Publication date: Available online 2 November 2019Source: Life SciencesAuthor(s): Xiaoxu Yang, Jun Lou, Weixi Shan, Yanxia Hu, Qian Du, Qiushi Liao, Rui Xie, Jingyu XuAbstractCytosolic calcium [Ca2+]cyt signaling plays a critical role in the regulation of multiple cellular functions, and Ca2+ channels/transporters are important to regulate calcium homeostasis whose abnormality may contribute human tumorogenesis including colorectal cancer (CRC). In this review, we summarized and discussed the current...
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Cancers, Vol. 11, Pages 1720: The Histone Methyltransferase DOT1L Is a Functional Component of Estrogen Receptor Alpha Signaling in Ovarian Cancer Cells Cancers doi: 10.3390/cancers11111720 Authors: Annamaria Salvati Valerio Gigantino Giovanni Nassa Giorgio Giurato Elena Alexandrova Francesca Rizzo Roberta Tarallo Alessandro Weisz Although a large fraction of high-grade serous epithelial ovarian cancers (OCs) expresses Estrogen Receptor alpha (ERα), anti-estrogen-based...
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Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM01584A, PaperYangjie Xu, Jiulong Zhao, Zhilun Zhang, Jing Zhang, Mingxian Huang, Shige Wang, Pei Xie In this research, the sodium alginate (ALG)/poly dopamine (PDA)-polyvinylpyrrolidone (PVP) nanocomposites was synthesized via the one-step electrostatic spraying method. The spinning solution of ALG and dopamine was electrostatically sprayed into... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest...
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Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01358J, PaperYu-Chih Chen, Saswat Sahoo, Riley Brien, Seungwon Jung, Brock Humphries, Woncheol Lee, Yu-Heng Cheng, Zhixiong Zhang, Kathryn E. Luker, Max S Wicha, Gary Luker, Euisik Yoon Considerable evidence suggests breast cancer metastasis arises from cells undergoing epithelial-to-mesenchymal-transition (EMT) and cancer stem-like cells (CSCs). Using a microfluidic device that enriches migratory breast cancer cells with enhanced capacity... The...
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Authors: Daniel Bremer Daniel Lüdecke Olaf von dem Knesebeck This paper investigates the associations between social relationships, age and the use of preventive health services among German adults. Data stem from the German Ageing Survey (10,324 respondents). The use of preventive health services was assessed by asking for regular use of flu vaccination and cancer screening in the past years. Predictors of interest were structural (having a partner, size of the social network) and...
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Abstract 5T4 (trophoblast glycoprotein, TPBG) is a transmembrane tumor antigen expressed on more than 90% of primary renal cell carcinomas (RCC) and a wide range of human carcinomas but not on most somatic adult tissues. The favorable expression pattern has encouraged the development and clinical testing of 5T4-targeted antibody and vaccine therapies. 5T4 also represents a compelling and unexplored target for T-cell receptor (TCR)-engineered T-cell therapy. Our group has previously...
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Cancers, Vol. 11, Pages 1719: Plasma Androgen Receptor in Prostate Cancer Cancers doi: 10.3390/cancers11111719 Authors: Vincenza Conteduca Giorgia Gurioli Nicole Brighi Cristian Lolli Giuseppe Schepisi Chiara Casadei Salvatore Luca Burgio Stefania Gargiulo Giorgia Ravaglia Lorena Rossi Amelia Altavilla Alberto Farolfi Cecilia Menna Sarah Pia Colangione Mario Pulvirenti Antonino Romeo Ugo De Giorgi The therapeutic landscape of prostate cancer...
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ConclusionR2-resections do not result in a survival benefit compared to non-surgical treatment in this non-randomized series. Patients with a high chance on a R2-resection could be offered non-surgical treatment, without local resection. (Source: European Journal of Surgical Oncology (EJSO))
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ConclusionsExcept for basic decision trees, predictive models derived from different machine-learning algorithms discriminated the QALY risk at 30 days well. Regarding calibration, artificial neural network model presented the best ability to estimate 30-day QALY in critically ill oncologic patients admitted to ICUs. (Source: Journal of Critical Care)
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Cancer Gene Therapy, Published online: 04 November 2019; doi:10.1038/s41417-019-0149-zMicroRNA-200 family expression analysis in metastatic clear cell renal cell carcinoma patients
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Publication date: Available online 25 September 2019Source: Saudi Pharmaceutical JournalAuthor(s): Anas Ahmad, Rakesh Kumar Mishra, Akshay Vyawahare, Ajay Kumar, Muneeb U. Rehman, Wajhul Qamar, Abdul Quaiyoom Khan, Rehan KhanAbstractCancer remains the topmost disorders of the mankind and number of cases is unceasingly growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the largest market in the modern treatment of cancer, natural agents have always been tried and...
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ConclusionsThe use of NSAIDs might reduce the risk of SC, but many factors including study population, drug subtype, and disease subclass affect the significance of the association.Graphical abstract (Source: Pharmacological Research)
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Publication date: Available online 3 November 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Byoungsook Goh, Jieun Choi, Jung-Ah Kang, Sung-Gyoo Park, Jiwon Seo, Tae-Young KimAbstractSodium taurocholate cotransporting polypeptide (NTCP) involved in bile acid transport in the liver is an entry receptor of hepatitis B virus (HBV). In the present study, we introduce a mass spectrometric screening assay for targeting HBV entry inhibitors that can reduce NTCP transporter activity...
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Publication date: Available online 2 November 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Aysenur Aygun, Fulya Gülbagca, Lutfiye Yildiz Ozer, Buket Ustaoglu, Yasemin Celik Altunoglu, Mehmet Cengiz Baloglu, Mehmet Nuri Atalar, Mehmet Hakkı Alma, Fatih SenAbstractHerein, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed...
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Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Shangnan Dai, Yunpeng Peng, Yi Zhu, Dalai Xu, Feng Zhu, Wenbin Xu, Qiuyang Chen, Xiaole Zhu, Tongtai Liu, Chaoqun Hou, Junli Wu, Yi MiaoAbstractPrevious studies have reported that increased glycolytic activity enhances chemotherapy resistance in some types of malignancies. However, whether glycolysis influences the curative effect of gemcitabine (GEM) on pancreatic cancer (PC) cells remains unclear. The...
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The publisher regrets the author Darcy Fidoe was incorrectly spelt as Darcy Fideo. (Source: Lung Cancer)
Sun Nov 03, 2019 09:15
Recent insight into the molecular basis of lung cancer has led to changes in the treatment of this disease. The identification of driver mutations, such as those affecting the epidermal growth factor receptor (EGFR)[1,2] and anaplastic lymphoma kinase (ALK) genes [3], has already been successfully translated into clinical practice. However, whereas most individuals with non –small cell lung cancer (NSCLC) who harbor sensitizing EGFR mutations show an initial marked response to 1st or 2nd generation...
Sun Nov 03, 2019 00:00
Although malignant mesothelioma (MM) is rare among thoracic malignancies, approximately 1500 and 3000 patients are newly diagnosed each year in Japan and the United States [1], respectively. Treatment of MM, including surgery, radiotherapy, and chemotherapy, is recommended according to stage, performance status, pulmonary function, complications, and patient preference. First-line chemotherapy for advanced MM involves a combination of cisplatin and pemetrexed as the standard treatment. Although this...
Sat Nov 02, 2019 00:00
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) provide dramatic antitumor activity in advanced non-small cell lung cancer (NSCLC) patients with EGFR-activating mutations. However, the majority of patients treated with standard EGFR-TKIs frequently acquire resistance within 1 to 2 years [1 –4], and the most common mechanism is T790 M mutation [5–7]. Osimertinib is a third-generation EGFR-TKI that is selective for both EGFR-activating and T790 M mutations in NSCLC patients...
Sat Nov 02, 2019 00:00
Image-based response assessment is often used as a surrogate for the efficacy of a treatment in patients. The radiological response assessment in patients with malignant pleural mesothelioma (MPM) is notoriously difficult, despite changes in the scoring system, modified Response Evaluation Criteria in Solid Tumors (modified RECIST). The current clinical method for tumor response assessment in mesothelioma is the modified RECIST guideline, which calls for two linear measurements of tumor thickness...
Sat Nov 02, 2019 00:00
Publication date: Available online 2 November 2019Source: Seminars in Cancer BiologyAuthor(s): Yian Ann Chen, Jamie K. Teer, Zeynep Eroglu, Jheng-Yu Wu, John M. Koomen, Florian A. Karreth, Jane L. Messina, Keiran S.M. SmalleyAbstractAcral melanomas arise on the non-hair bearing skin of the palms, soles and in the nail beds. These rare tumors comprise 2-3% of all melanomas, are not linked to UV-exposure, and represent the most frequent subtype of melanomas in patients of Asian, African and Hispanic...
Sun Nov 03, 2019 23:44
Publication date: Available online 2 November 2019Source: Seminars in Cancer BiologyAuthor(s): Avaniyapuram Kannan Murugan (Source: Seminars in Cancer Biology)
Sun Nov 03, 2019 23:44
Publication date: Available online 2 November 2019Source: Seminars in Cancer BiologyAuthor(s): Ira Skvortsova (Source: Seminars in Cancer Biology)
Sun Nov 03, 2019 23:44
Publication date: Available online 2 November 2019Source: Seminars in Cancer BiologyAuthor(s): Aikseng OoiAbstractHereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is an autosomal dominant hereditary cancer syndrome with incomplete penetrance. It is caused by a germline amorphic allele of the FH gene, which encodes the TCA cycle enzyme, fumarate hydratase (FH). HLRCC patients are genetically predisposed to develop skin leiomyomas, uterine fibroids, and the aggressive kidney cancer of type 2...
Sun Nov 03, 2019 23:44
ConclusionsAn EBCT is needed to estimate the proper dose at object volumes near the patient’s skin and can improve the accuracy of the calculated dose at target volumes. (Source: Reports of Practical Oncology and Radiotherapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Sun Nov 03, 2019 23:44
ConclusionThis study demonstrates preliminary clinical data of SCLC with bone metastases at the time of diagnosis, and more studies are needed. (Source: Journal of Bone Oncology)
Sun Nov 03, 2019 23:44
Publication date: Available online 2 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Valéria Tavares, Ricardo Pinto, Joana Assis, Deolinda Pereira, Rui MedeirosAbstractVenous thromboembolism (VTE) is a common cardiovascular disease thought to be the outcome of an intricate interplay between acquired and inherited factors that act together to modify disease risk. Over the years, several single-nucleotide polymorphisms (SNPs) in candidate genes have been associated...
Sun Nov 03, 2019 23:44
CONCLUSION The content of prehabilitation programmes was heterogeneous. Studies with a high therapeutic validity found unequivocal evidence that prehabilitation had beneficial effects on postoperative outcomes. Future research should focus on adequate selection and inclusion of high-risk surgical patients and provide personalised and probably multimodal (partly) supervised prehabilitation, with objective monitoring of progress. Measuring the incidence and impact of postoperative complications may...
Sun Nov 03, 2019 23:38
CONCLUSION: Primary PTC and distant metastases differ in their range of somatic alterations. Genomic analysis of distant metastases provides an opportunity to identify potentially clinically informative alterations not detected in primary tumors, which might influence decisions for personalized therapy in PTC patients with distant metastasis. PMID: 31668133 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Sun Nov 03, 2019 21:05
Authors: Hynes-Smith Swenson Vahle Wittorf Caplan Amador Hyde Buckley The hematopoietic system is maintained throughout life by stem cells that are capable of differentiating into all hematopoietic lineages. An intimate balance between self-renewal, differentiation, and quiescence is required to maintain hematopoiesis and disruption of this balance can result in malignant transformation. FBXO9, the substrate recognition component from the SCF E3 ubiquitin ligase...
Sun Nov 03, 2019 00:00
Conclusions: Electroporation is bringing new hopes in LAPC management. The first aim of IRE is to offer a palliative treatment. Further efforts are needed for patient selection, as well as the use of IRE for ‘margin accentuation’ during surgical resection. Even if promising, IRE needs to be validated in large, randomized, prospective series. (Source: Cancers)
Sun Nov 03, 2019 00:00
Authors: Polak Chernosky Smigiel Tamagno Jackson Driven by dysregulated IL-6 family member cytokine signaling in the tumor microenvironment (TME), aberrant signal transducer and activator of transcription (STAT3) and (STAT5) activation have been identified as key contributors to tumorigenesis. Following transformation, persistent STAT3 activation drives the emergence of mesenchymal/cancer-stem cell (CSC) properties, important determinants of metastatic potential and therapy...
Sun Nov 03, 2019 00:00
Authors: Singh K, Singh AK, Uppalapati SR, Kingston JJ, Parida M Abstract Burkholderia lethal factor 1 (BLF1), a glutamine deamidase, is a key virulence factor that plays significant role in B. pseudomallei pathogenesis. To elucidate the BLF1 immunological responses, two truncated BLF1 structural units, BLF1-C (90-211 amino acids) with structural similarity to T. maritima Chemoreceptor glutamine deamidase (CheD) protein, and BLF1-N (1-89 amino acids) disparate to CheD were identified from...
Tue Oct 29, 2019 00:00
Authors: Hou Y, Yang D, Xiang R, Wang H, Wang X, Zhang H, Wang P, Zhang Z, Che X, Liu Y, Gao Y, Yu X, Gao X, Zhang W, Yang J, Wu C Abstract Neutrophils have been traditionally considered as the major mediators of harmful inflammatory responses in ischemic stroke, whereas accumulating evidence indicates that neutrophils can be polarized into an N2 phenotype. Similar to M2 microglia, N2 neutrophils contribute to resolution of inflammation and may participate in neuroprotection. However, it...
Tue Oct 29, 2019 00:00
Authors: Fan YY, Ding W, Zhang C, Fu L, Xu DX, Chen X Abstract Liver fibrosis results from sustained liver injury and is characterized by inflammation, hepatic stellate cell (HSC) activation, extracellular matrix (ECM) accumulation and liver structure destruction. The Farnesoid-X receptor (FXR) antagonizes toxic liver injury and fibrosis, yet the mechanism in liver fibrosis remains unclear. We investigated the effects of FXR agonist obeticholic acid (OCA) on liver fibrosis in mice. Mice...
Mon Oct 28, 2019 00:00
Authors: Bailly C Abstract The drug edaravone (EDA) is prescribed for the treatment of patients with amyotrophic lateral sclerosis or after an acute cerebral infarction. This synthetic pyrazolone derivative is a potent scavenger of oxygen free radicals and also functions as a modulator of transcription factors, repressing NFκB and activating Nrf2, to regulate oxidative stress. EDA displays complementary anti-oxidative and anti-inflammatory effects. The injectable small molecule is currently...
Sat Oct 26, 2019 00:00
CONCLUSION: Our results provided new candidate SNPs for the prediction and prevention of NSCLC. PMID: 31670094 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Sat Oct 26, 2019 00:00
CONCLUSIONS: Taken together, our results show that the level of serum CD26 was associated with TGAb in HT patients with normal thyroid function. PMID: 31670093 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Sat Oct 26, 2019 00:00
Authors: Wu X, Xue R, Peng H, Gan X, Lu X, Yan W, Tian Y, Ni X, Shen H, Cheng F, Wang X, Wang X, Lu L Abstract Tumors escape immune attacks via various mechanisms, among which activation of regulatory pathways in effector immune cells and recruitment of immunosuppressive cells are usually employed. Traf6 is a member of the family of tumor necrosis factor receptor-associated factors and involved in many signaling pathways. While it plays important roles in both tumor biology and immune system,...
Sat Oct 26, 2019 00:00
Tear and serum interleukin-8 and serum CX3CL1, CCL2 and CCL5 in sulfur mustard eye-exposed patients.
CONCLUSION: The higher level of CX3CL1 and consistent levels of IL-8/CXCL8, MCP-1/CCL2, and RANTES/CCL5 in SM-exposed individuals may indicate an anti-inflammatory response against the destructive effects of SM gas. High tear level of IL-8/CXCL8 reflects the severity of ocular surface abnormalities, yet significantly low tear level found in mild SM-exposed subgroup compared with the control group. The lower levels of CX3CL1 and RANTES/CCL5 may represent the different pathophysiology which requires...
Thu Oct 24, 2019 00:00
CONCLUSION: α-HBDH could be used to evaluate the disease activity of SLE-related liver injury, and it may be a potential biomarker for diagnosing SLE-related liver injury. PMID: 31669891 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Thu Oct 24, 2019 00:00
CONCLUSIONS: The decline of peripheral Treg cells and serum IL-2 were found in PM/DM. ld-IL2 combination therapy could significantly increase the number of Treg cells. PMID: 31669890 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Thu Oct 24, 2019 00:00
Protostemonine alleviates heat-killed methicillin-resistant Staphylococcus aureus-induced acute lung injury through MAPK and NF-κB signaling pathways. Int Immunopharmacol. 2019 Oct 24;77:105964 Authors: Wu Y, Nie Y, Huang J, Qiu Y, Wan B, Liu G, Chen J, Chen D, Pang Q Abstract Acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) caused by gram-positive bacteria threatens human life because effective treatments and medicines is unavailable....
Thu Oct 24, 2019 00:00
This article focuses on the role of extra pleural pneumonectomy in MPM. A systematic review was performed by using electronic databases to identify studies that included patients treated by this procedure for MPM. Endpoints included overall survival, disease-free survival, recurrence rate, perioperative mortality and morbidity.Expert opinion: This paper offers an overview of the results that are currently obtained in patients undergoing extrapleural pneumonectomy for MPM. The benefit of surgical...
Sun Nov 03, 2019 20:09
Publication date: Available online 2 November 2019Source: Food ControlAuthor(s): Haftom Kebede, Xiumin Liu, Jing Jin, Fuguo XingAbstractMycotoxins are toxic secondary metabolites produced by fungi belongs to the genera Aspergillus, Fusarium and Penicillium that are capable of contaminating different types of food and feed. Mycotoxins can cause serious health complications to both humans and animals due to the carcinogenic, mutagenic, teratogenic and immunosuppressive characteristics of them. Therefore...
Sun Nov 03, 2019 20:05
Authors: Blsakova A, Kveton F, Kasak P, Tkac J Abstract Introduction. The review provides a comprehensive overview about applicability of serological detection of autoantibodies against aberrant glycans as cancer biomarkers.Areas covered. Clinical usefulness of autoantibodies as cancer biomarkers is discussed for seven types of cancers with sensitivity and specificity of such biomarkers provided. Moreover, an option of using serological antibodies against a non-natural form of sialic acid...
Sun Nov 03, 2019 19:52
In this study we used a metagenomic approach using ViroCap for DNA viruses in 20 FOSCC, 9 normal feline oral mucosal, and 8 suspected PV positive control samples. We tested the hypothesis that viruses would be enriched in FOSCC compared to normal oral mucosa. The virome of the FOSCC and normal feline oral mucosa consisted of feline foamy virus in 7/20 and 2/9 (35% and 22%), feline torque teno virus in 2/20 and 0/9 (10% and 0%), alphaherpesvirus in 2/10 and 0/9 (10% and 0%), FIV (0% and 22%), Epstein-Barr...
Sun Nov 03, 2019 19:11
In conclusion, imatinib reversed doxorubicin resistance by decreasing drug efflux in P-gp-overexpressing doxorubicin-resistant canine lymphoma cells. These results suggest that combining doxorubicin, one of the most widely used chemotherapeutic drugs in the treatment of canine lymphoma, with imatinib might potentially overcome doxorubicin resistance in a clinical setting. (Source: The Veterinary Journal)
Sun Nov 03, 2019 19:11
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Hannah L. Bromley, G. Bruce Mann, Dennis Petrie, Carolyn Nickson, Daniel Rea, Tracy E. RobertsAbstractBackgroundMammographic screening reduces breast cancer mortality but may lead to the overdiagnosis and overtreatment of low-risk breast cancers. Conservative management may reduce the potential harm of overtreatment, yet little is known about the impact upon quality of life.ObjectivesTo quantify women's preferences...
Sun Nov 03, 2019 21:37
Publication date: Available online 2 November 2019Source: Radiation Physics and ChemistryAuthor(s): Sazirul Islam, K.A. Mahmoud, M.I. Sayyed, Bünyamin Alim, MdM. Rahman, A.S. MollahAbstractIn radiation therapy field, bolus material is frequently utilized when treating different areas of a patient, like at the ears or nose, and to provide build-up of dose to the skin surface. The bolus material must be cost effective, suitably flexible to conform to the surface of the patient, and most importantly...
Sun Nov 03, 2019 18:39
Publication date: Available online 2 November 2019Source: Journal of Molecular BiologyAuthor(s): Victor Vasquez-Montes, Janessa Gerhart, Damien Thévenin, Alexey S. LadokhinABSTRACTThe pH-Low Insertion Peptide (pHLIP) has emerged as an important tool for targeting cancer cells; it has been assumed that its targeting mechanism depends solely on the mild acidic environment surrounding tumors. Here, we examine the role of Ca2+ and Mg2+ on pHLIP’s insertion, cellular targeting and drug delivery. We demonstrate...
Sun Nov 03, 2019 17:38
Publication date: Available online 2 November 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Mara Fernandes, Ana Luísa Teixeira, Rui MedeirosAbstractThere has been a shift in the paradigm of Non-Hodgkin lymphomas, changing from the classical genetic aberration-based model to a more complex and dynamic model involving tumor microenvironment interactions. In this instance, exosomes have emerged as important mediators in intercellular communication by providing survival and proliferation...
Sun Nov 03, 2019 19:20
Publication date: Available online 2 November 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Laura L. Meijer, Elisa Giovannetti
Sun Nov 03, 2019 19:20
Publication date: Available online 2 November 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Mohammad Amin Kerachian, Ali Poudineh, Jean Paul ThieryAbstractInnovative diagnostics are becoming an essential component in personalized cancer medicine. These diagnostics are increasingly based on cell-free nucleic acids and membrane vesicles. Isolating and sequencing cell free circulating DNA (cfDNA) in plasma may progressively substitute tumor biopsies. A small albeit now detectable fraction...
Sun Nov 03, 2019 19:20
This study systematically analyzed the anticancer potential of Acridocarpus orientalis (AO), a traditional medicinal plant of the Arabian Peninsula/East Africa known for its anti-inflammatory and pain relief properties. Tests of serial organic fractions from methanolic extracts of its leaves and stems revealed that only some fractions showed anti-proliferative potential with the dichloromethane fraction from leaves (AOD (L)) showing the most cytotoxic effect against both breast (MCF-7 and MDA-MB-231)...
Sun Nov 03, 2019 00:00
In conclusion, eugenol showed antiproliferative and cytotoxic effects via apoptosis and also synergism with cisplatin and ionizing radiation in the human cervical cancer cell line. (Source: Molecules)
Sun Nov 03, 2019 00:00
Abstract Purpose of Review There are an increasing number of studies using neuroimaging to understand associations between social conditions, including socioeconomic status, and the development of brain structure and function. From a population health perspective, this review summarizes the challenges of this work and highlights opportunities for collaboration with social epidemiologists as neuroimaging studies become more population-based....
Sun Nov 03, 2019 02:00
ConclusionThyroid paraganglioma is a rare type of tumor, it arises from inferior laryngeal paraganglioma within thyroid capsule and is as thus difficult to distinguish from thyroid carcinomas. A biopsy is the best diagnostic choice but immunohistochemistry is the only investigation which is considered as the gold standard for distinguishing between these two diseases. (Source: International Journal of Surgery Case Reports)
Sun Nov 03, 2019 14:38
ConclusionAlthough many cases with multiple primary cancers have been published, a case of patient with PNET, lymphoma, and SCC occurring as primary cancers has not been yet reported. (Source: International Journal of Surgery Case Reports)
Sun Nov 03, 2019 14:38
Conclusion: The diagnostic values of the biomarkers are reproducibly confirmed in the independent and large sample sets, providing an assay for lung cancer detection. PMID: 31674214 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
Sun Nov 03, 2019 14:25
Contributors : Sebastien Coassolo ; Guillaume Davidson ; Luc Negroni ; Giovanni Gambi ; Sylvain Daujat ; Christophe Romier ; Irwin DavidsonSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe Nuclesome Remodelling and Deacetylation (NuRD) complex is an epigenetic regulator of gene expression comprising two mutually exclusive ATPase subunits CHD3 or CHD4. Here we show that CHD4 silencing in multiple types of cancer cells de-represses expression of...
Sun Nov 03, 2019 05:00
Contributors : Sebastien Coassolo ; Guillaume Davidson ; Luc Negroni ; Giovanni Gambi ; Sylvain Daujat ; Christophe Romier ; Irwin DavidsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Nuclesome Remodelling and Deacetylation (NuRD) complex is an epigenetic regulator of gene expression comprising two mutually exclusive ATPase subunits CHD3 or CHD4. Here we show that CHD4 silencing in multiple types of cancer cells de-represses expression of the PADI1 (Protein...
Sun Nov 03, 2019 05:00
ConclusionE-RFA may be recommended for the initial treatment of HCC in patients with a severely impaired liver function. However, E-pHR should be avoided as the initial treatment of HCC in such patients. (Source: Surgery Today)
Sun Nov 03, 2019 00:00
ConclusionsThyroid carcinoma arising in struma ovarii or mature cystic teratoma should prompt clinical evaluation and imaging of the thyroid given the possibility of synchronous primaries, metastases, and recurrence. (Source: Archives of Gynecology and Obstetrics)
Sun Nov 03, 2019 00:00
ping real-world comparators for (Source: Gastric Cancer)
Sun Nov 03, 2019 00:00
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