Abstract Rationale: Vaccines have been developed as a potential treatment for methamphetamine (meth) use disorder (MUD). Immunization with the meth vaccine IXT-v100 has previously been shown to elicit antibodies with high affinity for meth and thus may be an effective treatment for MUD. Objectives: These studies were designed to determine the efficacy of...
02:00
Special Report, Coronary CT Angiography-derived Fractional Flow Reserve Testing in Patients with Stable Coronary Artery Disease: Recommendations on Interpretation and Reporting Expert opinion and recommendation was given by an independent group of physicians on a standardized interpretation and reporting approach for CT-derived fractional flow reserve testing supported by years of clinical experience. Bjarne L. Nørgaard, Timothy A. Fairbairn...Gilbert Raff
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Το πλουσιότερο όργανο του ανθρωπίνου σώματος σε ψευδάργυρο είναι το έσω ους. Βασική αιτία της πρεσβυακοίας και των εμβοών στα ηλικιωμένα άτομα είναι τα χαμηλά και οριακά επίπεδα ψευδαργύρου στο αίμα τους, διότι με την πάροδο της ηλικίας περιορίζεται η απορροφητικότητα του ψευδαργύρου των τροφών από το έντερο. Η ανεπάρκεια ή η έλλειψη του ψευδαργύρου συμβάλουν στην επιτάχυνση της γήρανσης του ανοσοποιητικού συστήματος. Περισσότερα βλέπε στο άρθρο: Ψευδάργυρος και ανοσογήρανση©
08:54
Immunotherapy and its advances in the management of head-and-neck cancerSajad Ahmad Buch, Laxmikanth ChatraCHRISMED Journal of Health and Research 2019 6(4):199-203Head-and-neck squamous cell carcinoma (HNSCC) consists of biologically aggressive tumors of a heterogeneous group. Despite the advances made in the surgical and radiological treatment methods for HNSCC, the limitations in the control of the disease and the treatment-associated toxicity have kept the 5-year overall survival at a dismal...
Thu Nov 21, 2019 11:39
Role of Ayurveda in end-of-life careMandip GoyalAYU (An international quarterly journal of research in Ayurveda) 2019 40(1):1-2Dashavidha Parikshya Bhava (tenfold of investigation) according to Acharya Charaka – An ancient method of researchVinay Ankush PawarAYU (An international quarterly journal of research in Ayurveda) 2019 40(1):3-7Research follows a scientific way of establishing facts. All those methods which are used by the researcher during the course of studying the research problem are...
Thu Nov 21, 2019 11:39
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, PeerJ Computer ScienceTranscriptome profiling analysis reveals key genes of different coat color in sheep skinBackground To investigate the molecular mechanisms determining the coat color of native breed sheep in Xinjiang. Methods Bashibai sheep, Yemule white sheep and Tulufan black sheep were selected. Illumina HiSeq X Ten sequencing technology was used to detect...
Thu Nov 21, 2019 11:38
http://authors.nejm.org/MSImageReview/18_02841_Diaz_gomez/DiazGomez_10_29_19_reduced.mp4
Thu Nov 21, 2019 02:00
High Altitude Medicine &Biology, Ahead of Print.
08:17
The Wartberg culture (WBC, 3,500-2,800 BCE) dates to the Late Neolithic period, a time of important demographic and cultural transformations in western Europe. We perform a genome-wide analysis of 42 individuals who were interred in a WBC collective burial in Niedertiefenbach, Germany (3,300-3,200 cal. BCE). Our results highlight that the Niedertiefenbach population indeed emerged at the beginning of the WBC. This farming community was genetically heterogeneous and carried a surprisingly large hunter-gatherer...
Thu Nov 21, 2019 02:00
The firefly Photinus pyralis inhabits a wide range of latitudinal and ecological niches, with populations living from temperate to tropical habitats. Its ample geographic distribution makes this species an ideal system for the study of local adaptation and demographic inference of wild populations. Therefore, in this study we modelled and inferred different demographic scenarios for North American populations of P. pyralis, collected from Texas to New Jersey. To do this, we used a combination of...
Thu Nov 21, 2019 02:00
The kisspeptin (Kp) system is a central modulator of the hypothalamic-pituitary-gonadal axis in vertebrates. Its existence outside the vertebrate lineage remains largely unknown. Here we report the identification and characterization of Kp system in the sea cucumber Apostichopus japonicus. The gene encoding the Kp precursor, generates two mature neuropeptides, AjKiss1a and AjKiss1b. The Kp receptors, AjKissR1 and AjKissR2, are strongly activated by synthetic A. japonicus and vertebrate Kps, triggering...
Thu Nov 21, 2019 02:00
Evidence is accumulating that evolutionary changes are not only common during biological invasions but may also contribute directly to invasion success. The genomic basis of such changes is still largely unexplored. Yet, understanding the genomic response to invasion may help to predict the conditions under which invasiveness can be enhanced or suppressed. Here we characterized the genome response of the spotted wing drosophila Drosophila suzukii during the worldwide invasion of this pest insect...
Thu Nov 21, 2019 02:00
Experiments comparing native to introduced populations or distinct introduced populations to each other show that phenotypic evolution is common and often involves a suit of interacting phenotypic traits. We define such sets of traits that evolve in concert and contribute to the success of invasive populations as an "invasion syndrome". The invasive Harlequin ladybug Harmonia axyridis displays such an invasion syndrome with, for instance, females from invasive populations being larger and heavier...
Thu Nov 21, 2019 02:00
Environmental changes can cause strong cascading effects in species communities due to altered biological interactions between species (Zarnetske et al., 2012). Highly specialized interactions arising from the co-evolution of hosts and parasites, such as bacteria and phages, and short generation times of these species could rapidly lead to considerable evolutionary changes in their biotic interactions (Kerr, 2012; Buck and Ripple, 2017), with potential large-scale ramifications to other trophic levels....
Thu Nov 21, 2019 02:00
Local adaptation patterns have been found in many plants and animals, highlighting the genetic heterogeneity of species along their range of distribution. In the next decades, global warming must induce a change in the selective pressures that drive this adaptive variation, forcing a reshuffling of the underlying adaptive allele distributions. For species with low dispersion capacity and long generation time such as trees, the rapidity of the change could imped the migration of beneficial alleles...
Thu Nov 21, 2019 02:00
The uniquely enlarged noses of male proboscis monkeys (Nasalis larvatus) are prominent adornments, and a sexually selected male masculine trait, as recently revealed by the significant correlations among nose, body, and testis sizes and the clear association between nose size and the number of females in a male's harem. However, till date, the analyses of other common male traits, i.e., canines, are lacking. Whereas male nose size had a positive correlation with body size, we unexpectedly found a...
Thu Nov 21, 2019 02:00
The Drosophila obscura species group shows dramatic variation in karyotype, including transitions among sex chromosomes. Members of the affinis and pseudoobscura subgroups contain a neo-X chromosome (a fusion of the X with an autosome), and it was shown that ancestral Y genes of Drosophila have become autosomal in species that contain the neo-X. Detailed analysis in species of the pseudoobscura subgroup revealed a translocation of ancestral Y genes to the small dot chromosome of that group. Here,...
Thu Nov 21, 2019 02:00
IQ-TREE (http://www.iqtree.org) is a user-friendly and widely used software package for phylogenetic inference using maximum likelihood. Since the release of version 1 in 2014, we have continuously expanded IQ-TREE to integrate a plethora of new models of sequence evolution and efficient computational approaches of phylogenetic inference to deal with genomic data. Here, we describe notable features of IQ-TREE version 2 and highlight the key advantages over other software.
Thu Nov 21, 2019 02:00
There are many methods for establishing a phylogeny available to researchers. Some of these are based on the mutational distance between ortholog sequences of DNA, and, from these, some are based on the analysis (presence/absence) of transposable elements in specific loci of ortholog sequences. We present a new approach: a method for inferring a phylogeny based on the mutational distance of transposable elements distributed along any segment of DNA. Our method doesnt require previously having ortholog...
Thu Nov 21, 2019 02:00
Tissue Engineering Part A, Ahead of Print.
06:07
Management of penetrating abdominal war injuries centers upon triage, echeloned care, and damage control. A civilian hospital based in a war zone can rarely rely upon these principles because it normally has l...
Thu Nov 21, 2019 02:00
Antibiotics are the pillar of surgery from prophylaxis to treatment; any failure is potentially a leading cause for increased morbidity and mortality. Robust data on the burden of SSI especially those due to a...
Thu Nov 21, 2019 02:00
Hemorrhagic shock can lead to intestinal damage with subsequent hyperinflammation and multiple organ dysfunction syndrome (MODS). The intestinal fatty acid-binding protein (I-FABP) is solely expressed in the i...
Thu Nov 21, 2019 02:00
Both epidemiological and experimental studies have demonstrated the crucial connection between air pollution exposure and skin disorders. The exact mechanisms by which air pollutants mediate skin damage remain largely unknown. Therefore, it is very necessary to investigate the mechanism of air pollution‐induced skin damage and explore some potential protective and therapeutic methods. In this review, we focus on the qualitative and quantitative skin exposure assessment methodologies ‐ a relatively...
Thu Nov 21, 2019 17:20
Abstract Combination therapy in the treatment of metastatic melanoma has been associated with more durable response rate compared to monotherapy. However, previous studies have shown that combined target therapy commonly causes a wide spectrum of adverse events. These adverse reactions are usually manageable, however, it is always necessary to compare drug efficacy with its potential adverse effects. Toxic epidermal necrolysis represents severe mucocutaneous reaction, usually triggered by medications...
Thu Nov 21, 2019 17:18
Background: Linear IgA dermatosis (LAD) is a rare autoimmune disorder in children. Case characteristics: A nine‐year‐old boy with blisters on the intact skin (face, body, arms, hands, soles, perigenital and perianal area) after amoxicillin treatment. Outcome: Systemic corticosteroids and dapson treatment for six weeks were successful. Message: Clinical and immunofluorescence examinations are the most important for differentiation of LAD and other drug induced bullous dermatoses. They enable an early...
Thu Nov 21, 2019 16:58
Rat lungworm is a parasitic disease, spread through contaminated food, which affects the brain and spinal cord. Now, researchers report that a detail analysis of the genetics of the rat lungworm parasite -- Angiostrongylus cantonensis -- reveal signatures of adaptive evolution that have let the parasite survive and may serve as future drug targets.
Thu Nov 21, 2019 21:14
The threespine stickleback, a small fish found throughout the coastal areas of the Northern Hemisphere, is famously variable in appearance from one location to another, making it an ideal subject for studying how species adapt to different environments. A new study shows that stickleback populations in estuaries along the coast of California have evolved over the past 40 years as climate change has altered their coastal habitats.
Thu Nov 21, 2019 16:50
Despite efforts over multiple decades, there are still no cell lines for marine invertebrates. For the first time, scientists have developed a breakthrough in marine invertebrate (sponge) cell culture, demonstrating exceptionally fast cell division and the ability to subculture the cells. This groundbreaking discovery forms the basis for developing marine invertebrate cell models to better understand early animal evolution, determine the role of secondary metabolites, predict the impact of climate...
Thu Nov 21, 2019 14:54
Dispersal is essential for terrestrial organisms living in disjunct habitats and constitutes a significant challenge for the evolution of wingless taxa. Springtails (Collembola), the sister-group of all insect...
Thu Nov 21, 2019 02:00
Following publication of the original article [1], we have been notified that Additional file 3 was published with track changes.
Wed Nov 20, 2019 02:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11658
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11915
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09219
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b02501
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09811
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09301
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09146
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08169
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10005
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10147
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11407
Thu Nov 21, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09340
Wed Nov 20, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09576
Wed Nov 20, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09885
Wed Nov 20, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10952
Wed Nov 20, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08988
Wed Nov 20, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10905
Wed Nov 20, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09945
Wed Nov 20, 2019 07:00
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