Pharmaceutics, Vol. 11, Pages 615: Efficient Delivery of Therapeutic siRNA by Fe3O4 Magnetic Nanoparticles into Oral Cancer Cells Pharmaceutics doi: 10.3390/pharmaceutics11110615 Authors: Lili Jin Qiuyu Wang Jiayu Chen Zixiang Wang Hongchuan Xin Dianbao Zhang The incidence of oral cancer is increasing due to smoking, drinking, and human papillomavirus (HPV) infection, while the current treatments are not satisfactory. Small interfering RNA (siRNA)-based therapy has brought...
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Pharmaceutics, Vol. 11, Pages 616: Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations Pharmaceutics doi: 10.3390/pharmaceutics11110616 Authors: Christina Haeuser Pierre Goldbach Joerg Huwyler Wolfgang Friess Andrea Allmendinger Short freeze-drying cycles for biopharmaceuticals are desirable. Formulations containing an amorphous disaccharide, such as sucrose, are prone to collapse upon aggressive primary drying at higher...
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Pharmaceutics, Vol. 11, Pages 618: Evaluation of the Effect of CYP2D6 Genotypes on Tramadol and O-Desmethyltramadol Pharmacokinetic Profiles in a Korean Population Using Physiologically-Based Pharmacokinetic Modeling Pharmaceutics doi: 10.3390/pharmaceutics11110618 Authors: Jeong Bae Bae Lee Kim Jang Shin Tramadol is a μ-opioid receptor agonist and a monoamine reuptake inhibitor. O-desmethyltramadol (M1), the major active metabolite of tramadol, is produced...
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Pharmaceutics, Vol. 11, Pages 617: Co-Encapsulation of Chlorin e6 and Chemotherapeutic Drugs in a PEGylated Liposome Enhance the Efficacy of Tumor Treatment: Pharmacokinetics and Therapeutic Efficacy Pharmaceutics doi: 10.3390/pharmaceutics11110617 Authors: Po-Chun Peng Ruey-Long Hong Tsuimin Tsai Chin-Tin Chen Long-circulating PEG-modified liposome has been shown to improve pharmacokinetic properties and reduce systemic toxicity in cancer treatment. However, drug bioavailability...
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Cells, Vol. 8, Pages 1450: HIF1α-Dependent Metabolic Signals Control the Differentiation of Follicular Helper T Cells Cells doi: 10.3390/cells8111450 Authors: Dong He Zhou Cao Li Bi Liu Follicular helper T (TFH) cells are critical for germinal center (GC) formation and are responsible for effective B cell-mediated immunity; metabolic signaling is an important regulatory mechanism for the differentiation of TFH cells. However, the precise roles of hypoxia inducible...
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Cells, Vol. 8, Pages 1449: Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin Cells doi: 10.3390/cells8111449 Authors: Miroslav Ferko Natália Andelová Barbara Szeiffová Bačová Magdaléna Jašová Therapies intended to mitigate cardiovascular complications cannot be applied in practice without detailed knowledge of molecular mechanisms. Mitochondria, as the end-effector of cardioprotection, represent one of the...
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Cells, Vol. 8, Pages 1451: Functional Ultrastructure of the Excretory Gland Cell in Zoonotic Anisakids (Anisakidae, Nematoda) Cells doi: 10.3390/cells8111451 Authors: Mladineo Hrabar Smodlaka Palmer Sakamaki Keklikoglou Katharios Excretory and secretory products are crucial for parasite infectivity and host immunomodulation, but the functioning and ultrastructure of the excretory gland cell (EC) that produces these products are still scarcely understood and described....
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