Related ArticlesSecondary Neurolymphomatosis of the Radial Nerve: A Diagnostic Challenge. Am J Case Rep. 2019 Nov 10;20:1652-1658 Authors: Iacobellis F, Di Serafino M, Blasio R, Barbuto L, Pezzullo F, Romano L Abstract BACKGROUND Secondary neurolymphomatosis is a rare clinical condition that may be observed in patients with hematologic malignancies. Clinical findings can overlap with other conditions. Diagnosis can be obtained by magnetic resonance imaging...
Mon Nov 11, 2019 13:31
Related ArticlesSingle-Port Laparoscopic Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Am J Case Rep. 2019 Nov 09;20:1648-1651 Authors: Alshammari T, Alshammari S, Hakami R, Alharbi A, Alyami M, Abdulla M, Bin Traiki T Abstract BACKGROUND Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is one of the treatment options in low-grade appendiceal mucinous neoplasm with peritoneal dissemination. The minimal invasive...
Mon Nov 11, 2019 13:31
Related ArticlesThe 42nd annual meeting of the American Primatological Society in Madison, Wisconsin. Evol Anthropol. 2019 Nov 09;: Authors: Kane EE, Robinson LM PMID: 31705773 [PubMed - as supplied by publisher]
Mon Nov 11, 2019 13:48
Related ArticlesDuplicate gallbladder: A case report of a patient with cholecystitis after cholecystectomy. Int J Surg Case Rep. 2019 Nov 03;65:156-160 Authors: Pera SJ, Huh N, Orcutt ST Abstract INTRODUCTION: Duplicate gallbladder is a congenital anomaly with various anatomical presentations that can pose difficult diagnostic dilemmas. This case presents the consequence of recurrent cholecystitis after prior cholecystectomy due to delay in diagnosis...
Mon Nov 11, 2019 13:47
Related ArticlesColonic metastasis of renal cell carcinoma following curative nephrectomy: A case report and review of the literature. Int J Surg Case Rep. 2019 Oct 23;65:152-155 Authors: Subaşı Ö, Aziret M, Karaman K, Ercan M Abstract INTRODUCTION: Renal cell carcinoma (RCC) is a rare tumor that comprises only 3% of adult cancers, while renal parenchymal tumors constitute 85% of all RCC cases. RCC frequently metastasizes to the lungs, bones, brain or...
Mon Nov 11, 2019 13:47
Related ArticlesA unique strategy for large-bowel perforation with ventriculoperitoneal shunt: Conversion to ventriculoatrial shunt: A case report. Int J Surg Case Rep. 2019 Oct 22;65:148-151 Authors: Akabane S, Iijima H, Kobayashi Y, Watanabe K Abstract INTRODUCTION: Large-bowel perforation can lead to critical sepsis, and urgent intervention including surgery is indispensable to control systemic infection. Here, we describe a strategy for large-bowel...
Mon Nov 11, 2019 13:47
Related ArticlesCombined laparoscopic and thoracoscopic approach for tension gastrothorax in a foramen of Bochdalek hernia. Int J Surg Case Rep. 2019 Nov 02;65:141-147 Authors: Gandhi S, Bhandarwar A, Sadhwani N, Patel C, Wagh A, Arora E Abstract INTRODUCTION: The incidence of Bochdalek hernias in adults is much more than previously reported. Though most of these are asymptomatic. Tension gastrothorax is a rare complication of these. Literature about...
Mon Nov 11, 2019 13:47
Related ArticlesSubchondral fracture caused by unevenly stiffened meniscus after radiofrequency-assisted arthroscopic knee meniscectomy: A case report and review of the literature. Int J Surg Case Rep. 2019 Oct 28;65:135-140 Authors: Fukui K, Shioya A, Tachi Y, Yonezawa K, Hirata H, Kawahara N Abstract INTRODUCTION: Causality for postarthroscopic osteonecrosis of the knee is unknown, and related mechanisms have been poorly characterized. PRESENTATION...
Mon Nov 11, 2019 13:47
Related ArticlesFibrous tumor of the stomach causing abdominal pain and melena: Case report with review of literature. Int J Surg Case Rep. 2019 Oct 31;65:97-101 Authors: Aldohuky W, Mohammed AA Abstract INTRODUCTION: Fibrous tumor of the stomach is a rare mesenchymal tumor composed of hyalinized fibrous tissue with spindle shaped fibroblasts. This type of tumor usually occurs in the subcutaneous tissues and the deep soft tissues. Its occurrence in stomach...
Mon Nov 11, 2019 13:47
Related ArticlesGigantic submandibular pleomorphic adenoma: A rare case report. Int J Surg Case Rep. 2019 Oct 24;65:91-96 Authors: Abdelkhalek M, Elmetwally M, Mazy A, Gad M, Elsaid A, Awny S, Refky B, Abdallah A, Elalfy AF, Shokeir FA, Abdallah S, Elfeky A, Aboelamayem R, Hegazy MA Abstract INTRODUCTION: Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. When neglected on some occasions, its size and weight can enormously augment....
Mon Nov 11, 2019 13:47
Related ArticlesLengthy complex lumbar fusion surgery in high-risk elderly patient under spinal anesthesia: A case report. Int J Surg Case Rep. 2019 Oct 30;65:131-134 Authors: Curto RA, Edwards CC, Lin C, Brown CH Abstract INTRODUCTION: Spinal Anesthesia (SA) continues to be an emerging technique for lumbar fusion surgery in the elderly population. SA is an appealing option in the high-risk geriatric population for several reasons, including the potential...
Mon Nov 11, 2019 13:47
Related ArticlesPenoscrotal Elephantiasis nostras verrucosa: A case report and literature review. Int J Surg Case Rep. 2019 Nov 02;65:127-130 Authors: Moussa Y, Moussa M, Abou Chakra M Abstract BACKGROUND: Elephantiasis Nostras Verrucosa (ENV) is a rare clinical condition associated with chronic non-filarial lymphedema caused by bacterial or non-infectious lymphatic obstruction. CASE DESCRIPTION: We reported an unusual case of isolated peno-scrotal...
Mon Nov 11, 2019 13:47
Related ArticlesAnomalous muscles and nerves in the hand of a 94-year-old cadaver-A case report. Int J Surg Case Rep. 2019 Oct 31;65:119-123 Authors: Nation HL, Jeong SY, Jeong SW, Occhialini AP Abstract INTRODUCTION: During an anatomical dissection of the distal upper extremities, numerous muscular and nervous anomalies were found in the forearm and hand of a 94-year-old cadaver. These anomalies are clinically relevant with regard to medical or surgical...
Mon Nov 11, 2019 13:47
Related ArticlesSurgery on aggressive fibroma of the posterior compartment of the knee: A case report. Int J Surg Case Rep. 2019 Nov 05;65:115-118 Authors: Magetsari RMSN, Irawan MNS Abstract INTRODUCTION: Fibroma is a benign tumor. More than 99% fibroma arises from tendon sheaths or tendons. Aggressive Fibroma at posterior compartment knee is a rare case. This report presents one case of fibroma at posterior compartment of the knee with the treatment....
Mon Nov 11, 2019 13:47
Related ArticlesPancreatic neuroendocrine tumor, lymphoma, and squamous cell carcinoma of hypopharynx; A case report of three primary cancers in one patient. Int J Surg Case Rep. 2019 Nov 02;65:111-114 Authors: Tangsirapat V, Wongta K, Chakrapan Na Ayudhya K, Chakrapan Na Ayudhya V, Sookpotarom P Abstract BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are rarely found and the majority of PNETs are nonfunctioning. At present, a patient with pancreatic...
Mon Nov 11, 2019 13:47
Related ArticlesLaparoscopic plug removal for chronic pain after inguinal hernia repair using the plug-and-patch technique: A case report. Int J Surg Case Rep. 2019 Oct 28;65:107-110 Authors: Tazaki T, Sasaki M, Kohyama M, Sugiyama Y, Shintakuya R, Hirano T, Takahashi S, Nakamitsu A Abstract INTRODUCTION: The use of tension-free mesh repair techniques for inguinal hernias has led to uniformly low recurrence rates. The main associated morbidity is chronic...
Mon Nov 11, 2019 13:47
Related ArticlesPancreaticogastrostomy as reconstruction choice in pancreatic trauma surgery: Case report and review of the literature. Int J Surg Case Rep. 2019 Oct 22;65:102-106 Authors: Serra F, Barbato G, Tazzioli G, Gelmini R Abstract INTRODUCTION: Due to its retroperitoneal location and its proximity to major vascular structures and other organs, isolated pancreatic injuries are rare. The optimal management for pancreatic injuries of grades III...
Mon Nov 11, 2019 13:47
Related ArticlesThree-dimensional analysis of the radiological risk factors for progression of the thoracic ossification of the posterior longitudinal ligament following posterior decompression and stabilization. World Neurosurg. 2019 Nov 07;: Authors: Yang X, Liu X, Liang C, Yu M, Liu X, Liu Z Abstract BACKGROUND: Although research shows that the ossified masses of ossification of the posterior longitudinal ligament (OPLL) continue to grow postoperatively,...
Mon Nov 11, 2019 13:22
Related Articles3D Real-Time Image-Guided Navigation Spine Corpectomy with Ultrasonic Bone Cutter: Technical Note. World Neurosurg. 2019 Nov 07;: Authors: Lin CW, Chang CC, Chen HT, Chen YJ, Lin CS, Hsu HC, Tsou HK Abstract BACKGROUND: Surgical interventions for congenital scoliosis is challenging for spine surgeons. The coordination of 3D real-time image-guided navigation with an ultrasonic bone cutter allows surgeons to localize the affected area of...
Mon Nov 11, 2019 13:22
Related ArticlesIndependent Validation of the Colloid Cyst Risk Score to Predict Symptoms and Hydrocephalus in Patients with Colloid Cysts of the Third Ventricle. World Neurosurg. 2019 Nov 07;: Authors: Alford EN, Rotman LE, Shank CD, Agee BS, Markert JM Abstract BACKGROUND: The Colloid Cyst Risk Score (CCRS) was devised to identify symptomatic colloid cyst patients and stratify risk of hydrocephalus. The CCRS considers patient age, presence of headache,...
Mon Nov 11, 2019 13:22
Related ArticlesAmbroise Paré: His contribution to the future advancement of neurosurgery and the hardships of his times affecting his life and brilliant career. World Neurosurg. 2019 Nov 07;: Authors: Splavski B, Rotim K, Boop FA, Gienapp AJ, Arnautović KI Abstract Ambroise Paré was celebrated surgeon of the 16th Century whose practical accomplishments, books, and ideas transformed surgery and was a precursor for the later development of neurosurgery....
Mon Nov 11, 2019 13:22
Related ArticlesMagnetic resonance spectrobiopsy for prediction of isocitrate dehydrogenase mutation in glioma. World Neurosurg. 2019 Nov 05;: Authors: Grasso G, Torregrossa F PMID: 31704363 [PubMed - as supplied by publisher]
Mon Nov 11, 2019 13:22
Related ArticlesA Case of Calcifying Pseudoneoplasms of the Neuraxis Coexisting with Interhemispheric Lipoma and Agenesis of the Corpus Callosum: Involvement of Infiltrating Macrophages: CAPNON and macrophage. World Neurosurg. 2019 Nov 05;: Authors: Inukai M, Shibahara I, Hotta M, Miyasaka K, Sato S, Hide T, Saegusa M, Kumabe T Abstract BACKGROUND: Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare clinical entity. We report an unusual case...
Mon Nov 11, 2019 13:22
Related ArticlesIntracranial inflammatory pseudotumor associated with Idiopathic hypertrophic pachymeningitis mimicking Malignant tumor or High grade meningioma: a case report. World Neurosurg. 2019 Nov 05;: Authors: Han MS, Moon KS, Lee KH, Jang WY, Kim SK, Jung S Abstract BACKGROUND: Idiopathic hypertrophic pachymeningitis (IHP) is a rare clinical disease characterized by inflammatory fibrosis causing diffuse thickening of the dura mater, which is...
Mon Nov 11, 2019 13:22
Related ArticlesPreoperative Light Transmission Aggregometry Values predict Thromboembolic Complications after Stent-assisted Coil Embolization: LTA predicts TE complications after stent-coiling. World Neurosurg. 2019 Nov 05;: Authors: Kan I, Ishibashi T, Sakuta K, Fujimura S, Yuki I, Kaku S, Kodama T, Kato N, Nishimura K, Aoki K, Sasaki Y, Karagiozov K, Murayama Y Abstract OBJECTIVE: Risk control of thromboembolic complications (TEC) during stent assisted...
Mon Nov 11, 2019 13:22
Related ArticlesPulvinar locus is highly relevant to patients' outcomes in surgically resected thalamic gliomas in children. World Neurosurg. 2019 Nov 05;: Authors: Chiba K, Aihara Y, Masui K, Abe K, Komori T, Kawamata T Abstract OBJECTIVE: Thalamic gliomas in children are less suitable for surgical resection due to their location. In cases of unavoidable resection, careful surgical planning in addition to histology and extent of resection (EOR) affects...
Mon Nov 11, 2019 13:22
Related ArticlesCSF FLOWMETRY IN PAEDIATRIC PATIENTS OF CHIARI 1 MALFORMATION WITH SURGICAL IMPLICATIONS. World Neurosurg. 2019 Nov 05;: Authors: Sadique SI, Pandey P, Chaudhuri AK Abstract INTRODUCTION: Chiari malformations include a large spectrum of anomalies of hindbrain formation which appear at different stages of development of the central nervous system. Chiari described these malformations as congenital anomalies of the hindbrain characterised...
Mon Nov 11, 2019 13:22
Related ArticlesOvershunting-Associated Myelopathy Treated with Endoscopic Third Ventriculostomy: A Case Report. World Neurosurg. 2019 Nov 05;: Authors: Ko Y, Takeshima Y, Nakagawa I, Motoyama Y, Park YS, Nakase H Abstract BACKGROUND: Overshunting-associated myelopathy (OSAM) is a rare complication of cerebrospinal fluid shunt placement. Previous reports have recommended removal or ligation of the shunt and use or revision of a pressure programmable...
Mon Nov 11, 2019 13:22
Related ArticlesLeft Radiofrequency Thalamotomy for Drug-Refractory Essential Tremor: Left Radiofrequency Thalamotomy. World Neurosurg. 2019 Nov 05;: Authors: Grewal S, Domingo RA, Wharen RE Abstract Essential tremor (ET) is an idiopathic movement disorder characterized by bilateral action tremor of the upper limbs with or without other neurological symptoms.1 Pharmacological management is the first-line treatment for this condition. Surgical treatment...
Mon Nov 11, 2019 13:22
Related ArticlesAnti-Proliferative Effect of Wogonin on Ovary Cancer Cells Involves Activation of Apoptosis and Cell Cycle Arrest. Med Sci Monit. 2019 Nov 10;25:8465-8471 Authors: Zhao Q, Chang W, Chen R, Liu Y Abstract BACKGROUND The present study was designed to investigate the effect of wogonin on Caov-3 and A2780 ovary cancer cell proliferation and the mechanisms involved. MATERIAL AND METHODS Cell viability changes and apoptosis induction by wogonin...
Mon Nov 11, 2019 13:33
Related ArticlesSmall molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomed Pharmacother. 2019 Nov 07;121:109502 Authors: Liu Z, Ge X, Gu Y, Huang Y, Liu H, Yu M, Liu Y Abstract Signal transducer and activator of transcription 3 (STAT3) protein frequently overexpressed in many malignancies and plays an essential role in regulating proliferation, apoptosis, migration and invasion in cancer cells. However, No STAT3...
Mon Nov 11, 2019 13:33
Related ArticlesProtective and anticancer effects of orange peel extract and naringin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse model. Biomed Pharmacother. 2019 Nov 07;121:109594 Authors: Tajaldini M, Samadi F, Khosravi A, Ghasemnejad A, Asadi J Abstract BACKGROUND: chemotherapy drugs are the common therapy for cancer cells with side effects. Recent studies reported that natural products may contribute to decreasing the...
Mon Nov 11, 2019 13:33
Related ArticlesPromotion of myotube differentiation and attenuation of muscle atrophy in murine C2C12 myoblast cells treated with teaghrelin. Chem Biol Interact. 2019 Nov 07;:108893 Authors: Hsieh SK, Lin HY, Chen CJ, Jhuo CF, Liao KY, Chen WY, Tzen JTC Abstract This study aimed to investigate the effects of teaghrelin, an active ingredient of Chin-shin oolong tea, on murine C2C12 myoblast cells. Under high serum conditions, teaghrelin inhibited C2C12 cell...
Mon Nov 11, 2019 13:33
Related ArticlesSelective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with d-amino acids in H358 cancer cells expressing KRASG12C. Eur J Med Chem. 2019 Nov 02;:111844 Authors: Xu LL, Li CC, An LY, Dai Z, Chen XY, You QD, Hu C, Di B Abstract Lung cancer is one of the most malignant tumors with the highest morbidity and mortality. Most of them are non-small cell lung cancer (NSCLC). KRASG12C gene mutation is an important driving...
Mon Nov 11, 2019 13:33
Related ArticlesSelected by gene co-expression network and molecular docking analyses, ENMD-2076 is highly effective in glioblastoma-bearing rats. Aging (Albany NY). 2019 Nov 09;11: Authors: Zhong S, Bai Y, Wu B, Ge J, Jiang S, Li W, Wang X, Ren J, Xu H, Chen Y, Zhao G Abstract BACKGROUND: Glioblastoma is the most common type of malignant brain tumor. Bioinformatics technology and structure biology were effectively and systematically used to identify...
Mon Nov 11, 2019 13:33
Related ArticlesRegulation of cell cycle by MDM2 in prostate cancer cells through Aurora Kinase-B and p21WAF1/CIP1 mediated pathways. Cell Signal. 2019 Nov 06;:109435 Authors: Kanagasabai T, Venkatesan T, Natarajan U, Alobid S, Alhazzani K, Algahtani M, Rathinavelu A Abstract Overexpression of MDM2 oncoprotein has been detected in a large number of diverse human malignancies and has been shown to play both p53-dependent and p53-independent roles in oncogenesis....
Mon Nov 11, 2019 13:33
Related ArticlesImmunosuppression of aquatic organisms exposed to elevated levels of manganese: From global to molecular perspective. Dev Comp Immunol. 2019 Nov 06;:103536 Authors: Hernroth B, Tassidis H, Baden SP Abstract Manganese (Mn) is an essential trace metal for all organisms. However, in excess it causes toxic effects but the impact on aquatic environments has so far been highly overlooked. Manganese is abundant both in costal and deep sea sediments...
Mon Nov 11, 2019 13:33
Related ArticlesFluoxetine Enhances Anti-tumor Activity of Paclitaxel in Gastric Adenocarcinoma Cells by Triggering Apoptosis and Necroptosis. Anticancer Res. 2019 Nov;39(11):6155-6163 Authors: Khing TM, Po WW, Sohn UD Abstract BACKGROUND/AIM: Fluoxetine, an antidepressant, has cytotoxic effects on several cancer cell lines, while paclitaxel is an antineoplastic agent for various cancers. The aim of this study was to evaluate whether fluoxetine enhances...
Mon Nov 11, 2019 13:33
Related ArticlesIn Vitro Study of the Anti-cancer Effect of Alternate-day 5-Fluorouracil in Head and Neck Cancer Cells. Anticancer Res. 2019 Nov;39(11):6041-6047 Authors: Moro Y, Kogashiwa Y, Sakurai H, Takahashi R, Kimura T, Hirasaki M, Matsumoto Y, Sugasawa M, Kohno N Abstract BACKGROUND/AIM: We have previously reported that alternate-day S-1 had comparable effects and milder adverse events than the respective consecutive-day regimen in head and neck...
Mon Nov 11, 2019 13:33
Related ArticlesEfficacy of Afatinib and Lapatinib Against HER2 Gene-amplified Trastuzumab-sensitive and -resistant Human Gastric Cancer Cells. Anticancer Res. 2019 Nov;39(11):5927-5932 Authors: Nakata S, Fujita M, Nakanishi H Abstract BACKGROUND/AIM: Trastuzumab is the only clinically approved targeted therapy for HER2 gene-amplified gastric cancer at present. However, the clinical significance of multi-targeting tyrosine kinase inhibitors (TKIs) in...
Mon Nov 11, 2019 13:33
Related ArticlesTBX3 deficiency accelerates apoptosis in cardiomyoblasts through regulation of P21 expression. Life Sci. 2019 Nov 05;:117040 Authors: Cao M, Zhu B, Sun Y, Zhao X, Qiu G, Fu W, Jiang H Abstract Congenital heart disease (CHD) is the most common birth defect in newborns. There is increasing evidence that apoptosis and remodeling of the cardiomyoblasts are the major pathology of CHD. Previous research found that T-box transcription factor...
Mon Nov 11, 2019 13:33
Related ArticlesTSGA10 overexpression inhibits angiogenesis of HUVECs: A HIF-2α biased perspective. Microvasc Res. 2019 Nov 05;:103952 Authors: Amoorahim M, Valipour E, Hoseinkhani Z, Mahnam A, Rezazadeh D, Ansari M, Shahlaei M, Gamizgy YH, Moradi S, Mansouri K Abstract Testis-specific gene antigen 10 (TSGA10) is a protein overexpressed in most cancers; except for some certain types where its expression is reduced. TSGA10 overexpression in HeLa cells...
Mon Nov 11, 2019 13:33
Related ArticlesCurcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer. J Exp Clin Cancer Res. 2019 Nov 08;38(1):460 Authors: Wang L, Wang C, Tao Z, Zhao L, Zhu Z, Wu W, He Y, Chen H, Zheng B, Huang X, Yu Y, Yang L, Liang G, Cui R, Chen T Abstract BACKGROUND: Breast cancer is the most prevalent cancer among women worldwide. WZ35, an analog of curcumin, has been demonstrated to remarkably improve the pharmacokinetic...
Mon Nov 11, 2019 13:33
Related ArticlesAnti-Cancer Activity of a 5-Aminopyrazole Derivative Lead Compound (BC-7) and Potential Synergistic Cytotoxicity with Cisplatin against Human Cervical Cancer Cells. Int J Mol Sci. 2019 Nov 07;20(22): Authors: Swanepoel B, Nitulescu GM, Olaru OT, Venables L, van de Venter M Abstract The use of some very well-known chemotherapeutic agents, such as cisplatin, is limited by toxicity in normal tissues and the development of drug resistance....
Mon Nov 11, 2019 13:33
Related ArticlesWEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage. Cancers (Basel). 2019 Nov 07;11(11): Authors: de Jong MRW, Langendonk M, Reitsma B, Herbers P, Nijland M, Huls G, van den Berg A, Ammatuna E, Visser L, van Meerten T Abstract Genomically unstable cancers are dependent on specific cell cycle checkpoints to maintain viability and prevent apoptosis. The cell cycle checkpoint protein...
Mon Nov 11, 2019 13:33
Related ArticlesGenotoxicity assessment of antiepileptic drugs (AEDs) in human embryonic stem cells. Epilepsy Res. 2019 Oct 31;158:106232 Authors: Kardoost M, Hajizadeh-Saffar E, Ghorbanian MT, Ghezelayagh Z, Pooshang Bagheri K, Behdani M, Habibi-Anbouhi M Abstract Several antiepileptic drugs (AEDs) are administrated during pregnancy according to recent therapeutic protocols. Ten percent of pregnant women with epilepsy give birth to offspring with malformations...
Mon Nov 11, 2019 14:32
Related ArticlesPrevalence and risk factors for hyponatremia in adult epilepsy patients: Large-scale cross-sectional cohort study. Seizure. 2019 Oct 23;73:26-30 Authors: Yamamoto Y, Takahashi Y, Imai K, Ohta A, Kagawa Y, Inoue Y Abstract PURPOSE: To evaluate the risk factors and prevalence of hyponatremia among epilepsy patients in relation to use of antiepileptic drugs (AEDs). METHODS: We retrospectively reviewed 14,620 adult patients (aged...
Mon Nov 11, 2019 14:32
Related ArticlesEvaluation of the impact of compound C11 a new anticonvulsant candidate on cognitive functions and hippocampal neurogenesis in mouse brain. Neuropharmacology. 2019 Nov 07;:107849 Authors: Andres-Mach M, Szewczyk A, Zagaja M, Luszczki J, Maj M, Rola R, Abram M, Kaminski K Abstract Searching for the new and effective anticonvulsants in our previous study we developed a new hybrid compound C-11 derived from 2-(2,5-dioxopyrrolidin-1-yl) propanamide....
Mon Nov 11, 2019 14:32
Related ArticlesBridging the divide between epilepsy and mental health to drive solutions. Epilepsy Behav. 2019 Nov 06;:106576 Authors: Kobau R, Manderscheid R, Owens S, Curt LaFrance W, Sajatovic M Abstract Since its establishment in 2000, Epilepsy & Behavior has published more than 1000 papers on mental health issues among people with epilepsy, including about 200 reviews. These studies on prevalence, treatment, and guidance for future research...
Mon Nov 11, 2019 14:32
Related ArticlesMedicinal cannabis in Latin America: History, current state of regulation, and the role of the pharmacist in a new clinical experience with cannabidiol oil. J Am Pharm Assoc (2003). 2019 Nov 06;: Authors: Cáceres Guido P, Riva N, Calle G, Dell'Orso M, Gatto M, Sberna N, Schaiquevich P Abstract OBJECTIVE: Cannabis sativa was introduced in Latin America in the 16th century. Nevertheless, many years have elapsed, and scientific progress...
Mon Nov 11, 2019 14:32
Related ArticlesA tiered strategy for investigating status epilepticus. Seizure. 2019 Oct 22;: Authors: Craig DP, Mitchell TN, Thomas RH Abstract In status epilepticus the imperative to start anti-seizure therapy, initially subjugates the need to investigate the cause. Once treatment is initiated this balance shifts in favour of identifying: the causes and consequences of the seizure; the factors that predetermined the occurrence of status epilepticus;...
Mon Nov 11, 2019 14:32
Related ArticlesComparison of the relapse rates in seizure-free patients in whom antiepileptic therapy was discontinued and those in whom the therapy was continued: A meta-analysis. Epilepsy Behav. 2019 Nov 06;101(Pt A):106577 Authors: Wang J, Huang P, Song Z Abstract About 70% of patients with epilepsy can be seizure-free with an appropriate treatment. When the seizures are under control, discontinuation of the antiepileptic drugs (AEDs) can help avoid...
Mon Nov 11, 2019 14:32
Related ArticlesEffects of Diazepam and Ketamine on Pilocarpine-Induced Status Epilepticus in Mice. Neuroscience. 2019 Nov 06;: Authors: Wang S, Lévesque M, Avoli M Abstract Status epilepticus (SE) is a life-threatening condition needing immediate care to prevent brain damage. SE with electrographic and behavioral features similar to those seen in humans is reproduced in rodents by i.p. pilocarpine injection, and can be terminated by diazepam and ketamine...
Mon Nov 11, 2019 14:32
Related ArticlesNonperiodic stimulation for the treatment of refractory epilepsy: Applications, mechanisms, and novel insights. Epilepsy Behav. 2019 Nov 05;:106609 Authors: Cota VR, de Oliveira JC, Damázio LCM, Moraes MFD Abstract Electrical stimulation of the central nervous system is a promising alternative for the treatment of pharmacoresistant epilepsy. Successful clinical and experimental stimulation is most usually carried out as continuous trains...
Mon Nov 11, 2019 14:32
Related ArticlesTopographic diversity of structural connectivity in schizophrenia. Schizophr Res. 2019 Nov 06;: Authors: Ruan H, Luo Q, Palaniyappan L, Lu W, Huang CC, Zac Lo CY, Yang AC, Liu ME, Tsai SJ, Lin CP, Feng J Abstract The neurobiological heterogeneity of schizophrenia is widely accepted, but it is unclear how mechanistic differences converge to produce the observed phenotype. Establishing a pathophysiological model that accounts for both neurobiological...
Mon Nov 11, 2019 13:16
Related ArticlesNUT midline carcinoma: Current concepts and future perspectives of a novel tumour entity. Crit Rev Oncol Hematol. 2019 Nov 01;144:102826 Authors: Salati M, Baldessari C, Bonetti LR, Messina C, Merz V, Cerbelli B, Botticelli A Abstract NMC is a recently recognized cancer type hallmarked by chromosomal translocation involving the NUT gene, a catastrophic event leading to fusion oncoprotein responsible for malignant transformation and tumor...
Mon Nov 11, 2019 13:02
Related ArticlesImproving diagnosis of genitourinary cancers: Biomarker discovery strategies through mass spectrometry-based metabolomics. J Pharm Biomed Anal. 2019 Oct 07;178:112905 Authors: Manzi M, Riquelme G, Zabalegui N, Monge ME Abstract The genitourinary oncology field needs integration of results from basic science, epidemiological studies, clinical and translational research to improve the current methods for diagnosis. MS-based metabolomics...
Mon Nov 11, 2019 13:02
Related Articlesdosimetric multicenter planning comparison studies for SBRT: methodology and future perspectives. Int J Radiat Oncol Biol Phys. 2019 Nov 07;: Authors: Giglioli FR, Garibaldi C, Blanck O, Villaggi E, Russo S, Esposito M, Marino C, Stasi M, Mancosu P Abstract In this review a summary of the published literature pertaining to the stereotactic body radiation therapy (SBRT) multiplanning comparison, data sharing strategies, and implementation...
Mon Nov 11, 2019 13:02
Related ArticlesSUMOylation homeostasis in tumorigenesis. Cancer Lett. 2019 Nov 06;: Authors: Xie M, Yu J, Ge S, Huang J, Fan X Abstract Small ubiquitin-like modifier (SUMO), a critical regulatory modification protein, is involved in various biological processes, such as gene expression, genome maintenance and DNA damage repair (DDR). Numerous recent studies have revealed that disturbed SUMOylation and deSUMOylation homeostasis contribute to tumorigenesis....
Mon Nov 11, 2019 13:02
Related ArticlesTargeted Therapy and Immunotherapy: Emerging Biomarkers in Metastatic Melanoma. Pigment Cell Melanoma Res. 2019 Nov 09;: Authors: LoRusso PM, Schalper K, Sosman J Abstract Targeted therapy directed against oncogenic BRAF mutations and immune checkpoint inhibitors have transformed melanoma therapy over the past decade and prominently improved patient outcomes. However, not all patients will respond to targeted therapy or immunotherapy...
Mon Nov 11, 2019 13:02
Related ArticlesSpatial correlation of linear energy transfer and relative biological effectiveness with suspected treatment related toxicities following proton therapy for intracranial tumors. Med Phys. 2019 Nov 09;: Authors: Ödén J, Toma-Dasu I, Witt Nyström P, Traneus E, Dasu A Abstract PURPOSE: The enhanced relative biological effectiveness (RBE) at the end of the proton range might increase the risk of radiation-induced toxicities. This is of special...
Mon Nov 11, 2019 13:02
Related ArticlesEfficiency score from data envelopment analysis can predict the future onset of hypertension and dyslipidemia: A cohort study. Sci Rep. 2019 Nov 08;9(1):16309 Authors: Nakamura S, Narimatsu H, Nakata Y, Sakaguchi M, Konta T, Watanabe M, Ueno Y, Ishizawa K, Yamashita H, Kayama T, Yoshioka T Abstract Primary prevention focuses on ensuring that healthy people remain healthy. As it is practically difficult to provide intervention for an entire...
Mon Nov 11, 2019 13:02
Related ArticlesResults of Tri-Modality Therapy for Rectal Cancer in Elderly Patients. Anticancer Res. 2019 Nov;39(11):6217-6222 Authors: Treder M, Janssen S, Schild SE, Rades D Abstract BACKGROUND/AIM: Elderly cancer patients are more prevalent and require special attention. This study focused on the outcome of elderly (≥65 years) rectal cancer patients treated with tri-modality therapy. PATIENTS AND METHODS: A total of 105 patients receiving...
Mon Nov 11, 2019 13:02
Related ArticlesStatement on advancing the assessment of chemical mixtures and their risks for human health and the environment. Environ Int. 2019 Nov 05;134:105267 Authors: Drakvik E, Altenburger R, Aoki Y, Backhaus T, Bahadori T, Barouki R, Brack W, Cronin MTD, Demeneix B, Hougaard Bennekou S, van Klaveren J, Kneuer C, Kolossa-Gehring M, Lebret E, Posthuma L, Reiber L, Rider C, Rüegg J, Testa G, van der Burg B, van der Voet H, Warhurst AM, van de Water B, Yamazaki K,...
Mon Nov 11, 2019 13:02
Related ArticlesEculizumab and Beyond: The Past, Present, and Future of Complement Therapeutics. Transfus Med Rev. 2019 Oct 22;: Authors: Patriquin CJ, Kuo KHM Abstract Dysregulation of the complement system underlies the pathophysiology of many diseases. Renewed interest in complement occurred with the recognition that its therapeutic inhibition was possible. Terminal complement blockade with the anti-C5 monoclonal antibody eculizumab significantly...
Mon Nov 11, 2019 13:02
Related ArticlesOrganoids of epithelial ovarian cancer as an emerging preclinical in vitro tool: a review. J Ovarian Res. 2019 Nov 08;12(1):105 Authors: Dumont S, Jan Z, Heremans R, Van Gorp T, Vergote I, Timmerman D Abstract Epithelial ovarian cancer (EOC) remains the most lethal gynecological cancer in developed countries, indicating the need for further research. Although current cancer models prove useful, they have major limitations. Organoids,...
Mon Nov 11, 2019 13:02
Related ArticlesCalcium signaling affects migration and proliferation differently in individual cancer cells due to nifedipine treatment. Biochem Pharmacol. 2019 Nov 07;:113695 Authors: Chovancova B, Liskova V, Miklikova S, Hudecova S, Babula P, Penesova A, Sevcikova A, Durinikova E, Novakova M, Matuskova M, Krizanova O Abstract Several papers have reported that calcium channel blocking drugs were associated with increased breast cancer risk and worsened...
Mon Nov 11, 2019 14:54
Related ArticlesEffectiveness and normal tissue toxicity of Auger electron (AE) radioimmunotherapy (RIT) with [111In]In-Bn-DTPA-nimotuzumab in mice with triple-negative or trastuzumab-resistant human breast cancer xenografts that overexpress EGFR. Nucl Med Biol. 2019 Oct 22;: Authors: Chan C, Fonge H, Lam K, Reilly RM Abstract INTRODUCTION: Our objective was to evaluate the effectiveness and normal tissue toxicity of nimotuzumab labeled with the Auger...
Mon Nov 11, 2019 14:54
Related ArticlesHO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies. Breast Cancer Res Treat. 2019 Nov 08;: Authors: Tracey N, Creedon H, Kemp AJ, Culley J, Muir M, Klinowska T, Brunton VG Abstract PURPOSE: Targeted therapies have resulted in major advances in the treatment of HER2-positive breast cancers. Despite this, up to 70% of patients will develop resistance to treatment within 2 years and new strategies for targeting...
Mon Nov 11, 2019 14:54
Related ArticlesA case report of total skin photon radiation therapy for cutaneous epitheliotropic lymphoma in a dog. BMC Vet Res. 2019 Nov 09;15(1):407 Authors: Deveau MA, Sutton M, Baetge C, Diesel AB Abstract BACKGROUND: Total skin electron beam radiation therapy (TSEBT) is an effective treatment for primary diffuse cutaneous lymphomas in humans. While several techniques exist, they all require significant commitment of staff time and resources. In...
Mon Nov 11, 2019 14:35
Related ArticlesPhotobiomodulation effects on head and neck squamous cell carcinoma (HNSCC) in an orthotopic animal model. Support Care Cancer. 2019 Nov 08;: Authors: Barasch A, Li H, Rajasekhar VK, Raber-Durlacher J, Epstein JB, Carroll J, Haimovitz-Friedman A Abstract BACKGROUND: Photobiomodulation (PBM) has shown efficacy in preventing and treating cancer therapy-induced mucositis and dermatitis. However, there is contradictory information regarding...
Mon Nov 11, 2019 14:35
Related ArticlesModulation of radiation-induced oral mucositis (mouse) by dermatan sulfate: effects on differentiation processes. Strahlenther Onkol. 2019 Nov 08;: Authors: Cini N, Gruber S, Arican Alicikus Z, Dörr W Abstract PURPOSE: During head and neck cancer radiotherapy, oral mucositis is the most frequent early side effect. Systemic dermatan sulfate (DS) administration has been shown to significantly decrease oral mucosal radiation reactions during...
Mon Nov 11, 2019 14:35
Related ArticlesImpact of caffeine on metabolic activity and biofilm formation of Candida albicans on acrylic denture resin in the presence of nicotine. J Prosthet Dent. 2019 Nov 05;: Authors: Alfaifi AA, Lin WS, Aldhaian BA, Levon JA, Gregory RL Abstract STATEMENT OF PROBLEM: Candida albicans has been implicated in denture stomatitis, and this effect is exacerbated by nicotine exposure. However, studies have also suggested that caffeine exposure inhibits...
Mon Nov 11, 2019 14:35
Related ArticlesPhase I clinical trial of the combination of eribulin and everolimus in patients with metastatic triple-negative breast cancer. Breast Cancer Res. 2019 Nov 08;21(1):119 Authors: Lee JS, Yost SE, Blanchard S, Schmolze D, Yin HH, Pillai R, Robinson K, Tang A, Martinez N, Portnow J, Wen W, Yim JH, Brauer HA, Ren Y, Luu T, Mortimer J, Yuan Y Abstract BACKGROUND: Alteration of the PI3K/AKT/mTOR pathway is a common genomic abnormality detected...
Mon Nov 11, 2019 14:35
Related ArticlesDetermination of the effects of cinnamon bark fractions on Candida albicans and oral epithelial cells. BMC Complement Altern Med. 2019 Nov 08;19(1):303 Authors: Veilleux MP, Grenier D Abstract BACKGROUND: Candida albicans is an opportunistic pathogen that causes oral candidiasis and denture stomatitis. It has also been reported to infect oral mucositis lesions in patients who suffer from cancer affecting the head and neck and who receive...
Mon Nov 11, 2019 14:35
Related ArticlesThe usage of a lactobacilli probiotic in the non-surgical therapy of peri-implantitis: A randomized pilot study. Clin Oral Implants Res. 2019 Nov 09;: Authors: Laleman I, Pauwels M, Quirynen M, Teughels W Abstract OBJECTIVES: Examine the clinical and microbiological benefits of a dual-strain Lactobacillus reuteri probiotic on the non-surgical therapy of initial peri-implantitis. MATERIALS AND METHODS: This randomized, double-blind...
Mon Nov 11, 2019 14:46
Related ArticlesSleep disordered breathing in Marfan syndrome: Value of standard screening questionnaires. Mol Genet Genomic Med. 2019 Nov 10;:e1039 Authors: Sowho MO, Patil S, Schneider H, MacCarrick G, Kirkness JP, Wolfe LF, Sterni L, Cistulli PA, Neptune ER Abstract BACKGROUND: A high prevalence of sleep disordered breathing (SDB) has been reported in persons with Marfan syndrome (MFS), a single gene disorder of connective tissue resulting in premature...
Mon Nov 11, 2019 13:22
Related ArticlesDo Mandated Weight Loss Goals Prior to Bariatric Surgery Improve Postoperative Outcomes? Obes Surg. 2019 Nov 09;: Authors: Monfared S, Athanasiadis DI, Furiya A, Butler A, Selzer D, Hilgendorf W, Banerjee A, Stefanidis D Abstract BACKGROUND: Most patients pursuing bariatric surgery undergo mandated preoperative weight management programs. The purpose of this study was to assess whether preoperative mandated weight loss goals lead to improved...
Mon Nov 11, 2019 13:22
Related ArticlesCardiovascular Consequences of Obstructive Sleep Apnea. Curr Cardiol Rep. 2019 Nov 09;21(11):137 Authors: Dredla BK, Castillo PR Abstract PURPOSE OF REVIEW: To review the clinical evidence for a relationship between obstructive sleep apnea and hypertension, arrhythmias, coronary artery disease, and congestive heart failure. RECENT FINDINGS: Current data show that obstructive sleep apnea is a risk for cardiovascular disease. Studies...
Mon Nov 11, 2019 13:22
Related ArticlesMetallothionein induction attenuates the progression of lung injury in mice exposed to long-term intermittent hypoxia. Inflamm Res. 2019 Nov 09;: Authors: Lin X, Jagadapillai R, Cai J, Cai L, Shao G, Gozal E Abstract BACKGROUND: Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is prevalent in older adults and associated with inflammation. We previously showed that IH induces renal fibrosis and cardiomyopathy and...
Mon Nov 11, 2019 13:22
Related ArticlesPostural control abnormalities related to sleep deprivation in patients with Marfan Syndrome. J Vestib Res. 2019 Nov 08;: Authors: Micarelli A, Viziano A, Lanzillotta A, Giorgino FM, Pisano C, Ruvolo G, Alessandrini M Abstract BACKGROUND: Marfan syndrome (MFS) is a rare autosomal dominant connective tissue disorder affecting virtually every organ. Sleep disturbances, associated to high collapsibility in upper airways, are common in MFS;...
Mon Nov 11, 2019 13:22
Related ArticlesSIESTA - Home sleep study with BresoDx for obstructive sleep apnea: a randomized controlled trial. Sleep Med. 2019 Jul 22;65:45-53 Authors: Fitzpatrick M, Rac VE, Mitsakakis N, Abrahamyan L, Pechlivanoglou P, Chung S, Carcone SM, Pham B, Kendzerska T, Zwarenstein M, Gottschalk R, George C, Kashgari A, Krahn M Abstract STUDY OBJECTIVES: The objectives of this study were to evaluate (1) the accuracy of the clinical diagnosis of obstructive...
Mon Nov 11, 2019 13:22
Related Articles"Real world assessment of asthma control and severity in children, adolescents, and adults with asthma: Relationships to care settings and co-morbidities". J Allergy Clin Immunol Pract. 2019 Nov 07;: Authors: Nyenhuis SM, Akkoyun E, Liu L, Schatz M, Casale TB Abstract BACKGROUND: Little is known about how patient-level factors and care settings relate to asthma outcomes in real-world settings. OBJECTIVE: We therefore examined...
Mon Nov 11, 2019 13:22
Related ArticlesObstructive sleep apnea syndrome in adults with Down syndrome: causes and consequences. Is it a "chicken and egg" question? Neurosci Biobehav Rev. 2019 Nov 07;: Authors: Dumortier L, Bricout VA Abstract Individuals with Down syndrome present many clinical characteristics, such as metabolic, endocrine, anatomic and neurologic dysfunctions, that contribute to the physiopathology of obstructive sleep apnea syndrome (OSAS). As a result, sleep...
Mon Nov 11, 2019 13:22
Related ArticlesAMPK activation increases postoperative cognitive impairment in intermittent hypoxia rats via direct activating PAK2. Behav Brain Res. 2019 Nov 07;:112344 Authors: Mei X, Tan G, Qing W Abstract The pathogenesis of postoperative cognitive impairment of obstructive sleep apnea-hypopnea syndrome (OSAHS) individuals remains unclear. AMP activated protein kinase (AMPK) is a ubiquitous sensor/effector of cell stresses. Thus we detected the...
Mon Nov 11, 2019 13:22
Related ArticlesPrevalence and neurophysiological correlates of sleep disordered breathing in pediatric type 1 narcolepsy. Sleep Med. 2019 Jul 11;65:8-12 Authors: Filardi M, Demir N, Pizza F, Vandi S, Antelmi E, Noce S, Bruni O, Plazzi G Abstract STUDY OBJECTIVES: To investigate the prevalence and neurophysiological correlates of obstructive sleep disordered breathing (OSA) in type 1 narcolepsy (NT1) children and adolescents. METHODS: Thirty-eight,...
Mon Nov 11, 2019 13:22
Related ArticlesComparative Effectiveness of Sleep Apnea Screening Instruments During Inpatient Rehabilitation Following Moderate to Severe TBI. Arch Phys Med Rehabil. 2019 Nov 06;: Authors: Nakase-Richardson R, Schwartz DJ, Drasher-Phillips L, Ketchum JM, Calero K, Dahdah MN, Monden KR, Bell K, Magalang U, Hoffman J, Whyte J, Bogner J, Zeitzer JM Abstract OBJECTIVE: To determine the diagnostic sensitivity and specificity and comparative effectiveness...
Mon Nov 11, 2019 13:22
Related ArticlesAssociations among sleep symptoms, physical examination, and polysomnographic findings in children with obstructive sleep apnea. Eur Arch Otorhinolaryngol. 2019 Nov 08;: Authors: Yan XH, Zhao Y, Wang J, Shen T, Yang W, Qiao Y, Cheng D, Chen M Abstract PURPOSE: The relationships among PSG findings, OSA symptoms, and tonsil and adenoid size are not clear. In this study, we aimed to investigate the associations between pediatric OSA and...
Mon Nov 11, 2019 13:22
Related ArticlesCoordinated program between primary care and sleep unit for the management of obstructive sleep apnea. NPJ Prim Care Respir Med. 2019 Nov 08;29(1):39 Authors: Mayos M, Peñacoba P, Pijoan AMP, Santiveri C, Flor X, Juvanteny J, Sampol G, Lloberes P, Aoiz JI, Bayó J, Grau N, Fortuna AM, Plaza V, Llauger MA Abstract The purpose of this study is to develop and validate a work model in the primary health-care setting for identifying patients...
Mon Nov 11, 2019 13:22
Related ArticlesOutcomes intensive care unit placement following pediatric adenotonsillectomy. Int J Pediatr Otorhinolaryngol. 2019 Oct 24;129:109736 Authors: Allen DZ, Worobetz N, Lukens J, Sheehan C, Onwuka A, Dopirak RM, Chiang T, Elmaraghy C Abstract INTRODUCTION: Adenotonsillectomy (AT) is the most common surgical procedure for the treatment of sleep related breathing issues in children. While overnight observation in the hospital setting is utilized...
Mon Nov 11, 2019 13:22
Related ArticlesThe spectrum of obstructive sleep apnea in infants and children with Down Syndrome. Int J Pediatr Otorhinolaryngol. 2019 Nov 01;129:109763 Authors: Waters KA, Castro C, Chawla J Abstract OBJECTIVE: Describe the spectrum of OSA across time in infants and children with Down syndrome. METHODS: Retrospective records review of children who underwent formal polysomnography (PSG) in one of two Australian tertiary sleep centres over...
Mon Nov 11, 2019 13:22
Related ArticlesMetabolic disorders and sleep. Cas Lek Cesk. 2019;158(5):185-192 Authors: Pretl M, Lattová Z, Polák AP, Westlake K Abstract Epidemiologic studies show that both atypical sleep time and obstructive sleep apnea (OSA) are independently associated with higher risk of metabolic disease development, particularly obesity and type 2 diabetes mellitus (T2DM). OSA is an independent risk factor for cardiovascular mortality, which is amongst the...
Mon Nov 11, 2019 13:22
Related ArticlesSleep apnea and cardiovascular disease. Cas Lek Cesk. 2019;158(5):178-184 Authors: Ludka O Abstract Sleep is a condition of physiological relaxation for the cardiovascular system, and sleep-disordered breathing disturbs it. Recurrent episodes of sleep apnea disrupt the physiological interactions between sleep and the cardiovascular system. Sleep apnea can affect not only patients quality of life with cardiovascular diseases, but also...
Mon Nov 11, 2019 13:22
Related ArticlesAdvance in sleep medicine and non-invasive ventilation in respiratory medicine. Cas Lek Cesk. 2019;158(5):175-177 Authors: Sova M Abstract Non-invasive ventilation represents one of the milestones in respiratory and sleep medicine. In this article is presented brief history of non-invasive ventilation and overview of different regimes of non-invasive ventilation used in the treatment of patients with obstructive sleep apnoea and chronic...
Mon Nov 11, 2019 13:22
Related ArticlesOtorhinolaryngology and sleep disorders. Cas Lek Cesk. 2019;158(5):170-174 Authors: Betka J, Klozar J, Plzák J Abstract In the field of sleep disorders, otorhinolaryngology is mainly concerned with snoring and obstructive sleep apnea (OSA). Prevalence of OSA is suggested between 14-49 % of male and 5-30 % of female population, which makes it most common sleep disorder. The treatment of choice is positive airway pressure (PAP) therapy...
Mon Nov 11, 2019 13:22
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