Publication date: Available online 31 October 2019Source: Cellular SignallingAuthor(s): George Karkoulias, Katie A. McCrink, Jennifer Maning, Celina M. Pollard, Victoria L. Desimine, Nicholas Patsouras, Miltiades Psallidopoulos, Stavros Taraviras, Anastasios Lymperopoulos, Christodoulos FlordellisAbstractMany aspects of neuronal development, such as neuronal survival and differentiation, are regulated by the transcription factor cAMP-response element-binding protein (CREB). We have previously reported...
Thu Oct 31, 2019 23:01
Publication date: Available online 31 October 2019Source: Cellular SignallingAuthor(s): Lili Cai, Liang Liu, Lihui Li, Lijun JiaAbstractThe F-box protein is the substrate recognition subunit of SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase complex, a multicomponent RING-type E3 ligase involved in the regulation of numerous cellular processes by targeting critical regulatory proteins for ubiquitination. However, whether and how F-box proteins are regulated is largely unknown. Here we report that FBXO28,...
Thu Oct 31, 2019 23:01
Publication date: Available online 31 October 2019Source: Cellular SignallingAuthor(s): Rodrigo A. da Silva, Geórgia da S. Feltran, Célio Júnior da C. Fernandes, Willian F. ZambuzziAbstractThe understanding of vascular calcification-based mechanism is an urgent pending task in vascular biology and this prompted us to better address this issue by investigating whether DNA methylation mechanism might drive osteogenic marker genes modulation in primary human vascular smooth muscle cells (VSMCs) responding...
Thu Oct 31, 2019 23:01
Publication date: Available online 31 October 2019Source: Cellular SignallingAuthor(s): Li Cheng, Baoming Wu, Lei Zhang, Erbao Bian, Ran An, Shuisheng Yu, Wei Liu, Zhigang XiongAbstractBackgroundAlthough gankyrin has been identified as a vital regulator of tumorigenesis, its role and regulatory mechanism in osteosarcoma (OS) remain unclear.MethodsQRT-PCR, western blot and IHC staining were conducted to detect the expression of gankyrin in OS. Pearson’s χ² test was adopted to examine the associations...
Thu Oct 31, 2019 23:01
Publication date: Available online 30 October 2019Source: Cellular SignallingAuthor(s): Hidetada Matsuoka, Keita Harada, Keisuke Mashima, Masumi InoueAbstractMuscarinic receptor stimulation or protein kinase C (PKC) activation in rat adrenal medullary and PC12 cells rapidly induces tyrosine phosphorylation of TWIK-related-acid-sensitive K+ 1 (TASK1) channels with the subsequent clathrin-dependent endocytosis. Our previous study suggested that the muscarinic signal is transmitted to the non-receptor...
Thu Oct 31, 2019 23:01
Publication date: Available online 30 October 2019Source: Cellular SignallingAuthor(s): Hongqi Li, Qinfang Li, Jingjing Lian, Yuan Chu, Kang Fang, Aiping Xu, Tao Chen, Meidong XuAbstractEsophageal squamous cell carcinoma (ESCC) presents with lymph node metastasis in the early stages, limiting the opportunities for curative local resection, including endoscopic submucosal dissection (ESD). ESD is regarded as the standard treatment for early-stage ESCCs. However, radical surgery is recommended when...
Thu Oct 31, 2019 23:01
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Aishwarya Pawar, Paradesi Naidu Gollavilli, Shaomeng Wang, Irfan A. Asangani
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Mark Aizenberg, Solymar Rolón-Martínez, Tuan Pham, Winnie Rao, Julie S. Haas, Maria N. Geffen
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Susanne Stefanie Babl, Brian Paul Rummell, Torfi SigurdssonSummaryOptogenetic stimulation of inhibitory interneurons has become a commonly used strategy for silencing neuronal activity. This is typically achieved using transgenic mice expressing excitatory opsins in inhibitory interneurons throughout the brain, raising the question of how spatially extensive the resulting inhibition is. Here, we characterize neuronal...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Qingqing Yan, Emily J. Shields, Roberto Bonasio, Kavitha SarmaSummaryR-loops are three-stranded DNA:RNA hybrids that are implicated in many nuclear processes. While R-loops may have physiological roles, the formation of stable, aberrant R-loops has been observed in neurological disorders and cancers. Current methods to assess their genome-wide distribution rely on affinity purification, which is plagued by large input...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Anna L. Mallam, Wisath Sae-Lee, Jeffrey M. Schaub, Fan Tu, Anna Battenhouse, Yu Jin Jang, Jonghwan Kim, John B. Wallingford, Ilya J. Finkelstein, Edward M. Marcotte, Kevin DrewSummaryRNA-binding proteins (RBPs) play essential roles in biology and are frequently associated with human disease. Although recent studies have systematically identified individual RNA-binding proteins, their higher-order assembly into ribonucleoprotein...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Matthew Dunne, Beatrice Rupf, Marc Tala, Xhem Qabrati, Patrick Ernst, Yang Shen, Eric Sumrall, Laura Heeb, Andreas Plückthun, Martin J. Loessner, Samuel KilcherSummaryBacteriophages provide excellent tools for diagnostics, remediation, and targeted microbiome manipulation, yet isolating viruses with suitable host specificity remains challenging. Using Listeria phage PSA, we present a synthetic biology blueprint for...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Vanesa Álvarez, Camilla Frattini, María P. Sacristán, Alfonso Gallego-Sánchez, Rodrigo Bermejo, Avelino BuenoSummaryDNA damage tolerance plays a key role in protecting cell viability through translesion synthesis and template switching-mediated bypass of genotoxic polymerase-blocking base lesions. Both tolerance pathways critically rely on ubiquitylation of the proliferating-cell nuclear antigen (PCNA) on lysine 164...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Wenyi Xu, Huijuan Hua, Yueh-Ho Chiu, Guannan Li, Huihan Zhi, Zhengquan Yu, Fazheng Ren, Yongting Luo, Wei CuiSummaryThe mechanistic target of rapamycin complex 2 (mTORC2) coordinates cell proliferation, survival, and metabolism with environmental inputs, yet how extracellular stimuli such as growth factors (GFs) activate mTORC2 remains enigmatic. Here we demonstrate that in human endothelial cells, activation of mTORC2...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Caitlyn E. Bowman, Ebru S. Selen Alpergin, Kyle Cavagnini, Danielle M. Smith, Susanna Scafidi, Michael J. WolfgangSummaryThe extreme metabolic demands of pregnancy require coordinated metabolic adaptations between mother and fetus to balance fetal growth and maternal health with nutrient availability. To determine maternal and fetal contributions to metabolic flexibility during gestation, pregnant mice with genetic...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. MurphySummaryGlutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L. Seifert, Marshall W. Hogarth, Davi A. Mazala, Kai Ting Huang, Rita Horvath, Jyoti K. Jaiswal, György HajnóczkySummaryMuscle function is regulated by Ca2+, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca2+ delivery to the mitochondrial matrix via the mitochondrial...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Hiroshi Maekawa, Tsuyoshi Inoue, Haruki Ouchi, Tzu-Ming Jao, Reiko Inoue, Hiroshi Nishi, Rie Fujii, Fumiyoshi Ishidate, Tetsuhiro Tanaka, Yosuke Tanaka, Nobutaka Hirokawa, Masaomi Nangaku, Reiko InagiSummaryAcute kidney injury (AKI) is characterized by mitochondrial dysfunction and activation of the innate immune system. The cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway detects cytosolic...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Dapei Li, Rongsheng Wu, Wen Guo, Lifen Xie, Zigang Qiao, Shengchuan Chen, Jingfei Zhu, Chaohao Huang, Jian Huang, Bicheng Chen, Yanghua Qin, Feng Xu, Feng MaSummaryγ-interferon-inducible protein-16 (IFI16), a key DNA sensor, triggers downstream STING-dependent type I interferon (IFN-I) production and antiviral immunity. However, it is still unclear how to negatively regulate IFI16 to avoid excessive IFN-I production...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Linda Schadt, Colin Sparano, Nicole Angelika Schweiger, Karina Silina, Virginia Cecconi, Giulia Lucchiari, Hideo Yagita, Emilien Guggisberg, Sascha Saba, Zuzana Nascakova, Winfried Barchet, Maries van den BroekSummarySensing of cytoplasmic DNA by cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) results in production of the dinucleotide cGAMP and consecutive activation of stimulator of...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Sander Tuit, Camilla Salvagno, Theodore S. Kapellos, Cheei-Sing Hau, Lea Seep, Marie Oestreich, Kathrin Klee, Karin E. de Visser, Thomas Ulas, Joachim L. SchultzeSummaryTumor-associated macrophages (TAMs) are frequently the most abundant immune cells in cancers and are associated with poor survival. Here, we generated TAM molecular signatures from K14cre;Cdh1flox/flox;Trp53flox/flox (KEP) and MMTV-NeuT (NeuT) transgenic...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Duy Pham, Carson E. Moseley, Min Gao, Daniel Savic, Colleen J. Winstead, Mengxi Sun, Barbara L. Kee, Richard M. Myers, Casey T. Weaver, Robin D. HattonSummaryThe basic leucine zipper transcription factor activating transcription factor-like (Batf) contributes to transcriptional programming of multiple effector T cells and is required for T helper 17 (Th17) and T follicular helper (Tfh) cell development. Here, we examine...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Zhihui Xu, Ines Mandic-Mulec, Huihui Zhang, Yan Liu, Xinli Sun, Haichao Feng, Weibing Xun, Nan Zhang, Qirong Shen, Ruifu ZhangSummaryBacillus spp. produce a wide range of secondary metabolites, including antibiotics, which have been well studied for their antibacterial properties but less so as signaling molecules. Previous results indicated that the lipopeptide bacillomycin D is a signal that promotes biofilm development...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Maria Daglas, Dominik F. Draxler, Heidi Ho, Fiona McCutcheon, Adam Galle, Amanda E. Au, Pia Larsson, Julia Gregory, Frank Alderuccio, Maithili Sashindranath, Robert L. MedcalfSummaryTraumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged immune response in the brain may cause neurodegeneration, resulting in chronic neurological disturbances. In this study, using a TBI mouse model,...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw, Duyang Kim, Isabel Hubbard, Samantha Fennessey, Nadia Propp, Hemali Phatnani, Justin Kwan, Dhruv Sareen, James R. Broach, Zachary Simmons, Ximena Arcila-Londono, Edward B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, Lyle W. Ostrow, Frank Baas, Noah ZaitlenSummaryAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Miriam E. Bocarsly, Daniel da Silva e Silva, Vanessa Kolb, Kathryn D. Luderman, Sannidhi Shashikiran, Marcelo Rubinstein, David R. Sibley, Lauren K. Dobbs, Veronica A. AlvarezSummaryAlcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Edoardo Moretto, Anna Longatti, Luca Murru, Ingrid Chamma, Alessandro Sessa, Jonathan Zapata, Eric Hosy, Matthieu Sainlos, Julien Saint-Pol, Eric Rubinstein, Daniel Choquet, Vania Broccoli, Giampietro Schiavo, Olivier Thoumine, Maria PassafaroSummaryTetraspanins are a class of evolutionarily conserved transmembrane proteins with 33 members identified in mammals that have the ability to organize specific membrane domains,...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Mariko Komabayashi-Suzuki, Emiko Yamanishi, Chisato Watanabe, Megumi Okamura, Hidenori Tabata, Ryota Iwai, Itsuki Ajioka, Jun Matsushita, Hiroyasu Kidoya, Nobuyuki Takakura, Tadashi Okamoto, Kazuo Kinoshita, Masamitsu Ichihashi, Koh-ichi Nagata, Masatsugu Ema, Ken-ichi MizutaniSummaryTo facilitate efficient oxygen and nutrient delivery, blood vessels in the brain form three-dimensional patterns. However, little is...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Soledad Domínguez, Christophe Clément Rey, Ludivine Therreau, Aurélien Fanton, Dominique Massotte, Laure Verret, Rebecca Ann Piskorowski, Vivien ChevaleyreSummaryAdolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood. We find that a long-term depression of inhibitory transmission (iLTD) from parvalbumin-expressing...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Ana-Maria Oprişoreanu, Hannah L. Smith, Sukrat Arya, Richard Webster, Zhen Zhong, Daniel Wehner, Marcos J. Cardozo, Thomas Becker, Kevin Talbot, Catherina G. BeckerSummaryChondrolectin (Chodl) is needed for motor axon extension in zebrafish and is dysregulated in mouse models of spinal muscular atrophy (SMA). However, the mechanistic basis of Chodl function is not known. Here, we use Chodl-deficient zebrafish and...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Anette Schulz, Long Jiang, Lisanne de Vor, Marcus Ehrström, Fredrik Wermeling, Liv Eidsmo, Keira MelicanSummaryStaphylococcus aureus is a leading cause of skin and soft issue infection, but paradoxically, it also transiently, and often harmlessly, colonizes human skin. An obstacle to understanding this contradiction has been a shortage of in vivo models reproducing the unique structure and immunology of human skin....
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Michael Meyer-HermannSummaryBroadly neutralizing antibodies are crucial for the control of many life-threatening viral infections like HIV, influenza, or hepatitis. Their induction is a prime goal in vaccine research. Using computer simulations, we identify strategies to promote the generation of broadly neutralizing antibodies in natural germinal center (GC) reactions. The simulations predict a feedback loop based...
Thu Oct 31, 2019 19:15
Publication date: 29 October 2019Source: Cell Reports, Volume 29, Issue 5Author(s): Daniel J. Salamango, Terumasa Ikeda, Seyed Arad Moghadasi, Jiayi Wang, Jennifer L. McCann, Artur A. Serebrenik, Diako Ebrahimi, Matthew C. Jarvis, William L. Brown, Reuben S. HarrisSummaryHIV-1 Vif hijacks a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes and PP2A phosphatase regulators (PPP2R5A–E). APOBEC3 counteraction is essential for viral pathogenesis. However, Vif also functions through...
Thu Oct 31, 2019 19:15
Cells, Vol. 8, Pages 1371: Erratum: Hopp, A.K., et al. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells 2019, 8, 890 Cells doi: 10.3390/cells8111371 Authors: Hopp Grüter Hottiger Change in References list order. [...]
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1370: Phosphatidylethanolamine-Binding Protein 1 Ameliorates Ischemia-Induced Inflammation and Neuronal Damage in the Rabbit Spinal Cord Cells doi: 10.3390/cells8111370 Authors: Kim Cho Jung Yoo Oh Choi Cho Kim Hwang Choi Moon In a previous study, we utilized a proteomic approach and found a significant reduction in phosphatidylethanolamine-binding protein 1 (PEBP1) protein level in the spinal cord at 3 h after ischemia. In...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1366: ACVR1 Function in Health and Disease Cells doi: 10.3390/cells8111366 Authors: Valer Sánchez-de-Diego Pimenta-Lopes Rosa Ventura Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1368: Mitotic Chromosomes in Live Cells Characterized Using High-Speed and Label-Free Optical Diffraction Tomography Cells doi: 10.3390/cells8111368 Authors: Kim Lee Fujii Lee Lee Park Kim Lee Pack The cell nucleus is a three-dimensional, dynamic organelle organized into subnuclear compartments such as chromatin and nucleoli. The structure and function of these compartments are maintained by diffusion and interactions between related...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1367: Metabolic, Physiological, and Transcriptomics Analysis of Batch Cultures of the Green Microalga Chlamydomonas Grown on Different Acetate Concentrations Cells doi: 10.3390/cells8111367 Authors: Bogaert Perez Rumin Giltay Carone Coosemans Radoux Eppe Levine Remacle Remacle Acetate can be efficiently metabolized by the green microalga Chlamydomonas reinhardtii. The regular concentration is 17 mM, although higher concentrations...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1369: Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions Cells doi: 10.3390/cells8111369 Authors: Rattila Dunk Im Grichenko Zhou Yanez-Mo Blois Yamada Erez Gomez-Lopez Lye Hinz Romero Cohen Dveksler Human pregnancy-specific glycoproteins (PSGs) serve immunomodulatory and pro-angiogenic functions during pregnancy and are mainly expressed...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1364: Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System Cells doi: 10.3390/cells8111364 Authors: Tan Roth Wickremesekera Davis Kaye Mantamadiotis Stylli Tan Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of 14.6 months following neurosurgical resection and adjuvant chemoradiotherapy. Quiescent GB cancer stem cells (CSCs) invariably cause...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1365: Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs Cells doi: 10.3390/cells8111365 Authors: Robaina Mazzoccoli Esteves Klumb Background: The transcription factor MYC regulates several biological cellular processes, and its target gene network comprises approximately 15% of all human genes, including microRNAs (miRNAs), that also contribute to MYC regulatory activity. Although miRNAs are emerging as key regulators...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1362: Phosphorylation of TIP3 Aquaporins during Phaseolus vulgaris Embryo Development Cells doi: 10.3390/cells8111362 Authors: Mark J. Daniels Mark Yeager The membrane phosphoproteome in plant seed changes dynamically during embryo development. We examined the patterns of Phaseolus vulgaris (common bean) seed membrane protein phosphorylation from the mid-maturation stage until two days after germination. Serine and threonine phosphorylation declined during seed...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1363: Laquinimod Supports Remyelination in Non-Supportive Environments Cells doi: 10.3390/cells8111363 Authors: Stella Nyamoya Julia Steinle Uta Chrzanowski Joel Kaye Christoph Schmitz Cordian Beyer Markus Kipp Inflammatory demyelination, which is a characteristic of multiple sclerosis lesions, leads to acute functional deficits and, in the long term, to progressive axonal degeneration. While remyelination is believed to protect axons, the endogenous-regenerative...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1360: HOXA9 Transcriptionally Promotes Apoptosis and Represses Autophagy by Targeting NF-κB in Cutaneous Squamous Cell Carcinoma Cells doi: 10.3390/cells8111360 Authors: Shuo Han Xue Li Xiaoting Liang Liang Zhou Tumor suppressor HOXA9 has been identified to promote apoptosis in cutaneous squamous cell carcinoma (cSCC). However, the mechanism of such pro-apoptotic role of HOXA9 remains obscure. KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis of RNA-seq...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1361: MicroRNAs Contribute to Breast Cancer Invasiveness Cells doi: 10.3390/cells8111361 Authors: Ivana Fridrichova Iveta Zmetakova Cancer statistics in 2018 highlight an 8.6 million incidence in female cancers, and 4.2 million cancer deaths globally. Moreover, breast cancer is the most frequent malignancy in females and twenty percent of these develop metastasis. This provides only a small chance for successful therapy, and identification of new molecular markers...
Thu Oct 31, 2019 02:00
Abstract Objectives Long non‐coding RNA (lncRNA) MATN1‐AS1 is a newfound lncRNA that has been rarely explored in cancers. Herein, we would like to investigate its role in glioma. Materials and methods qRT‐PCR was conducted to examine gene expression in glioma. Then, MTT assay, colony formation assay and flow cytometry analysis were applied to evaluate the function of MATN1‐AS1 on glioma cells. Western blot was performed to measure the protein levels of genes. Besides, the luciferase...
Wed Oct 30, 2019 14:58
Abstract Objective Clinical trials have demonstrated the efficacy of indigo naturalis, a traditional Chinese medicine ingredient, against psoriasis, a skin disease characterized by keratinocyte hyperproliferation and inflammation. The present study investigates the efficacy of tryptanthrin, a bioactive compound in indigo naturalis, against non‐melanoma skin cancer (NMSC) and the signalling events involved. Methods Efficacy of tryptanthrin against NMSC was assessed using DMBA/PMA‐induced...
Wed Oct 30, 2019 13:41
A single 2‐day treatment of Activin‐A in the premineralization period of osteoblast cultures significantly reduced extracellular matrix mineralization 5–7 days later. Activin‐A treatment induced a transient change in osteoblast gene expression in a 2‐wave‐fashion over time. Differentially regulated genes were involved in transcription regulation, extracellular matrix structure, and associated to transforming growth factor beta signaling. Activin‐A modulated osteoblast microRNA profiles. Abstract...
Wed Oct 30, 2019 18:05
CXCL3 was significantly overexpressed in uterine cervical cancer (UCC), and its upregulation was positively related to the clinical stage. In vitro and in vivo, CXCL3 may act as a tumor promoter involved in the malignant processes of UCC through the Bcl‐2/Bax and ERK pathways. Abstract CXCL3 belongs to the CXC‐type chemokine family and is known to play a multifaceted role in various human malignancies. While its clinical significance and mechanisms of action in uterine cervical cancer (UCC) remain...
Wed Oct 30, 2019 18:04
high‐mobility group box 1/Toll‐like receptor 2 (HMGB1/TLR2) protects against ECM deposition and proteinuria, at least partly through regulation of MyD88/NF‐κB signaling. Pharmacological targeting of HMGB1/TLR2‐mediated NF‐κB signaling pathways at multiple levels may provide a novel approach for the treatment of lupus nephritis Abstract Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus. Patients with LN mostly die of sclerosing glomerulonephritis and renal failure....
Wed Oct 30, 2019 18:04
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου