 864 female; mean age 31 years) who were referred to the University Hospitals Leuven for third molar removal. Eight reasons for retaining the third molars were identified: (1) risk of damaging adjacent structures, (2) compromised health status, (3) adequate space for eruption, (4) third molar serves as abutment tooth, (5) orthodontic...
Wed Nov 06, 2019 02:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02248
Wed Nov 06, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03653
Wed Nov 06, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03685
Wed Nov 06, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03661
Wed Nov 06, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03736
Wed Nov 06, 2019 07:00
Here is the annual list of Evolutionary Anthropology Society (EAS) Sessions at the 2019 AAA/CASCA Annual Meeting (Vancouver, Canada). Selected non-EAS Sessions and events of interest from Wednesday through Saturday are also included. Events are listed by day, time, title, session number, section, and location. Use the session number to index more information available from the online PDF program or interactive program. Select mentoring events are marked by (**). EAS Sessions are in bold. We look...
Wed Nov 06, 2019 22:30
Dear Graduate Student, Here we are, well into another semester. Many of you are in the field already or preparing for the field. If you are already there, you may be having a “WTF am I doing” moment. It will be your first of many. If you are preparing for the field, you may be having a “WTF am I supposed to be doing” moment. It probably won’t be your last. [pquote]I fear that in our messaging, we privilege the gregarious, the able-bodied, and the linguistically agile. When I entered the field,...
Wed Nov 06, 2019 19:30
The Society for Latin American and Caribbean Anthropology (SLACA) is proud to award the 2019 Roseberry-Nash Graduate Student Paper Prize to Daniel Salas of Dalhousie University for his essay, “Practices of Double Currency: Value and Politics in Rural Cuba.” Felipe Fernández Lozano of the Free University of Berlin received honorable mention for his paper, “Diseños para escalar la infraestructura: a propósito de la intervención estatal en el casco urbano de Buenaventura, Colombia.” Salas’s paper is...
Wed Nov 06, 2019 16:30
Abstract Hypereosinophilia (HE) is caused by a variety of disorders, ranging from parasite infections to autoimmune diseases and cancer. Only a small proportion of HE cases are clonal malignancies, and one of these, the group of eosinophilia‐associated tyrosine kinase fusion‐driven neoplasms, is sensitive to tyrosine kinase inhibitors, while most subtypes lack specific treatment. Eosinophil functions are highly dependent on actin polymerization, promoting priming, shape change, and infiltration...
Wed Nov 06, 2019 11:17
Το σύστημα γενετικής τροποποίησης CRISPR, γνωστό ευρύτερα ως «μοριακό ψαλίδι», επειδή μπορεί και αποκόπτει συγκεκριμένες αλληλουχίες του γονιδιώματος και να τις αντικαθιστά με άλλες, χρησιμοποιήθηκε για πρώτη φορά για την αντιμετώπιση του καρκίνου. Ερευνητές του Πανεπιστημίου της Πενσιλβάνια δημοσίευσαν τα πρώτα δεδομένα από κλινική δοκιμή του CRISPR σε τρεις ασθενείς με καρκίνο. Τα προκαταρκτικά στοιχεία δείχνουν ότι η θεραπευτική τακτική φαίνεται να είναι ασφαλής, αν και είναι πολύ νωρίς να πουν...
Wed Nov 06, 2019 18:49
Αν και οι μηχανισμοί που ελέγχουν την αρτηριακή πίεση του αίματος είναι ακόμα υπό επιστημονική διερεύνηση, Ιάπωνες ερευνητές ανακοίνωσαν ότι μεταξύ των εμπλεκόμενων παραγόντων στην ρύθμιση της συμπεριφοράς των αιμοφόρων αγγείων περιλαμβάνεται ο υποδοχέας απελίνης (APJ), ο οποίος έχει ήδη φανεί ότι παίζει σημαντικό ρόλο στην ελαστικότητά τους. Σε άρθρο που δημοσιεύουν στο Journal of Biochemistry οι ειδικοί από το Πανεπιστήμιο Tsukuba αναλύουν την δραστηριότητα του APJ, ενός υποδοχέα επιφανείας που...
Wed Nov 06, 2019 13:27
Η ανάλυση δειγμάτων αίματος, σε συνδυασμό με ένα πρόγραμμα τεχνητής νοημοσύνης, αποτελεί ένα νέο τεστ, που μπορεί να επιταχύνει την διάγνωση καρκινικών όγκων στον εγκέφαλο, όπως ανακοίνωσαν Βρετανοί επιστήμονες. Οι εγκεφαλικοί όγκοι συχνά έχουν ασαφή συμπτώματα, όπως πονοκεφάλους και προβλήματα μνήμης, με συνέπεια να μην διαγιγνώσκονται πάντα έγκαιρα. Η μόνη αξιόπιστη μέθοδος διάγνωσης τους είναι σήμερα η σάρωση του εγκεφάλου με μηχάνημα απεικόνισης. Οι ερευνητές, με επικεφαλής τον Δρ. Πολ Μπρέναν...
Wed Nov 06, 2019 13:04
Νέα έρευνα που δημοσιεύθηκε στο Psychological Medicine και διεξήχθη από ερευνητές του Πανεπιστημίου του Μπρίστολ διαπιστώνει ότι το κάπνισμα μπορεί να αυξήσει τον κίνδυνο εμφάνισης κατάθλιψης και σχιζοφρένειας. Είναι γνωστό ότι το κάπνισμα είναι σύνηθες μεταξύ όσων υποφέρουν από ψυχικές νόσους, ιδιαίτερα κατάθλιψη και σχιζοφρένεια. Ωστόσο δεν έχει καταστεί σαφές αν υπάρχει σχέση αιτίου αποτελέσματος και αν ναι, προς ποια κατεύθυνση. Οι ψυχικές νόσοι αυξάνουν την πιθανότητα καπνίσματος ή το κάπνισμα...
Wed Nov 06, 2019 12:39
Μια νέα έρευνα του Πανεπιστημίου του Σίδνει αποδεικνύει ότι αληθεύει η έκφραση ο «καλύτερος φίλος του ανθρώπου» διαπιστώνοντας ότι το δείγμα ιδιοκτητών σκύλων που εξετάστηκαν παρουσίασαν σημαντική μείωση της μοναξιάς που ένιωθαν μέσα σε τρεις μήνες από τότε που απέκτησαν τον τετράποδο φίλο τους. Η δοκιμή PAWS είναι η πρώτη μακροχρόνια ελεγχόμενη μελέτη που εξέτασε την σχέση ανάμεσα στην ιδιοκτησία ενός ζώου και την ψυχική υγεία σε μέλη μιας κοινότητας. Η μελέτη που δημοσιεύθηκε στην BMC Public Health...
Wed Nov 06, 2019 12:31
Ένα πρωτοποριακό επίθεμα υπόσχεται να προλάβει την εκδήλωση χιλιάδων εγκεφαλικών επεισοδίων που άλλες ιατρικές διαγνωστικές συσκευές αποτυγχάνουν να το κάνουν, σύμφωνα με σχετικό άρθρο στο European Journal of Medical Research. Τουλάχιστον αυτό υποστηρίζουν ερευνητές του Βασιλικού Κολεγίου του Λονδίνου που δοκίμασαν το αδιάβροχο επίθεμα με την ονομασία Zio σε 120 ασθενείς με κολπική μαρμαρυγή. Η κολπική μαρμαρυγή είναι συχνότερη καρδιακή αρρυθμία, κατά την οποία ο καρδιακός μυς χτυπά ακανόνιστα...
Wed Nov 06, 2019 10:00
Μπορεί οι περισσότερες μελέτες να εστιάζουν στους παράγοντες που προκαλούν παχυσαρκία στα νήπια, εντούτοις οι επιστήμονες δεν έχουν εστιάσει στους πληθυσμούς που βρίσκονται περισσότερο σε κίνδυνο. Μία μελέτη του Πανεπιστημίου του Μπάφαλο που παρουσιάστηκε στα πλαίσια της Εβδομάδας για την Παχυσαρκία που διεξάγεται στο Λας Βέγκας βρίσκεται ανάμεσα στις πρώτες που εξετάζουν το πώς οι συμπεριφορές της μητέρας επηρεάζουν τα παιδιά σε οικογένειες με χαμηλό κοινωνικοοικονομικό υπόβαθρο. Σχεδόν όλες οι...
Wed Nov 06, 2019 09:10
Δείγματα ούρων ή κολπικών υγρών μπορεί να είναι το ίδιο αποτελεσματικά με το τεστ Παπανικολάου στον εντοπισμό των γυναικών που διατρέχουν αυξημένο κίνδυνο εμφάνισης καρκίνου του τραχήλου της μήτρας, σύμφωνα με νέα έρευνα. Ο καρκίνος του τραχήλου της μήτρας είναι η τέταρτη πιο συχνή μορφή καρκίνου παγκοσμίως. Τα ευρήματα της συγκεκριμένης μελέτης, που παρουσιάστηκαν στο φετινό Συνέδριο του Βρετανικού Ινστιτούτου Έρευνας για τον Καρκίνο, έδειξαν ότι η διαδικασία συλλογής δείγματος ούρων και κολπικών...
Wed Nov 06, 2019 08:50
Οι ηπατικές νόσοι και η κίρρωση του ήπατος που αποτελούν αιτία χιλιάδων θανάτων ετησίως, σύντομα αναμένεται να ανήκουν στον παρελθόν. Σύμφωνα με νέα έρευνα οι επιστήμονες της Κλινικής Mayo υποστηρίζουν ότι οι βλάβες του ήπατος που προκαλούνται από παράγοντες όπως η αυξημένη κατανάλωση αλκοόλ, η ηλικία, άλλες νόσοι ή οι επαναλαμβανόμενοι τραυματισμοί είναι δυνατό να αναστραφούν. Οι επιστήμονες ανακάλυψαν ότι μπορούν να αποκλείσουν τις δύο πρωτεΐνες που μεταφέρουν τις οδηγίες για την δημιουργία των...
Wed Nov 06, 2019 08:15
Abstract Purpose The primary objective of this study is to investigate post-operative morbidity and shunt revision rates of patients with shunt-dependent hydrocephalus (SDH) undergoing posterior vault distraction osteogenesis (PVDO) compared to patients undergoing conventional posterior vault reconstruction (PVR). Methods A retrospective case-controlled cohort...
Wed Nov 06, 2019 02:00
Abstract Introduction Headache is a frequent complaint in children and adolescents. Decision-making for neuroimaging should take into account the cost and the need for sedation in young children. Aim To evaluate the yield of MRI in pediatric headache patients seen in two large tertiary hospitals. ...
Wed Nov 06, 2019 02:00
Abstract Purpose Recent studies aim to reduce radiation exposure associated with computed tomography (CT) using rapid-sequence magnetic resonance imaging (MRI). We evaluated imaging modalities used for hydrocephalus and traumatic brain injury (TBI) to identify opportunities for further radiation exposure reduction. Methods Pediatric (≤ 18 years) patients,...
Wed Nov 06, 2019 02:00
Abstract Anatomical variation is discovered frequently in humans, and much such variation in the musculoskeletal system has been reported. We present a rare case of unilateral congenital patellar tendon aplasia with concomitant apparent shortness of the bilateral halluces as a result of shortened first metatarsals as an anatomical variant.
Wed Nov 06, 2019 02:00
Publication date: Available online 6 November 2019Source: Gait & PostureAuthor(s):
Wed Nov 06, 2019 21:20
Summary In the present study, the antitumoral properties of a series of 7-chloroquinoline-1,2,3-triazoyl-carboxamides (QTCA) were investigated by analyzing their cytotoxic activities against human bladder cells (5637; grade II carcinoma). In addition, their effects on cell viability, cell cycle arrest mechanisms, apoptosis induction, in silico molecular docking, and detection of pro-apoptotic and anti-apoptotic proteins were evaluated. The cytotoxicity assay identified major dose-...
Wed Nov 06, 2019 02:00
Monitoring neurons and other excitable cells in vivo for research and clinical applications has usually required the use of electrode arrays. These are quite limited in their electrode density and the area that they can cover. Moreover, the amount of signal generated by the neurological system overwhelms any attempts at building large scale electronic microelectrode arrays. Fluorescent probes are another modality, but they come with a host of limitations and incompatibilities for use on living humans....
Wed Nov 06, 2019 20:59
Omega Medical Imaging, a firm based in Sanford, Florida, has won FDA clearance for its FluoroShield technology, as well as the 2020 Cardiac Flat Panel Detector. FluoroShield automatically aims the radiation beam across the area of interest during interventional procedures utilizing fluoro or cine (short X-ray movies of the beating heart) imaging. This is thanks to Omega’s TruBlock auto collimation technology. The tissues around the region are not exposed to radiation, but they’re...
Wed Nov 06, 2019 18:48
Magnetic resonance imaging (MRI) requires very expensive scanners, and special facilities to host them. As things stand, most hospitals around the world can’t afford an MRI machine. Things may soon get a bit easier thanks to new metamaterials, developed at Boston University, that improve the quality of MRI imaging. This development may allow lower power MRI scanners, which also cost less, to deliver imaging quality that is comparable with that of more powerful devices. The most obvious way...
Wed Nov 06, 2019 18:15
Publication date: Available online 6 November 2019Source: CortexAuthor(s): Molly Memel, Aubrey A. Wank, Lee Ryan, Matthew D. GrilliAbstractEpisodic details populate autobiographical memories with vivid representations of people, objects, and event happenings, and they link events to a specific time and place. Episodic detail generation is believed to be a function of medial temporal lobe (MTL)-cortical interaction, but much remains unclear about how this retrieval process unfolds. In the present...
Wed Nov 06, 2019 20:38
Publication date: Available online 5 November 2019Source: CortexAuthor(s): Benjamin L. Chernoff, Alex Teghipco, Frank E. Garcea, Raouf Belkhir, Max H. Sims, David A. Paul, Madalina E. Tivarus, Susan O. Smith, Eric Hintz, Webster H. Pilcher, Bradford Z. MahonAbstractUnderstanding the neural mechanisms that support spontaneous recovery of cognitive abilities can place important constraints on mechanistic theories of brain organization and function, and holds potential to inform clinical interventions....
Wed Nov 06, 2019 20:38
Journal of Cutaneous Medicine and Surgery, Volume 23, Issue 5_suppl, Page 3S-11S, November/December 2019. Pediatric atopic dermatitis (AD) is one of the most common dermatoses encountered by health-care providers treating children. Diagnosis of AD is clinical, with no universally accepted biomarkers or assessment tools. Patient-reported outcomes and subjective assessments of quality of life in both the patient and family are important considerations when treating pediatric AD. Here, we provide an...
Wed Nov 06, 2019 06:51
Journal of Cutaneous Medicine and Surgery, Volume 23, Issue 5_suppl, Page 19S-31S, November/December 2019. Because atopic dermatitis (AD) is a chronic, relapsing disease, treatment requires the use of both active therapy to control flares and preventative maintenance therapy to promote integrity of the skin barrier. In this third of four sections, important clinical considerations for the treatment of pediatric AD are reviewed. Emerging therapies in development for pediatric AD are introduced.
Wed Nov 06, 2019 06:51
Journal of Cutaneous Medicine and Surgery, Volume 23, Issue 5_suppl, Page 32S-39S, November/December 2019. This document is intended to provide practical guidance to physicians treating pediatric atopic dermatitis (AD), especially dermatologists, pediatricians, allergists, and other health-care professionals. The recommendations contained here were formalized based on a consensus of 12 Canadian pediatric dermatologists, dermatologists, pediatricians, and pediatric allergists with extensive experience...
Wed Nov 06, 2019 06:51
Journal of Cutaneous Medicine and Surgery, Volume 23, Issue 5_suppl, Page 12S-18S, November/December 2019. Pediatric atopic dermatitis (AD) is one of the most common skin conditions encountered by health-care providers caring for infants, children, and adolescents. Pediatric patients with AD may present with other allergic and nonallergic comorbidities that require appropriate treatment and referral. They may also experience a trajectory of allergic diseases known as the atopic march, which depends...
Wed Nov 06, 2019 06:51
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Pityriasis rubra pilaris (PRP) is an uncommon, inflammatory, papulosquamous skin disease. Treatment of PRP is challenging as the disease is often refractory to conventional therapies, such as retinoids and methotrexate. There has been an increasing number of studies reporting the successful use of biologic therapy in patients with PRP; however, the data on the efficacy and safety are limited. Our objective was to evaluate the existing evidence...
Wed Nov 06, 2019 03:14
The emergence of immunotherapy has dramatically changed how non–small‐cell lung cancer is treated, and longer survival is now possible for some patients, even those with advanced disease. Although some patients achieve durable responses to checkpoint blockade, not all experience such benefits, and some suffer from significant immunotoxicities. Given this, biomarkers that predict response to therapy are essential, and testing for tumor programmed death ligand 1(PD‐L1) expression is the current standard....
Wed Nov 06, 2019 13:33
Background Desmoid tumors (or aggressive fibromatosis) are locally infiltrative connective‐tissue tumors that can arise in any anatomic location; they can be asymptomatic, or they can result in pain, deformity, swelling, and loss of mobility and/or threaten visceral organs with bowel perforation, hydronephrosis, neurovascular damage, and other complications. Existing clinical trial endpoints such as the Response Evaluation Criteria in Solid Tumors (version 1.1) and progression‐free survival are...
Wed Nov 06, 2019 11:01
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Weijian Li, Youjian Li, Wenliang Ma, Jun Zhou, Zhongxu Sun, Xiang YanAbstractBladder cancer (BC) brings a heavy burden to afflicted patients worldwide. In order to find new diagnostic markers and therapeutic targets for this disease, we investigated the role of a novel lncRNA, AC114812.8, in bladder cancer progression. Clone formation and CCK-8 assays were used to detect the proliferative capacity of the...
Wed Nov 06, 2019 20:10
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Rongqi Sun, Tianli Chen, Meng Li, Zengli Liu, Bo Qiu, Zhipeng Li, Yunfei Xu, Chang Pan, Zongli ZhangAbstractBackgroundPerihilar cholangiocarcinoma (PHCCA) is the most common type of human cholangiocarcinoma with a very dismal prognosis. Tumor markers and target drugs of PHCCA are desperately needed. Protein phosphatase N3 (PTPN3) has dual roles in the progression of human cancers, but its expression and...
Wed Nov 06, 2019 20:10
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Shiqing Shao, Chen Wang, Shelian Wang, Hongxia Zhang, Yongyan ZhangAbstractIncreasing evidence revealed that circular RNAs (circRNAs) play important roles in tumor progression. In the present study, we explored the roles and underlying mechanisms of hsa_circ_0075341 in cervical cancer development. Our data showed that the expression of hsa_circ_0075341 was significantly upregulated and associated with larger...
Wed Nov 06, 2019 20:10
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Wei Li, Dan Li, Hongying Kuang, Xiaoling Feng, Wenxia Ai, Ying Wang, Simao Shi, Jing Chen, Ruifeng FanAbstractObjectiveBerberine improves insulin sensitivity and ovulation function in PCOS patients. However, the mechanism by which berberine initiates glucose metabolism-related signaling pathways in ovarian cells remains unknown. This study unveiled a new mechanism by which berberine promotes ovarian cell...
Wed Nov 06, 2019 20:10
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Feifei Feng, Nannan Li, Peng Cheng, Huanan Zhang, Hui Wang, Yongbin Wang, Wei WangAbstractTransforming growth factor-β 1 (TGF-β1) is a key mediator in fibrogenesis, and is upregulated and activated in fibrotic diseases. The exact role of TGF-β1-Smad signaling in the progression of silicosis fibrosis is yet to be conclusively determined. Using a Wistar rat silicosis model, we examined whether tanshinone IIA...
Wed Nov 06, 2019 20:10
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Yuxin Song, Zhan Wang, Lin Liu, Suifeng Zhang, Hui Zhang, Yaowen QianAbstractIntervertebral disc degeneration (IVDD) is a major cause of many spinal diseases characterized mainly by nucleus pulposus degradation. 1,4-dihydropyridine (DHP), a new activator of sirtuin-1 (sirt1), has been reported to have anti-oxidative effects. The aim of this study is to investigate the effect of DHP on nucleus pulposus (NP)...
Wed Nov 06, 2019 20:10
We report three cases of unilateral 18F-FDG uptake in the orbicularis oculi muscle in subjects with contralateral peripheral facial nerve palsy. We argue that this asymmetric uptake pattern in fact reflects lack of metabolism on the side affected by facial nerve palsy, owing to denervation. Since the unilateral periorbital uptake resembles a monocle, we chose to call this finding the monocle sign. The monocle sign should not be confused with inflammation or tumor, but should prompt a neurological...
Wed Oct 23, 2019 03:00
Purpose of the Report The aim of the study was to prospectively compare performance of 18F-fluorocholine (FCH) and 18F-prostate-specific membrane antigen (PSMA)-1007 PET/CT in patients with biochemical relapse (BCR) of prostate cancer and low prostate-specific antigen levels. Methods We prospectively enrolled 40 BCR patients after radical treatment and prostate-specific antigen levels 2.0 ng/mL or less. 18F-FCH and 18F-PSMA-1007 PET/CT imaging was performed within a mean interval of 54 ±...
Wed Oct 23, 2019 03:00
Urothelial carcinoma is the fourth most common genitourinary tumor with the majority of the tumor involving the urinary bladder. Only 5% involves the renal pelvis and ureter. Metastatic urothelial carcinoma of the renal pelvis frequently involves the lymph nodes, lung, liver, bone, and peritoneum. We share rare interesting 18F-FDG PET/CT images of a 60-year-old man with metastatic urothelial carcinoma of the renal pelvis to the bowel. Received for publication June 9, 2019; revision accepted July...
Wed Oct 23, 2019 03:00
Prostate cancer (PCa) treatment monitoring usually relies on prostate-specific antigen to detect disease progression or relapse. PET/CT with prostate-specific membrane antigen (PSMA) ligands has shown high accuracy in detecting metastatic PCa lesions and could help assess response to therapy. We describe herein the early relapse detection of a hormone-sensitive metastatic upfront PCa treated with docetaxel on 68Ga-PSMA-11 PET/CT before biochemical progression. PSMA PET/CT should be considered to...
Wed Oct 23, 2019 03:00
Breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy with isolated case reports of FDG uptake on FDG PET/CT. We present 4 cases of pathology-confirmed BIA-ALCL to illustrate varying presentations and imaging features of this disease process. Breast implant–associated anaplastic large cell lymphoma presents most commonly approximately 10 years after implantation of textured silicone or saline breast implants. Patients may present with breast enlargement, peri-implant...
Wed Oct 23, 2019 03:00
Glioblastoma is the most common primary malignant tumor of the central nervous system, most of which occur in the brain. Primary spinal cord glioblastoma is extremely rare. A 47-year-old woman presented with recurrent and progressive paresthesia and paralysis of right lower extremity. MR examination revealed a marked nodular enlargement of spinal cord at the T12 level, showing heterogeneous enhancement. FDG PET/CT showed this intraspinal lesion with high FDG uptake. Imaging findings indicated a possible...
Wed Oct 23, 2019 03:00
Purpose We sought to distinguish lung adenocarcinoma (ADC) from squamous cell carcinoma using a machine-learning algorithm with PET-based radiomic features. Methods A total of 396 patients with 210 ADCs and 186 squamous cell carcinomas who underwent FDG PET/CT prior to treatment were retrospectively analyzed. Four clinical features (age, sex, tumor size, and smoking status) and 40 radiomic features were investigated in terms of lung ADC subtype prediction. Radiomic features were extracted...
Wed Oct 23, 2019 03:00
Fecal retention can be exacerbated in older patients, bedridden patients, as well as those receiving opioids analgesics or anticholinergic medications. It can lead to impaction, which can have serious consequences, sometimes even requiring surgical intervention. We describe herein the incidental detection of a giant hypometabolic fecaloma on PET/CT with 18F-FDG during the initial staging of a patient with osteosarcoma using opioids for pain management. Received for publication July 18, 2019; revision...
Wed Oct 23, 2019 03:00
Lymphoma involving many different organs can be occasionally observed. However, lymphoma involvement of multiple hormone-producing organs is rare. In this report, we described our FDG PET/CT findings in a 21-year-old man whose Burkitt's lymphoma involved not only lymph nodes, the spleen, the brain, and the bones, but also 4 organs in the endocrine system, including the thyroid, right adrenal, the pancreas, and the right testicle. Received for publication July 15, 2019; revision accepted August...
Wed Oct 23, 2019 03:00
The use of PET/CT with prostate-specific membrane antigen radioligands for staging prostate cancer patients presenting a biochemical recurrence is increasing. As a consequence, the number of reports of diagnostic pitfall of this imaging modality is also increasing. A 75-year-old man referred for a second episode of biochemical recurrence of prostate cancer presented an isolated intense prostate-specific membrane antigen-11 uptake from a right lung abnormality. This abnormality was suggestive of pulmonary...
Wed Oct 23, 2019 03:00
A 57-year-old man, on octreotide treatment for metastatic neuroendocrine tumor pancreas, was referred for whole-body 68Ga-DOTANOC PET/CT scan to evaluate treatment response. PET/CT scan revealed DOTANOC-avid lesion in the head of the pancreas with multiple tracer-avid soft tissue lesions in the liver, bilateral adrenal glands, and periportal lymph nodes. In addition, diffuse intense DOTANOC-avid mural thickening with intraluminal polypoidal mass formation was noted within the stomach causing significant...
Wed Oct 23, 2019 03:00
We report a large mobile bladder calculus with intense 99mTc-MDP uptake demonstrated on both whole-body bone scintigraphy and SPECT/CT images in a patient with complicated chronic history of urolithiasis and urinary tract infection. Bone tracer uptake in bladder calculus is a rare phenomenon and might be related to the composition and matrix of calculus, direct exposure to excreted radiotracer, and bacterial colonization on the surface of calculus. Received for publication April 30, 2019; revision...
Wed Oct 23, 2019 03:00
A 70-year-old woman with breast cancer underwent 18F-FDG PET/CT for restaging. An FDG-avid focus corresponding to a rib on CT images was identified and interpreted as suggestive of an osseous metastasis. A PET/CT-guided biopsy was planned with the patient in prone position. Prone images demonstrated the FDG focus “moved” to the anterior chest and corresponding to pleural fluid. The diagnosis was altered from osseous metastases to pleural malignancy, and the bone biopsy was not performed. This case...
Wed Oct 23, 2019 03:00
Purpose The objective of this study was to evaluate the accuracy of using CT attenuation and SUVs to differentiate enostoses from untreated and treated osteoblastic metastases on the attenuation-correction CT component of 18F-FDG PET/CTs. Methods We retrospectively reviewed 18F-FDG PET/CT studies of 117 patients (169 lesions), of which 65 had imaging of enostoses, and 52 had imaging showing the transition of lesions from untreated to treated osteoblastic metastases. We measured the mean CT...
Wed Oct 23, 2019 03:00
Our patient was a 72-year-old man with absent activity of the right femoral artery and mildly decreased 99mTc-DPD activity on the right leg as indicated on the blood pool and delayed images, respectively. Subsequent peripheral angiography revealed a total occlusion of the right external iliac artery with good collateral flow. Careful review of blood flow and blood pool images of 3-phase bone scintigraphy could provide additional information about peripheral vascular disease. Received for publication...
Wed Oct 23, 2019 03:00
Primary hepatic angiosarcoma was diagnosed in a 59-year-old woman who presented an arthralgia of limbs and dry cough for 6 weeks. Physical examination revealed digital clubbing. A 99mTc-MDP bone scintigraphy showed diffusely increased uptake along the cortical margins of long bones, suggesting hypertrophic osteoarthropathy. Received for publication April 29, 2019; revision accepted August 6, 2019. Conflicts of interest and sources of funding: This study was supported by Zhejiang Province Medical...
Wed Oct 23, 2019 03:00
β-Lactam antibiotics are proconvulsive. In laboratory animals, this effect seems to be predominantly mediated through inhibition of GABA-A receptors, but it has not been demonstrated in humans in vivo. We report images of a [11C]Ro15-4513 PET from a 40-year-old man who had completed a 1-week course of flucloxacillin before it. Relative to healthy controls, the participant had significantly lower mean gray matter binding. These novel data suggest that, in humans, the proconvulsive effect of β-lactam...
Wed Oct 23, 2019 03:00
Primary leiomyosarcoma of the bronchus is an extremely rare malignant neoplasm. A 29-year-old man presented with persisting cough and sputum over 1 month. Unenhanced and contrast-enhanced chest CT showed a nodular lesion in the main bronchus of the left lower lobe and multiple enlarged lymph nodes in the mediastinum. Preoperative staging 18F-FDG PET/CT scan displayed a hypermetabolic lesion of the known nodule and mild FDG uptake of mediastinal lymph nodes. The histological examination confirmed...
Wed Oct 23, 2019 03:00
Purpose The aim of this study was to assess the value of intravenously contrast-enhanced CT in conjunction with 99mTc-MIBI SPECT for preoperative localization of parathyroid adenoma. Methods One hundred ninety-two patients with primary hyperparathyroidism were enrolled in the study between May 2015 and May 2017. The patients underwent a preoperative “one-stop shop” examination with 99mTc-MIBI SPECT/CT by using dual time-point (10 and 90 minutes) protocol and both nonenhanced CT and contrast-enhanced...
Wed Oct 23, 2019 03:00
Introduction Autoimmune lymphoproliferative syndrome (ALPS) is a rare immune dysregulatory condition, usually presenting in childhood with massive lymphadenopathy, splenomegaly, and an increased incidence of lymphoma. Methods to differentiate between benign ALPS adenopathy and lymphoma are needed. To this end, we evaluated the usefulness of FDG PET. Methods We prospectively evaluated 76 ALPS/ALPS-like patients including FS-7–associated surface antigen (FAS) germline mutation with (n = 4)...
Wed Oct 23, 2019 03:00
A patient enrolled in a clinical trial (NCT02802969) with suspicion of chordoma underwent an [18F]FAZA PET/CT, a radiolabeled nitroimidazole analog of hypoxia PET imaging. The patient's images showed a different tumor profile compared to those observed in other hypoxic or nonhypoxic chordoma patients. The motivation for using [18F]FAZA pharmacokinetic imaging was to compare this profile with histologically confirmed cases of chordoma. Through visual imaging and quantification of blood and tumor time-activity...
Wed Oct 23, 2019 03:00
Graft versus host disease (GVHD) is the most frequent and serious complication of allogenic hematopoietic stem cell transplant. Polymyositis is a rare neuromuscular manifestation of GVHD, which often responds well to corticosteroid and immunosuppression therapy. We present a case of a 38-year-old man with a known case of mixed-phenotype acute leukemia after hematopoietic stem cell transplant presenting with GVHD-associated polymyositis. 18F-FDG PET/CT done in this case not only helped in the detection...
Wed Oct 23, 2019 03:00
A 57-year-old woman with a history of uterine endometrial carcinoma underwent PET/CT examinations for initial staging and posttreatment survey. Multiple patchy accumulations were noted in the muscles, particularly in both thighs. These accumulations resolved spontaneously 6 months after the follow-up examination. However, 3.5 years after the surgery, the multiple patchy accumulations reappeared in the muscle of the upper and lower extremities showing an increase in signal intensity from previous...
Wed Oct 23, 2019 03:00
A 64-year-old woman with metastatic breast cancer on follow-up had suspicious recurrent brain metastases. She underwent 18F-FDG PET/CT, 18F-PSMA 1007 brain PET/CT, and brain MRI. 18F-PSMA 1007 showed intense tracer localization in the suspected recurrent brain metastasis in right parietal lobe and also picked up 2 more metastatic brain lesions, which had concurrent findings of metastasis in subsequent MRI. Our case highlights the feasibility of 18F-PSMA 1007 PET/CT imaging of brain metastases from...
Wed Oct 23, 2019 03:00
Pancreatic cancer metastasizing to the testis is extremely rare. We present the case of a 65-year-old man who complained of painless swelling of the left scrotum for 9 months. Scrotal ultrasonography revealed a mass in the left testis. Serum CA199 and CA242 were significantly elevated. 18F-FDG PET/CT was recommended for identifying potential malignancy and showed several hypermetabolic masses in the pancreas, left testis, and right lung. Resection of left testicular and pancreatic masses and fine-needle...
Wed Oct 23, 2019 03:00
A 48-year-old woman with intermittent lower back pain for 9 months and known retroperitoneal neurofibroma underwent 18F-NaF PET/CT scan to assess possible bony lesions causing the pain. Incidentally, the images showed elevated NaF activity in the retroperitoneal neurofibroma. In addition, uterine leiomyoma with heterogeneous calcifications revealed increased NaF activity. Received for publication July 10, 2019; revision accepted August 10, 2019. Conflicts of interest and sources of funding: none...
Wed Oct 23, 2019 03:00
We presented a promising result of radionuclide therapy using 177Lu-PSMA and 177Lu-DOTATATE in a patient with prostatic adenocarcinoma and neuroendocrine differentiation. Functional imaging of somatostatin receptors in patients with metastatic castration-resistant prostate cancer may pave the way toward implementation of novel radionuclide targets for the treatment of this aggressive subtype of prostate cancer. Received for publication May 21, 2019; revision accepted August 11, 2019. Conflicts...
Wed Oct 23, 2019 03:00
A 39-year-old previously healthy woman presented possible hematuria. An ultrasound examination showed right adrenal mass and suggested pheochromocytoma. A 99mTc-HYNIC-TOC SPECT/CT was performed, which incidentally detected situs inversus totalis and suspicion of polysplenia without definite normal spleen in the right upper abdomen. In order to differentiate the polysplenia from other etiologies, a heat-damaged 99mTc RBC scintigraphy was performed. The images showed significant activity in the multiple...
Wed Oct 23, 2019 03:00
Wed Nov 06, 2019 18:32
Abstract Objectives Stable isotope values for historic period human remains from Elmina, Ghana, are compared to isotope data from 18th‐ and 19th‐century North American sites as a test case for examining African origins and identifying first generation Africans in the Mid‐Atlantic region of the United States. Materials and methods Stable carbon, nitrogen, and oxygen isotope values were measured in skeletal remains. Values from the cosmopolitan port city of Elmina provide the first available...
Tue Nov 05, 2019 22:00
Abstract Objectives This article explores the scale and seasonal patterns of mobility at the complex settlement site of Qızqala during the Middle Bronze Age (2400–1,500 BCE). By integrating human bone, teeth, and environmental samples this research tests the hypothesis of the persistent importance of community‐wide seasonal pastoral transhumance during the early formation of complex settlement systems of the South Caucasus. Methods This research applies stable oxygen and radiogenic strontium...
Tue Nov 05, 2019 22:00
Publication date: Available online 6 November 2019Source: International ImmunopharmacologyAuthor(s): Lan-Lan Lin, Guo-Fu Lin, Qiong Luo, Xiang-Qi ChenAbstractBackgroundThe programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors have shown encouraging merits in non-small cell lung cancer (NSCLC) patients, however, they are often related to potentially fatal immune-related adverse events (irAEs) including colitis. Considering the incidence and characteristics of immune-related...
Wed Nov 06, 2019 19:29
Publication date: Available online 6 November 2019Source: International ImmunopharmacologyAuthor(s): Mixue Xie, Xianbo Huang, Xiujin Ye, Wenbin QianAbstractBackgroundRecently, unprecedented clinical efficacy was observed during treatment of many solid tumors because of the introduction of programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) immune checkpoint inhibitors. Preliminary clinical data indicates that checkpoint inhibition also represents a promising therapeutic strategy...
Wed Nov 06, 2019 19:29
Publication date: Available online 6 November 2019Source: International ImmunopharmacologyAuthor(s): Ying Jiang, Feifei Hu, Qiao Li, Chen Shen, Ji Yang, Ming LiAbstractSystemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder leading to progressive tissue fibrosis. Tanshinone IIA (Tan IIA) is a phytochemical extracted from the Chinese herb Salvia miltiorrhiza that exhibits diverse activities. In this study, we attempted to evaluate the potential impact of Tan IIA on the skin fibrosis-related...
Wed Nov 06, 2019 19:29
Publication date: Available online 6 November 2019Source: International ImmunopharmacologyAuthor(s): Zhonghua Xu, Haoyu Yang, Xindie Zhou, Jin Li, Lifeng Jiang, Dong Li, Lidong Wu, Yong Huang, Nanwei XuAbstractThe mTOR signaling pathway has been demonstrated to be related to the development of osteoarthritis (OA) by regulating expression of autophagy regulators. Few studies have shed light on the association of mTOR-pathway-related gene variants with OA risk. Totally 441 OA patients and 533 controls...
Wed Nov 06, 2019 19:29
Publication date: Available online 5 November 2019Source: International ImmunopharmacologyAuthor(s): Tianxin Ye, Cui Zhang, Gang Wu, Weiguo Wan, Jinjun Liang, Xin Liu, Dishiwen Liu, Bo YangAbstractPrevious studies indicate that myocardial infarction (MI) may contribute to atrial fibrillation (AF). Emerging evidence has shown that pinocembrin protects myocardial ischemic injury (I/R)-induced cardiac fibrosis and arrhythmias in animals via its anti-inflammatory or antioxidant activities. However, the...
Wed Nov 06, 2019 19:29
Muscle synergies are now widely discussed as a method for evaluating the existence of redundant neural networks that can be activated to enhance stroke rehabilitation. However, this approach was initially conc...
Mon Nov 04, 2019 02:00
Compensatory movements are commonly employed by stroke survivors during seated reaching and may have negative effects on their long-term recovery. Detecting compensation is useful for coaching the patient to r...
Mon Nov 04, 2019 02:00
Journal of International Medical Research, Ahead of Print.
Tue Nov 05, 2019 09:43
Performance of endoscopic ultrasound for diagnosis of agenesis of the dorsal pancreas: a case report
Journal of International Medical Research, Ahead of Print.
Mon Nov 04, 2019 13:32
Journal of International Medical Research, Ahead of Print.
Mon Nov 04, 2019 13:30
Journal of International Medical Research, Ahead of Print.
Mon Nov 04, 2019 13:25
Journal of International Medical Research, Ahead of Print.
Mon Nov 04, 2019 13:22
Journal of International Medical Research, Ahead of Print.
Mon Nov 04, 2019 13:17
Journal of International Medical Research, Ahead of Print.
Mon Nov 04, 2019 13:15
Journal of International Medical Research, Ahead of Print.
Mon Nov 04, 2019 11:14
Journal of International Medical Research, Ahead of Print.
Mon Nov 04, 2019 10:53
Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Francesca Martora, Maria Elena Della Pepa, Elena Grimaldi, Gianluigi Franci, Veronica Folliero, Arianna Petrillo, Maria Teresa Schettino, Pasquale De Franciscis, Marilena Galdiero, Massimiliano GaldieroAbstractBackgroundThe objective of this work was to provide an update information on HPV age/genotype distribution by retrospectively analyzing a cohort of women living in the metropolitan area of Naples.MethodsFrom January...
Wed Nov 06, 2019 19:10
Publication date: Available online 5 November 2019Source: Journal of ProteomicsAuthor(s): Nilesh Vikram Lande, Pragya Barua, Dipak Gayen, Sunil Kumar, Subhra Chakraborty, Niranjan ChakrabortyAbstractChloroplast, the photosynthetic machinery, converts photoenergy to ATP and NADPH, which powers the production of carbohydrates from atmospheric CO2 and H2O. It also serves as a major production site of multivariate pro-defense molecules, and coordinate with other organelles for cell defense. Chloroplast...
Wed Nov 06, 2019 19:03
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