Nature Communications, Published online: 14 November 2019; doi:10.1038/s41467-019-13170-wThe brain’s capacity to produce new neurons in response to injury is limited. Here, the authors transplant GABAergic progenitor cells and show that they synaptically incorporate into the damaged hippocampus and rescue memory problems and post-traumatic seizures caused by traumatic brain injury.
Thu Nov 14, 2019 02:00
Nature Communications, Published online: 14 November 2019; doi:10.1038/s41467-019-13153-xFor packaging enzymes into metal–organic frameworks (MOFs), crystalline MOFs are usually used. Here, the authors encapsulated enzymes in amorphous MOFs a via one-pot co-precipitation process under ambient condition, which led to higher enzymatic activity than in a corresponding crystalline MOF composite.
Thu Nov 14, 2019 02:00
Nature Communications, Published online: 14 November 2019; doi:10.1038/s41467-019-13211-4Steroidal glycoalkaloids (SGAs) accumulate in Solanum, but their hydroxylating enzymes are unknown. Here, the authors report 2-OXOGLUTARATE DEPENDENT DIOXYGENASE enzymes that catalyze the committed hydroxylation steps in the biosynthesis of leptinine insecticidal compounds in wild potato or non-bitter SGAs in cultivated tomato.
Thu Nov 14, 2019 02:00
Nature Communications, Published online: 14 November 2019; doi:10.1038/s41467-019-12951-7The power conversion efficiencies of most organic solar cells roll off quickly with thickness more than 100 nm. Here, Wu et al. show that avoiding excessive charge accumulation in the intra-bandgap tail states is vital to maintain the photocurrent generation at high thickness.
Thu Nov 14, 2019 02:00
Nature Communications, Published online: 14 November 2019; doi:10.1038/s41467-019-13221-2Fish consumption is considered to be the only significant dietary source of MeHg. Here the authors show that rice could also be a significant global dietary source, especially in South and Southeast Asia. International rice trade and joint ingestion of fish and rice could aggravate the MeHg exposure levels in many areas.
Thu Nov 14, 2019 02:00
Nature Communications, Published online: 14 November 2019; doi:10.1038/s41467-019-13033-4Mutations in the chloride channel ClC-2 have been associated with familial forms of hyperaldosteronism. Here, Schewe et al. generated a mouse model carrying the most common mutation found in patients and find it recapitulates key features of the disease, providing a unique tool for future studies on its pathogenesis.
Thu Nov 14, 2019 02:00
Nature Communications, Published online: 14 November 2019; doi:10.1038/s41467-019-13042-3Nuclear spins in diamond have applications in quantum technologies and NMR methods but their performance can be limited by relaxation processes that are difficult to characterise. Ajoy et al. develop a T1 noise spectroscopy method to identify the dominant relaxation channel and propose a mitigation strategy.
Thu Nov 14, 2019 02:00
Nature Communications, Published online: 14 November 2019; doi:10.1038/s41467-019-12477-yMAPK-targeted therapies fail to achieve complete remission. Here, the authors show that anti-apoptosis resistance is acquired in these targeted therapies through the mRNA destabilization of NOXA which leads to dependence on MCL-1, and that sequential combination of MCL-1 inhibition with targeted therapies overcomes this resistance.
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