Publication date: Available online 14 November 2019Source: International Journal of PsychophysiologyAuthor(s): Alexandra Hering, Nele Wild-Wall, Michael Falkenstein, Patrick D. Gajewski, Katharina Zinke, Mareike Altgassen, Matthias KliegelAbstractCombining behavioral and electrophysiological measures, we investigated the role of memory processes for prospective memory development in three different age groups over the lifespan. We focused on age differences during intention encoding, retention and...
Thu Nov 14, 2019 20:37
Publication date: Available online 14 November 2019Source: International Journal of PsychophysiologyAuthor(s): Qian Zhang, Lin Li, Xiuyan Guo, Li Zheng, Yuyan Wu, Chu ZhouAbstractTheories of the neural basis of implicit learning postulated that specific regions were responsible for specific structures (e.g., supra-finite state) regardless of domain (e.g., vision, movement); others assumed that implicit learning was the adaptation that occurred within neural regions dealing with each domain. We explored...
Thu Nov 14, 2019 20:37
New Findings •What is the central question of this study? Does modulating the expression of Klotho affect myogenesis following acute injury of healthy, non‐senescent muscle. •What is the main finding and its importance? Klotho can accelerate muscle growth following acute injury of healthy, adult mice, which supports the possibility that increased delivery of Klotho could have therapeutic value for improving repair of damaged muscle. Abstract Skeletal muscle injuries activate...
Thu Nov 14, 2019 13:43
Wed Nov 13, 2019 19:19
Abstract Septic shock with heart dysfunction is common in intensive care units. However, the mechanism underlying myocardial depression is still unclear. Whether circular RNA (circRNA) or microRNA (miRNA) profiles differ between patients with and without myocardial depression is unknown. We generated a hypodynamic septic shock model induced by lipopolysaccharide (LPS) in adolescent rats. A total of 12 rats were utilized and heart...
Thu Nov 14, 2019 11:37
Abstract Osteoarthritis (OA) is a common cause of joint pain and physical disability in the elderly. It is highly associated with local inflammatory reactions and cartilage degradation. Isorhapontigenin (ISO), a natural compound existing in various plants, has shown prominent anti-inflammatory and anti-oxidative properties in several inflammatory diseases. However, the effects of ISO on OA remain to be elucidated. Here, we investigated the effects of ISO on interleukin-1β (IL-1β)-treated...
Thu Nov 14, 2019 11:37
Abstract Sepsis is a life-threatening condition caused by the dysregulated host immune response to infection characterized by excessive secretion of inflammatory factors. AZD4547 is a selective inhibitor of fibroblast growth factor receptors that participates in the inflammatory response. The aim of this study was to investigate the inflammation-targeting effects and related molecular mechanisms of AZD4547 in sepsis using a cecal...
Thu Nov 14, 2019 11:37
Abstract The present study investigated changes in cellular phenotype and oxidative stress during the inflammatory response in PC12 cells stimulated by lipopolysaccharide (LPS) and assessed the effects of minocycline, astragalus (AST), and baicalin on inflammation. PC12 cells were exposed to LPS with or without minocycline, AST, or baicalin. Cell viability was measured by a thiazolyl blue tetrazolium bromide (MTT) assay. Contrast...
Thu Nov 14, 2019 11:37
Abstract Liver ischemia-reperfusion injury (IRI) can severely compromise the prognosis of patients receiving liver surgery. While inflammation contributes to the damage resulting from IRI, only a limited number of inflammation biomarkers have been identified as being associated with the different stages of hepatic IRI. As an approach to identify some of these inflammatory cytokines and the molecular mechanisms involved within different stages of hepatic IRI, we used an advanced...
Thu Nov 14, 2019 11:37
Abstract Mitogen- and stress-activated protein kinase (MSK) is a recently identified nuclear cAMP-regulated enhancer B (CREB) and histone H3 kinase that responds to both mitogen- and stress-activated protein kinases. This study was designed to investigate the protective effect of MSK on the rats with focal ischemia-reperfusion injury. The rat model was established by inserting thread into the middle cerebral artery. The protein expression...
Thu Nov 14, 2019 11:37
Abstract Inflammatory bowel disease (IBD) in humans is closely related to bacterial infection and the disruption of the intestinal barrier. Paeoniflorin (PF), a bioactive compound from Paeonia lactiflora Pallas plants, exerts a potential effect of anti-inflammatory reported in various researches. However, the effect of PF on intestinal barrier function and its related mechanisms has not been identified. Here, we investigate the PF...
Thu Nov 14, 2019 11:37
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