Prenatal stem cell-based regenerative therapies have progressed substantially and have been demonstrated as effective treatment options for fetal diseases that were previously deemed untreatable. Due to immunoregulatory properties, self-renewal capacity, and multilineage potential, autologous human placental chorionic villus-derived mesenchymal stromal cells (CV-MSCs) are an attractive cell source for fetal regenerative therapies. However, as a general issue for MSC transplantation, the poor survival...
A frequent observation in several malignancies is the development of resistance to therapy that results in frequent tumor relapse and metastasis. Much of the tumor resistance phenotype comes from its heterogeneity that halts the ability of therapeutic agents to eliminate all cancer cells effectively. Tumor heterogeneity is, in part, controlled by cancer stem cells (CSC). CSC may be considered the reservoir of cancer cells as they exhibit properties of self-renewal and plasticity and the capability...
Pterygium is a common eye disease, linked to an increased exposure to UV radiation and dry environments. The associated pathology culminates in visual impairment and, in some rare cases, blindness. However, there remains a lot of uncertainty concerning the pathogenesis of this fibrovascular lesion. As the composition of the tear film provides a reflection into the pathological changes at the ocular surface, tear analysis represents an ideal approach to gain insight in the progression of disease following...
Iron deficiency anemia (IDA) during pregnancy arises because of preexisting inadequate stores or complex physiological changes and can lead to serious maternal and fetal complications. Oral iron, either as iron sulfate or fumarate, with or without folic acid, is the most commonly used treatment for IDA in pregnancy. Intravenous (IV) iron has a role in the treatment of IDA in pregnancy, particularly in women who present late, display severe anemia (Hb ≤ 9 g/dL), or risk factors, and are intolerant/noncompliant...
Purpose. To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms in patients with laryngeal squamous cell carcinoma (LSCC). Methods. A total of 944 subjects were evaluated, which includes 144 patients with LSCC and 800 healthy controls. The genotyping of STAT3 rs744166,...
The MIMO-OFDM system fully exploits the advantages of MIMO and OFDM, effectively resisting the channel multipath fading and inter-symbol interference while increasing the data transmission rate. Studies show that it is the principal technical mean for building underwater acoustic networks (UANs) of high performance. As the core, a signal detection algorithm determines the performance and complexity of the MIMO-OFDM system. However, low computational complexity and high performance cannot be achieved...
Thymoma is an uncommon slowly growing neoplasm. It usually presents with paraneoplastic syndromes including the immunodeficiency syndrome called Good syndrome and hematological disorders. Pure red cell aplasia is a well-recognized complication of thymoma, and aplastic anemia is very rare in association with GS. We report a case of GS in a heavily treated patient with stage IV thymoma associated with a pure red cell aplasia and an amegakaryocytic thrombocytopenia that evolved into an AA and provide...
In order to avoid unexpected damage of structural specimens in the test, at the beginning, a signal with small amplitude is adopted to input the shake table device to gain the transfer function and corresponding drive signal, and then a strong earthquake output can be reproduced by amplifying the drive signal proportionally. However, as there are obvious nonlinearities inherent in the shake table device and structural specimen under strong earthquakes, errors inevitably exist in the replayed and...
The fastener-based computational model is improved and extended to predict the shear performance of reinforced cold-formed steel (RCFS) shear walls. The failure mechanism of sheathing-to-stud connections with double-layer wallboards is first analysed, and a method for determining those connections’ shear properties is proposed. Numerical models of RCFS shear walls are then established and analysed. Based on simulated results that have been fully validated by previous test results, an equivalent method...
Background. Sclerocornea is a rare congenital disorder characterized with the opacification of the cornea. Here, we report a nonconsanguineous Chinese family with multiple peripheral sclerocornea patients spanning across three generations inherited in an autosomal dominant manner. Methods. This is a retrospective case series of a peripheral sclerocornea pedigree. Comprehensive ophthalmic examinations were conducted and assessed on 14 pedigree members. Whole-exome sequencing was used to identify the...
Introduction. The purpose of this study was to evaluate the prognostic value of texture features on contrast-enhanced magnetic resonance imaging (MRI) for patients with primary central nervous system lymphoma (PCNSL). Methods. In this retrospective study, fifty-two patients diagnosed with PCNSL were enrolled from October 2010 to March 2017. The texture feature of tumor tissue on the histogram-based matrix (histo-) and the grey-level co-occurrence matrix (GLCM) was retrieved by contrast-enhanced T1-weighted...
Anti-cytokine antibodies are used in treating chronic inflammatory diseases and autoimmune diseases such as inflammatory bowel disease and rheumatic diseases. Patients with these diseases often have a compromised gut barrier function, suggesting that anti-cytokine antibodies may contribute to the re-establishment of gut barrier integrity, in addition to their immunomodulatory effects. This paper reviews the effects of anti-cytokine antibodies on gut barrier function and their mechanisms.
There are a large number of insulators on the transmission line, and insulator damage will have a major impact on power supply security. Image-based segmentation of the insulators in the power transmission lines is a premise and also a critical task for power line inspection. In this paper, a modified conditional generative adversarial network for insulator pixel-level segmentation is proposed. The generator is reconstructed by encoder-decoder layers with asymmetric convolution kernel which can simplify...
In the study, ultrasonic longitudinal mode guided waves were employed to detect defects in elbowed tubes (without welds) with a diameter of 10 mm. Finite element simulation results highlighted that the emitted L(0,1) mode guided waves experienced strong reflection and mode conversion at the elbow region to generate F(1,1) mode, followed by slow and weak F(2,1) mode. The guided wave reflected from the elbow with a through-wall defect was manifested as two overlapped wave packets, which were good indicators...
Infection with the Peste des petits ruminants virus (PPRV) is a highly devastating viral infection of small ruminants. Dromedary camels live in close proximity of small ruminants in Arabian Peninsula (AP) and many other regions in the world. Little is known about the reasons behind continuous PPRV emergence in Saudi Arabia (KSA). Our objective was to test some dromedary camel population across the kingdom for the presence of specific PPRV antibodies. Our results show detection of specific PPRV antibodies...
Nilotinib is a tyrosine kinase inhibitor used to treat patients with chronic myeloid leukemia (CML). This agent is also being studied in neurodegenerative disorders including Parkinson disease. Studies have shown that nilotinib may decrease the accumulation of parkin substrates and decrease the loss of dopaminergic cells. The use of nilotinib in neurologic disorders is relatively new, and little information about this use has been published. We report on a patient receiving nilotinib for CML. The...
Calcium alkali syndrome (CAS), a relatively unusual etiology of hypercalcemia, is characterized by a classical triad of hypercalcemia, azotemia, and metabolic alkalosis. This condition has been described in patients who have taken an excess dose of calcium with an alkali or with a volume-depletion status. To diagnose CAS it requires a high index of suspicion and a detailed history of medication/supplement intake specifically for calcium-containing drugs and a history of all possible ingested alkali....
Background. Given that the dysregulation of iron homeostasis leads to genomic instability, iron has been linked to cellular aging. However, epidemiological research on dietary iron intake and cellular aging markers is scarce. The aim of this study was to explore the relationship between dietary iron intake and cellular aging markers and to investigate whether tumor necrosis factor-α (TNFα) mediated this relationship. Methods. We conducted a cross-sectional analysis with a total of 467 subjects. Detailed...
The novel strategy against ischemic stroke in metabolic syndrome (MetS) targeting at oxidative stress and inflammation has gained attention due to the limitation of the current therapy. Due to the antioxidant and anti-inflammation of the combined extract of Oryza sativa and Anethum graveolens, the cerebroprotective effect against cerebral ischemia in MetS condition has been focused. Since no data were available, this study was set up to determine the effects of the combined extract of Oryza sativa...
The health benefits of natural products have long been recognized. Consumption of dietary compounds such as supplements provides an alternative source of natural products to those obtained from the diet. There is a growing concern regarding the possible side effects of using different food supplements simultaneously, since their possible interactions are less known. For the first time, we have tested genotoxic and antigenotoxic effects of Biochaga, in combination with dihydroquercetin. No genotoxic...
Kalanchoe brasiliensis Cambess. is a native Brazilian plant popularly known as “saião”, and the juice of its fresh leaves is traditionally used to treat several disorders, including inflammatory and infectious processes such as dysentery. The goals of this study were to characterize the phytochemical composition and investigate the antioxidant activity, the antibiotic effect, and the mode of action against Salmonella of the hydroethanolic extracts from K. brasiliensis leaves collected in the summer...
Influencing the redox balance of pancreatic beta cells could be a promising strategy for the treatment of diabetes. Nuclear factor erythroid 2p45-related factor 2 (Nrf2) is present in beta cells and regulates numerous genes involved in antioxidant defense. As reactive oxygen species (ROS) are important for beta cell signaling but induce oxidative stress when present in excess, this study elucidates the influence of Nrf2-activating compounds on different kinds of ROS and correlates changes in redox...
Purpose. To investigate the frequency and activation status of peripheral plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) as well as gastric mucosa DC subset distribution in Helicobacter pylori- (H. pylori-) infected and noninfected children. Materials and Methods. Thirty-six children were studied; twenty-one had H. pylori. The frequencies of circulating pDCs (lineage-HLA-DR+CD123+) and mDCs (lineage-HLA-DR+CD11c+) and their activation status (CD83, CD86, and HLA-DR expression) were assessed by flow...
Two-dimensional porous ZnO nanosheets were synthesized by a facile hydrothermal method for ethanol gas-sensing application. The morphology, composition, and structure of the synthesized materials were characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, powder X-ray diffraction, and high-resolution transmission electron microcopy. Results showed that the synthesized ZnO materials were porous nanosheets with a smooth surface and a thickness of 100 nm and a large pore...
The impedance matrix of an arbitrary multiport array antenna with Ohmic losses was studied. It was assumed that the partial current distributions in the array, corresponding to the alternate exciting one of its terminals while the other ones are open-circuited, are known. Consideration of the power balance in the lossy array antenna has allowed ascertaining that its impedance matrix is a sum of the radiation resistance matrix and loss resistance matrix, which are in general case complex Hermitian...
Fatty acid (FA) profile appears to be critical to infertility, and the effects of dietary FAs on sperm FA content are a current focus of studies in the field of nutrition and reproduction. Starting from a validated “OXISTRESS” model in which modification of FA content results to influence reactive oxygen species, antioxidants, isoprostanes, cytokines, sperm kinetic, and acrosome reaction, we developed a virtual reality game where the player, in order to improve the health of some virtual spermatozoa,...
Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin. However, patients’ metabolic control is inadequate in a high percentage of them and a major cause of chronic diseases like diabetic retinopathy. Approximately 15% of patients have some degree of diabetic retinopathy when diabetes is first diagnosed, and most will have developed this microvascular complication after 20 years. Early diagnosis of the disease is the best tool to prevent or delay vision loss and reduce...
Sarcopenia is a syndrome characterized by a progressive and generalized skeletal muscle mass and strength loss, as well as a poor physical performance, which as strongly been associated with aging. Sedentary lifestyle in the elderly contributes to this condition; however, physical activity improves health, reducing morbidity and mortality. Recent studies have shown that metformin (MTF) can also prevent muscle damage promoting muscular performance. To date, there is great controversy if MTF treatment...
The performance of bare TiO2 photoanodes in photoelectrochemical devices and other applications is suboptimal due to the narrow light absorption range and poor electron-hole separation. Here, heterostructured films of Ni-doped lead titanate (PbTiNiO3, PTN)-coated titania (TiO2) nanorod arrays were fabricated via a two-step process comprising hydrothermal and sol-gel methods. In the PTN/TiO2 composite films, the PTN component served as a visible light-responsive photosensitizer and the TiO2 nanorod...
Background. It is reported that hopeful thinking plays a positive role in encouraging patients to achieve functional goals during the rehabilitation process. Hope is a key concept in evaluating stroke outcomes in research and rehabilitation practice. Aims. The purpose of this study was to investigate the psychometric properties of the Korean Dispositional Hope Scale (K-DHS) using the Rasch analysis in patients with hemiplegic stroke. Methods. The K-DHS was completed by 166 community-dwelling hemiplegic...
Several orthopedic procedures have been used in early treatment to reduce the need for orthognathic surgery in skeletal Class III. The most used treatment is Rapid Maxillary Expansion and Facemask. This procedure also determines a clockwise rotation of the mandible, increasing the vertical dimensions of the lower third of the face. Therefore, the control of vertical dimension appears to be a key objective in Class III hyperdivergent patients. This article shows two skeletal Class III patients treated...
Every day, people are hired in different organizations and old and retiring employees are eliminated from enterprise systems. Eliminating these individuals from organizations leads to the loss of their spatial experiences. In addition, since new employees lack relevant experience, they need a long time to develop the correct skills for the company and may even cause damage to the organization during this learning process. Therefore, storing the spatial experience of individuals is a critical issue....
Purpose. Liver metastasis remains the leading cause of cancer-related mortality in colorectal cancer. The mechanism of occurrence and development of liver metastasis from colorectal cancer is unclear. Methods. The primary tumor tissues and blood samples of 8 patients with liver metastasis of colorectal cancer were collected, followed by nucleic acid extraction and library construction. Whole-exome sequencing was performed to detect the genomic variations. Bioinformatics was used to comprehensively...
Three new nonplanar barbituric derivatives, named as TTB, TTTB, and TOB, were synthesized. The D-π-A type conjugated compounds showed obvious intramolecular charge transfer (ICT) property, which was evidenced by theoretical calculations and spectral analyses. All of them exhibited aggregation induced emission (AIE) when formed nanoaggregates. These nanoaggregates also showed reversible mechanofluorochromism (MFC). Their red light emission became deep red after grinding and then recovered with dichloromethane...
This paper discusses the behavior of grouted noncontact lap splices under monotonic tension load. Deformed bars lapped through a grout-filled corrugated duct, and a spiral reinforcement was preembedded in the connection to improve tensile strength of the splice. The experimental results show that bond failure splices are always failed by the pullout of the preembedded bar other than the grouted bar. As the spiral pitch distance is not greater than 75 mm, the tensile strength generally improves with...
Titania nanocrystalline particles were synthesized by hydrolysis-condensation of titanium tetraisopropoxide in water-in-oil micellar solutions of water/cyclohexane/Triton X-100 system, and the effects of reflux time and water-to-surfactant molar ratio on the particle uniformity, crystallinity, and surface area were studied. Several characterization techniques including TEM and SEM, as well as X-ray diffraction and FT-IR spectroscopy, helium pycnometry, and nitrogen physisorption, were employed to...
Information spreading on multiplex networks has been investigated widely. For multiplex networks, the relations of each layer possess different extents of intimacy, which can be described as weighted multiplex networks. Nevertheless, the effect of weighted multiplex network structures on information spreading has not been analyzed comprehensively. We herein propose an information spreading model on a weighted multiplex network. Then, we develop an edge-weight-based compartmental theory to describe...
Artificial intelligence (AI) proves to have enormous potential in many areas of healthcare including research and chemical discoveries. Using large amounts of aggregated data, the AI can discover and learn further transforming these data into “usable” knowledge. Being well aware of this, the world’s leading pharmaceutical companies have already begun to use artificial intelligence to improve their research regarding new drugs. The goal is to exploit modern computational biology and machine learning...
The unique case of a rare 3-level extensor mechanism failure in a 28-year-old male, involving a tibial tubercle avulsion fracture, a patellar tendon avulsion off the tibial tubercle fragment, and a severely comminuted patella fracture, and the surgical technique required to repair such an injury is presented. Focus is spent on the unique repair of a tendon injury when both proximal and distal bony attachments are damaged. Trifocal knee extensor mechanism is a rare clinical entity with minimal literature...
Recently, multigranularity has been an interesting topic, since different levels of granularity can provide different information from the viewpoint of Granular Computing (GrC). However, established researches have focused less on investigating attribute reduction from multigranularity view. This paper proposes an algorithm based on the multigranularity view. To construct a framework of multigranularity attribute reduction, two main problems can be addressed as follows: (1) The multigranularity structure...
Exploring the propagation of stress waves in rocks with preexisting discontinuities is of great importance to reveal rock and geological engineering problems, particularly dynamic disasters like earthquakes and rockbursts in underground coal mining. In this paper, six 3D models established with COMSOL Multiphysics are employed to explore the influence of two preexisting faults with different orientations on the propagation process of explosion-induced stress waves and the reflection effect. Considering...
Globally, the prevalence of metabolic syndrome (MetS) and its components which are the major cardiovascular disease (CVD) risk factors, is higher among patients with severe mental illness (SMI) compared to the general population. This is mainly due to the deleterious lifestyles characterized by physical inactivity, excessive alcohol consumption, smoking, and unhealthy diets common among patients with SMI as well as due to cardiometabolic effects of psychotropic medications. Despite these conditions...
In assessing the impact of climate change, the use of a multimodel ensemble (MME) is required to quantify uncertainties between scenarios and produce downscaled outlines for the simulation of climate under the influence of different factors including topography. This study of climate change scenarios from 13 global climate models (GCMs) assesses the impacts of future climate change. Unlike South Korea, North Korea lacks studies using climate change scenarios of the Coupled Model Intercomparison Project...
A novel electret sensor, made from a polytetrafluoroethylene (PTFE) foil, is proposed for monitoring of radon concentration in closed spaces. A triode air system was implemented to form the electret foil. In order to calibrate the electret sensor, the ionization chamber with the electret embedded at its bottom, was placed in an emanation chamber containing radon of known concentration. The change in the effective charge density of the electret resulting from the interaction of the electret sensor...
Background. Colorectal cancer (CRC) incidence and mortality has been declining in the U.S. Despite success in reducing CRC incidence, incidence of early-onset CRC has increased markedly. In this study, we identified age-related disparities in CRC incidence and mortality, and investigated differences in anatomical distribution of colon cancers between populations. Methods. CRC trends were evaluated using Surveillance, Epidemiology, and End Results Program Data from 1980–2016 for individuals under...
Eu:CROPIS is DLR’s first mission of the Compact Satellite Program. Its primary payload focuses on the research of closed-loop biological, regenerative life support systems, in a simulated gravitational environment of the Moon and Mars over months at a time. This is achieved by rotation of the satellite around its central body axis, using only magnetic torquers as actuators. A secondary payload (“PowerCells”) by the NASA Ames Research Center also utilizes the artificial gravity to conduct growth experiments...
Keratoacanthomas (KA) are self-regressing, destructively expanding keratinocyte skin neoplasms typically characterized by sudden onset of explosive growth followed by complete involution. Cryosurgery, intralesional methotrexate and imiquimod have been used alone or in combination of two for the treatment of KA. Presently 3 patients (49, 60, and 65 years old; two females, one suspected with Ferguson-Smith syndrome), with 5 KA (6–24 mm maximal diameter) were treated with the combination of cryosurgery...
A novel Filippov forest-pest system with threshold policy control (TPC) is established while an economic threshold () is used to guide switching. The aim of our work is to address how to reasonably and successfully control pests by means of sliding dynamics for the Filippov system. On the basis of the above considerations, conditions for the existence and stability of equilibria of subsystems are addressed, and the sliding segments and several types of equilibria of the proposed system are defined....
Kidney renal papillary renal cell carcinoma (KIRP) accounts for 10–15% of renal cell carcinoma (RCC). The need to find more therapeutic targets for KIRP is urgent because most targeted drugs have limited effects on advanced KIRP. Insulin-like growth factor (IGF) binding protein 5 (IGFBP5) is a secreted protein related to cell proliferation, cell adhesion, cell migration, the inflammatory response and fibrosis; these functions are independent of IGF. In our study, we determined the expression and...
Today, the economic and social importance of occupational accidents is undeniable worldwide. Hence, research aimed at reducing this type of accident is considered a discipline of great interest for society in general. In this environment, working conditions play a fundamental role in the occurrence of accidents, and from their study, results can be obtained that provide information for decision-making that guarantee optimum conditions for the development of the employees’ tasks. Organizing the conditions...
Background. Very few nationwide studies have focused on the variations in the incidence and prevalence of dementia and Alzheimer’s disease (AD) in Asian countries. This study aims to describe the gender and age differences in the incidence and prevalence of dementia and AD in Taiwan. Methods. The data on dementia and AD were acquired from the Taiwan National Health Insurance Research Database from 2004 to 2010. The sex and age-specific rates were standardized, and the differences of gender and age...
For several years, research has been carried out on the effectiveness of solutions for perfusion and preservation of organs, including the liver. There is a search for an optimal pharmacological composition of these solutions, allowing to preserve or improve vital functions of the organ for as long as possible until it is transplanted into a recipient. Hormones due to their properties, often resulting from their pleiotropic effects, may be a valuable component for optimizing the composition of liver...
Background. The pedicle screw is one of the main tools used in spinal deformity correction surgery. Robotic and navigated surgeries are usually used, and they provide superior accuracy in pedicle screw placement than free-hand and fluoroscopy-guided techniques. However, their high cost and space limitation are problematic. We provide a new solution using 3D printing technology to facilitate spinal deformity surgery. Methods. A workflow was developed to assist spinal deformity surgery using 3D printing...
Due to the lack of true ship angular flexure data, it is difficult to evaluate its measurement error of the angular velocity matching method in practice. In this paper, the cause of the measurement error of the ship flexure angle is analyzed in theory, and an evaluation method for the ship angular flexure measurement error based on the principle of relevance is proposed. The proposed method provides a prediction formula to describe the estimation error of the static flexure angle based on the off-diagonal...
We proposed ten requisite conditions for successful development of wearable I-o-T smart magnetic sensors considering recent development of some successful micromagnetic sensors. We reported application topics using the amorphous wire CMOS IC magnetoimpedance micromagnetic sensor (MI sensor) on the geomagnetic field sensor for the electronic compass installed in the smartphones, the pitching ball self-spin analyzer installed in the professional baseball, self-driving magnetic guidance system, and...
Polycystic ovary syndrome (PCOS) is a chronic metabolic disease that is associated with obesity and adipose tissue dysfunction. This study aimed to explore the roles of Dicer (an enzyme that processes primary microRNAs) and microRNAs in PCOS. Protein levels were detected by western blotting, and mRNA and microRNA levels were detected by RT-PCR. Dicer-deficient pre-adipocytes were established by lentiviral transfection, and an miR-223 mimic and miR-223 inhibitor were used to overexpress and inhibit...
Direct-acting antivirals (DAAs) are modern treatments for chronic hepatitis C infection, but majority of available evidence on its treatment effect covers genotypes 1 to 4. Therefore, the efficacy and safety of DAAs for genotypes 5 and 6 need to be analysed. Studies were identified from Medline, Scopus, and CENTRAL and a Chinese database CNKI, from inception until Dec 4, 2018. Clinical trials were included if they enrolled patients with genotypes 5 and/or 6 infection, any type of second-generation...
Disintegration of municipal waste activated sludge (WAS) using thermo-alkaline (TA) and electro-Fenton (EF) methods was investigated and compared in terms of the efficiency of sludge solubilisation and enhancement of anaerobic biodegradability. Performance of organic matter solubilisation (soluble COD, proteins, polysaccharides) of sludge pretreated with EF was proved to be better than that with TA pretreatment, which resulted in the enhancement of anaerobic biodegradability. Comparison of results...
The performance of convolutional neural network- (CNN-) based object detection has achieved incredible success. Howbeit, existing CNN-based algorithms suffer from a problem that small-scale objects are difficult to detect because it may have lost its response when the feature map has reached a certain depth, and it is common that the scale of objects (such as cars, buses, and pedestrians) contained in traffic images and videos varies greatly. In this paper, we present a 32-layer multibranch convolutional...
In this study, a shooting experiment is carried out with an acoustic sensor array that can detect shock wave at high-sound pressures and withstand the shock wave of the bullet. Delta- and H-type of acoustic sensor units are constructed. The measured values of the temporal arrival differences estimated based on the distance between the acoustic sensors are then compared with the theoretical calculations according to the types of bullets and shooting distance. In addition, an impact-point estimation...
Polyphenols are secondary metabolites of plants and include a variety of chemical structures, from simple molecules such as phenolic acids to condensed tannins and highly polymerized compounds. Caffeic acid (3,4-dihydroxycinnamic acid) is one of the hydroxycinnamate metabolites more widely distributed in plant tissues. It is present in many food sources, including coffee drinks, blueberries, apples, and cider, and also in several medications of popular use, mainly those based on propolis. Its derivatives...
Background. To evaluate the feasibility and applicability of using office hysteroscopy in women with intact hymen. Methods. We recruited 836 patients with intact hymen with different indications who underwent diagnostic hysteroscopy without anesthesia in an outpatient setting from 2007 to 2016 at Chang Gung Memorial Hospital at Linkou. Results. Patients’ mean age was 35 ± 10.6 years (range 3–69 years). Most patients (86.4%) with postmenopausal bleeding had intrauterine lesions, and they were especially...
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