Τετάρτη 6 Νοεμβρίου 2019


ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients
To determine the biological correlation between apparent diffusion coefficient (ADC) values and Sirtuin1 (SIRT1) levels of tumour tissues in patients with esophageal carcinoma (EC), and to ascertain the treatm...
Radiation Oncology - Latest Articles
Mon Nov 04, 2019 02:00
Benchmarking techniques for stereotactic body radiotherapy for early-stage glottic laryngeal cancer: LINAC-based non-coplanar VMAT vs. Cyberknife planning
Stereotactic body radiation therapy (SBRT) was found effective in treating laryngeal cancer with only five treatment fractions by a recent clinical trial (NCT01984502, ClinicalTrials.gov). Nevertheless, this t...
Radiation Oncology - Latest Articles
Mon Nov 04, 2019 02:00
Letter to the editor: Wasted research time and its impact on training in plastic surgery
Publication date: Available online 6 November 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Daisy Ryan, James K-K. Chan, Fadi Issa, Jeremy N. Rodrigues
British Association of Plastic Surgeons
Wed Nov 06, 2019 18:49
Response to: Letter to the editor: Wasted research time and its impact on training in Plastic Surgery
Publication date: Available online 6 November 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): S. Sepehripour, B.S. Dheansa
British Association of Plastic Surgeons
Wed Nov 06, 2019 18:49
Warfare in an evolutionary perspective
Abstract The importance of warfare for human evolution is hotly debated in anthropology. Some authors hypothesize that warfare emerged at least 200,000–100,000 years BP, was frequent, and significantly shaped human social evolution. Other authors claim that warfare is a recent phenomenon, linked to the emergence of agriculture, and mostly explained by cultural rather than evolutionary forces. Here I highlight and critically evaluate six controversial points on the evolutionary bases of warfare....
Wiley: Evolutionary Anthropology: Issues, News, and Reviews: Table of Contents
Tue Nov 05, 2019 21:37
Increased radiation toxicity with germline ATM variant of uncertain clinical significance
Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Brandon T. Mullins, Gaorav GuptaAbstractBackgroundWhile patients with ataxia telangiectasia are known to have increased radiation sensitivity, patients with germline heterozygous ataxia telangiectasia mutated (ATM) mutations can have widely varying functional and clinical effects, which can make management decisions difficult. With an increased prevalence of gene panel-based...
Reports of Practical Oncology & Radiotherapy
Wed Nov 06, 2019 18:37
An electromyographer recalls the history of the Federation on the 70<sup>th</sup> anniversary of its journal, <em>Clinical Neurophysiology</em>
Publication date: Available online 5 November 2019Source: Clinical NeurophysiologyAuthor(s): Jun Kimura
Clinical Neurophysiology
Wed Nov 06, 2019 18:33
Biophysical Reconstruction of the Signal Conduction Underlying Short-Latency Cortical Evoked Potentials Generated by Subthalamic Deep Brain Stimulation
Publication date: Available online 5 November 2019Source: Clinical NeurophysiologyAuthor(s): Kabilar Gunalan, Cameron C. McIntyreAbstractObjectiveDirect activation of the hyperdirect (HD) pathway has been linked to therapeutic benefit from subthalamic deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD). We sought to quantify the axonal conduction biophysics of corticofugal axons directly stimulated by subthalamic DBS and reconcile those findings with short-latency cortical...
Clinical Neurophysiology
Wed Nov 06, 2019 18:33
Improved Detection of Parkinsonian Resting Tremor with Feature Engineering and Kalman Filtering
Publication date: Available online 5 November 2019Source: Clinical NeurophysiologyAuthor(s): Lin Yao, Peter Brown, Mahsa ShoaranAbstractObjectiveAccurate and reliable detection of tremor onset in Parkinson’s disease (PD) is critical to the success of adaptive deep brain stimulation (aDBS) therapy. Here, we investigated the potential use of feature engineering and machine learning methods for more accurate detection of rest tremor in PD.MethodsWe analyzed the local field potential (LFP) recordings...
Clinical Neurophysiology
Wed Nov 06, 2019 18:33
Standards of instrumentation of EMG
Publication date: Available online 5 November 2019Source: Clinical NeurophysiologyAuthor(s): Hatice Tankisi, David Burke, Liying Cui, Mamede de Carvalho, Satoshi Kuwabara, Sanjeev D. Nandedkar, Seward Rutkove, Erik Stålberg, Michel J.A.M. van Putten, Anders Fuglsang-FrederiksenAbstractStandardization of Electromyography (EMG) instrumentation is of particular importance to ensure high quality recordings. This consensus report on “Standards of Instrumentation of EMG” is an update and extension of the...
Clinical Neurophysiology
Wed Nov 06, 2019 18:33
Seventy years of our journal
Publication date: Available online 5 November 2019Source: Clinical NeurophysiologyAuthor(s): Ulf Ziemann
Clinical Neurophysiology
Wed Nov 06, 2019 18:33
The role of blink reflex R1 latency as an electrophysiological marker in diabetic distal symmetrical polyneuropathy
Publication date: Available online 5 November 2019Source: Clinical NeurophysiologyAuthor(s): Yun-Ru Lai, Chih-Cheng Huang, Wen-Chan Chiu, Rue-Tsuan Liu, Nai-Wen Tsai, Hung-Chen Wang, Wei-Che Lin, Ben-Chung Cheng, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Pei-Wen Wang, Jung-Fu Chen, Jih-Yang Ko, Cheng-Hsien LuAbstractObjectiveStudies showed a relatively prolonged blink R1 latency in patients with diabetic distal symmetrical polyneuropathy (DSPN) compared to that without DSPN. We tested the hypothesis...
Clinical Neurophysiology
Wed Nov 06, 2019 18:33
Advanced Invasive Extramammary Paget’s Disease Concomitant with Cecal Cancer Possessing Rare Variant of TP53 Single Nucleotide Polymorphism
Patients with invasive extramammary Paget’s disease have an increased risk of secondary malignancy, mostly occurring colorectal carcinoma. TP53 is a regulator of apoptosis, cell cycle arrest, and DNA damage response pathways, and has been reported as one of the genetic biomarkers for colorectal carcinoma. In this report, we describe a case of advanced invasive EMPD concomitant with cecal cancer with a rare variant of TP53 single nucleotide polymorphism (rs121912665). To our knowledge, there is no...
Case Reports in Oncology
Wed Nov 06, 2019 17:28
The Experiences of Young Adults Living with Metastatic/Advanced Cancer: A Scoping Review
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Journal of Adolescent and Young Adult Oncology
Wed Nov 06, 2019 10:00
Humans migrated from Europe to the Levant 40,000 years ago
Researchers now report that Aurignacians, culturally sophisticated yet mysterious early humans, migrated from Europe to the Levant some 40,000 years ago, shedding light on a significant era in the region's history.
Evolutionary Biology News -- ScienceDaily
Tue Nov 05, 2019 18:34
Portal Hypertension evolving from Sickled Hepatopathy: Could Hepatic venous Doppler ultrasound be beneficial in its evaluation?
Publication date: Available online 5 November 2019Source: Medical HypothesesAuthor(s): O.O. Ayoola, R.A. Bolarinwa, A.S. Aderibigbe, S.O. Onigbinde, B.P. OguntadeAbstractPurposeSickle cell intrahepatic cholestasis involves sickling within hepatic sinusoids leading to vascular stasis and localized hypoxia resulting in ballooning of the hepatocytes causing a direct back pressure effect with resultant intracanalicular cholestasis. Vascular stasis may ultimately lead to portal hypertension. We proposed...
ScienceDirect Publication: Medical Hypotheses
Wed Nov 06, 2019 18:24
Modernizing Medicare: Proposed Legislation Addresses Audiology Access Gaps
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Identifying Unrecognized Hearing Loss
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
How Does Audiology Fit into the Public Health Domain?
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Benefits of Social Capital in Adolescents with Hearing Loss
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Defying the Odds: Hearing Care for Young Athletes with Hearing Loss
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Cannabis Precautions for Early Life Stages
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Tips to Include Children with Hearing Loss in Team Sports
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Incorporating Tinnitus Management Services into Your Audiology Practice
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Counseling with the Audiogram
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Do Smartphone Hearing Aid Apps Work?
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Can Age at Cochlear Implantation Predict Learning and Cognitive Abilities?
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Symptom: Mixed Hearing Loss
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
The Hearing Loss, Psychological Distress, and Cardiovascular Disease Connection
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Manufacturers News
No abstract available
The Hearing Journal - Current Issue
Fri Nov 01, 2019 02:00
Dental care during pregnancy based on the pregnancy risk assessment monitoring system in Utah
Abstract Background Although receiving dental care is recommended for women during pregnancy, getting such care remains low. This study will identify the level of dental care received during pregnancy and factors associated with care for a group of pregnant women in Utah. Methods Analyses were based on 2793 pregnant women completing the 2014–2015...
Latest Results for BMC Oral Health
Wed Nov 06, 2019 02:00
Revisiting multifocal breast Cancer: a Clonality study of ductal carcinoma using whole exome sequencing
Publication date: Available online 6 November 2019Source: Human PathologyAuthor(s): Christopher J. Schwartz, Igor Dolgalev, Varshini Vasudevaraja, Stephen Kelly, Adriana Heguy, Matija Snuderl, Paolo Cotzia, George Jour, Farbod DarvishianSummaryMultifocal breast cancer (MFBC), ductal type, has been hypothesized to arise by one of two mechanisms: either through intramammary/intralymphatic spread from a single index tumor (MBC-1), or as multiple independent tumors with each focus carrying its corresponding...
Human Pathology
Wed Nov 06, 2019 18:05
Intratumoral heterogeneity and loss of ARID1A expression in gastric cancer correlates with increased PD-L1 expression in Western patients
Publication date: Available online 6 November 2019Source: Human PathologyAuthor(s): Julia Maria Tober, Christine Halske, Hans-Michael Behrens, Sandra Krüger, Christoph RöckenSummaryRecent whole-genome sequencing showed frequent mutations of ARID1A in gastric cancer (GC). In this study of a large independent Central European cohort we evaluated the expression of ARID1A in whole tissue sections (WTS) of GC testing the following hypotheses: ARID1A shows intratumoral heterogeneity; ARID1A expression...
Human Pathology
Wed Nov 06, 2019 18:05
From Breslow to BRAF and immunotherapy: evolving concepts in melanoma pathogenesis and disease progression and their implications for changing management over the last 50 years
Publication date: Available online 6 November 2019Source: Human PathologyAuthor(s): Robert V. Rawson, Richard A. ScolyerSummarySince it was first recognized as a disease entity more than two centuries ago, advanced melanoma has, until recently, followed a very aggressive and almost universally fatal clinical course. However, over the past 50 years crucial ground breaking research has greatly enhance our understanding of melanoma etiology, risk factors, genomic pathogenesis, immunological interactions,...
Human Pathology
Wed Nov 06, 2019 18:05
Parallel attentional facilitation of features and objects in early visual cortex
Abstract Selective attention can enhance the processing of attended features across the entire visual field. Attention also spreads within objects, enhancing all internal locations and task‐irrelevant features of selected objects. Here, we examine the extent to which attentional enhancement of a feature spreads across attended and unattended objects. Two fully overlapping counter‐rotating bicolored surfaces of light and dark random dots were presented on a gray background of intermediate luminance....
Psychophysiology
Wed Nov 06, 2019 11:44
Use of Biologics in Pityriasis Rubra Pilaris Refractory to First-Line Systemic Therapy: A Systematic Review
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Pityriasis rubra pilaris (PRP) is an uncommon, inflammatory, papulosquamous skin disease. Treatment of PRP is challenging as the disease is often refractory to conventional therapies, such as retinoids and methotrexate. There has been an increasing number of studies reporting the successful use of biologic therapy in patients with PRP; however, the data on the efficacy and safety are limited. Our objective was to evaluate the existing evidence...
SAGE-Journals: Journal of Cutaneous Medicine and Surgery: Table of Contents
Wed Nov 06, 2019 03:14
Management of Pearly Penile Papules: A Review of the Literature
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Pearly penile papules (PPPs) are benign, dome-shaped lesions found around the corona of the penis. Despite being asymptomatic and benign in nature, the appearance of PPPs may cause a great deal of psychological distress to both the patient and their sexual partner. While patient reassurance may be the first-line treatment, several other treatment modalities including cryotherapy, electrodessication and curettage, and laser therapy have all...
SAGE-Journals: Journal of Cutaneous Medicine and Surgery: Table of Contents
Wed Nov 06, 2019 07:19
Nonmedicinal Ingredients in Topical Corticosteroids Available in Canada
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundNonmedicinal ingredients in topical corticosteroids might exacerbate pre-existing conditions in patients with contact allergies. In Canada, no database exists to help the clinician identify rapidly the ingredients in a topical product. Thus, prescribing topical corticosteroids to patients with contact allergies represents a challenge.ObjectivesThis study aimed to identify potential allergens contained in topical corticosteroids...
SAGE-Journals: Journal of Cutaneous Medicine and Surgery: Table of Contents
Wed Nov 06, 2019 07:13
Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy‐induced neuropathy: the role of spinal 5‐HT3 receptors
Abstract Chemotherapy‐induced neuropathy (CIN) is a common complication of cancer treatment. Although CIN is treated with antidepressants that act at serotonin (5‐HT) reuptake, the mechanisms of serotoninergic modulation of nociceptive transmission during CIN remain unknown, namely as to the involvement of the rostroventromedial medulla (RVM) and the role of spinal 5‐HT3 receptors (5‐HT3R). Male Wistar rats were injected with the cytostatic paclitaxel or vehicle solution. One month after CIN induction,...
European Journal of Neuroscience
Tue Nov 05, 2019 19:45

Arterial and venous cerebral blood flow responses to long‐term head‐down bed rest in male volunteers
New Findings •What is the central question of this study? It has been demonstrated that there was a heterogeneous cerebral blood flow (CBF) response in the cerebral arteries during several physiological conditions and it may be owing to differing physiological properties. However, a whole cerebral hemodynamic response to weightlessness remains unknown. •What is the main finding and its importance? Long‐term head‐down bed rest caused a heterogeneous CBF response between the anterior and posterior...
Experimental Physiology
Wed Nov 06, 2019 11:33
Contrast‐enhanced XROMM reveals in vivo soft tissue interactions in the hip of Alligator mississippiensis
We assessed the kinematic relationship of hip joint soft tissues in the American alligator during the high walk using XROMM and DiceCT techniques. Repeated kinematic patterns allow interpretation of a non‐pivoting femoral head, engagement between the femoral neck and antitrochanter, ligament movement, as well as labrum compression. These results allow us to propose functional hypotheses of crocodylian joint tissues and expand our knowledge on the role of vertebrate joint tissues. Abstract Extant...
Journal of Anatomy
Wed Nov 06, 2019 14:11
The mental artery: anatomical study and literature review
The mental artery is a terminal branch of the inferior alveolar artery arising from the maxillary artery. However, few reports have described its anatomy and clinical significance in detail. The aim of this study was to clarify the anatomy of the mental artery. The inferior labial artery tended to anastomose with the mental artery superior to the mental foramen and was likely to anastomose with the submental artery anterior to the mental foramen. Abstract The mental artery is a terminal branch...
Journal of Anatomy
Wed Nov 06, 2019 12:32
Cranial growth in isolated sagittal craniosynostosis compared with normal growth in the first 6 months of age
Normal growth vs. growth in sagittal craniosynostosis. (A) Mediolateral displacement: positive values indicate medial movement (can be interpreted as suture closure) and negative values indicate lateral movement (mostly associated with the overall growth of the skull). (B) Superoinferior displacement: positive values indicate a superior movement. (C) Anteroposterior displacement: positive values indicate anterior, and negative values indicate posterior movement with respect to basion. Abstract Sagittal...
Journal of Anatomy
Wed Nov 06, 2019 12:02
Inflammation in myocardial disease: From myocarditis to dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a heterogeneous group of myocardial diseases clinically defined by the presence of left ventricular dilatation and contractile dysfunction. Among various causes of DCM, a progression from viral myocarditis to DCM has long been hypothesized. Supporting this possibility, studies by endomyocardial biopsy, the only method to obtain a definite diagnosis of myocarditis at present, have provided evidence of inflammation in the myocardium in DCM patients. A number of experimental...
Pathology International
Tue Nov 05, 2019 21:19
Analysis of Quality of Life after Pleurodesis in Patients with Malignant Pleural Effusion
Background: Malignant pleural effusion is one of the most important complications of metastatic cancer, and recurrent pleural effusions do not only have an impact on survival but also cause a huge repercussion on a patient’s quality of life. Objectives: The main objective was to describe quality of life status before and after pleurodesis in patients with malignant pleural effusion. Secondary, we aimed to find predictors of quality of life improvement in such a population. Methods: Retrospective...
Respiration
Wed Nov 06, 2019 16:36
FeNO Variability When Using Different Analyzers at the Joint ATS/ERS Guideline Cutoff
Respiration
Respiration
Wed Nov 06, 2019 16:35
Regular Treatment and Disease Outcomes in Patients with Chronic Obstructive Pulmonary Disease Group A
Respiration
Respiration
Wed Nov 06, 2019 16:35
Identification of Asthma-COPD Overlap, Asthma, and Chronic Obstructive Pulmonary Disease Phenotypes in Patients with Airway Obstruction: Influence on Treatment Approach
Background: Many studies have described asthma-COPD overlap (ACO) among patients diagnosed with asthma or chronic obstructive pulmonary disease (COPD), but less so in broad populations of patients with chronic airway obstruction. Objective: This study aimed to (i) examine the prevalence of ACO, asthma, and COPD phenotypes among subjects referred for pulmonary function testing (PFT), who had airway obstruction in spirometry (forced expiratory volume in 1 s [FEV1]/forced vital capacity [FVC] #x3c;0.7);...
Respiration
Wed Nov 06, 2019 12:33
Clinical, cytologic, and immunohistochemical features of sarcomas involving body cavity fluids
Background Sarcomas are uncommon findings in body cavity fluids. Diagnosis may be challenging because sarcoma cells in fluids can round up and lose their characteristic appearance seen on smears and histologic sections. This study characterizes the cytologic features of sarcomas involving body cavity fluids. Methods Effusion fluids and cerebrospinal fluids diagnosed as positive for sarcoma were reviewed. Results Forty‐three fluids from 28 patients (median age, 47 years) were positive...
Cancer Cytopathology
Wed Nov 06, 2019 16:33
Rethinking academic reward for educators in pathology
Cancer Cytopathology
Wed Nov 06, 2019 16:32
The Application of Magnetic Resonance Imaging-Deformed <sup>11</sup>C-Methionine-Positron Emission Tomography Images in Stereotactic Radiosurgery
Background: Although 11C-methionine positron emission tomography (MET-PET) images can be fused with magnetic resonance (MR) images using planning software for gamma knife radiosurgery (GKR), the stereotactic information has limited value in patients with recurrent malignant brain tumor due to the difference in imaging protocols between MET-PET and MR images. The aim of this study was to evaluate the clinical application of MR imaging (MRI)-deformed MET-PET images in GKR using a deformable registration...
American Society for Stereotactic and Functional Neurosurgery
Wed Nov 06, 2019 16:34
A Novel, Hybrid, Stereotactic Approach (Radiosurgery and Dual Ommaya Reservoirs) for the Treatment of Mixed (Polycystic and Solid) Craniopharyngioma
Background: Craniopharyngioma is a difficult entity to treat, which is particularly true for mixed craniopharyngioma (i.e., a mixture of both solid and cystic components). The present case report illustrates a minimally invasive, two-component, stereotactic treatment approach as an alternative to standard microsurgery. Case Description: A 38-year-old patient presented with progressive intracranial hypertension followed by pan-hypopituitarism, deterioration of the visual field, and cognitive impairment....
American Society for Stereotactic and Functional Neurosurgery
Wed Nov 06, 2019 15:38
In the Hotseat
Publication date: Available online 5 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): June Corry
Radiation Molecular Biology.
Wed Nov 06, 2019 17:06
Treatment of Laryngeal Contact Granuloma: Surgical Therapy or Conservative Treatment
Objective: Despite the fact that there are many treatment alternatives, laryngeal contact granuloma has a high tendency of persistence, spontaneous disappearance without treatment, and recurrence. A comparison of the effects of conservative treatment and surgical therapy on laryngeal contact granuloma was made in a retrospective review. Methods: A total of 124 patients with laryngeal contact granuloma were divided into 2 groups according to treatment: simple surgical excision (n = 36) and conservative...
O.R.L. Journal for oto-rhino-laryngology and its borderlands
Wed Nov 06, 2019 16:36
Cognitive performance of the MAM-E17 schizophrenia model rats in different age-periods
Publication date: Available online 5 November 2019Source: Behavioural Brain ResearchAuthor(s): Veronika Kállai, László Lénárd, László Péczely, Rita Gálosi, Daniella Dusa, Attila Tóth, Kristóf László, Erika Kertes, Anita Kovács, Olga Zagoracz, Beáta Berta, Zoltán Karádi, Tamás OllmannAbstractCognitive disturbances are among the most important features of schizophrenia, and have a significant role in the outcome of the disease. However, the treatment of cognitive symptoms is poorly effective. In order...
Behavioural Brain Research
Wed Nov 06, 2019 16:49
Methodology of preparation of corrosive specimens from human placenta – a technical note
Publication date: Available online 6 November 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): ZYGMUNT DOMAGAŁA, JURAND DOMAŃSKI, ALEKSANDRA ZIMMER, ANNA TARCZYNSKA, JAKUB SLIWA, BOHDAN GWORYSAbstractDetailed knowledge of the anatomy of human placenta vessels is clinically essential and requires the use of many different anatomical and histological techniques. One of the interesting methods of visualising vessels is the corrosion technique. It enables spatial visualisation of the vascular...
ScienceDirect Publication: Annals of Anatomy - Anatomischer Anzeiger
Wed Nov 06, 2019 16:48
Histological mapping of porcine carotid arteries — An animal model for the assessment of artificial conduits suitable for coronary bypass grafting in humans
Publication date: Available online 6 November 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Petr Tomášek, Zbyněk Tonar, Martina Grajciarová, Tomáš Kural, Daniel Turek, Jana Horáková, Richard Pálek, Lada Eberlová, Milena Králíčková, Václav LiškaAbstractBackgroundUsing animal models in experimental medicine requires mapping of their anatomical variability. Porcine common carotid arteries (CCA) are often preferred for the preclinical testing of vascular grafts due to their anatomical...
ScienceDirect Publication: Annals of Anatomy - Anatomischer Anzeiger
Wed Nov 06, 2019 16:48
Oral Epithelial Dysplasia Informational Needs Questionnaire
Conditions:   Oral Epithelial Dysplasia;   Precancerous Conditions;   Precancerous Lesions;   Oral Lichen Planus;   Oral Leukoplakia;   Oral Leukoplakia of Tongue;   Oral Leukoplakia of Lips;   Oral Leukoplakia of Gingiva;   Oral Erythroplakia;   Chronic Hyperplastic Candidosis;   Oral Submucous Fibrosis;   Oral Submucosal Fibrosis, Including of Tongue;   Oral Disease;   Dental Diseases;   Dysplasia;   Information Seeking Behavior;   Patient Preference;   Information Needs;   Health Behavior;  ...
ClinicalTrials
Wed Nov 06, 2019 16:45
“The giant Hans Kraus” (1553): a Renaissance acromegaly by anonymous painter
Abstract The Wunderkammer of Schloss Ambras in Innsbruck was one of the first cabinets of curiosities, created in the sixteenth century. Among the many curiosities, the cabinet includes an anonymous Renaissance painting called “Der Riese Hans Kraus” (The giant Hans Kraus). The details suggest us that it could be a representation of an individual affected by acromegaly.
Journal of Endocrinological Investigation
Wed Nov 06, 2019 16:35

Low frequency of positive antithyroid antibodies is observed in patients with thyroid dysfunction related to immune check point inhibitors
Abstract Introduction Immune checkpoint inhibitors (ICI), such as programmed death-1 inhibitors (anti-PD1), have become a cornerstone for the treatment of different advanced cancers. These antibodies act as modulators of immune checkpoint proteins. However, ICI can lead to the breaking of immune self-tolerance, inducing autoimmune side effects (irAEs), including endocrinopathies. One of the most frequent endocrine irAE of anti-PD1...
Journal of Endocrinological Investigation
Wed Nov 06, 2019 16:35
The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues
Reg (regenerating gene) family proteins are known to be overexpressed in gastrointestinal (GI) tissues under conditions of inflammation. However, the pathophysiological significance of Reg family protein overexpression and its regulation is still unclear. In the present study, we investigated the profile of Reg family gene expression in a colitis model and focused on the regulation of Reg IIIβ and IIIγ, which are overexpressed in inflamed colonic mucosa. C57BL/6 mice were administered 2% dextran...
Mediators of Inflammation
Wed Nov 06, 2019 15:05
The Association between Use of Hypofractionation and Treatment Completion among Recipients of Radiation Therapy Post-Mastectomy
Publication date: Available online 6 November 2019Source: Practical Radiation OncologyAuthor(s): Adam Powell, Teresa Rogstad, Nandita Jacob, James Long, Uday Deshmukh, Bryan Loy, Amin MirhadiAbstractBackgroundAlthough there is some evidence to support the use of hypofractionated (HF) radiation therapy (RT) post-mastectomy, it is not currently the standard of care. RT noncompletion and delayed completion has been shown to lead to inferior outcomes. This study assesses the association between the choice...
Practical Radiation Oncology
Wed Nov 06, 2019 16:32
Nutrition and Athlete Bone Health
Abstract Athletes should pay more attention to their bone health, whether this relates to their longer-term bone health (e.g. risk of osteopenia and osteoporosis) or their shorter-term risk of bony injuries. Perhaps the easiest way to do this would be to modify their training loads, although this advice rarely seems popular with coaches and athletes for obvious reasons. As such, other possibilities to support the athletes’ bone health need to be explored. Given that bone is a nutritionally...
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Comment on: “Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-analysis” and Subsequent Comment/Author Reply from Li et al.
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Reply to Borszcz & de Lucas: Comment on: “Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-Analysis”
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Does Hypohydration Really Impair Endurance Performance? Methodological Considerations for Interpreting Hydration Research
Abstract The impact of alterations in hydration status on human physiology and performance responses during exercise is one of the oldest research topics in sport and exercise nutrition. This body of work has mainly focussed on the impact of reduced body water stores (i.e. hypohydration) on these outcomes, on the whole demonstrating that hypohydration impairs endurance performance, likely via detrimental effects on a number of physiological functions. However, an important consideration,...
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
The Role of Energy Availability in Reproductive Function in the Female Athlete Triad and Extension of its Effects to Men: An Initial Working Model of a Similar Syndrome in Male Athletes
Abstract The Female Athlete Triad represents three interrelated conditions of (i) low energy availability (energy deficiency), presenting with or without disordered eating, (ii) menstrual dysfunction, and (iii) poor bone health, each of which can exist along a continuum of severity ranging from mild and moderate subclinical health concerns to severe clinical outcomes, including eating disorders, amenorrhea, and osteoporosis. This review provides a brief overview of the Female Athlete...
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Muscle Cramping During Exercise: Causes, Solutions, and Questions Remaining
Abstract Muscle cramp is a temporary but intense and painful involuntary contraction of skeletal muscle that can occur in many different situations. The causes of, and cures for, the cramps that occur during or soon after exercise remain uncertain, although there is evidence that some cases may be associated with disturbances of water and salt balance, while others appear to involve sustained abnormal spinal reflex activity secondary to fatigue of the affected muscles. Evidence...
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Blood Biomarker Profiling and Monitoring for High-Performance Physiology and Nutrition: Current Perspectives, Limitations and Recommendations
Abstract Blood test data were traditionally confined to the clinic for diagnostic purposes, but are now becoming more routinely used in many professional and elite high-performance settings as a physiological profiling and monitoring tool. A wealth of information based on robust research evidence can be gleaned from blood tests, including: the identification of iron, vitamin or energy deficiency; the identification of oxidative stress and inflammation; and the status of red blood...
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Nutrition and Altitude: Strategies to Enhance Adaptation, Improve Performance and Maintain Health: A Narrative Review
Abstract Training at low to moderate altitudes (~ 1600–2400 m) is a common approach used by endurance athletes to provide a distinctive environmental stressor to augment training stimulus in the anticipation of increasing subsequent altitude- and sea-level-based performance. Despite some scientific progress being made on the impact of various nutrition-related changes in physiology and associated interventions at mountaineering altitudes (> 3000 m), the impact of nutrition and/or...
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Genetic Approaches for Sports Performance: How Far Away Are We?
Abstract Humans vary in their ‘natural ability’ related to sports performance. One facet of natural ability reflects so-called intrinsic ability or the ability to do well with minimal training. A second facet of natural ability is how rapidly an individual adapts to training; this is termed trainability. A third facet is the upper limit achievable after years of prolonged intense training; this represents both intrinsic ability and also trainability. There are other features of...
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Sports Nutrition for Optimal Athletic Performance and Health: Old, New and Future Perspectives
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Nutrition and Athlete Immune Health: New Perspectives on an Old Paradigm
Abstract Respiratory and gastrointestinal infections limit an athlete’s availability to train and compete. To better understand how sick an athlete will become when they have an infection, a paradigm recently adopted from ecological immunology is presented that includes the concepts of immune resistance (the ability to destroy microbes) and immune tolerance (the ability to dampen defence yet control infection at a non-damaging level). This affords a new theoretical perspective...
Latest Results for Sports Medicine
Wed Nov 06, 2019 02:00
Comparison of infection control practices in a Dutch and US hospital using the infection risk scan (IRIS) method
Publication date: Available online 6 November 2019Source: American Journal of Infection ControlAuthor(s): Ina Willemsen, Julie Jefferson, Leonard Mermel, Jan KluytmansBackgroundThe infection risk scan (IRIS) is a tool to measure the quality of infection control (IC) and antimicrobial use in a standardized way. We describe the feasilibility of the IRIS in a Dutch hospital (the Netherlands, NL) and a hospital in the United States (US).MethodsCross-sectional measurements were performed. Variables included...
ScienceDirect Publication: American Journal of Infection Control
Wed Nov 06, 2019 16:15
Brain volumes as predictors of tDCS effects in primary progressive aphasia
Publication date: January 2020Source: Brain and Language, Volume 200Author(s): Vânia de Aguiar, Yi Zhao, Andreia Faria, Bronte Ficek, Kimberly T. Webster, Haley Wendt, Zeyi Wang, Argye E. Hillis, Chiadi U. Onyike, Constantine Frangakis, Brian Caffo, Kyrana TsapkiniAbstractThe current study aims to determine the brain areas critical for response to anodal transcranial direct current stimulation (tDCS) in PPA. Anodal tDCS and sham were administered over the left inferior frontal gyrus (IFG), combined...
Brain and Language
Wed Nov 06, 2019 16:13
Enhanced left inferior frontal to left superior temporal effective connectivity for complex sentence comprehension: fMRI evidence from Chinese relative clause processing
Publication date: January 2020Source: Brain and Language, Volume 200Author(s): Kunyu Xu, Denise H. Wu, Jeng-Ren DuannAbstractPrevious studies investigating the processing of complex sentences have demonstrated the involvement of the left inferior frontal gyrus (LIFG) and left superior temporal gyrus (LSTG), which might subserve ordering and storage of linguistic components, respectively, for sentence comprehension. However, how these brain regions are interconnected, especially during the processing...
Brain and Language
Wed Nov 06, 2019 16:13
Rehabilitation Is a Global Health Priority
Publication date: Available online 6 November 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Allen W. Heinemann, Michael Feuerstein, Walter R. Frontera, Steven A. Gard, Leonard A. Kaminsky, Stefano Negrini, Lorie Gage Richards, Catherine Vallée, Maria Zalm
Archives of Physical Medicine and Rehabilitation
Wed Nov 06, 2019 16:10
Root and root canal diversity in human permanent maxillary first premolars and upper/lower first molars from a 14th–17th and 18th–19th century Radom population
Publication date: Available online 5 November 2019Source: Archives of Oral BiologyAuthor(s): Agata Przesmycka, Krystyna Jędrychowska-Dańska, Alicja Masłowska, Henryk Witas, Piotr Regulski, Jacek TomczykAbstractObjectiveThe aim of this study was to assess whether analyzed groups from two historical periods: Late Medieval (LMP), and Modern (MP) from Radom varied in the number of tooth roots and root canal system morphology.MethodsRoot morphology of 229 permanent human teeth were analyzed using Cone...
Oral Biology
Wed Nov 06, 2019 15:57
<em>Streptococcus mutans</em> isolated from children with severe-early childhood caries form higher levels of persisters
Publication date: Available online 5 November 2019Source: Archives of Oral BiologyAuthor(s): Aaron Bottner, Richard Y. He, Andrea Sarbu, SM Hashim Nainar, Delphine Dufour, Siew-Ging Gong, Céline M. LévesqueAbstractObjectivesDental caries is the most common chronic infectious disease in children. Streptococcus mutans, the main cariogenic bacterial species, produces persisters, nongrowing dormant variants of regular cells associated with chronicity of diseases. We hypothesized that the recurrent nature...
Oral Biology
Wed Nov 06, 2019 15:57

Systematic review of biological therapy to accelerate orthodontic tooth movement in animals: translational approach
Publication date: Available online 5 November 2019Source: Archives of Oral BiologyAuthor(s): Lucas SantanaAbstractObjectivesTo systematically review and evaluate what is known regarding contemporary biological therapy capable of accelerating orthodontic tooth movement (OTM) in animal model.Materials and MethodsMedLine, Scopus, Web of Science and OpenGrey were searched without restrictions until June 2019. Following study retrieval and selection, relevant data was extracted using a standardized table....
Oral Biology
Wed Nov 06, 2019 15:57
A bacterial metabolite induces Nrf2-mediated anti-oxidative responses in gingival epithelial cells by activating the MAPK signaling pathway
Publication date: Available online 5 November 2019Source: Archives of Oral BiologyAuthor(s): Mai Yokoji-Takeuchi, Naoki Takahashi, Miki Yamada-Hara, Benso Sulijaya, Takahiro Tsuzuno, Yukari Aoki-Nonaka, Koichi Tabeta, Shigenobu Kishino, Jun Ogawa, Kazuhisa YamazakiAbstractObjectiveOxidative stress, which is defined as an imbalance between pro-oxidant and antioxidant systems, has been implicated in the development and/or progression of several inflammatory diseases, including periodontal disease....
Oral Biology
Wed Nov 06, 2019 15:57
An automated framework for localization, segmentation and super-resolution reconstruction of fetal brain MRI
Publication date: Available online 6 November 2019Source: NeuroImageAuthor(s): Michael Ebner, Guotai Wang, Wenqi Li, Michael Aertsen, Premal A. Patel, Rosalind Aughwane, Andrew Melbourne, Tom Doel, Steven Dymarkowski, Paolo De Coppi, Anna L. David, Jan Deprest, Sébastien Ourselin, Tom VercauterenAbstractHigh-resolution volume reconstruction from multiple motion-corrupted stacks of 2D slices plays an increasing role for fetal brain Magnetic Resonance Imaging (MRI) studies. Currently existing reconstruction...
NeuroImage
Wed Nov 06, 2019 15:48
Age-related differences in the neural correlates of vivid remembering
Publication date: Available online 5 November 2019Source: NeuroImageAuthor(s): Adrien Folville, Mohamed Ali Bahri, Emma Delhaye, Eric Salmon, Arnaud D'Argembeau, Christine BastinAbstractWhen recollecting events, older adults typically report similar memory vividness levels as young adults, while they actually retrieve fewer episodic details. This suggests that young and older adults use episodic details differently to calibrate their vividness judgements. Capitalizing on the idea that remembering...
NeuroImage
Wed Nov 06, 2019 15:48
Modular segregation of task-dependent brain networks contributes to the development of executive function in children
Publication date: Available online 5 November 2019Source: NeuroImageAuthor(s): Chunjie Wang, Yuzheng Hu, Jian Weng, Feiyan Chen, Huafeng LiuAbstractExecutive function (EF) refers as to a set of high-level cognitive abilities that are critical to many aspects of daily life. Despite its importance in human daily life, the neural networks responsible for the development of EF in childhood are not well understood. The present study thus aimed to examine the development of task-dependent brain network...
NeuroImage
Wed Nov 06, 2019 15:48
Quelle est la prise en charge des embolies pulmonaires sous-segmentaires ?
Publication date: Available online 6 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): Y. Benhamou, A. Delluc, O. Sanchez, groupe de travail Recommandations de bonne pratique pour la prise en charge de la MVTE
Revue des Maladies Respiratoires
Wed Nov 06, 2019 15:44
Comment gérer les traitements anticoagulants en cas de geste invasif programmé (chirurgie, endoscopie…) ?
Publication date: Available online 6 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): A. Godier, C. Gut-Gobert, O. Sanchez, groupe de travail Recommandations de bonne pratique pour la prise en charge de la MVTE
Revue des Maladies Respiratoires
Wed Nov 06, 2019 15:44
Quelles sont les particularités thérapeutiques de la MVTE au cours du cancer ?
Publication date: Available online 6 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): I. Mahé, G. Meyer, O. Sanchez, groupe de travail Recommandations de bonne pratique pour la prise en charge de la MVTE
Revue des Maladies Respiratoires
Wed Nov 06, 2019 15:44
Quel parcours de soins proposer aux patients avec une thrombose veineuse profonde proximale ? Quels malades hospitaliser ?
Publication date: Available online 5 November 2019Source: Revue des Maladies RespiratoiresAuthor(s): M.-A. Sevestre, O. Sanchez, pour le groupe de travail Recommandations de bonne pratique pour la prise en charge de la MVTE
Revue des Maladies Respiratoires
Wed Nov 06, 2019 15:44
Persistent Idiopathic Facial Pain Originating from Cervical Abnormalities
Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Yuan-jie ZengBackgroundPersistent idiopathic facial pain is characterized by persistent facial or oral pain in the absence of a neurologic deficit. This underexplored pain may be conducted by various nerves, including cranial nerves and upper cervical spinal roots, and its etiology is unclear.Case DescriptionA patient presented with persistent idiopathic facial pain associated with occipital muscle stiffness after an improper...
World Neurosurgery
Wed Nov 06, 2019 15:43
Severe Spinal Cord Compression by Anomalous Vertebral Arteries Treated with Gore-Tex Tape Transposition Technique
Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Tanefumi Baba, Han Soo Chang, Mitsunori MatsumaeRare anomalous courses of vertebral arteries in the craniovertebral junction may compress the spinal cord causing myelopathy. We report here the severest form of this pathologic condition successfully treated with transposition of bilateral vertebral artery using Gore-Tex tapes. A 73-year-old man presented with progressive tetraparesis and gait disturbance. Imaging studies...
World Neurosurgery
Wed Nov 06, 2019 15:43
Refractory Chronic Subdural Hematoma Associated with Dural Metastasis of Lung Adenocarcinoma Treated with Endovascular Embolization for the Middle Meningeal Artery: A Case Report and Review of the Literature
Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Takuya Kosaka, Naokado Ikeda, Motomasa Furuse, Naosuke Nonoguchi, Ryo Hiramatsu, Ryokichi Yagi, Shinji Kawabata, Shigeru Miyachi, Toshihiko Kuroiwa, Masahiko WanibuchiBackgroundEndovascular embolization of the middle meningeal artery (MMA) is effective for recurrent chronic subdural hematoma (CSDH). CSDH associated with dural metastasis is generally refractory to burr hole surgery and has poor prognosis even if any interventions...
World Neurosurgery
Wed Nov 06, 2019 15:43
Impact of continuous positive airway pressure on glucose metabolism
Publication date: Available online 6 November 2019Source: Sleep MedicineAuthor(s): Xuping Cheng, Weimin Zhang
Sleep Medicine
Wed Nov 06, 2019 15:42
The Epidemiology of Sleep Disorders in Israel: Results from a Population-wide Study
Publication date: Available online 6 November 2019Source: Sleep MedicineAuthor(s): Naama Fund, Amit Green, Gabriel Chodick, Melanie Orin, Gideon Koren, Varda Shalev, Yaron DaganAbstractBackgroundStudies on the prevalence of sleep disorders have found great variability due to different data collection methods and case definitions. We aimed at assessing the prevalence of sleep disorders in a large, unselected population using validated clinical patient records.To the best of our knowledge, this is...
Sleep Medicine
Wed Nov 06, 2019 15:42
Bruno J. Strasser, Collecting Experiments. Making Big Data Biology (University of Chicago Press, 2019), 386 pp., $37.62 Paper, ISBN: 978-0226635040
Latest Results for Journal of the History of Biology
Wed Nov 06, 2019 02:00
Regularized logistic regression for obstructive sleep apnea screening during wakefulness using daytime tracheal breathing sounds and anthropometric information
Abstract Obstructive sleep apnea (OSA) is a prevalent health problem. Developing a technology for quick OSA screening is momentous. In this study, we used regularized logistic regression to predict the OSA severity level of 199 individuals (116 males) with apnea/hypopnea index (AHI) ≥ 15 (moderate/severe OSA) and AHI < 5 (non-OSA) using their tracheal breathing sounds (TBS) recorded during daytime, while they were awake. The participants were guided to breathe through their...
Latest Results for Medical
Wed Nov 06, 2019 02:00
A unified framework for mapping individual interregional high-order morphological connectivity based on regional cortical features from anatomical MRI
Publication date: Available online 5 November 2019Source: Magnetic Resonance ImagingAuthor(s): Xun-Heng Wang, Yun Jiao, Lihua LiAbstractBuilding individual brain networks form the single volume of anatomical MRI is a challenging task. Furthermore, the high-order connectivity of morphological networks remains unexplored. This paper aimed to investigate the individual high-order morphological connectivity from anatomical MRI. Towards this goal, a unified framework based on six feature distances (euclidean,...
Magnetic Resonance Imaging
Wed Nov 06, 2019 15:27
Lack of evidence and criteria to evaluate artificial intelligence and radiomics tools to be implemented in clinical settings
European Journal of Nuclear Medicine and Molecular Imaging
Wed Nov 06, 2019 02:00
Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease
Abstract Purpose Cerebral blood flow (CBF) and glucose metabolism are important and significant factors in ischaemic cerebrovascular disease. The objective of this study was to use quantitative hybrid PET/MR to evaluate the effects of surgery treatment on the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease. Methods ...
European Journal of Nuclear Medicine and Molecular Imaging
Wed Nov 06, 2019 02:00
Establishment of humanized tumor microenvironment mouse models based on the injection of peripheral blood mononuclear cells and IFN-γ to evaluate the efficacy of PD-L1/PD-1-targeted immunotherapy
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Cancer Biology & Therapy: Table of Contents: Taylor and Francis
Wed Nov 06, 2019 11:45

The Mechanism of Electroacupuncture at Zusanli Promotes Macrophage Polarization during the Fibrotic Process in Contused Skeletal Muscle
Introduction: Currently, many clinical experiments are being conducted to study the effect of acupuncture on skeletal muscle contusions, and its therapeutic effect has been confirmed to some extent. However, the mechanism of recovery by electroacupuncture (EA) in skeletal muscles after blunt trauma remains unknown. Objective: To determine whether EA at Zusanli can contribute to the regeneration of contused skeletal muscle and the molecular mechanism involved. Methods: Masson’s trichrome staining...
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
Wed Nov 06, 2019 14:30
Orphan Medicines for Pediatric Use: A Focus on the European Union
Publication date: Available online 5 November 2019Source: Clinical TherapeuticsAuthor(s): Winona Rei Bolislis, Solange Corriol-Rohou, Claire Hill-Venning, Hans Hoogland, Angelika Joos, David King, Victoria Kitcatt, Genevieve Le Visage, Thomas C. KühlerAbstractPurposeEuropean policy makers have provided a number of incentives for the development of medicines for orphan diseases as early as 1999 through the Orphan Regulation and created obligations for medicines developers to investigate their products...
Clinical Therapeutics
Wed Nov 06, 2019 15:10

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