Poliomyelitis: An acute and sometimes devastating viral disease. Man is the only natural host for poliovirus. The virus enters the mouth and multiplies in lymphoid tissues in the pharynx and intestine. Small numbers of virus enter the blood and go to other sites where the virus multiplies more extensively. Another round of viremia (virus in the bloodstream) leads to invasion of the central nervous system (CNS), the spinal cord and brain, the key sites struck by the virus.In polio, there is inflammation...
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This study explored the relationship between community social capital and cognitive impairment, with a focus on the buffering role of community social capital in the association between educational disadvantag...
Fri Nov 01, 2019 02:00
Nature, Published online: 04 November 2019; doi:10.1038/d41586-019-03357-yThe contest for 18–25-year-olds received more than 660 entries from 68 countries.
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Nature, Published online: 04 November 2019; doi:10.1038/d41586-019-03360-3Same-sex partners should one day be able to raise a biological descendant together. Runner-up in the Young Scientist Essay Competition 2019.
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Nature, Published online: 04 November 2019; doi:10.1038/d41586-019-03359-wNuclear-fusion power plants could be part of a solution to the climate crisis. Runner-up in the Young Scientist Essay Competition 2019.
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Nature, Published online: 04 November 2019; doi:10.1038/d41586-019-03358-xThe composer wished for a cure for his hearing loss. Soon, research could make it a reality for my twin brother − and millions more. Winner of the Young Scientist Essay Competition 2019.
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Craniopharyngiomas (CP) are rare embryonic malformations of the sellar/parasellar region with low histological grade. Clinical manifestations are related to hypothalamic/pituitary deficiencies, visual impairment, and increased intracranial pressure. Recent insight in molecular pathogenesis of CP opens new perspectives on targeted therapy in papillary CP harboring BRAF-V600E mutations. Further research to elucidate pathogenic mechanisms and hopefully prevent hypothalamic involvement of CP is warranted....
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AbstractBackgroundThe transcription factor STAT3 drives progression in glioblastoma, suggesting STAT3 as a therapeutic target. Surprisingly however, glioblastoma cells generally show primary resistance to STAT3 blockade.MethodsHuman glioblastoma cell lines LN229, U87, SF767 and U373, and patient-derived xenografts (PDX) GBM8 and GBM43 were used to evaluate EGFR activation during STAT3 inhibition. Protein and gene expression experiments, protein stability assays, cytokine arrays, phospho-tyrosine...
Sun Nov 03, 2019 02:00
Publication date: December 2019Source: Neurobiology of Disease, Volume 132Author(s):
Sun Nov 03, 2019 21:20
Publication date: Available online 2 November 2019Source: Neurobiology of DiseaseAuthor(s): Chun Chen, Amy E. Vincent, Alasdair P. Blain, Anna L. Smith, Doug M. Turnbull, Amy K. ReeveAbstractMitochondrial respiratory chain deficiency and mitochondrial DNA deletions are reported in substantia nigra neurons from healthy aged and Parkinson's disease cases, with extensive neuronal loss only seen in the latter. This study aimed to understand the pathological relevance of mitochondrial defects for neuronal...
Sun Nov 03, 2019 21:20
Publication date: Available online 2 November 2019Source: Neurobiology of DiseaseAuthor(s): Mathilde Millot, Yosuke Saga, Sandra Duperrier, Elise Météreau, Maude Beaudoin-Gobert, Véronique SgambatoAbstractThe aim of this study was to investigate the causal role of an early serotonin injury on parkinsonian-like motor symptomatology. Monkeys were pretreated with 3,4-methylenedioxy-N-methamphetamine (MDMA, or “ecstasy”), known to lesion serotonergic fibers, before being administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...
Sun Nov 03, 2019 21:20
Publication date: Available online 2 November 2019Source: Neurobiology of DiseaseAuthor(s): Ivan Pilipović, Zorica Stojić-Vukanić, Ivana Prijić, Nebojša Jasnić, Gordana LeposavićAbstractSympathetic dysfunction is suggested to contribute to development of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of microglia in development/resolution of neuroinflammation, contribution of noradrenaline, the key sympathetic end-point mediator, in modulation...
Sun Nov 03, 2019 21:20
Viruses, Vol. 11, Pages 1022: Single-Stranded DNA Viruses in Antarctic Cryoconite Holes Viruses doi: 10.3390/v11111022 Authors: Pacifica Sommers Rafaela S. Fontenele Tayele Kringen Simona Kraberger Dorota L. Porazinska John L. Darcy Steven K. Schmidt Arvind Varsani Antarctic cryoconite holes, or small melt-holes in the surfaces of glaciers, create habitable oases for isolated microbial communities with tightly linked microbial population structures. Viruses may influence...
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Viruses, Vol. 11, Pages 1021: Porcine Circovirus Type 2 Induces Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR) Downregulation to Promote Interleukin-1β Upregulation in Porcine Alveolar Macrophage Viruses doi: 10.3390/v11111021 Authors: Yang Liu Yin Shang Zhang Khan Liu Cai Multisystemic inflammation in pigs affected by porcine circovirus type 2 (PCV2) indicates the disordered expression of inflammatory cytokines. However, the PCV2-induced...
Sun Nov 03, 2019 02:00
Publication date: December 2019Source: Oral Oncology, Volume 99Author(s): Zongtai Qi, Thomas Barrett, Anuraag S. Parikh, Itay Tirosh, Sidharth V. PuramAbstractHead and neck squamous cell carcinoma (HNSCC), like many tumors, is characterized by significant intra-tumoral heterogeneity, namely transcriptional, genetic, and epigenetic differences that define distinct cellular subpopulations. While it has been established that intra-tumoral heterogeneity may have prognostic significance in HNSCC, we are...
Sun Nov 03, 2019 21:38
Objective: To analyze the predictors of both distant metastasis and survival in patients with adenoid cystic carcinoma of the external auditory canal. Study Design: Retrospective patient review. Setting: A single university hospital. Patients: Eighty-two cases with adenoid cystic carcinoma of the external auditory canal were referred to our institution between 2004 and 2016. Main Outcome Measures: Distant metastasis was detected by lung computed tomography, proton emission...
Mon Oct 28, 2019 02:00
Objective: To improve patient satisfaction and understanding of what to expect after chronic ear surgery and reduce call volume to an otology clinic at an academic tertiary referral center. Study Design: Quality improvement initiative. Setting: A single-academic tertiary referral center. Patients: One hundred and ten patients who underwent chronic ear surgery in March to May 2018. Intervention: Preoperative counseling over the phone 1 week before surgery. Main Outcome Measures:...
Mon Oct 28, 2019 02:00
Objective: To examine opioid prescribing patterns and consumption among patients undergoing common otologic surgeries. Study Design: Retrospective cohort study with chart review and telephone survey. Setting: Tertiary academic medical center. Methods: Retrospective chart review and telephone survey of those undergoing tympanoplasty, tympanomastoidectomy, stapedectomy, and cochlear implantation in 2018. The survey consisted of questions regarding the details of the number of pills...
Mon Oct 28, 2019 02:00
Objective: To describe the presentations and treatment results for patients with concurrent otosclerosis and superior semicircular canal dehiscence (SCD). Study Design: Retrospective case series and literature review. Setting: Tertiary academic medical center. Patients: Patients with concurrent diagnoses of otosclerosis (radiographically and/or surgically confirmed) and SCD (radiographically confirmed) in the same ear. Intervention(s): Review of medical records. Main Outcome...
Mon Oct 28, 2019 02:00
Background: Bone anchored hearing implants (BAHI) are widely used and highly successful, accompanied with a high level of patient satisfaction across most techniques. A large UK teaching hospital switched from the previously used wide diameter titanium fixture and drilling system to the novel minimally invasive technique and laser ablated titanium implant. Before this change the rates of fixture failure and skin problems necessitating abutment change were 1% each. Methods: Retrospective case...
Mon Oct 28, 2019 02:00
Objective: To examine the relationships among self-assessment of knowledge in otology via an individualized learning plan (ILP), otology milestone achievement rate, and otolaryngology training exam (OTE) otology scores. Study Design: Prospective study. Setting: One otolaryngology residency covering a tertiary care facility, trauma and hospital center, outpatient ambulatory surgery center, and outpatient clinics. Participants: Twenty otolaryngology residents, four from each class. ...
Mon Oct 28, 2019 02:00
Preventing disease in the twenty-first century: “Life is short, the Art long, opportunity fleeting…”
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Publication date: Available online 2 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Andras Czigler, Luca Toth, Nikolett Szarka, Krisztina Szilágyi, Zoltan Kellermayer, Alexandra Harci, Monika Vecsernyes, Zoltan Ungvari, Alex Szolics, Akos Koller, Andras Buki, Peter TothAbstractThere is considerable controversy regarding the vasoactive action of prostaglandin E2 (PGE2). On the one hand, indirect evidence implicates that astrocytic release of PGE2 contributes to neurovascular...
Sun Nov 03, 2019 17:44
Source: Science Daily - Top HealthHow well eight-year-olds score on a test of thinking skills may be a predictor of how they will perform on tests of thinking and memory skills when they are 70 years old, according to a study. The study also found that education level and socioeconomic status were also predictors of thinking and memory performance.
Sun Nov 03, 2019 13:18
Source: Yahoo News - Top HeadlinesThe words from California’s former governor could barely have been more stark.“I said it was the new normal a few years ago,’’ said Jerry Brown. “This is serious, but this is only the beginning. This is only a taste of the horror and the terror that will occur in decades.”.
Sun Nov 03, 2019 13:17
Source: United Press International - Health NewsA study of more than 6 million adults and children in Northern California highlights increase in diagnoses across the board, but particularly among adults, researchers report.
Sun Nov 03, 2019 13:17
Source: Yahoo News - Top HeadlinesVietnamese smugglers call it the "CO2" route: a poorly ventilated, oxygen-deficient trip across the English Channel in shipping containers or trailers piled high with pallets of merchandise, the last leg of a perilous, 6,000-mile trek across Asia and into Western Europe.
Sun Nov 03, 2019 13:17
Source: BBC News - Top HeadlinesThe US airline was criticised after showing censored versions of Rocketman and Booksmart.
Sun Nov 03, 2019 13:15
Source: BBC News - AsiaAntónio Guterres says Asian countries must use greener energy sources to tackle the climate crisis.
Sun Nov 03, 2019 13:14
When constantly making the wrong choice of dating partners isn’t a sign of a problem, but a profoundly important clue about the kind of life that is best for you
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Why do we self-sabotage? The answer may lie in an adaptive mechanism gone haywire—and what causes us to flip the switch.
Sat Nov 02, 2019 18:39
Special bilinguals have a regular, but also at times, a unique relationship with their languages.
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The sociopath is not next door. He’s playing golf. Donald Trump is an exaggerated textbook prototype of an individual with Antisocial Personality Disorder. Take a look.
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Love is not a rule-free zone. Abiding by the rules of intimacy will help you love and experience love better.
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Using motion to get past commotion? Putting walking to work.
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Are your late night food cravings wearing you down? These five power principles to overcome nighttime overeating might be just what you need.
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Effective couples therapy alters how partners structure their life together, share what is meaningful, creatively negotiate challenges, and conceptualize their journey.
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Most widows want to return to partner lovemaking. But friends and family often wag fingers. Joan Price, a prominent expert on senior sex, offers help for sex after grieving.
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Sex Education. Let's talk the talk so our youth can walk the walk. But wait! Seniors are getting sexually transmitted infections too??? Looks like we have work to do at all ages.
Sun Nov 03, 2019 23:19
Much of the world's great literature is about women having to choose between passion and security in their relationships with men. Why is this such a compelling theme?
Sun Nov 03, 2019 22:25
This is a wakeup call! Chronic "undersleeping" affects more than 50% of US kids, and this interferes with all aspects of development. If your kid is one of them, here's what to do.
Sun Nov 03, 2019 22:23
How do teens define leadership? Let's ask and find out. Part 2 of a two-part series.
Sun Nov 03, 2019 21:42
Political ads and the four fake news problems: Confusion about facts. Susceptibility to deception. Tarnishing political opponents. Repetition to create familiarity with fake news.
Sun Nov 03, 2019 21:35
When I was finally picked up by police for trespassing on my former university campus, I was confused, thinking it was all a mistake. I needed treatment, not jail time.
Sun Nov 03, 2019 20:41
Can you detect a liar? Probably not, if you believe these myths about lying.
Sun Nov 03, 2019 20:39
Toxic people can seem attractive at first, but they should come with warning labels.
Sun Nov 03, 2019 20:27
What can an Iranian film maker teach us about ourselves? A lot.
Sun Nov 03, 2019 20:04
The workforce will continue to evolve and employees will demand company perks that better align with their life style and gender equity.
Sun Nov 03, 2019 18:38
Research seldom recognizes the developmental spectrum of sexual activities and yet this might have consequences for our understanding of youths.
Sun Nov 03, 2019 18:12
Empowering children is part of optimizing child outcomes.
Sun Nov 03, 2019 18:01
The goal of the conference will be to develop policies and guidelines for legislators, policymakers and professional practitioners with respect to best practices.
Sun Nov 03, 2019 17:44
The key to success in life lies in developing your emotional intelligence skills. Here's how you can do so!
Sun Nov 03, 2019 17:35
What are the interesting questions concerning dreams that foretell the future?
Sun Nov 03, 2019 15:56
Is graduate school a good choice for you? Perhaps--but you need to do some hard thinking before committing.
Sun Nov 03, 2019 15:41
New study explains how "Culture" is key to innovation, profits, and influence.
Sun Nov 03, 2019 15:07
People trying to find their way on a spiritual path can seem flaky or inconsistent. What if this means there's something right, not wrong, with them?
Sun Nov 03, 2019 14:14
Publication date: Available online 2 November 2019Source: Quaternary GeochronologyAuthor(s): David W. Marchetti, Allen Stork, D. Kip Solomon, Thure E. Cerling, Wil MaceAbstractDetermining the ages of young volcanic rocks is important for understanding the tectono-magmatic development of geologic terranes. Usually, if rocks are old enough the 40Ar/39Ar or K–Ar techniques can provide reliable ages. However, when rocks are younger, they often lack enough daughter product to resolve an age. Cosmogenic...
Sun Nov 03, 2019 16:04
I have a basic Creality Ender-3 with a black rough bed cover. I'm printing with PLA. After assembly, I printed 3 or 4 small toys sliced by Cura with basic settings. All were printed very well! However, after that, extruded filament would not stick to the bed. I tried the following: Bed calibration with A4 paper (each corner with a tight nozzle to paper and repeated calibration again) Once raised up the bed temperature from stock 50 to 60 °C Washed the bed with a soap and water (and dried)...
Sun Nov 03, 2019 17:41
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