ACS NanoDOI: 10.1021/acsnano.9b04303
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b05383
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b06740
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b03868
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b07563
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b02926
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b04740
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b08115
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b06354
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b05793
Mon Nov 11, 2019 07:00
ACS NanoDOI: 10.1021/acsnano.9b08259
Mon Nov 11, 2019 07:00
We report a case of hypersensitivity pneumonitis (HP) in a young person secondary to vaping. He presented with a putative diagnosis of asthma and required extracorporeal membrane oxygenationbecause of intractable respiratory failure. He developed a critical illness and steroid myopathy and required prolonged rehabilitation. Our patient fulfils diagnostic criteria for HP secondary to e-cigarettes with a positive exposure history, deterioration after skin prick testing, specific serum IgM antibodies...
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Authors: Culemann S, Grüneboom A, Krönke G Abstract Mononuclear phagocytes, including monocytes and macrophages, are a central component of the host's innate immune system designated to protect against invading pathogens. However, these cells do not only interact with various parts of the innate and adaptive immune system, but also fulfill indispensable duties during the control of tissue homeostasis and organ function. Moreover, macrophages are crucially involved in tissue remodeling and...
Wed Oct 16, 2019 09:15
Authors: Daniels CN, Saunders KO Abstract Neutralizing antibodies against human immunodeficiency virus subtype 1 (HIV-1) bind to its envelope glycoprotein (Env). Half of the molecular mass of Env is carbohydrate making it one of the most heavily glycosylated proteins known in nature. HIV-1 Env glycans are derived from the host and present a formidable challenge for host anti-glycan antibody induction. Anti-glycan antibody induction is challenging because anti-HIV-1 glycan antibodies should...
Wed Oct 16, 2019 09:15
Authors: Anderson DA, Murphy KM Abstract Rapid advances have been made to uncover the mechanisms that regulate dendritic cell (DC) development, and in turn, how models of development can be employed to define dendritic cell function. Models of DC development have been used to define the unique functions of DC subsets during immune responses to distinct pathogens. More recently, models of DC function have expanded to include their homeostatic and inflammatory physiology, modes of communication...
Wed Oct 16, 2019 09:15
Authors: Moriyama S, Artis D Abstract Diverse infectious, inflammatory, and environmental stimuli induce type 2 inflammation in the body. Group 2 innate lymphoid cells (ILC2s) are potent producers of type 2 cytokines and play important roles in promoting type 2 inflammation. In addition to alarmins and other cytokines which are known to regulate ILC2 responses, emerging studies identified the regulation of ILC2s by the nervous system through neurotransmitter and neuropeptides. In this review,...
Wed Oct 16, 2019 09:15
94 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/11/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Nov 11, 2019 14:20
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As more of our students choose to live out their authentic gender expression, school-based speech-language pathologists can play a role in supporting and serving them. Some SLPs they already work with students on their caseload to align their voice and communication with their gender identity and expression. Giving Voice to Teachers on World Voice Day—or Any Day Holistic Voice Therapy for the Whole Person Can Students Qualify for Voice Treatment? For others, learning how to provide appropriate...
Mon Nov 11, 2019 22:00
Enantioselective cleavage of methylene C(sp3)−H bonds was achieved by using an achiral Cp*RhIII catalyst combined with a binaphthyl‐based chiral carboxylic acid. Directing‐group‐assisted C−H amidation reactions of 8‐alkylquinolines with dioxazolones proceed with high enantioselectivity under mild conditions in the presence of various functional groups. Abstract Catalytic enantioselective directed methylene C(sp3)−H amidation reactions of 8‐alkylquinolines using a Cp*RhIII/chiral carboxylic...
Mon Nov 11, 2019 20:46
It takes two: Enantioselective synthesis of 1,4‐dicarbonyl compounds directly from readily available aldehydes was accomplished with good yield and enantioselectivity through the synergistic combination of a neutral eosin Y hydrogen atom transfer photocatalyst and a bis‐cyclometalated rhodium catalyst. Abstract Enantioenriched 1,4‐dicarbonyl compounds are versatile synthons in natural product and pharmaceutical drug synthesis. We herein report a mild pathway for the efficient enantioselective...
Mon Nov 11, 2019 17:12
Visible light irradiation of 2‐iodophenyl‐thionocarbonates enabled Barton–McCombie‐type radical deoxygenations to proceed in the absence of a photocatalyst, a radical initiator, or tin or silicon hydrides. Applying this strategy to deoxygenative borylation reactions allowed a wide range of structurally diverse aliphatic alcohols to be transformed into synthetically valuable boronic esters. Abstract A photochemical method for converting aliphatic alcohols into boronic esters is described. Preactivation...
Mon Nov 11, 2019 16:20
Funky cold medina: The field of low‐temperature batteries has been historically dominated by the study of Li‐ion cells operating under the “rocking‐chair” mechanism. This design choice is challenged via the rational design of “salt‐splitting” dual‐graphite batteries which exploit cation and anion storage mechanics to circumvent sluggish desolvation during discharge. Abstract Improving the extremely low temperature operation of rechargeable batteries is vital to the operation of electronics...
Mon Nov 11, 2019 16:19
A new citrulline 4‐hydroxylase was identified from the biosynthesis of the nonribosomal tetrapeptide GE81112. Using bioinformatics‐guided rational engineering, the substrate specificity of the enzyme was switched from citrulline to arginine with just four mutations. The synthetic utility of the engineered enzyme was demonstrated by the synthesis of a key dipeptide unit of enduracidin. Abstract The GE81112 tetrapeptides are a small family of unusual nonribosomal peptide congeners with potent...
Mon Nov 11, 2019 16:19
Three's a crowd: A highly enantioselective RhII‐catalyzed cyclopropenation reaction of difluorodiazoethane (PhSO2CF2CHN2) with challenging internal alkynes is reported (up to 99 % yield, 97 % ee). Versatile stereoselective transformations of these unique strained cyclopropenes are also demonstrated. Abstract Herein we described an efficient RhII‐catalyzed enantioselective cyclopropenation reaction of internal alkynes with a masked difluorodiazoethane reagent (PhSO2CF2CHN2, Ps‐DFA). This asymmetric...
Mon Nov 11, 2019 16:17
N ‐Tritylsulfinylamine, aryldiazonium tetrafluoroborates, and N‐hydroxybenzotriazole hydrate react to give O‐benzotriazolyl sulfonimidates, which can be converted into sulfonimidamides in good yields. The two processes are mild and enable the preparation of a wide range of functionalized products. The synthetic utility was demonstrated by the syntheses of a novel azasaccharine derivate and a sulfonimidamide analogue of sildenafil. Abstract Sulfonimidamides are obtained in moderate to...
Mon Nov 11, 2019 16:17
Bpin it: A practical, atom‐economical method for the synthesis of 1,1,1‐triborylalkanes based on sequential dehydrogenative borylation and double hydroboration of terminal alkynes with HBpin is described. The 1,1,1‐triborylalkane products are useful synthetic intermediates for the construction of multiple C−C and C−O bonds to give carbocyclic organoboronates and unsymmetric tertiary alcohols. Abstract A convenient and efficient one‐step synthesis of 1,1,1‐triborylalkanes was achieved via sequential...
Mon Nov 11, 2019 16:15
Analogical 3D extension: The lithiacarborane [Li−CB11H11]− plays a central role in carborane chemistry and is an organometallic species of fundamental interest because it represents a 3D analogue of phenyllithium featuring an exo C−Li bond as well as a spherically delocalized negative endo charge. The high‐yield isolation and detailed structural characterization of the lithiate and zincate are presented alongside DFT calculations. Abstract The lithiacarborane [Li−CB11H11]− plays a central role...
Mon Nov 11, 2019 16:14
FeN4 moieties embedded in partially graphitized carbon are efficient active sites for the oxygen reduction reaction in acidic proton‐exchange membrane fuel cells. The mechanisms leading to the formation of these active sites were studied by introducing Fe ions into a nitrogen‐doped carbon followed by controlled thermal activation. Abstract FeN4 moieties embedded in partially graphitized carbon are the most efficient platinum group metal free active sites for the oxygen reduction reaction in...
Mon Nov 11, 2019 16:13
Carbon nanotubes (CNTs) have unusual physical properties which are valuable for nanotechnology and electronics but the chemical synthesis of chirality‐ and diameter‐specified CNTs and π‐conjugated CNT segments is still a great challenge. Herein we report the selective synthesis, isolation, characterizations, and photophysical properties of two novel chiral conjugated macrocycles ([4]cyclo‐2,6‐anthracene, [4]CAn2,6) as (‐)/(+)‐(12,4) carbon nanotube segment. These conjugated macrocyclic molecules...
Mon Nov 11, 2019 15:18
The current research of thermally activated fluorescence (TADF) emitters is mainly based on the molecular levels, while the aggregation states of TADF emitters are to be explored deeply. Here we report two multifunctional emitters with simultaneous TADF, aggregation induced emission (AIE), and multicolor mechanochromic luminescence (MCL) features. Moreover, both emitters show polymorph‐dependent TADF emission. Crystal structure analysis reveals that the polymorphism is ascribed to the mutable conformations...
Mon Nov 11, 2019 14:44
A highly asymmetric Au(III) η3 allyl complex has been generated by treating Au(η1‐allyl)Br(tpy) (tpy = 2‐(p‐tolyl)pyridine) with AgNTf2. The resulting η3 allyl complex has been characterized by NMR and X‐ray crystallography. DFT calculations and variable temperature 1H NMR suggest that the allyl ligand is highly fluxional.
Mon Nov 11, 2019 12:17
Two‐dimensional (2D) Ti 3 C 2 nanosheets have been widely used as co‐catalysts for photocatalysis. However, how 2D Ti 3 C 2 enhances the photocatalytic efficiency remains unclear. Here, we, for the first time, report that it is graphene quantum dots (GQDs) derived from Ti 3 C 2 , other than 2D Ti 3 C 2 itself, that play as the co‐catalyst for La 2 Ti 2 O 7 /Ti 3 C 2 (LTC) composites during the photocatalytic reaction. After modification of Ti 3 C 2 derivatives, the photocatalytic...
Mon Nov 11, 2019 12:17
We developed cobalt‐catalyzed highly ( E )‐selective cross‐dimerization of terminal alkynes with terminal silylacetylenes, tert ‐butylacetylene, or 1‐trimethylsilyloxy‐1,1‐diphenyl‐2‐propyne in the presence of dichlorocobalt(II) complex 1a bearing a sterically demanding 2,9‐bis(2,4,6‐triisopropylphenyl)‐1,10‐phenanthroline upon activation with two equivalents of EtMgBr, giving a variety of ( E )‐1,3‐enynes. We found that the well‐characterized diolefin‐Co(0) complex 13 with divinyltetramethyldisiloxane...
Mon Nov 11, 2019 11:44
Zeise’s salt, KPt(C2H4)Cl3, was the first characterized organometallic compound; it was also the first olefin pi‐complex. But as it was discovered in 1827‐30 in the middle of a fight between Dumas on the one hand and Berzelius and Liebig on the other, defending the etherin (ethylene) and radical theories, respectively, Zeise was unavoidably drawn into the fierce and highly personal dispute. Although Zeise’s formulation as a compound containing ethylene was vindicated, the fight went on, with bitter...
Mon Nov 11, 2019 11:31
In this issue, Conroy and colleagues report the results of a trial of a behavioral intervention for weight loss maintenance delivered through the electronic health record. The editorialist discusses the findings and how they may facilitate the incorporation of obesity treatment into routine primary care.
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Background:Weight regain after intentional loss is common. Most evidence-based weight management programs focus on short-term loss rather than long-term maintenance.Objective:To evaluate the benefit of coaching in an electronic health record (EHR)–based weight maintenance intervention.Design:Randomized controlled trial. (ClinicalTrials.gov: NCT01946191)Setting:Practices affiliated with an academic medical center.Participants:Adult outpatients with body mass index (BMI) of 25 kg/m2 or higher, intentional...
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Recent discussions about the increasing prices of prescription drugs have focused on pharmacy benefit managers (PBMs), third-party intermediaries for various types of employers and government purchasers who negotiate drug prices in health plans and thus play a crucial role in determining the amount millions of Americans pay for medications. In this position paper, the American College of Physicians expands on its position paper from 2016 by offering additional recommendations to improve transparency...
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Kent and colleagues describe 2 alternatives to subgroup analyses to help personalize clinical trial results: “risk modeling” and “effect modeling.” The editorialists commend the authors for moving beyond subgroup analyses and look forward to methodological enhancements that address the substantial complexities of identifying and evaluating treatment effect heterogeneity.
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The PATH (Predictive Approaches to Treatment effect Heterogeneity) Statement was developed to promote the conduct of, and provide guidance for, predictive analyses of heterogeneity of treatment effects (HTE) in clinical trials. The goal of predictive HTE analysis is to provide patient-centered estimates of outcome risk with versus without the intervention, taking into account all relevant patient attributes simultaneously, to support more personalized clinical decision making than can be made on...
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Background:The 3 Wishes Project (3WP) is an end-of-life program that aims to honor the dignity of dying patients by creating meaningful patient- and family-centered memories while promoting humanistic interprofessional care.Objective:To determine whether this palliative intervention could be successfully implemented—defined as demonstrating value, transferability, affordability, and sustainability—beyond the intensive care unit in which it was created.Design:Mixed-methods formative program evaluation....
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Heterogeneity of treatment effect (HTE) refers to the nonrandom variation in the magnitude or direction of a treatment effect across levels of a covariate, as measured on a selected scale, against a clinical outcome. In randomized controlled trials (RCTs), HTE is typically examined through a subgroup analysis that contrasts effects in groups of patients defined “1 variable at a time” (for example, male vs. female or old vs. young). The authors of this statement present guidance on an alternative...
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The increasing price of prescription drugs is an ongoing concern for Medicare and Medicaid, particularly for patients with chronic health conditions who are using multiple medications and patients in these programs taking high-priced brand-name specialty drugs. Shifts in benefit design, including higher deductibles and a movement away from copayments to coinsurance, have increased patient out-of-pocket costs and put pressure on program budgets. In this paper, the American College of Physicians expands...
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In this issue, the American College of Physicians expands on its prior policy recommendations aimed at improving prescription drug market competition, decreasing out-of-pocket burden, and increasing the federal government's purchasing power. The editorialists discuss the recommendations and note tradeoffs that will need to be considered before implementation of policies to curb drug prices.
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Antibiotics, Vol. 8, Pages 218: Hibiscus Acid and Chromatographic Fractions from Hibiscus Sabdariffa Calyces: Antimicrobial Activity against Multidrug-Resistant Pathogenic Bacteria Antibiotics doi: 10.3390/antibiotics8040218 Authors: Lizbeth Anahí Portillo-Torres Aurea Bernardino-Nicanor Carlos Alberto Gómez-Aldapa Simplicio González-Montiel Esmeralda Rangel-Vargas José Roberto Villagómez-Ibarra Leopoldo González-Cruz Humberto Cortés-López Javier Castro-Rosas The...
Mon Nov 11, 2019 02:00
Antibiotics, Vol. 8, Pages 217: Recent Progress in the Development of Small-Molecule FtsZ Inhibitors as Chemical Tools for the Development of Novel Antibiotics Antibiotics doi: 10.3390/antibiotics8040217 Authors: Laura Carro Antibiotics are potent pharmacological weapons against bacterial pathogens, nevertheless their efficacy is becoming compromised due to the worldwide emergence and spread of multidrug-resistant bacteria or “superbugs”. Antibiotic resistance is...
Mon Nov 11, 2019 02:00
Mon Nov 11, 2019 10:41
Atmosphere, Vol. 10, Pages 696: Statistical Analysis of the Spatiotemporal Distribution of Ozone Induced by Cut-Off Lows in the Upper Troposphere and Lower Stratosphere over Northeast Asia Atmosphere doi: 10.3390/atmos10110696 Authors: Dan Chen Tian-Jiao Zhou Li-Yun Ma Chun-Hua Shi Dong Guo Li Chen This paper presents the results of a statistical study of the spatiotemporal distribution of ozone in the upper troposphere and lower stratosphere (UTLS) regions induced by...
Mon Nov 11, 2019 02:00
Atmosphere, Vol. 10, Pages 695: Estimation of Low-Flow in South Korean River Basins Using a Canonical Correlation Analysis and Neural Network (CCA-NN) Based Regional Frequency Analysis Atmosphere doi: 10.3390/atmos10110695 Authors: Kichul Jung Eunji Kim Boosik Kang Low-flow quantiles at ungauged locations are generally estimated based on hydrological methods, such as the drainage area ratio and frequency analysis methods. In practice, the drainage area ratio approach is a popular...
Mon Nov 11, 2019 02:00
Atmosphere, Vol. 10, Pages 694: Evaluating Forecast Skills of Moisture from Convective-Permitting WRF-ARW Model during 2017 North American Monsoon Season Atmosphere doi: 10.3390/atmos10110694 Authors: Christoforus Bayu Risanto Christopher L. Castro James M. Moker Avelino F. Arellano David K. Adams Lourdes M. Fierro Carlos M. Minjarez Sosa This paper examines the ability of the Weather Research and Forecasting model forecast to simulate moisture and precipitation during...
Mon Nov 11, 2019 02:00
Fresh evidence has emerged of the health dangers of vaping. In a case report...Read more on AuntMinnieEurope.comRelated Reading: Belgian team warns about health effects of vaping Italians unveil new data on prolonged CT lung screening Video from ECR 2019: Mathias Prokop on lung cancer screening NELSON gives Europeans go-ahead for CT lung screening Kauczor: Lung cancer screening works if you do it right
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Researchers from the Hospital for Special Surgery (HSS) have begun enrolling...Read more on AuntMinnieEurope.comRelated Reading: EOS reports net loss in 1st half of 2019 EOS secures deal with French radiology group EOS announces revenue growth in Q2 EOS reports revenue downturn EOS completes 1st installation in UAE
Mon Nov 11, 2019 21:14
Publication date: Available online 10 November 2019Source: Behavioural Brain ResearchAuthor(s): Jie Mei, Joel Kohler, Claudia Spies, Matthias Endres, Stefanie Banneke, Julius Valentin EmmrichAbstractThe radial arm maze (RAM) is a common behavioral test to assess spatial working and reference memory in mice. However, conventional RAM experiments require a substantial degree of manual handling and animals are usually subjected to prolonged periods of food or water deprivation to achieve sufficient...
Mon Nov 11, 2019 14:48
Publication date: Available online 10 November 2019Source: Behavioural Brain ResearchAuthor(s): Kimberly M. Christian, Guo-li Ming, Hongjun SongAbstractHypotheses about the functional properties of the dentate gyrus and adult dentate neurogenesis have been shaped by early observations of the anatomy of this region, mostly in rodents. This has led to the development of a few core propositions that have guided research over the past several years, including the predicted role of this region in pattern...
Mon Nov 11, 2019 14:48
Gerontogenes include those that modulate life expectancy in various species and may be the actual longevity genes. We believe that a long (relative to body weight) lifespan in individual rodent and primate spe...
Sat Nov 09, 2019 02:00
Journal Name: Biological ChemistryIssue: Ahead of print
Mon Nov 11, 2019 22:56
Journal Name: Biological ChemistryIssue: Ahead of print
Mon Nov 11, 2019 22:56
Journal Name: Biological ChemistryIssue: Ahead of print
Mon Nov 11, 2019 22:56
Journal Name: Biological ChemistryIssue: Ahead of print
Mon Nov 11, 2019 22:56
Journal Name: Biological ChemistryIssue: Ahead of print
Mon Nov 11, 2019 22:56
Genetic correlations between traits may cause correlated responses to selection. Previous models described the conditions under which genetic correlations are expected to be maintained. Selection, mutation and migration are all proposed to affect genetic correlations, regardless of whether the underlying genetic architecture consists of pleiotropic or tightly-linked loci affecting the traits. Here, we investigate the conditions under which pleiotropy and linkage have differential effects on the genetic...
Mon Nov 11, 2019 02:00
The origin of 'orphan' genes, species-specific sequences that lack detectable homologues, has remained mysterious since the dawn of the genomic era. There are two dominant explanations for orphan genes: complete sequence divergence from ancestral genes, such that homologues are not readily detectable; and de novo emergence from ancestral non-genic sequences, such that homologues genuinely do not exist. The relative contribution of the two processes remains unknown. Here, we harness the special circumstance...
Mon Nov 11, 2019 02:00
piRNA clusters are thought to repress transposable element activity in mammals and invertebrates. Here we show that a simple population genetics model reveals a constraint on the size of piRNA clusters: the total size of the piRNA clusters of an organism ought to exceed 0.2% of a genome. Larger piRNA clusters accounting for up to 3% of the genome may be necessary when populations are small, transposition rates are high and TE insertions recessive. If piRNA clusters are too small the load of deleterious...
Mon Nov 11, 2019 02:00
Studies of life rely on classifying organisms into species. However, since Darwin, there is no agreement about how to separate species from varieties. Contrary to a frequent belief, quantitative standards for species delineation are lacking and overdue, and debates about species delimitation create obstacles for conservation biology, agriculture, legislation, and education. To tackle this key biological question, we have chosen butterflies as model organisms. We sequenced and analyzed transcriptomes...
Mon Nov 11, 2019 02:00
The Hippo pathway is a central regulator of organ size and a key tumor suppressor via coordinating cell proliferation and death. Initially discovered in Drosophila, the Hippo pathway has been implicated as an evolutionarily conserved pathway in mammals; however, how this pathway was evolved to be functional from its origin is still largely unknown. In this study, we traced the Hippo pathway in premetazoan species, characterized the intrinsic functions of its ancestor components, and unveiled the...
Mon Nov 11, 2019 02:00
A.The concept of the evolutionary stable strategy (ESS) has been fundamental to the development of evolutionary game theory. It represents an equilibrial evolutionary state in which no rare invader can grow in population size. With additional work, the ESS concept has been formalized and united with other stability concepts such as convergent stability, neighborhood invasion stability, and mutual invisibility. Other work on evolutionary models, however, shows the possibility of unstable and/or non-equilibrial...
Mon Nov 11, 2019 02:00
In non-model organisms, evolutionary questions are frequently addressed using reduced representation sequencing techniques due to their low cost, ease of use, and because they do not require genomic resources such as a reference genome. However, evidence is accumulating that such techniques may be affected by specific biases, questioning the accuracy of obtained genotypes, and as a consequence, their usefulness in evolutionary studies. Here we introduce three strategies to estimate genotyping error...
Mon Nov 11, 2019 02:00
The first molecular model of modern human origins published in 1983 had the mtDNA phylogenetic tree rooted in Asia. This model was subsequently overlooked and superseded by the African Eve model in 1987 that was premised on the unrealistic infinite site assumption and the now failed molecular clock hypothesis. We have recently developed a new framework of molecular evolution, the maximum genetic diversity (MGD) hypothesis, which has in turn led us to discover a new model of modern human origins with...
Mon Nov 11, 2019 02:00
The number of Global Emergency Medicine (GEM) Fellowship training programs are increasing worldwide. Despite the increasing number of GEM fellowships, there is not an agreed upon approach for assessment of GEM...
Mon Nov 11, 2019 02:00
Overcrowding in emergency departments (ED) is a major concern worldwide. To answer increasing health care demands, new models of care including advanced practice physiotherapists (APP) have been implemented in...
Sun Nov 10, 2019 02:00
Despite the documented and well known patient benefits of ACP, the completion of ACP, only a minority of patients, during the advanced or EOL stage of their illnesses, receive such care. The misconceptions abo... (Source: BMC Palliative Care)
Mon Nov 11, 2019 01:00
Spiritual care is an important aspect of palliative care. In the Netherlands, general practitioners and district nurses play a leading role in palliative care in the primary care setting. When they are unable ... (Source: BMC Palliative Care)
Sat Nov 09, 2019 01:00
Patients with palliative care needs, require support with their physical needs, but also with their emotional, spiritual and social needs. Patient-Centred Care (PCC) may help organizations to support these pat... (Source: BMC Palliative Care)
Fri Nov 08, 2019 01:00
IntroductionAsthma exacerbations spike in the spring and autumn months, yet the seasonal variation of asthma symptoms and lung function is poorly studied. MethodsSeasonal variation of lung function, rescue medication use and patient-reported symptoms was evaluated by posthoc analyses of the Phase III lebrikizumab (anti-IL-13) LAVOLTA I and II studies in 2148 subjects with uncontrolled asthma. Lung function measurements (prebronchodilator FEV1, forced vital capacity (FVC) and peak expiratory flow...
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HypothesisWe hypothesise that the validated HUNT Lung Cancer Risk Model would perform better than the NLST (USA) and the NELSON (Dutch-Belgian) criteria in the Danish Lung Cancer Screening Trial (DLCST). MethodsThe DLCST measured only five out of the seven variables included in validated HUNT Lung Cancer Model. Therefore a ‘Reduced’ model was retrained in the Norwegian HUNT2-cohort using the same statistical methodology as in the original HUNT model but based only on age, pack years, smoking intensity,...
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Abstract Objectives To compare on the bench the physical and mechanical properties of Magmaris, a magnesium bioresorbable scaffold (BRS), with Absorb and DESolve polymeric BRS and a permanent metallic stent. Background Understanding the mechanical and physical properties of BRS is crucial for appropriate implantation and postdilatation. Methods Testing was performed in fluid at 37°C and in silicone bifurcation phantoms with a 30° angle between main branch (MB) and side branch. ...
Mon Nov 11, 2019 15:17
AbstractAtypical sensory reactivities are pervasive among people with autism spectrum disorder (ASD). With respect to olfaction, most previous studies have used psychophysical or questionnaire-based methodologies; thus, the neural basis of olfactory processing in ASD remains unclear. This study aimed to determine the stages of olfactory processing that are altered in ASD. Fourteen young adults with high-functioning ASD (mean age, 21 years; 3 females) were compared with 19 age-matched typically developing...
Mon Nov 11, 2019 02:00
Abstract PBC is a chronic progressive autoimmune disorder involving the destruction of intrahepatic small bile ducts, cholestasis, fibrosis, and ultimately cirrhosis if left untreated. It is largely driven by the autoimmune response, but bile acids and the intestinal microbiota are implicated in disease progression as well. The only drugs licensed for PBC are UDCA and OCA. UDCA as a first-line and OCA as a second-line therapy are safe and effective, but the lack of response in...
Mon Nov 11, 2019 02:00
Abstract Background There are no studies that have evaluated the correlation between self‐rated pain, peri‐implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)‐1β, IL‐6, and tumor necrosis factor‐alpha (TNF‐α) levels among patients with and without peri‐implantitis. Purpose The objective was to evaluate the correlation between self‐evaluated pain, peri‐implant clinical...
Mon Nov 11, 2019 11:22
Abstract Background The hypothesis is that self‐rated peri‐implant oral symptoms (OS) and clinical (plaque index [PI] and probing depth [PD]) and radiographic (crestal bone loss [CBL]) are higher in (cigarette‐smokers [CS]) and (waterpipe‐users) than (nonsmokers [NS]). The aim was to relate peri‐implant self‐perceived OS with clinico‐radiographic parameters among CS, waterpipe‐users, and NS. Materials and Methods This study was performed on self‐reported CS, waterpipe‐users, and NS with...
Mon Nov 11, 2019 11:21
Abstract Background Clinical studies on immediate implant placement for a single anterior maxillary tooth with a facial bone wall defect are rarely reported. Objective To study the clinical outcomes of immediate implant placement combined with flap surgery, guided bone regeneration and non‐submerged healing for a single anterior maxillary tooth with a facial bone wall defect. Materials and Methods Forty‐five patients with a single failing tooth in the anterior maxillary region showing...
Mon Nov 11, 2019 11:20
AbstractBackgroundCarbapenemase-producing K. pneumoniae have become a global priority, not least in low-middle income countries. Here, we report the emergence and clinical impact of a novel KPC-K. pneumoniae ST16 clone in a Clonal Complex (CC)258 endemic setting.MethodsIn a teaching Brazilian hospital, a retrospective cohort of adult KPC-KP bloodstream infections (BSI) cases (January 2014 to December 2016) was established to study the molecular epidemiology and its impact on outcome (30-day all-cause...
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Shiga toxin-producing Escherichia coliReservoirPerson-to-person spreadFood handler
Mon Nov 11, 2019 02:00
A 6-year-old girl with high-risk neuroblastoma underwent a 123I-MIBG scan to monitor the disease status. In addition to the known lesion in the right retroperitoneal region, there were additional foci of increased activity in the right upper quadrate of the abdomen, which were not typical bowel activity. SPECT/CT images located the activity in the cortex of the lower pole of the right kidney, which was partially calcified. Subsequent biopsy confirmed neuroblastoma metastasis to the right kidney,...
Wed Nov 06, 2019 02:00
Ectopic Cushing syndrome secondary to corticotropin releasing hormone (CRH)–secreting tumors or CRH and adrenocorticotropin hormone cosecreting tumors is extremely rare. We report here the case of a 54-year-old man who experienced CRH-secreting pancreatic neuroendocrine tumor causing Cushing syndrome, initially detected by SSTR (somatostatin receptor) scintigraphy, then significantly progressed with multiple liver metastases, demonstrating significantly increased SSTR expression on 68Ga-DOTATOC PET/CT...
Wed Nov 06, 2019 02:00
A 56-year-old man presented with intermittent epistaxis. Nasopharyngoscope revealed a hemorrhagic mass occupying the left nasal cavity. The patient had a history of renal clear cell carcinoma. 18F-FDG PET/CT was performed to evaluate the potential lesions systematically. PET/CT images showed low to moderate activity in the region of nasal cavity and paranasal sinuses. No abnormal uptake of 18F-FDG was observed in the rest of the body. Eventually, the mass was pathologically proved to be metastatic...
Wed Nov 06, 2019 02:00
Purpose The outcome of locally advanced adenocarcinoma of the esophagogastric junction (AEG) treated with preoperative chemoradiotherapy is heterogeneous, and favorable response to this treatment is a key factor in the patient's prognosis. The aim of this study was to evaluate 18F-FDG PET/CT in assessing metabolic response in patients with AEG. Materials and Methods This prospective study evaluated all consecutive patients with potentially operable locally advanced AEG who were candidates...
Wed Nov 06, 2019 02:00
Chorea induced by diabetic nonketotic hyperglycemia is a rare and poorly understood entity with a favorable prognosis after correction of the hyperglycemia. We present a case of elderly diabetic woman with poorly controlled blood glucose levels, presenting with choreiform movements limited to the right side. 18F-FDG PET/CT showed marked hypometabolism in the basal ganglia contralateral to the side with hemichorea. The metabolic dysfunctions lead to nonketotic hyperglycemic chorea, although poorly...
Wed Nov 06, 2019 02:00
Immunoglobulin G4–related disease (IgG4-RD) is a systemic inflammatory condition that can manifest in atypical locations. We present the case of a middle-aged woman presenting with isolated IgG4-RD of left maxilla and nasal septum, confirmed with 18F-FDG PET/CT. She achieved complete metabolic response with multiple pharmacologic treatment, but 1 year later, she experienced local relapse, and FDG PET/CT found new additional lesions in humeral vasculature and lungs. This case illustrates the usefulness...
Wed Nov 06, 2019 02:00
We report a case of an adult male patient with multifocal urinary bladder paragangliomas, which were negative on 68Ga-DOTATATE PET/CT scan, but positive on 123I-MIBG SPECT/CT scan. While the 68Ga-DOTA analog PET/CT exhibits superior performance in diagnosis and staging of pheochromocytoma and paraganglioma, our case demonstrates negative somatostatin receptor expression in this rare entity and indicates that 123I-MIBG SPECT/CT still plays a vital role in characterization of bladder paraganglioma. ...
Wed Nov 06, 2019 02:00
A 50-year-old man with recently diagnosed prostate adenocarcinoma was referred for whole-body 68Ga–prostate-specific membrane antigen (PSMA) PET/CT scan for staging. Apart from some nonspecific findings, 68Ga-PSMA PET/CT revealed large soft tissue mass in the left upper abdomen showing heterogeneous tracer uptake. Histological examination of the mass was interpreted as gastrointestinal/extragastrointestinal stromal tumor by pathologists. Prostate-specific membrane antigen is considered specific for...
Wed Nov 06, 2019 02:00
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