Mon Nov 11, 2019 17:45
Mon Nov 11, 2019 17:30
Mon Nov 11, 2019 17:30
Mon Nov 11, 2019 17:15
Abstract Background We analyzed the Bureau of Labor Statistics (BLS) fatal and nonfatal injuries and illness data on U.S. workers in the wholesale and retail trade (WRT) sector from 2006 to 2016. The purpose was to identify elevated fatal and nonfatal injury and illness rates in WRT subsectors. Methods To assess the WRT health and economic burden, we retrieved multiple BLS data sets for fatal and nonfatal injury and illness data, affecting more than 20 million employees. We examined yearly...
Mon Nov 11, 2019 12:47
Abstract Objectives Stressful experiences may initiate developmentally plastic responses toward a faster reproductive strategy. This study tests whether adverse childhood experiences (ACEs) are associated with characteristics of faster reproductive strategies: earlier menarche and reduced prenatal investment in offspring in a well‐nourished, low‐immune system burden population. Materials and Methods We analyzed the first 214 enrollees of the prenatal‐birth Albany Infant and Mother Study....
Mon Nov 11, 2019 21:05
Abstract Objectives Small‐bodied vertical clinging and leaping primates have elongated calcanei which enhance leap performance by optimizing leap velocity, distance, and acceleration, but at the expense of experiencing relatively large forces during takeoff and landing. This study tests the hypothesis that the elongated calcaneus of leaping galagids is adapted to resist larger and more stereotyped bending loads compared to more quadrupedal galagids. Materials and Methods The calcanei of...
Mon Nov 11, 2019 21:03
Abstract Objectives A marked asymmetry was previously reported in the sacral alae and S1‐L5 facets orientation of the Neandertal individual Regourdou 1. Here, we provide a detailed description and quantification of the morphology and degree of asymmetry of this sacrum. Material and methods Regourdou 1 was compared to a modern human sample composed of 24 females and 17 males, and to other Neandertal individuals. Both traditional and geometric morphometric analyses were used in order to quantify...
Mon Nov 11, 2019 21:02
Abstract Objectives Here, we quantify and compare the cross‐sectional shape of the mandibular corpus between M1 and M2 during growth in Pan paniscus, Pan troglodytes, and Pongo pygmaeus. The goal is to assess the hypothesis that the shape of the corpus is influenced by the development of permanent molars in their crypts, by examining ontogenetic changes in corpus shape and investigating covariation between corpus shape and M2 and M3 molar crypt forms. Materials and Methods Ontogenetic changes...
Mon Nov 11, 2019 21:02
Abstract Objectives With a growing interest in the mother–infant dyad and the Developmental Origins of Health and Disease hypothesis among biological and medical anthropologists, this study set out to provide all the information required to evaluate if mineralization defects in dentine might be caused by vitamin D deficiency in the critical first 1000 days of life. Materials and Methods Information was compiled on dentine formation in utero to approximately 18 years, and a method for determining...
Mon Nov 11, 2019 11:00
Captive environments affect the gut microbiome of folivorous primates more than that of non‐folivorous primates. Abstract Despite careful attention to animal nutrition and wellbeing, gastrointestinal distress remains relatively common in captive non‐human primates (NHPs), particularly dietary specialists such as folivores. These patterns may be a result of marked dietary differences between captive and wild settings and associated impacts on the gut microbiome. However, given that most existing...
Mon Nov 11, 2019 18:19
Abstract The development of the adrenal cortex varies considerably across primates, being most conspicuous in humans, where a functional zona reticularis–the site of dehydroepiandrosterone‐sulfate (DHEA/S) production–does not develop until middle childhood (5–8 years). Prior reports suggest that a human‐like adrenarche, associated with a sharp prepubertal increase in DHEA/S, may only occur in the genus Pan. However, the timing and variability in adrenarche in chimpanzees remain poorly described,...
Sun Nov 10, 2019 22:00
Journal of Pathology Informatics 2019 10(1):32-32
Mon Nov 11, 2019 00:00
Abstract Introduction Several small studies have reviewed the efficacy of abiraterone acetate plus prednisolone (AAP) in clinical practice outside a trial setting. We report the largest cohort study of clinical outcomes in metastatic castrate‐resistant prostate cancer (mCRPC) patients treated with AAP in a multicenter multiracial clinical setting. Methods A retrospective analysis on mCRPC patients treated at four tertiary hospitals in Singapore from 2012 to 2017 was conducted. Disease characteristics,...
Mon Nov 11, 2019 17:38
European Journal of Clinical Nutrition, Published online: 11 November 2019; doi:10.1038/s41430-019-0528-4Effect of milk fat on LDL cholesterol and other cardiovascular risk markers in healthy humans: the INNOVALAIT project
Mon Nov 11, 2019 02:00
European Journal of Clinical Nutrition, Published online: 11 November 2019; doi:10.1038/s41430-019-0527-5Effects of enteral nutritional rich in n-3 polyunsaturated fatty acids on the nutritional status of gastrointestinal cancer patients: a systematic review and meta-analysis
Mon Nov 11, 2019 02:00
An ageing population leads to more age related diseases, such as complex abdominal aortic aneurysms (AAA). Patients with complex AAAs and multiple comorbidities benefit from fenestrated endovascular aneurysm repair (FEVAR), but for the elderly this benefit is not completely clear.
Mon Nov 11, 2019 02:00
Current clinical guidelines for surgical repair of abdominal aortic aneurysms (AAAs) are primarily based on maximum diameter assessment. From a biomechanical point of view, not only the diameter but also peak wall stresses will play an important role in rupture risk assessment. These methods require patient specific geometry which typically uses computed tomography (CT) or magnetic resonance imaging. Recently, wall stress analysis based on 3D ultrasound (US) has been proposed, and shows promising...
Mon Nov 11, 2019 02:00
Related ArticlesCriticality in tailoring the treatment for tracheoesophageal fistulas in children. Eur Arch Otorhinolaryngol. 2019 Nov 09;: Authors: Asik MB, Almre I, Duchoud L, Sandu K Abstract OBJECTIVE: Tracheo-oesophageal fistula (TOF) is a rare pathology. It can be congenital and concurrent with other congenital anomalies such as oesophageal atresia, laryngeal and tracheal agenesis, or it can be acquired. The purpose of this study was to analyse...
Mon Nov 11, 2019 13:40
Related ArticlesMeasurement of mucociliary clearance in the patients with multiple sclerosis. Eur Arch Otorhinolaryngol. 2019 Nov 09;: Authors: Sahin E, Hamamcı M, Kantekin Y Abstract OBJECTIVES: The aim of the present study was to measure nasal mucociliary clearance (NMC) time in the patients with MS and to compare the findings with healthy population. METHODS: Totally 97 individuals including 47 patients with relapsing-remitting multiple sclerosis...
Mon Nov 11, 2019 13:40
Related ArticlesSurgical repair of mechanical ventilation induced tracheoesophageal fistula. Eur Arch Otorhinolaryngol. 2019 Nov 08;: Authors: Dhiwakar M, Ronen O, Supriya M, Mehta S Abstract PURPOSE: To evaluate the outcomes of surgery to repair tracheoesophageal fistula (TEF) caused by mechanical ventilation. METHOD: Case series and review of all cases reported in English literature. Only reports of TEF following mechanical ventilation and...
Mon Nov 11, 2019 13:40
Related ArticlesAssociations among sleep symptoms, physical examination, and polysomnographic findings in children with obstructive sleep apnea. Eur Arch Otorhinolaryngol. 2019 Nov 08;: Authors: Yan XH, Zhao Y, Wang J, Shen T, Yang W, Qiao Y, Cheng D, Chen M Abstract PURPOSE: The relationships among PSG findings, OSA symptoms, and tonsil and adenoid size are not clear. In this study, we aimed to investigate the associations between pediatric OSA and...
Mon Nov 11, 2019 13:40
Abstract Aim To compare the efficacy of ultrasonically activated irrigation (UAI), photon‐induced photoacoustic streaming (PIPS), and shock wave enhanced emission photoacoustic streaming (SWEEPS) activation for the removal of accumulated hard‐tissue debris (AHTD) from the root canal system of mandibular molars when assessed using microcomputed tomography (micro‐CT). Methodology A total of 30 mandibular first and second molars with joining mesial root canals containing an isthmus and a single...
Mon Nov 11, 2019 15:31
AbstractWe explore the different types of causes that are commonly investigated by epidemiologists. We first distinguish between causes which are events (including actions) and causes which are states. Second, we distinguish between modifiable and non-modifiable states. This yields three types of causes: fixed states (non-modifiable), dynamic states (modifiable) and events (including actions). Different causes may have different characteristics: the methods available to study them, the types of possible...
Sat Nov 09, 2019 02:00
Mon Nov 11, 2019 13:15
Abstract Background Speech‐sound development in preschoolers with unilateral cleft lip and palate (UCLP) as a group is delayed/disordered, and obstruents comprise the most vulnerable sound class. Aims To evaluate the development of obstruent correctness (PCC‐obs) and error types (cleft speech characteristics (CSCs) and developmental speech characteristics (DSCs)) from ages 3–5 and to investigate possible predictors (error types, velopharyngeal dysfunction (VPD) and gender) of PCC‐obs at...
Mon Nov 11, 2019 13:01
IJMS, Vol. 20, Pages 5646: DNA Methylation-Governed Gene Expression in Autoimmune Arthritis International Journal of Molecular Sciences doi: 10.3390/ijms20225646 Authors: Barbara Brandt Shima Rashidiani Ágnes Bán Tibor A. Rauch Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease hallmarked by progressive and irreversible joint destruction. RA pathogenesis is a T cell-regulated and B cell-mediated process in which activated lymphocyte-produced chemokines and...
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IJMS, Vol. 20, Pages 5647: Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins International Journal of Molecular Sciences doi: 10.3390/ijms20225647 Authors: Vedud Purde Florian Busch Elena Kudryashova Vicki H. Wysocki Dmitri S. Kudryashov Actin-depolymerizing factor (ADF)/cofilins accelerate actin turnover by severing aged actin filaments and promoting the dissociation of actin subunits. In the cell, ADF/cofilins...
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IJMS, Vol. 20, Pages 5645: Cell-Free Nucleic Acids International Journal of Molecular Sciences doi: 10.3390/ijms20225645 Authors: Balint Nagy The discovery of cell-free DNA (cfDNA) dates back to 1948, when Mandel and Metais found it in the sera of cancer patients [...]
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IJMS, Vol. 20, Pages 5643: A Brief History of Mitochondrial Pathologies International Journal of Molecular Sciences doi: 10.3390/ijms20225643 Authors: Salvatore DiMauro The history of “mitochondrial pathologies”, namely genetic pathologies affecting mitochondrial metabolism because of mutations in nuclear DNA-encoded genes for proteins active inside mitochondria or mutations in mitochondrial DNA-encoded genes, began in 1988. In that year, two different groups of researchers...
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IJMS, Vol. 20, Pages 5642: Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies International Journal of Molecular Sciences doi: 10.3390/ijms20225642 Authors: Ehlert Roszek Jędrzejewski Bartmański Radtke The increasing need for novel bone replacement materials has been driving numerous studies on modifying their surface to stimulate osteogenic cells expansion and to accelerate bone tissue regeneration. The goal of the presented...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5644: Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1 International Journal of Molecular Sciences doi: 10.3390/ijms20225644 Authors: Kalathiya Padariya Pawlicka Verma Houston Hupp Alfaro Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that recognizes post-transcriptionally abnormal transcripts and mediates their degradation. The master regulator of...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5640: Novel Descriptors and Digital Signal Processing- Based Method for Protein Sequence Activity Relationship Study International Journal of Molecular Sciences doi: 10.3390/ijms20225640 Authors: Fontaine Cadet Vetrivel The work aiming to unravel the correlation between protein sequence and function in the absence of structural information can be highly rewarding. We present a new way of considering descriptors from the amino acids index database for modeling...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5641: Cytonemes, Their Formation, Regulation, and Roles in Signaling and Communication in Tumorigenesis International Journal of Molecular Sciences doi: 10.3390/ijms20225641 Authors: Casas-Tintó Portela Increasing evidence during the past two decades shows that cells interconnect and communicate through cytonemes. These cytoskeleton-driven extensions of specialized membrane territories are involved in cell–cell signaling in development, patterning,...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5637: Cloning and Expression Analysis of the BocMBF1c Gene Involved in Heat Tolerance in Chinese Kale International Journal of Molecular Sciences doi: 10.3390/ijms20225637 Authors: Lifang Zou Bingwei Yu Xing-Liang Ma Bihao Cao Guoju Chen Changming Chen Jianjun Lei Chinese kale (Brassica oleracea var. chinensis Lei) is an important vegetable crop in South China, valued for its nutritional content and taste. Nonetheless, the thermal tolerance of Chinese...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5638: The Novel Perspectives of Adipokines on Brain Health International Journal of Molecular Sciences doi: 10.3390/ijms20225638 Authors: Thomas Ho-yin Lee Kenneth King-yip Cheng Ruby Lai-chong Hoo Parco Ming-fai Siu Suk-yu Yau First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the endocrine system. Precisely, adipose tissue can produce an array of bioactive factors, including cytokines, lipids, and extracellular...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5635: Anti-Inflammatory and Anti-Hyperuricemic Functions of Two Synthetic Hybrid Drugs with Dual Biological Active Sites International Journal of Molecular Sciences doi: 10.3390/ijms20225635 Authors: Rafa S. Almeer Sherif F. Hammad Ola F. Leheta Ahmed E. Abdel Moneim Hatem K. Amin The present study aimed to test the anti-inflammatory and xanthine oxidase inhibitory activities of two synthesized molecules and compare them to routinely prescribed nonsteroidal...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5636: Exploring the Molecular Mechanism underlying the Stable Purple-Red Leaf Phenotype in Lagerstroemia indica cv. Ebony Embers International Journal of Molecular Sciences doi: 10.3390/ijms20225636 Authors: Qiao Liu Zeng Li Wang Chen Wang Cai Lagerstroemia indica is an important ornamental tree worldwide. The development of cultivars with colorful leaves and increased ornamental value represents one of the current main research topics....
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5633: Microcalcifications Drive Breast Cancer Occurrence and Development by Macrophage-Mediated Epithelial to Mesenchymal Transition International Journal of Molecular Sciences doi: 10.3390/ijms20225633 Authors: Manuel Scimeca Rita Bonfiglio Erika Menichini Loredana Albonici Nicoletta Urbano Maria Teresa De Caro Alessandro Mauriello Orazio Schillaci Alessandra Gambacurta Elena Bonanno Background: This study aims to investigate: (a) the...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5639: Maternal Platelets of the Human Placenta: Friend or Foe? International Journal of Molecular Sciences doi: 10.3390/ijms20225639 Authors: Moser Guettler Forstner Gauster Human pregnancy relies on hemochorial placentation, including implantation of the blastocyst and deep invasion of fetal trophoblast cells into maternal uterine blood vessels, enabling direct contact of maternal blood with placental villi. Hemochorial placentation requires fast and...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5632: Mechanisms of Neuronal Death in the Cerebral Cortex during Aging and Development of Alzheimer’s Disease-Like Pathology in Rats International Journal of Molecular Sciences doi: 10.3390/ijms20225632 Authors: Darya V. Telegina Gleb K. Suvorov Oyuna S. Kozhevnikova Nataliya G. Kolosova Alzheimer’s disease (AD) is the commonest type of late-life dementia and damages the cerebral cortex, a vulnerable brain region implicated in memory, emotion,...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5634: Identification of MicroRNAs That Respond to Soybean Cyst Nematode Infection in Early Stages in Resistant and Susceptible Soybean Cultivars International Journal of Molecular Sciences doi: 10.3390/ijms20225634 Authors: Piao Lei Bing Han Yuanyuan Wang Xiaofeng Zhu Yuanhu Xuan Xiaoyu Liu Haiyan Fan Lijie Chen Yuxi Duan Soybean cyst nematode (SCN) causes heavy losses to soybean yield. In order to investigate the roles of soybean miRNAs during...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5631: The Bile Acid-Phospholipid Conjugate Ursodeoxycholyl-Lysophosphatidylethanolamide (UDCA-LPE) Disintegrates the Lipid Backbone of Raft Plasma Membrane Domains by the Removal of the Membrane Phospholipase A2 International Journal of Molecular Sciences doi: 10.3390/ijms20225631 Authors: Wolfgang Stremmel Simone Staffer Gert Fricker Ralf Weiskirchen The bile acid-phospholipid conjugate ursodeoxycholyl-lysophosphatidylethanolamide (UDCA-LPE) was shown to...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5629: Using PAR4 Inhibition as an Anti-Thrombotic Approach: Why, How, and When?
IJMS, Vol. 20, Pages 5629: Using PAR4 Inhibition as an Anti-Thrombotic Approach: Why, How, and When? International Journal of Molecular Sciences doi: 10.3390/ijms20225629 Authors: Simeng Li Volga Tarlac Justin R. Hamilton Protease-activated receptors (PARs) are a family of four GPCRs with a variety of cellular functions, yet the only advanced clinical endeavours to target these receptors for therapeutic gain to date relates to the impairment of platelet function for anti-thrombotic...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5628: RgsA Attenuates the PKA Signaling, Stress Response, and Virulence in the Human Opportunistic Pathogen Aspergillus fumigatus International Journal of Molecular Sciences doi: 10.3390/ijms20225628 Authors: Hnin Phyu Lwin Yong-Ho Choi Min-Woo Lee Jae-Hyuk Yu Kwang-Soo Shin The regulator of G-protein signaling (RGS) proteins play an important role in upstream control of heterotrimeric G-protein signaling pathways. In the genome of the human opportunistic...
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5630: A Multiple Protease Strategy to Optimise the Shotgun Proteomics of Mature Medicinal Cannabis Buds International Journal of Molecular Sciences doi: 10.3390/ijms20225630 Authors: Delphine Vincent Vilnis Ezernieks Simone Rochfort German Spangenberg Earlier this year we published a method article aimed at optimising protein extraction from mature buds of medicinal cannabis for trypsin-based shotgun proteomics (Vincent, D., et al. Molecules 2019, 24, 659)....
Mon Nov 11, 2019 02:00
IJMS, Vol. 20, Pages 5626: Epinephrine Infiltration of Adipose Tissue Impacts MCF7 Breast Cancer Cells and Total Lipid Content International Journal of Molecular Sciences doi: 10.3390/ijms20225626 Authors: Pierre Avril Luciano Vidal Sophie Barille-Nion Louis-Romée Le Nail Françoise Redini Pierre Layrolle Michelle Pinault Stéphane Chevalier Pierre Perrot Valérie Trichet Background: Considering the positive or negative potential effects of adipocytes, depending...
Mon Nov 11, 2019 02:00
International Journal of Obesity, Published online: 12 November 2019; doi:10.1038/s41366-019-0459-0Association of BMI category with change in children’s physical activity between ages 6 and 11 years: a longitudinal study
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Mon Nov 11, 2019 05:47
We assessed the outcome of dysphagia rehabilitation in all the 139 patients with post-stroke dysphagia admitted to our Neurorehabilitation Unit during 2 years (2017 and 2018), divided into two groups: old (aged 65–84 years) and oldest-old (aged 85 or above). We studied which factors predicted dysphagia improvement in the two groups. The potential association of improvement with type of discharge was also evaluated. On admission, ‘old’ patients had more frequently aphasia (P = 0.02) and less frequently...
Thu Nov 07, 2019 02:00
This study was a descriptive type, and the research population was the patients between the age of 30 and 75, who went to 18 different Family Health Centres in dif ferent places in Turkey for any reason in July–September 2016. The survey was completed by face-to-face interview and consisted of 20 questions about the socio-demographic attributes, level of cancer and cancer screenings knowledge, causes of screening, and reasons for not doing. Screening rates w as self-reported by patients. A total...
Mon Nov 11, 2019 00:00
AbstractDisparities in cancer incidence and mortality rates among racial and ethnic minorities (African Americans, Asian Americans, Pacific Islanders, American Indians, and Latinos/Hispanic Americans) in the USA are well documented. Enrollment of underrepresented populations in cancer therapeutic clinical trials, however, is very low. This is true despite federal mandates to ensure accrual rates adequate for analyses and the evidence that the effectiveness of specific therapies and medications varies...
Mon Nov 11, 2019 00:00
AbstractBreast cancer is the most commonly diagnosed cancer among women in the USA. Despite the availability of screening mammograms, significant disparities still exist in breast cancer outcomes of racial/ethnic and sexual/gender minorities. To address these disparities, the Mount Sinai Mobile Breast Health Program in New York City collaborated with local organizations to develop culturally and linguistically appropriate breast cancer education programs aimed at increasing screening mammogram utilization....
Mon Nov 11, 2019 00:00
ConclusionsStrengths include an innovative model of referral and funding, through a life insurance provider, the involvement of a multidisciplinary collaborative team to design, develop and implement the pilot, and considerable consumer involvement.Implications for Cancer SurvivorsThe refined intervention will address a critical gap to improve reintegration into work and society, contributing to improved quality of life for cancer survivors in Australia. Models of referral through insurers to rehabilitation...
Mon Nov 11, 2019 00:00
Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF‐kB/NLRP3 pathway
Via experiments, we found that Rg1 could attenuate lipopolysaccharide induced inflammation and apoptosis both in neonatal rat cardiomyocytes and septic mice and restore the impaired cardiac function. Moreover, Rg1 exerted its role may via blocking Toll‐like receptor 4 TLR4/nuclear factor‐κB/NOD‐like receptor 3 pathway. Abstract Sepsis‐induced myocardial dysfunction (SIMD) causes high mortality in seriously ill patients. Ginsenoside Rg1 has been proven to have effective anti‐inflammatory and antiapoptotic...
Mon Nov 11, 2019 12:50
In this study, we first explored the role of RIL in autophagy during antitumor process. Our data first indicated that RIL could block the complete autophagic flux, inhibiting autophagy in pancreatic cancer cells. Abstract Pancreatic cancer is always diagnosed at an advanced stage. Hence, chemotherapy becomes the best choice for patients. Therefore, new anticancer drugs for pancreatic cancer are needed. Riluzole (RIL) is mainly used to treat amyotrophic lateral sclerosis clinically, but many previous...
Mon Nov 11, 2019 12:50
Peroxisome proliferator activated receptor γ (PPARγ) promotes mineralization and differentiation in cementoblasts by inhibiting the Wnt/β‐catenin signaling, and PPARγ not only inhibits the expression of inflammatory cytokines but also promotes the expression of mineralization genes under inflammatory condition in cementoblasts. Abstract Peroxisome proliferator activated receptor γ (PPARγ) is a member of the nuclear receptor family of transcription factors, which involved in inflammation regulating...
Mon Nov 11, 2019 12:50
Epithelial‐mesenchymal transformation (EMT) is associated with drug resistance in human lung adenocarcinoma cells, but its specific mechanism has not been clarified. In this study, we investigated the effect of miRNA‐146b on EMT in cisplatin (DDP) resistant human lung adenocarcinoma cells and the corresponding mechanism, to provide valuable molecular markers for clinical individualized treatment of lung adenocarcinoma, and to find new molecular therapeutic targets for reversing its chemotherapy resistance....
Mon Nov 11, 2019 12:50
EIF3J‐AS1 level was elevated in colorectal cancer (CRC), and silencing it reduced proliferation whilst increased apoptosis. EIF3J‐AS1 was induced by CBP‐mediated H327ac in CRC cells. Abstract Long noncoding RNAs (lncRNAs) are found to be aberrantly expressed and pose significant impacts in colorectal cancer (CRC), the most prevalent type malignancy in the gastrointestinal tract. This study aimed to find out the regulation of lncRNA EIF3J antisense RNA 1 (EIF3J‐AS1) on CRC progression. Expressions...
Mon Nov 11, 2019 12:50
Preterm birth (PTB) is a major cause of neonatal mortality, with a poorly understood etiology. Using liquid chromatography‐mass spectrometry (LC‐MS), we found 322 significantly different peptides in myometrium tissues between term nonlabor (TNL) and term labor (TL) groups.The characteristics of these peptides provide a deeper understanding of peptides in labor onset and further insight into PTB therapy. Abstract Preterm birth (PTB) is a major cause of neonatal mortality, with a poorly understood...
Mon Nov 11, 2019 12:50
Out of 11 adipokines studied NAMPT, APLN, GRN, SERPINE1, and CCL2 messenger RNA (mRNA) levels were significantly upregulated in both low grade gliomas (LGG) and glioblastoma mutiforme (GBM). Whereas, Interleukin 6 (IL6) mRNA was found be significantly upregulated in GBM only. NAMPT, GRN, SERPINE1, and IL6 showed reduced overall survival (OS) as well as worst disease‐free survival (DFS) for patients having higher mRNA expression in LGG. Whereas, increased expression of CCL2 showed the worst OS in...
Mon Nov 11, 2019 12:38
Background Term infants learn word–object relations in their first year during multisensory interactions with caregivers. Although preterm infants often experience language delays, little is known about how caregivers contribute to their early word–object learning. The present longitudinal study compared maternal naming and word learning in these infant groups. Methods Forty moderately preterm and 40 term infants participated at 6–9 and 12 months with their mothers. At each visit, mothers...
Mon Nov 11, 2019 14:16
Mon Nov 11, 2019 02:00
JCM, Vol. 8, Pages 1941: The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing Journal of Clinical Medicine doi: 10.3390/jcm8111941 Authors: Manciula Berce Tabaran Trombitaș Albu . Background: Wound healing of the nasal mucosa after endoscopic sinus surgery (ESS) is frequently complicated by scaring and consequently recurrences are encountered. Methods of optimizing results have been sought. In the present study we evaluated the effects...
Mon Nov 11, 2019 02:00
JCM, Vol. 8, Pages 1942: Cancer Risk in Collagenous Colitis Journal of Clinical Medicine doi: 10.3390/jcm8111942 Authors: Larsson Dabos Höglund Bohr Münch Giannakou Nemeth Wurm-Johansson Toth Plevris Fineron Koulaouzidis Sjöberg Data on malignancy in patients with collagenous colitis (CC) is scarce. We aimed to determine the incidence of cancers in patients with CC. In a two-stages, observational study, data on cancers in patients diagnosed...
Mon Nov 11, 2019 02:00
JCM, Vol. 8, Pages 1939: Comments from the Editor of the Special Issue “Type 2 Diabetes: Update on Pathophysiology and Treatment” Journal of Clinical Medicine doi: 10.3390/jcm8111939 Authors: Tomoaki Morioka The editor would like to offer the Special Issue “Type 2 Diabetes: Update on Pathophysiology and Treatment” to the community of diabetes clinicians and researchers. This Special Issue aims to update our understanding of the pathophysiology and treatment of type...
Mon Nov 11, 2019 02:00
JCM, Vol. 8, Pages 1940: First Evaluation of an Index of Low Vagally-Mediated Heart Rate Variability as a Marker of Health Risks in Human Adults: Proof of Concept Journal of Clinical Medicine doi: 10.3390/jcm8111940 Authors: Marc N. Jarczok Julian Koenig Arne Wittling Joachim E. Fischer Julian F. Thayer Multiple studies have demonstrated low vagally-mediated heart rate variability (HRV) being associated with a range of risk factors for heart disease and stroke, including...
Mon Nov 11, 2019 02:00
The authors reported a case of extensive maxillary osteoradionecrosis. The maxilla was resected and reconstructed with fibula musculocutaneous flap. It was the first reported that the osteoradionecrotic maxilla was reconstructed with free vascularized bone. The musculocutaneous flap might be a better choice of maxillary osteoradionecrosis reconstruction instead of the simple soft-tissue flap. Address correspondence and reprint requests to Yue He, PhD, Department of Oral Maxillofacial—Head and Neck...
Mon Nov 04, 2019 02:00
No abstract available
Mon Nov 04, 2019 02:00
Large skull bone defects of the cranial vault can result from various reasons. Reconstruction of these defects is performed for protective and aesthetic reasons but is also required for adequate intracranial homeostasis. Computer-aided-design/computer-aided-manufacturing (CAD/CAM) patient-specific skull implants have become the most valuable alternative to the traditional methods of reconstruction and a growing number of publications is dealing with this topic in adults. Literature related to the...
Mon Nov 04, 2019 02:00
The authors report a patient with masticator space abscess due to an ascending infection following a wisdom tooth extraction. They administered antibiotics and did an incision and drainage; however, osteomyelitis of the mandible and compartment syndrome of the temporal muscle complicated the course. The authors suggest a physiopathology and discuss the management of this study. Address correspondence and reprint requests to Gian Battista Bottini, MD, DMD, Department of Oral and Maxillofacial Surgery,...
Mon Nov 04, 2019 02:00
Abstract Objective This study examines monomer permeation of commercial dental adhesive through nitrile‐based gloves, and correlates findings with clinical case studies of dental students having localized skin eruptions following resin placement on a gloved hand to manipulate composite. Methods Three dental students self‐reported presenting itchy, red skin lesions underneath the area where they placed uncured adhesive resin on a nitrile‐gloved hand. Histories and cursory examinations were...
Mon Nov 11, 2019 11:50
Abstract Objective To evaluate the long‐term color stainability, translucency, and contrast ratio (CR) of different resins used to fabricate interim prostheses after immersion in acidic/staining solutions. Materials and Methods A total of 160 specimens were divided into 16 groups (n = 10) according to the material (heat‐polymerized acrylic resin [HPAR], auto‐polymerized acrylic resin [APR], nanoparticulated bis‐acrylic resin [BR], and prefabricated poly(methyl methacrylate) block for CAD/CAM...
Mon Nov 11, 2019 11:43
Establishing a system of consumer product use categories to support rapid modeling of human exposure
Journal of Exposure Science & Environmental Epidemiology, Published online: 11 November 2019; doi:10.1038/s41370-019-0187-5Establishing a system of consumer product use categories to support rapid modeling of human exposure
Mon Nov 11, 2019 02:00
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