Oncology

CAR T cell therapy: A new era for cancer treatment (Review) Rimjhim Mohanty, Chitran Roy Chowdhury, Solomon Arega, Prakriti Sen, Pooja Ganguly, Niladri Ganguly View Abstract ❯
Cytotoxicity of Cichorium intybus L. metabolites (Review) Khandaker Md Sharif Uddin Imam, Yingying Xie, Yusi Liu, Fengzhong Wang, Fengjiao Xin View Abstract ❯
Ibrutinib in CLL/SLL: From bench to bedside (Review) Fuming Zi, Li Yu, Qingzhi Shi, Aiping Tang, Jing Cheng View Abstract ❯
Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review) Theodore Krasanakis, Taxiarchis Konstantinos Nikolouzakis, Markos Sgantzos, Theodore Mariolis‑Sapsakos, John Souglakos, Demetrios A. Spandidos, Christina Tsitsimpikou, Aristidis Tsatsakis, John Tsiaoussis View Abstract ❯
Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin‑mediated mitophagy Zheng Li, Yongqiang Wang, Linbo Wu, Yalu Dong, Jing Zhang, Fan Chen, Wei Xie, Jianguo Huang, Ning Lu View Abstract ❯
Genetic interactions between ANLN and KDR are prognostic for breast cancer survival Xiaofeng Dai, Xiao Chen, Olivier Hakizimana, Yi Mei View Abstract ❯
Activation of the Toll‑like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro Yi Chen, Zuxiong Huang, Xuzheng Chen, Hanhui Ye View Abstract ❯
Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma Shu Li, Zhou Jiang, Yirun Li, Yang Xu View Abstract ❯
p53 deficiency augments nucleolar instability after ionizing irradiation Sangeeta Kakoti, Motohiro Yamauchi, Wenchao Gu, Reona Kato, Takaaki Yasuhara, Yoshihiko Hagiwara, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano, Atsushi Shibata View Abstract ❯
Mutations of RAS genes in endometrial polyps Takashi Takeda, Kouji Banno, Yusuke Kobayashi, Masataka Adachi, Megumi Yanokura, Eiichiro Tominaga, Kenjiro Kosaki, Daisuke Aoki View Abstract ❯
HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma Yangzhi Qi, Gang Deng, Pengfei Xu, Huikai Zhang, Fanen Yuan, Rongxin Geng, Hongxiang Jiang, Baohui Liu, Qianxue Chen View Abstract ❯
Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma Akiko Shimbo, Hiroaki Kajiyama, Satoshi Tamauchi, Nobuhisa Yoshikawa, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Kaoru Niimi, Jun Sakata, Fumitaka Kikkawa View Abstract ❯
Gene mutation profile and risk stratification in AML1‑ETO‑positive acute myeloid leukemia based on next‑generation sequencing Guopan Yu, Changxin Yin, Fuqun Wu, Ling Jiang, Zhongxin Zheng, Dan Xu, Jiaheng Zhou, Xuejie Jiang, Qifa Liu, Fanyi Meng View Abstract ❯
Antitumor activity of tetrandrine citrate in human glioma U87 cells in vitro and in vivo Jingyu Sun, Yang Zhang, Yongzhan Zhen, Ju Cui, Gang Hu, Yajun Lin View Abstract ❯
Acquisition of temozolomide resistance by the rat C6 glioma cell line increases cell migration and side population phenotype Ya Xu, Xiangcai Yang, Shuting Mei, Yi Sun, Jiejing Li View Abstract ❯
Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy Hongmei Zheng, Yuting Zhang, Yuting Zhan, Sile Liu, Junmi Lu, Qiuyuan Wen, Songqing Fan View Abstract ❯
miRNA‑183‑5p.1 promotes the migration and invasion of gastric cancer AGS cells by targeting TPM1 Jun Lin, Juan Shen, Hao Yue, Zhongwei Cao View Abstract ❯
Highly sensitive detection of sentinel lymph node metastasis of breast cancer by digital PCR for RASSF1A methylation Mizuho Abe, Naofumi Kagara, Tomohiro Miyake, Tomonori Tanei, Yasuto Naoi, Masafumi Shimoda, Kenzo Shimazu, Seung Jin Kim , Shinzaburo Noguchi View Abstract ❯
miR‑489 promotes apoptosis and inhibits invasiveness of glioma cells by targeting PAK5/RAF1 signaling pathways Wei Wang, Luyang Zhang, Wei Gao, Dongyong Zhang, Zilong Zhao, Yijun Bao View Abstract ❯
Construction of a competing endogenous RNA network using differentially expressed lncRNAs, miRNAs and mRNAs in non‑small cell lung cancer Xi‑Wen Wang, Qi‑Qiang Guo, Yang Wei, Kai‑Ming Ren, Fu‑Shuang Zheng, Jun Tang, Hong‑Yan Zhang, Jun‑Gang Zhao View Abstract ❯
BH3 profiling discriminates the anti‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells Kazuma Ishikawa, Yutaka Kawano, Yohei Arihara, Tomohiro Kubo, Kohichi Takada, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato View Abstract ❯
Targeting RAD51 enhances chemosensitivity of adult T‑cell leukemia‑lymphoma cells by reducing DNA double‑strand break repair Meng Yang, Xiaoxue Tian, Zhuoyi Fan, Wenlei Yu, Zheng Li, Jie Zhou, Wenjun Zhang, Aibin Liang View Abstract ❯
Receptor‑interacting serine/threonine‑protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer Guangwei Zhu, Qiang Du, Xiao Chen, Xiaoqian Wang, Nanhong Tang, Feifei She, Yanling Chen View Abstract ❯
Systematic profiling of a novel prognostic alternative splicing signature in hepatocellular carcinoma Dong Zhang, Yi Duan, Zhe Wang, Jie Lin View Abstract ❯
Weighted gene coexpression analysis indicates that PLAGL2 and POFUT1 are related to the differential features of proximal and distal colorectal cancer Yiming Lv, Binbin Xie, Bingjun Bai, Lina Shan, Wenqian Zheng, Xuefeng Huang, Hongbo Zhu View Abstract ❯
Ku80 gene knockdown by the CRISPR/Cas9 technique affects the biological functions of human thyroid carcinoma cells Yali Fan, Jianying Li, Wei Wei, Hangrong Fang, Ying Duan, Namiao Li, Yingying Zhang, Jun Yu, Juanhong Wang View Abstract ❯
Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor‑associated macrophages Gaili An, Fang Wu, Shangke Huang, Lu Feng, Jun Bai, Shanzhi Gu, Xinhan Zhao View Abstract ❯
Core‑shell type thermo‑nanoparticles loaded with temozolomide combined with photothermal therapy in melanoma cells Xiaoyang Hou, Yanyu Pang, Xinxin Li, Chunsheng Yang, Wenlou Liu, Guan Jiang, Yanqun Liu View Abstract ❯
Bradykinin promotes proliferation, migration, and invasion of cervical cancer cells through STAT3 signaling pathways Wei Wang, Ying Zhou, Rui Wei, Guiying Jiang, Fei Li, Xi Chen, Xueqian Wang, Ding Ma, Ling Xi View Abstract ❯
Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration Bingrui Wu, Dalong Sun, Lijie Ma, Yiran Deng, Si Zhang, Ling Dong, She Chen View Abstract ❯
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer Zhiwei Cai, Yun Liang, Chun Xing, Hongwei Wang, Pengfei Hu, Jialin Li, Haiyan Huang, Wei Wang, Chongyi Jiang View Abstract ❯
miR‑425‑5p is associated with poor prognosis in patients with breast cancer and promotes cancer cell progression by targeting PTEN Sheng Xiao, Hongjia Zhu, Jian Luo, Zhenru Wu, Mingjun Xie View Abstract ❯
β‑elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A‑VEGFA pathway based on network pharmacology Junqiu Zhu, Bo Li, Yongsuo Ji, Linglin Zhu, Yanfei Zhu, Hong Zhao View Abstract ❯
Comprehensive analysis of the lncRNA‑associated competing endogenous RNA network in breast cancer Jing‑Jing Wang, Yue‑Qing Huang, Wei Song, Yi‑Fan Li, Han Wang, Wen‑Jie Wang, Min Huang View Abstract ❯
Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma Cheng‑Yun Li, Wen‑Wen Zhang, Ji‑Lian Xiang, Xing‑Hua Wang, Jun‑Ling Wang, Jin Li View Abstract ❯
Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway Xiaocong Xiang, Rong Xiong, Chunlei Yu, Li Deng, Jun Bie, Dongqin Xiao, Zhu Chen, Yuchuan Zhou, Xiaolei Li, Kang Liu, Gang Feng View Abstract ❯
Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma Shoji Ryumon, Tatsuo Okui, Yuki Kunisada, Koji Kishimoto, Tsuyoshi Shimo, Kazuaki Hasegawa, Soichiro Ibaragi, Kentaro Akiyama, Nguyen Thi Thu Ha, Nur Mohammad Monsur Hassan, Akira Sasaki View Abstract ❯
Identification of TPD52 and DNAJB1 as two novel bile biomarkers for cholangiocarcinoma by iTRAQ‑based quantitative proteomics analysis Hongyue Ren, Mingxu Luo, Jinzhong Chen, Yanming Zhou, Xiumei Li, Yanyan Zhan, Dongyan Shen, Bo Chen View Abstract ❯
IFN‑β sensitizes TRAIL‑induced apoptosis by upregulation of death receptor 5 in malignant glioma cells Sodai Yoshimura, Emiko Sano, Yuya Hanashima, Shun Yamamuro, Koichiro Sumi, Takuya Ueda, Tomohiro Nakayama, Hiroyuki Hara, Atsuo Yoshino, Yoichi Katayama View Abstract ❯
Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis Jingyan Ge, Hongyan Sun, Jing Li, Yidi Shan, Yang Zhao, Fangwei Liao, Yu Yang, Xueling Cui, Zhonghui Liu View Abstract ❯
Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer Li Zhang, Sijuan Tian, Meili Pei, Minyi Zhao, Li Wang, Yifan Jiang, Ting Yang, Juan Zhao, Lihua Song, Xiaofeng Yang View Abstract ❯
Knockdown of Nedd8‑conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells Bin Zhao, Caiyan Gao, Daixiu Shi, Jie Mao, Jun Zhao, Lingyun Guo, Jiwu Guo, Zuoyi Jiao View Abstract ❯
Development of recurrence risk score using 95‑gene classifier and its application to formalin‑fixed paraffin‑embedded tissues in ER‑positive, HER2‑negative and node‑negative breast cancer Yasuto Naoi, Yuria Saito, Kazuki Kishi, Masafumi Shimoda, Naofumi Kagara, Tomohiro Miyake, Tomonori Tanei, Kenzo Shimazu, Seung Jin Kim, Shinzaburo Noguchi View Abstract ❯
A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells So Hee Dho, Eun Ha Cho, Ji Yeon Lee, So‑Young Lee, Sung Hee Jung, Lark Kyun Kim, Jae Cheong Lim View Abstract ❯
The prednisolone phosphate‑induced suppression of the angiogenic function of tumor‑associated macrophages enhances the antitumor effects of doxorubicin on B16.F10 murine melanoma cells in vitro Emilia Licarete, Valentin Florian Rauca, Lavinia Luput, Laura Patras, Alina Sesarman, Manuela Banciu View Abstract ❯
SRPX and HMCN1 regulate cancer‑associated fibroblasts to promote the invasiveness of ovarian carcinoma Chao Lien Liu, Hung Wei Pan, Pao Ling Torng, Ming Huei Fan, Tsui Lien Mao View Abstract ❯
Downregulation of MUTYH contributes to cisplatin‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT Yanxia Guo, Yuxiu Jia, Shikang Wang, Ning Liu, Dongfang Gao, Lu Zhang, Zhaomin Lin, Shuling Wang, Feng Kong, Chuanliang Peng, Yongqing Liu View Abstract ❯
Upregulation of circular RNA circ‑FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR‑646/VAMP2 and miR‑647/MDM2 signaling pathways Dan Sun, Jianing Liu, Lili Zhou View Abstract ❯
Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma Wei Deng, Wei Peng, Tao Wang, Jingxin Chen, Xunding Qiu, Liangbin Fu, Shuangxi Zhu View Abstract ❯
High levels of Notch intracellular cleaved domain are associated with stemness and reduced bevacizumab efficacy in patients with advanced colon cancer Francesca Negri, Cecilia Bozzetti, Giuseppe Pedrazzi, Cinzia Azzoni, Lorena Bottarelli, Anna Squadrilli, Costanza Lagrasta, Ione Tamagnini, Alessandra Bisagni, Moira Ragazzi, Rosa Porzio, Gianluca Tomasello, Daniele Mori, Francesco Leonardi, Letizia Gnetti, Pellegrino Crafa, Roberto Sala, Stefano Cascinu View Abstract ❯
Downregulation of miR‑143 modulates KRAS expression in colorectal carcinoma cells Hong Liu, Jiansheng Liu, Junkai Huo, Kaihua Li, Kai Li, Haosu Guo, Yirong Yang View Abstract ❯
Targeting YAP suppresses ovarian cancer progression through regulation of the PI3K/Akt/mTOR pathway Xiao Wei, Yijuan Jia, Hua Lou, Jingjing Ma, Quanfu Huang, Yunchong Meng, Chaoyang Sun, Zongyuan Yang, Xiaoting Li, Sen Xu, Xin Yang, Teng Ji, Qinglei Gao View Abstract ❯
RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer Hong Huo, Xinqing Ye, Honghe Yang, Qiuyun Li, Yi Jiang View Abstract ❯
Palmitoylome profiling indicates that androgens regulate the palmitoylation of α‑tubulin in prostate cancer‑derived LNCaP cells and supernatants Wenqing Li, Junhua Zhang, Lihui Zou, Jian Cui, Fei Su, Junhua Jin, Fei Xiao, Ming Liu, Gang Zhao View Abstract ❯
Suppressive effects of the sodium‑glucose cotransporter 2 inhibitor tofogliflozin on colorectal tumorigenesis in diabetic and obese mice Junichi Kato, Yohei Shirakami, Masaya Ohnishi, Taku Mizutani, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Takuji Tanaka, Masahito Shimizu View Abstract ❯
Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway Xingang Peng, Peige Wang, Shikuan Li, Yingjun Jiang, Changliang Wu View Abstract ❯
Οlive tree blossom polyphenolic extracts exert antioxidant and antimutagenic activities in vitro and in various cell lines Paraskevi Kouka, Fotios Tekos, Kalliopi Valta, Panagiotis Mavros, Aristidis S. Veskoukis, Apostolis Angelis, Alexios-Leandros Skaltsounis, Demetrios Kouretas View Abstract ❯
Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules Karolina Lhotakova, Adrianna Grzelak, Ingrid Polakova, Julie Vackova, Michal Smahel View Abstract ❯
Potential role for second‑generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia harboring additional clonal chromosome abnormalities: A retrospective CML Cooperative Study Group analysis Maho Ishikawa, Noriyoshi Iriyama, Michihide Tokuhira, Tomoiku Takaku, Eriko Sato, Kei‑Ji Sugimoto, Tomonori Nakazato, Hiroyuki Fujita, Yuta Kimura, Isao Fujioka, Norio Komatsu, Norio Asou, Masahiro Kizaki, Yoshihiro Hatta, Tatsuya Kawaguchi View Abstract ❯
DDR1 promotes breast tumor growth by suppressing antitumor immunity Xing Zhong, Weiwei Zhang, Tianhao Sun View Abstract ❯
[Corrigendum] A 19‑miRNA Support Vector Machine classifier and a 6‑miRNA risk score system designed for ovarian cancer patients Jingwei Dong, Mingjun Xu View Abstract ❯
[Corrigendum] Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells Wuyi Liu, Qian Zhang, Qin Tang, Changpeng Hu, Jingbin Huang, Yali Liu, Yanyi Lu, Qing Wang, Guobing Li, Rong Zhang View Abstract ❯

26-28 March, 2020, Park Plaza Hotel, Santiago, Chile 25th International Symposium on Molecular Medicine

7-9 May, 2019, Grand Hotel, Duca D'Este, Rome, Italy 26 th International Symposium on Molecular Medicine