Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN02107H, PaperAnni Wang, Xuewei Li, Yong Ju, Dong-ying Chen, Jianzhong LuD-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. Herein, the iodination of D-luciferin was excised...The content of this RSS Feed (c) The Royal Society of Chemistry
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Publication date: Available online 6 November 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Kun Huang, Zhiqun Bai, Donglin Bian, Puxu Yang, Xiangyi Li, Yanjun LiuAbstractWe explored the diagnostic accuracy of ultrasonography (US) in papillary thyroid microcarcinoma (PTMC), studying nodular growths according to size via 3-D color Doppler US (3-DCDUS) and contrast-enhanced US (CEUS). A total of 109 patients undergoing CEUS and surgery of thyroid nodules at the First Hospital of China Medical...
Wed Nov 06, 2019 15:08
Publication date: Available online 6 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Areej A. Alfaifi, Wei-Shao Lin, Bader A. Aldhaian, John A. Levon, Richard L. GregoryAbstractStatement of problemCandida albicans has been implicated in denture stomatitis, and this effect is exacerbated by nicotine exposure. However, studies have also suggested that caffeine exposure inhibits the growth of C. albicans. The interaction effects of nicotine and caffeine are not yet clear on the growth...
Wed Nov 06, 2019 14:59
Publication date: Available online 6 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Fabíola Jardim Barbon, Rafael R. Moraes, Cristina Pereira Isolan, Aloísio Oro Spazzin, Noéli BoscatoAbstractStatement of problemThe inorganic filler of resin-based luting agents and the use of an adhesive layer could influence the bonding ability, mechanical performance, and interface morphology of bonded feldspathic ceramic.PurposeThe purpose of this in vitro study was to investigate the influence...
Wed Nov 06, 2019 14:59
Publication date: Available online 6 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): David Fraser, Paul Funkenbusch, Carlo Ercoli, Luiz MeirellesAbstractStatement of problemAlthough implants containing porous tantalum undergo osseointegration, whether this material significantly alters new bone formation and improves implant stability during healing in comparison to titanium is unclear.PurposeThe purpose of this in vivo study was to determine the influence of the inclusion of porous...
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Nadine Anika Hansen, Sebastian Wille, Matthias KernAbstractStatement of problemThe optimal conditioning of zirconia is essential for a durable bond between zirconia copings and titanium inserts in 2-piece dental implant abutments. Low-pressure activation of the zirconia surface may be adequate for retention.PurposeThe purpose of this in vitro study was to evaluate the influence of airborne particle...
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Faisal D. al-Qarni, Charles J. Goodacre, Mathew T. Kattadiyil, Nadim Z. Baba, Rade D. ParavinaAbstractStatement of problemThe effect of staining beverages on the color of dentures made with computer-aided design and computer-aided manufacturing (CAD-CAM) is unknown.PurposeThe purpose of this in vitro study was to evaluate the stainability of acrylic resins used in CAD-CAM–fabricated complete dentures...
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Rubén Agustín-Panadero, Sergio Soriano-Valero, Carlos Labaig-Rueda, Lucía Fernández-Estevan, Ma Fernanda Solá-RuízAbstractStatement of problemBecause of market demand for innovation, new restoration materials have been introduced without adequate testing; clinical failure may be the consequence, and clinical studies are needed.PurposeThe purpose of this clinical study was to evaluate the biological...
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Esra Incesu, Nuran YanikogluAbstractStatement of problemHow the finishing and polishing of ceramic restorations may affect their surface properties is unclear.PurposeThe purpose of this in vitro study was to evaluate the effect of different polishing systems on the surface roughness of dental ceramics by using a profilometer, an environmental scanning electron microscope (ESEM), and an atomic force...
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Li Chen, Zhen Yang, Xiaoqiang Liu, Wei-Shao Lin, Jianguo TanAbstractThe socket-shield technique can be challenging and time-consuming. This article presents a digital approach to fabricating a computer-aided design and computer-aided manufacturing (CAD-CAM) titanium preparation template for the socket-shield technique. Preoperative cone beam computed tomography (CBCT) was used to map the remaining...
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Maria Bousnaki, Maria Chatziparaskeva, Athina Bakopoulou, Argiris Pissiotis, Petros KoidisAbstractStatement of problemDifferent parameters affect the marginal and internal fit of zirconia fixed partial dentures (FPDs) on natural teeth. Determining a way to optimize these restorations is essential.PurposeThe purpose of this systematic review was to determine the variables affecting the marginal...
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s):
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Byrasandra Channappa Muddugangadhar, Dipal P. Mawani, Arindam Das, Arindam MukhopadhyayAbstractStatement of problemOccasional debonding between soft liners and denture base resin is common and limits the longevity of a relined prosthesis.PurposeThe purpose of this systematic review was to compare the bond strength of commercially available soft liners with that of polymethyl methacrylate (PMMA)...
Wed Nov 06, 2019 14:59
Publication date: Available online 5 November 2019Source: The Journal of Prosthetic DentistryAuthor(s): Taiseer A. Sulaiman, Aous A. Abdulmajeed, Alex Delgado, Terence E. DonovanAbstractStatement of problemThe use of ceramic materials has increased significantly because of high esthetic demands, low costs, and ease of fabrication. Long-term, clinically based evidence is scarce, and laboratory studies have limited relevance in determining clinical durability.PurposeThe purpose of this dental laboratory...
Wed Nov 06, 2019 14:59
Abstract Cortical injury, such as injuries after stroke or age-related ischemic events, triggers a cascade of degeneration accompanied by inflammatory responses that mediate neurological deficits. Therapeutics that modulate such neuroinflammatory responses in the aging brain have the potential to reduce neurological dysfunction and promote recovery. Extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) are lipid-bound, nanoscale vesicles that can modulate inflammation...
Wed Nov 06, 2019 02:00
Abstract There is a critical need for quality oncology education in Canadian baccalaureate nursing programs considering the vast amount of cancer diagnoses and deaths in the Canadian population, as well as the likelihood that all nurses will care for oncology patients in various settings. The incidence and mortality of cancer within the Canadian population impact the need to incorporate an all-inclusive view of cancer care into baccalaureate nursing curriculums and develop nurse...
Wed Nov 06, 2019 02:00
Abstract The establishment of baseline data on parasites from wild primates is essential to understand how changes in habitat or climatic disturbances will impact parasite–host relationships. In nature, multiparasitic infections of primates usually fluctuate temporally and seasonally, implying that the acquisition of reliable data must occur over time. Individual parasite infection data from two wild populations of New World primates, the saddleback (Leontocebus weddelli) and emperor (Saguinus...
Wed Nov 06, 2019 14:18
Publication date: Available online 6 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Trevor ST Thang, Anil Kishen, Massieh Moayedi, Pascal N Tyrrell, Wenda Zhao, Susanne PerschbacherObjectiveTo evaluate how physical photostimulable phosphor (PSP) plate artifacts, such as those created by scratches, phosphor degradation, and surface peeling, affect the radiologic interpretation of periapical inflammatory disease.MethodsA novel technique was developed to...
Wed Nov 06, 2019 14:20
Publication date: Available online 5 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Namiaki Takahara, Atsushi Kimura, Nobuyoshi Tomomatsu, Koichi Nakakuki, Tetsuya YodaObjectiveTo investigate postoperative horizontal relapse of the mandible in terms of the effects of the magnitude of mandibular setback movement and ramus inclination after Le Fort I osteotomy and sagittal split ramus osteotomy.Study DesignA retrospective study of patients who underwent...
Wed Nov 06, 2019 14:20
Publication date: Available online 5 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Hongshi Cai, Yue Zhu, Cheng Wang, Yadong Zhang, Jinsong HouABSTRACTObjectiveThe clinical management of the neck of patients with oral squamous cell carcinoma (OSCC) who are at T1-2 and clinically node-negative neck (cN0) continues to be controversial. We systematically reviewed the literature to assess the outcomes of elective neck dissection (END) and neck observation...
Wed Nov 06, 2019 14:20
Publication date: Available online 5 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Dr. Vishal Bansal, Dr Apoorva Mowar, Dr. Prajesh Dubey, Dr. Saloni GuptaAbstractObjectiveThis study entails application of cryosurgery with certain modifications as a treatment modality for patients diagnosed with trigeminal neuralgia refractory to pharmacological treatments.Study Design49 patients diagnosed with trigeminal neuralgia were treated with cryosurgery which...
Wed Nov 06, 2019 14:20
Cancers, Vol. 11, Pages 1741: Cell-Free DNA Methylation Profiling Analysis—Technologies and Bioinformatics Cancers doi: 10.3390/cancers11111741 Authors: Huang Wang Analysis of circulating nucleic acids in bodily fluids, referred to as “liquid biopsies”, is rapidly gaining prominence. Studies have shown that cell-free DNA (cfDNA) has great potential in characterizing tumor status and heterogeneity, as well as the response to therapy and tumor recurrence. DNA methylation...
Wed Nov 06, 2019 02:00
Cancers, Vol. 11, Pages 1742: Streptomyces sp. MUM256: A Source for Apoptosis Inducing and Cell Cycle-Arresting Bioactive Compounds against Colon Cancer Cells Cancers doi: 10.3390/cancers11111742 Authors: Tan Chan Chan Pusparajah Khan Ser Lee Goh New and effective anticancer compounds are much needed as the incidence of cancer continues to rise. Microorganisms from a variety of environments are promising sources of new drugs; Streptomyces sp. MUM256, which...
Wed Nov 06, 2019 02:00
Cancers, Vol. 11, Pages 1740: Phosphodiesterase 5 (PDE5) Is Highly Expressed in Cancer-Associated Fibroblasts and Enhances Breast Tumor Progression Cancers doi: 10.3390/cancers11111740 Authors: Catalano Panza Augimeri Giordano Malivindi Gelsomino Marsico Giordano Győrffy Bonofiglio Andò Barone The overexpression of phosphodiesterase (PDE) 5 is frequently found in various human cancers, such as those of the breast. However, PDE5’s...
Wed Nov 06, 2019 02:00
Cancers, Vol. 11, Pages 1738: The Role and Function of microRNA in the Pathogenesis of Multiple Myeloma Cancers doi: 10.3390/cancers11111738 Authors: Hiroshi Handa Yuki Murakami Rei Ishihara Kei Kimura-Masuda Yuta Masuda Recently, attention has been drawn to the role of non-coding regions of the genome in cancer pathogenesis. MicroRNAs (miRNAs) are small non-coding RNAs with 19–25 bases of length that control gene expression by destroying messenger RNA or inhibiting...
Wed Nov 06, 2019 02:00
Cancers, Vol. 11, Pages 1739: Synergistic Antitumorigenic Activity of Calcitriol with Curcumin or Resveratrol is Mediated by Angiogenesis Inhibition in Triple Negative Breast Cancer Xenografts Cancers doi: 10.3390/cancers11111739 Authors: Janice García-Quiroz Rocío García-Becerra Clara Santos-Cuevas Gerardo J. Ramírez-Nava Gabriela Morales-Guadarrama Nohemí Cárdenas-Ochoa Mariana Segovia-Mendoza Heriberto Prado-Garcia David Ordaz-Rosado Euclides Avila Andrea Olmos-Ortiz...
Wed Nov 06, 2019 02:00
Cancers, Vol. 11, Pages 1737: Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy Cancers doi: 10.3390/cancers11111737 Authors: Samson Mathews Samuel Noothan Jyothi Satheesh Suparna Ghosh Dietrich Büsselberg Yasser Majeed Hong Ding Chris R. Triggle Metformin, the most widely used anti-diabetic drug, also exhibits anti-cancer properties; however, the...
Wed Nov 06, 2019 02:00
Publication date: Available online 6 November 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): Lieselotte De Bruyn, Myrthel Vranckx, Reinhilde Jacobs, Constantinus PolitisAbstractThe primary goal of this study was to identify and quantify indications for retaining third molars. This retrospective cohort study included 1682 patients (818 male, 864 female; mean age 31 years) who were referred to the University Hospitals Leuven for third molar removal. Eight reasons for...
Wed Nov 06, 2019 14:18
Abstract Computational fluid dynamics models are increasingly proposed for assisting the diagnosis and management of vascular diseases. Ideally, patient‐specific flow mea‐ surements are used to impose flow boundary conditions. When patient‐specific flow measurements are unavailable, mean values of flow measurements across small cohorts are used as normative values. In reality, both the between‐subjects and within‐subject flow variabilities are large. Consequently, neither one‐shot flow measurements...
Tue Nov 05, 2019 20:34
Abstract Despite the high success rate achieved in current dental implantation, there are still important problems to solve like incomplete early osteointegration, bone damage and long‐term implant loosening. Highly compliant stress absorbers are a possible solution to these problems. Although several works examined the stress‐strain distribution in bone without and with absorbers to show their favorable results, none of them analyzed their impact on long‐term remodeling. Here, we analyze this...
Tue Nov 05, 2019 20:29
Abstract Pre‐ and post‐operative hepatic perfusion is modelled with one‐dimensional (1D) Navier‐Stokes equations. Flow rates obtained from ultrasound (US) data and impedance resulted from structured trees are the inflow and outflow bound‐ ary condition (BC), respectively. Structured trees terminate at the size of the arterioles, which can enlarge their size after hepatectomy. In clinical studies, the resistance to pul‐ satile arterial flow caused by the microvascular bed can be reflected by the...
Tue Nov 05, 2019 20:29
Nature Communications, Published online: 06 November 2019; doi:10.1038/s41467-019-13108-2Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitulate the key processes for antibody persistence in circulation.
Wed Nov 06, 2019 02:00
Nature Communications, Published online: 06 November 2019; doi:10.1038/s41467-019-13051-2While water splitting electrocatalysis provides a means to store electrical energy as fuel, the water oxidation catalysts typically show low performances. Here, authors employ metal-organic frameworks with missing-linkers as highly active oxygen evolution electrocatalysts.
Wed Nov 06, 2019 02:00
Nature Communications, Published online: 06 November 2019; doi:10.1038/s41467-019-12909-9Tyrosyl-tRNA synthetase (TyrRS) is a translation factor and predominantly cytoplasmic, but can also be found in the nucleus. Here authors show using a fly model of Charcot-Marie-Tooth (CMT) disease that nuclear localization of mutant TyrRS contributes to the CMT-like phenotype.
Wed Nov 06, 2019 02:00
Nature Communications, Published online: 06 November 2019; doi:10.1038/s41467-019-12923-xThe N6-methyladenosine (m6A) RNA modification is an evolutionarily conserved epitranscriptomic mechanism that impacts several cellular processes. Here the authors present a structure-function analysis of the ZCCHC4, 28S RNA-specific m6A methyltransferase, shedding light on its regulation and mechanisms that ensure substrate specificity.
Wed Nov 06, 2019 02:00
Nature Communications, Published online: 06 November 2019; doi:10.1038/s41467-019-13049-wUnderstanding the relationship between biodiversity and infectious disease is important for predicting the effects of biodiversity loss. Here, the authors analyze 205 published biodiversity–disease relationships and show that these tend to be nonlinear and might depend on spatial scale.
Wed Nov 06, 2019 02:00
Nature Communications, Published online: 06 November 2019; doi:10.1038/s41467-019-12999-5Polysaccharide molecules chitooligosaccharides (COs) and peptidoglycan not only activate plant immunity but also trigger plant symbiosis signalling. Here the authors show that a combination of COs and lipochitooligosaccharides (LCOs) act synergistically to suppress immunity and promote symbiosis to facilitate beneficial fungal associations.
Wed Nov 06, 2019 02:00
Nature Communications, Published online: 06 November 2019; doi:10.1038/s41467-019-13131-3The optical properties of certain metals can be reversibly switched by hydrogen loading but challenges remain to achieve electrical and reversible control. Here, the authors report a nanoscale proton switch that allows for electrical control of optical properties through electrochemical hydrogen gating.
Wed Nov 06, 2019 02:00
Nature Communications, Published online: 06 November 2019; doi:10.1038/s41467-019-12346-8Chiral inversion of amino acids is thought to modulate the structure and function of amyloid beta (Aβ) but these processes are poorly understood. Here, the authors develop an ion mobility-mass spectrometry based approach to study chirality-regulated structural features of Aβ fragments and their influence on receptor recognition.
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Publication date: Available online 5 November 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Mohamad Bydon, Mohammed Ali Alvi, Panagiotis Kerezoudis, Joseph A. Hyder, Elizabeth B. Habermann, Samuel Hohmann, Alfredo Quinones-Hinojosa, Frederic B. Meyer, Robert J. SpinnerAbstractObjectiveOverlapping surgery, accepted by many as two distinct operations occurring at the same time but without coincident critical portions, has been said to improve patient access to surgical care. With recent...
Wed Nov 06, 2019 13:51
Publication date: Available online 5 November 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Graciela Ordoñez, Verónica Rivas, Marcos Santos, Montserrat Mondragon, Benjamín Pineda, Karla Rodríguez, Teresa Corona, José Flores, Julio SoteloAbstractObjectiveOptic Neuritis (ON) might unfold either as a single intracranial neuritis or as multiple sclerosis, a widespread demyelinating disorder. Different herpes viruses have been proposed as potential participants in the etiology of multiple...
Wed Nov 06, 2019 13:51
Publication date: Available online 6 November 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Peter D. Arkwright, M. Zulf Mughal
Wed Nov 06, 2019 13:45
Publication date: Available online 6 November 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Karen A. Robbins, Robert A. Wood, Corinne A. Keet
Wed Nov 06, 2019 13:45
Publication date: Available online 6 November 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Thomas Greuter, Ikuo Hirano, Evan S. DellonAbstractDespite advances in the pathological understanding of eosinophilic esophagitis (EoE), as of yet no single agent has been approved by the Food and Drug Agency to treat EoE. Off-label, EoE is currently treated by the three D’s, which are drugs (particularly swallowed topical corticosteroids), dietary restriction and endoscopic dilation. In...
Wed Nov 06, 2019 13:45
Publication date: Available online 6 November 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Joanne E. Sordillo, Brent A. Coull, Sheryl L. Rifas-Shiman, Ann Chen Wu, Sharon M. Lutz, Marie-France Hivert, Emily Oken, Diane R. Gold
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s): Marc E. Rothenberg, Jean Bousquet
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s): Zuhair K. Ballas, Associate Editors of the JACI
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s): Grégory Seumois, Pandurangan VijayanandSingle-cell next-generation sequencing assays are powerful tools to understand the nature of the immune cells that drive disease pathogenesis. In this brief review we explain the value of performing assays at single-cell resolution to better understand the pathogenesis of allergy, asthma, and other lung diseases. We explain the challenges in performing...
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s): Ting Wen, Marc E. RothenbergTechnical advances in single-cell RNA sequencing (scRNA-seq) render it possible to examine the transcriptomes of single cells in patients with allergic inflammation with high resolution in the context of their specific microenvironment, treatment, and disease status. Using a recently published scRNA-seq study of tissue T cells as an example, we introduce the...
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
Publication date: November 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 5Author(s):
Wed Nov 06, 2019 13:45
The plasma pancreatic polypeptide response to modified sham feeding, which assesses vagal integrity, is impaired in up to 30% of healthy controls, more likely to be associated with cardiovagal dysfunctions in T1DM than in T2DM, and more useful when it is normal than abnormal. Abstract Background Nutrient‐mediated release of cholecystokinin and glucagon‐like peptide‐1 (GLP‐1) regulates gastric emptying (GE) via duodenogastric feedback mechanisms; GLP‐1 also regulates postprandial insulin secretion....
Tue Nov 05, 2019 17:20
Publication date: Available online 5 November 2019Source: European Journal of Surgical OncologyAuthor(s): Khadra Bashir Mohamed, Christine Haangard Hansen, Peter-Martin Krarup, Tina Fransgård, Michael Tvilling Madsen, Ismail GögenurAbstractBackground/ObjectiveAnastomotic leakage (AL) is one of the most severe complications following colorectal cancer surgery and is associated with increased short and long term mortality. The literature is conflicting regarding increased risk of recurrence after AL....
Wed Nov 06, 2019 13:40
Publication date: Available online 6 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Lennart Ocker, Anna Adamus, Laura Hempfling, Benedikt Wagner, Reza Vahdad, Frederik A. Verburg, Markus Luster, Tino Schurrat, Dirk Bier, Marcus Frank, Jan Lisec, Nadja Engel, Guido SeitzAbstractBackgroundAlveolar rhabdomyosarcoma (RMA) is a highly malignant soft tissue tumor in children with poor prognosis and failure of established therapies in advanced stages. Therefore, novel treatment options...
Wed Nov 06, 2019 13:35
Publication date: Available online 5 November 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Zhijia Li, Yajie Wang, Jingying Wang, Songshan Li, Zixuan Xiao, Yingjun Feng, Jingjing Gu, Junpeng Li, Xiaoming Peng, Changxing Li, Kang ZengAbstractBackgroundThis study aimed to evaluate the effects of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) on the improvement of symptoms and recurrence rate in patients with vulvar lichen sclerosus (VLS) and observe its side effects.MethodsThe...
Wed Nov 06, 2019 13:35
Abstract Background Post-haemorrhagic ventricular dilatation can be measured accurately by MRI. However, two-dimensional (2-D) cranial US can be used at the bedside on a daily basis. Objective To assess whether the ventricular volume can be determined accurately using US. Materials and methods ...
Wed Nov 06, 2019 02:00
Publication date: Available online 5 November 2019Source: Journal of Communication DisordersAuthor(s): Alan G. Kamhi
Wed Nov 06, 2019 12:57
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Dirk Schadendorf, Anna Maria Di Giacomo, Lev Demidov, Barbara Merelli, Igor Bondarenko, Paolo A. Ascierto, Christopher Herbert, Andrzej Mackiewicz, Piotr Rutkowski, Alexander Guminski, Grant R. Goodman, Brian Simmons, Chenglin Ye, Agnes Hong, Karl Lewis, the BRIM8 InvestigatorsAbstractAim of studyThe aim of the study was to assess the impact of treatment with adjuvant vemurafenib monotherapy on health-related...
Wed Nov 06, 2019 12:51
Afforestation is a key approach used to effectively prevent ecosystem degradation, which in itself is a key reason for the obstruction of sustainable societal development. In order to suppress sand and dust storms as a result of ecological environmental degradation in North China, the Government of China has sanctioned the planting of a large number of trees in Inner Mongolia. However, water resources in the Inner Mongolian Plateau are insufficient to sustain this effort because such a large number...
Wed Nov 06, 2019 02:00
Background Spatial genetic structure (SGS) analysis is a powerful approach to quantifying gene flow between trees, thus clarifying the functional connectivity of trees at population and landscape scales. The findings of SGS analysis may be useful for conservation and management of natural populations and plantations. Pinus cembroides is a widely distributed tree species, covering an area of about 2.5 million hectares in Mexico. The aim of this study was to examine five natural seed...
Wed Nov 06, 2019 02:00
Background Vasoactive drugs are frequently used in combination with endoscopic variceal ligation (EVL) in treatment of acute esophageal variceal bleeding (EVB). The aim of study was to assess physicians’ preference of vasoactive agents in acute EVB, their reasons of preference and efficacy and safety of these short course regimens. Methods Cirrhotic patients with suspected EVB were screened (n = 352). Eligible patients...
Wed Nov 06, 2019 02:00
A fundamental question in ecology is how the success of a taxon changes through time and what drives this change. This question is commonly approached using trajectories averaged over a group of taxa. Using results from probability theory, we show analytically and using examples that averaged trajectories will be more symmetric as the number of averaged trajectories increases, even if none of the original trajectories they were derived from is symmetric. This effect is not only based on averaging,...
Wed Nov 06, 2019 02:00
The sauropterygian clade Plesiosauria arose in the Late Triassic and survived to the very end of the Cretaceous. Plesiosauria evolved the greatest species diversity of any marine reptile clade, attaining a global distribution. Plesiosauria consist of two clades, Rhomaleosauridae and Neoplesiosauria. Basal Neoplesiosauria have long necks with at least 30 cervicals, but show qualitative osteological evidence for a stiff neck. Here we quantify neck mobility in lateral, ventral, and dorsal directions...
Wed Nov 06, 2019 02:00
Abstract Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Next to smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, yet there is no disease modifying treatment. The biggest drawback of today's COPD treatment regime is the ‘one size fits all' pharmacological intervention, mainly...
Tue Nov 05, 2019 21:42
Abstract Rationale Understanding the neurobiological mechanisms mediating dominance and competitive aggression is essential to understanding the development and treatment of various psychiatric disorders. Previous research suggests that these mechanisms are both sexually differentiated and influenced substantially by social experience. In numerous species, GABAA receptors in the lateral septum have been shown to play a significant role...
Wed Nov 06, 2019 02:00
Stimulating the clitoris activates the brain to instigate changes in the female genital tract, namely, the enhancement of vaginal blood flow that increases vaginal luminal pO2, vaginal transudate (lubrication) facilitating painless penile penetration and partial neutralization of the basal luminal acidic pH, vaginal tenting, and ballooning delaying sperm transport and allowing semen de‐coagulation and capacitation (sperm activation) factors to act until arousal ends (often by orgasm induction). All...
Tue Nov 05, 2019 19:03
Introduction Greater trochanteric pain syndrome (GTPS) is prevalent in women and severely impacts quality of life. A key muscle group demonstrating reduced strength are the hip abductors. An understanding of specific muscles affected will help guide targeted rehabilitation. Objectives of this case‐control study were to compare gluteal and tensor fasciae latae (TFL) muscle size and quality (fatty infiltration) in women with symptomatic GTPS to asymptomatic age‐matched female controls. Materials...
Tue Nov 05, 2019 18:04
Introduction The aim of this anatomical study was to investigate the genial spinal canal histologically and to reconstruct it three‐dimensionally to improve understanding of its anatomy and to reveal any differences between dentate and edentulous specimens. Materials and Methods Two tissue blocks from the mandible between the left and right second incisors, one dentate and one edentulous, were fixed in 4.5% formaldehyde, decalcified and embedded in paraffin. Serial histological sections were...
Tue Nov 05, 2019 18:03
INTRODUCTION Hepatic arterial variations are relatively common, but usually overlooked by radiologists, leading to iatrogenic complications or prolonging interventional or surgical procedures. Michels in 1966 classified hepatic arterial variations in ten categories, based on a cadaveric study. Establishment of MDCT provides useful anatomical information. The purpose of our study is to highlight these variations and to propose of a user‐friendly algorithm when studying a CT examination. MATERIALS...
Tue Nov 05, 2019 18:03
Introduction Glabellar augmentation is one of the most popular cosmetic procedures but can entail severe complications caused by inadvertent intravascular injection of filler. Nevertheless, few studies have investigated the arteries on the glabellar and central forehead regions. The aim of this study was to correlate the topography and location of the arteries in this area with anatomical landmarks to propose a safety guideline. Materials and Methods Two methods were used to investigate the...
Tue Nov 05, 2019 18:02
INTRODUCTION Identification of cadaveric structures during anatomy summative practical examinations is a challenge for first‐year medical students. To assist in cultivating this skill, we offered 12 formative laboratory activities (anatomy boot camps = ABCs) that approximated the summative practical examination format using reciprocal and near‐peer teaching. METHODS Students assisted in crafting the formative practical examination, then engaged in a self‐review by scoring their individual...
Tue Nov 05, 2019 18:02
Morphological and functional characteristics of aging kidneys based on two‐photon microscopy in vivo
Abstract Age‐related kidney disease, which is chronic and naturally occurring, is a general term for a set of heterogeneous disorders affecting kidney structures and characterized by a decline in renal function. Age‐related renal insufficiency has important implications with regard to body homeostasis, drug toxicity, and renal transplantation. In our study, two‐photon microscopy (TPM) was employed to image kidney morphological and functional characteristics in an age‐related rat model in vivo. The...
Tue Nov 05, 2019 18:22
Tue Nov 05, 2019 18:36
AbstractBezoars, and to lesser extent phytobezoars, are among the rare causes of small bowel obstruction. A bezoar generally describes retained concretions of indigestible foreign material that accumulate and conglomerate in the gastrointestinal tract, most commonly in the stomach. We present an unusual case of phytobezoar-induced sub-acute small bowel obstruction originating from unfamiliar plant material in a 74-year-old woman. The past history was insignificant regarding comorbidities other than...
Wed Nov 06, 2019 02:00
AbstractThis case report documents the medical progression of a 56-year-old man who presented with a small bowel obstruction and was found to have acute fulminant necrotizing mesenteric lymphadenitis causing small intestinal ischemia. A large portion of the proximal jejunal mesentery was necrotic with vascular thrombosis leading to small bowel ischemia and obstruction. He was successfully managed surgically and survived. The evaluation and possible aetiologies are discussed.
Wed Nov 06, 2019 02:00
AbstractArterial leiomyosarcoma (A-LMS) is a very rare tumour and no cases originating from the superior mesenteric artery (SMA) have been described. We present a case of A-LMS originating from distal part of SMA and incorporating superior mesenteric vein (SMV). SMA and SMV were prepared along their course by laparotomy. Prior to resection, the superior mesenteric vessels were clamped, and intra-operative infrared angiography after intravenous injection of indocyanine green was performed. Once confirmed...
Wed Nov 06, 2019 02:00
AbstractA thyroglossal duct cyst (TGDC) is a common pediatric midline neck mass. Most TGDCs occur in the region of the hyoid bone but have been found less commonly in areas from the oral cavity to the sternum. We present the first reported case of a multifocal floor of mouth (FOM)/cervical TGDC representing an atypical embryonic course. We also review atypical presentations of TGDC and provide a summary of cases involving FOM and multifocal cysts.
Wed Nov 06, 2019 02:00
AbstractFemoral hernias account for ~4% of all groin hernias but are much more common in females, especially those over the age of 70. Risk of incarceration is overall low but can include structures such as bowel, omentum, bladder, ovary and very rarely, the appendix. The subset of femoral hernias containing the vermiform appendix is known as de Garengeot hernias. We describe a rare case of an 87-year-old female patient who presented with an incarcerated right femoral hernia confirmed on contrast-enhanced...
Wed Nov 06, 2019 02:00
AbstractChronic constrictive pericarditis (CCP) is the most common pericardial pathology. CCP complicating with intracardiac thrombus is a rare entity, the detection of thrombus preoperatively is life-saving in avoiding the risk of pulmonary thromboembolism during anterior pericardiectomy. Transesophageal echocardiography has been shown to have better sensitivity in detecting atrial thrombus than transthoracic echocardiography. Surgical removal of right atrial thrombus under cardiopulmonary bypass...
Wed Nov 06, 2019 02:00
AbstractLumbar spine fusion has become a common and effective procedure in orthopedic practice, and a spinal subdural hygroma development is a rare complication following this procedure. We report here the case of a revision lumbar spine fusion at levels L4-5, L5-S1, where the patient subsequently developed cauda equina syndrome 2 days post-operatively. Magnetic resonance imaging (MRI) showed a subdural, extra-arachnoid fluid collection from T12-L2, cephalad to the site of spine fusion. It appears...
Wed Nov 06, 2019 02:00
Sensorineural hearing loss is mainly acquired and affects an estimated 1.3 billion humans worldwide. It is related to aging, noise, infection, ototoxic drugs, and genetic defects. It is essential to identify reversible and preventable causes to be able to reduce the burden of this disease. Inflammation is involved in most causes and leads to tissue injury through vasospasm-associated ischemia. Vasospasm is reversible. This review summarized evidence linking inflammation-induced vasospasm to several...
Wed Nov 06, 2019 09:05
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