ACS Applied Materials& InterfacesDOI: 10.1021/acsami.9b11237 (Source: ACS Applied Materials and Interfaces)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 31, 2019 05:00
ACS NanoDOI: 10.1021/acsnano.9b04676 (Source: ACS Nano)
Thu Oct 31, 2019 05:00
Publication date: Available online 31 October 2019Source: Clinica Chimica ActaAuthor(s): Feihu Chu, Lusha Xue, Haiyan MiaoAbstractLong noncoding RNAs (lncRNAs) play an important role in tumor development. With the development of sequencing technology, many new lncRNAs have been discovered. lncRNA TP73-AS1 is abnormally expressed in many cancers. A summary of the current literature related to TP73-AS1 reveals that TP73-AS1 mainly regulates the occurrence and development of tumors through the mechanism...
Thu Oct 31, 2019 20:35
Transplantation of gene-modified haematopoietic stem cells: Application and clinical considerations.
Authors: Alessandrini M, Krause KH, Speck RF, Pepper MS Abstract Autologous and allogeneic haematopoietic stem cell (HSC) transplantation has been performed in patients with various malignant and non-malignant haematological disorders for more than 50 years. Ex vivo gene modification of HSCs for autologous transplantation opens up new therapeutic avenues for genetic and infectious diseases. Major advances have been made over the last three decades with respect to gene modification of HSCs...
Thu Oct 31, 2019 20:31
We present a rational approach for the use of diagnostic tests during the workup of HIV-infected patients presenting with cytopenia, and discuss how HIV impacts on haematopoietic stem/progenitor cells (HSPCs) resulting in impaired haematopoiesis. Finally, we describe the direct and indirect effects of HIV on HSPCs which result in defective haematopoiesis leading to cytopenias. PMID: 31662148 [PubMed - in process] (Source: South African Medical Journal)
Thu Oct 31, 2019 20:31
Authors: Grobbelaar S, Mercier AE, Verburgh E, Brittain D, Pepper MS Abstract The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. HSCT provides life-changing and potentially curative therapy for a range of pathologies including haematological malignancies; other indications include certain congenital and acquired disorders of the haematopoietic system, autoimmune conditions and hereditary...
Thu Oct 31, 2019 20:31
CONCLUSIONS: FGFR3 and FGFR1 proteins are expressed in a subpopulation of choroid plexus tumors. Further studies using larger cohorts of patients will allow identification of the clinicopathological implications of FGFR1 and FGFR3 expression in choroid plexus tumors. PMID: 31660579 [PubMed - as supplied by publisher] (Source: Histology and Histopathology)
Thu Oct 31, 2019 20:24
In conclusion, dysregulation of miR-195-5p/-218-5p/BIRC5 axis predicts a poor prognosis in patients with gastric cancer. PMID: 31663299 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Thu Oct 31, 2019 20:18
Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Chaoliang Liao, Min Li, Xiang Li, Namei Li, Xu Zhao, Xiaoyi Wang, Yawen Song, Jing Quan, Can Cheng, Jikai Liu, Ann M. Bode, Ya Cao, Xiangjian LuoAbstractLipid metabolic abnormalities have received intensified concerns and increased de novo synthesis of lipids is recognized as a common feature of many human cancers. Nevertheless, the role of lipid metabolism...
Thu Oct 31, 2019 20:08
Authors: Fitzgibbons PL PMID: 31661310 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Oct 31, 2019 19:49
CONCLUSIONS.—: Leiomyosarcoma of bone is a rare but well-recognized primary osseous sarcoma that may arise de novo or in association with radiation. Although it is diagnostically challenging, awareness of this rare sarcoma and knowledge of its key histomorphologic and immunohistochemical features allow for accurate diagnosis. PMID: 31661313 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Thu Oct 31, 2019 19:49
CONCLUSIONS.—: Despite their relative rarity in many surgical pathology practices, sinonasal papillomas and carcinomas frequently demonstrate characteristic morphologic features that are important for accurate diagnosis. Given our emerging understanding of the molecular basis for these tumors, judicious use of available ancillary tools-including immunohistochemistry and in situ hybridization-may be helpful in subsets of cases, whereas additional molecular testing may be useful for diagnostically...
Thu Oct 31, 2019 19:49
In this study, we introduced theHemA1 andpgr7 genes from the higher plantArabidopsis thaliana into recombinantEscherichia coli to overproduce extracellular 5-aminolevulinic acid via the C5 pathway. In theE. coli BL21 (DE3) strain background, the ALA concentration of the strain expressing bothHemA1 andpgr7 was the highest and reached 3080.62 mg/L. Among the 7 tested hosts, ALA production was the highest inE. coli Transetta (DE3). InE. coli Transetta GTR/GBP, the expression levels ofzwf, gnd, pgl...
Thu Oct 31, 2019 00:00
In this study, we demonstrate that HPV E6 is ubiquitinated by E6AP in presence of p53. Crucially, ubiquitination of E6 is important for p53 degradation and blockage of E6 ubiquitination negatively interferes with E6-mediated p53 degradation and enhances the apoptotic effects of p53 and the cytotoxicity of DNA damage in HPV-positive cervical cancer cells. Importantly, our data suggest that the HPV oncogene E6 might be an optimal pharmacologic. (Source: Frontiers in Microbiology)
Thu Oct 31, 2019 00:00
Contributor : Fenghuang ZhanSeries Type : Expression profiling by arrayOrganism : Homo sapiensAnalysis of sorted SP/LC population and a CD138+ main population cells. Results provide insight into which gene is involed in the drug resistance and tumor growth enriches for cancer stem-like cells.Keywords: multiple myeloma, cancer stem cell (Source: GEO: Gene Expression Omnibus)
Thu Oct 31, 2019 05:00
Contributors : Yun-Han Huang ; Joan MassagueSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWe perform ChIPseq, ATACseq, and RNAseq to characterize the role of ID1 in PDA cells. (Source: GEO: Gene Expression Omnibus)
Thu Oct 31, 2019 05:00
Contributors : Antje Wick ; Tobias Kessler ; Michael Platten ; Christoph Meisner ; Michael Bamberg ; Ulrich Herrlinger ; J örg Felsberg ; Astrid Weyerbrock ; Clemens Seidel ; Joachim P Steinbach ; Michael Sabel ; Jan Vesper ; Jürgen Debus ; Felix Sahm ; Jürgen Meixensberger ; Ralf Ketter ; Regine Mayer-Steinacker ; Andreas von Deimling ; Guido Reifenberger ; Michael Weller ; Wolfgang WickSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe data contains Illumina 450k/EPIC array...
Thu Oct 31, 2019 05:00
Contributors : Thiviya Jeyakumar ; David LanglaisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe incidence of colorectal cancer (CRC) is increased in patients afflicted by inflammatory bowel diseases (IBD) The cellular and molecular mechanisms that link chronic inflammation of the gut and increased CRC susceptibility are poorly understood. Risk of IBD is strongly influenced by genetic factors, including the IBD5 locus (5q31), harboring the IRF1 gene. A cause...
Thu Oct 31, 2019 05:00
Contributors : Stephanie Roessler ; Carolina DelatorreSeries Type : Expression profiling by arrayOrganism : Homo sapiensNotch signaling plays a pivotal role in liver development and aberrant Notch signaling may lead to hepatocellular (HCC) or cholangiocellular carcinoma (CCA) development. Using whole exome sequencing of 54 human HCC samples, we discovered 19 somatic missense mutations in 15 different Notch pathway genes affecting 24.6% (14 of 57) of patients. Prediction of functional impact of these...
Thu Oct 31, 2019 05:00
Contributor : nadiah abuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensDrug resistant HCT116 cells were developed and the circular RNA profiles were compared between the cellular RNA and exosomal RNA (Source: GEO: Gene Expression Omnibus)
Thu Oct 31, 2019 05:00
Contributors : Antje Wick ; Tobias Kessler ; Michael Platten ; Christoph Meisner ; Michael Bamberg ; Ulrich Herrlinger ; J örg FElsberg ; Astrid Weyerbrock ; Clemens Seidel ; Joachim P Steinbach ; Michael Sabel ; Jan Esper ; Jürgen Debus ; Felix Sahm ; Jürgen Meixensberger ; Ralf Ketter ; Regine Mayer-Steinacker ; Andreas von Deimling ; Guido Reifenberger ; Michael Weller ; Wolfgang WickSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe data contains Illumina 450k/EPIC array methylation...
Thu Oct 31, 2019 05:00
Contributors : Miyong Yun ; Sung-Hoon KimSeries Type : Expression profiling by arrayOrganism : Homo sapiensCNOT2 depletion partially decreased number of colony in colony forming assay and cell number in proliferation assay for NSCLC cells. Co-treatment with TRAIL and depletion of CNOT2 dramatically declined survival rate and increased apoptosis compared with TRAIL only in TRAIL resistant NSCLC cells. So, to find major signaling molecules in CNOT2 depleted condition of A549 cells, gene expression...
Thu Oct 31, 2019 05:00
[Ghanaian Times] THE 37 Military Hospital has diagnosed a total of 152 cases of breast cancer from January to October this year as compared to 162 cases diagnosed last year. (Source: AllAfrica News: Health and Medicine)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Oct 31, 2019 11:38
Publication date: Available online 31 October 2019Source: Linguistics and EducationAuthor(s): Asta CekaiteAbstractThis paper is a video-ethnographic language socialization study that examines the discursive, linguistic and embodied features of the teachers’ and children's ways of conflict mediation and resolution. The study describes the ways in which young children (three to five-year olds) in several preschools in Sweden are being socialized into the interactional competences and perspective taking...
Thu Oct 31, 2019 14:41
This study describes the phonological skills of Finnish-speaking children at 3;6 and compares them with early lexicon size at 2;0 and lexical ability at 3;6 (N = 67). The children's phonological development was measured using The Finnish Phonology Test. Lexical development was evaluated using the Finnish, long-form version of the Communicative Development Inventory at 2;0 and the Boston naming test at 3;6 At 3;6, all children mastered the vowels and diphthongs fully, and most of the children also...
Tue Oct 29, 2019 00:00
Authors: Overby M, Belardi K, Schreiber J Abstract Canonical babbling and volubility are common indicators of infant vocal development. If either indicator falls below values found in typical infants, it may be an early signal of a developmental disorder. The aim of this retrospective investigation was to examine home videos for the frequency of canonical babbles, age of canonical babbling onset, and overall volubility of eight infants later diagnosed with childhood apraxia of speech and...
Tue Oct 29, 2019 00:00
Authors: D'Ortenzio S, Volpato F Abstract In this paper, we analyse how Italian-speaking children with cochlear implants produce subject and object questions introduced by who and which+NP. The aim of the study is to analyse whether a correlation exists between the accuracy of the responses of an elicitation task of wh-questions and clinical variables (i.e. age of hearing aid fitting; age of cochlear implantation; duration of hearing experience) in a group of children with cochlear implants,...
Tue Oct 29, 2019 00:00
Publication date: Available online 31 October 2019Source: Molecular Aspects of MedicineAuthor(s): Jianhong Liu, Dongpei Li, Hui Luo, Xiao ZhuAbstractCircular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a closed loop structure. These RNAs are produced by pre-mRNA through variable shear processing and are highly conserved. Such highly conserved molecules play an important role in biology, especially in cancer biology. With the development of experimental techniques such as circRNA...
Thu Oct 31, 2019 16:38
Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Imran Khan, J. Matthew Rhett, John P. O'BryanAbstractRAS is the most frequently mutated oncogene in cancer and a critical driver of oncogenesis. Therapeutic targeting of RAS has been a goal of cancer research for>30 years due to its essential role in tumor formation and maintenance. Yet the quest to inhibit this challenging foe has been elusive. Although once considered...
Thu Oct 31, 2019 16:38
Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Neelu Yadav, Raghu Gogada, Jordan O'Malley, Ravi Kumar Gundampati, Srinivas Jayanthi, Sana Hashmi, Ravi Lella, Dianmu Zhang, Jianmin Wang, Rahul Kumar, Suresh Kumar Thallapuranam, Dhyan ChandraAbstractCytochrome c (Cyt c) released from mitochondria interacts with Apaf-1 to form the heptameric apoptosome, which initiates the caspase cascade to execute apoptosis. Although...
Thu Oct 31, 2019 16:38
Publication date: Available online 30 October 2019Source: Advances in Biological RegulationAuthor(s): Javier Arranz-Nicolás, Isabel MéridaAbstractIn the recent years, the arsenal of anti-cancer therapies has evolved to target T lymphocytes and restore their capacity to destroy tumor cells. However, the clinical success is limited, with a large number of patients that never responds and others that ultimately develop resistances. Overcoming the hypofunctional state imposed by solid tumors to T cells...
Thu Oct 31, 2019 16:06
This study elucidates the underlying mechanisms of Copper-TA in PaCa cells. Control and Copper-TA (IC50) treated PaCa cells were processed by next-generation sequencing (NGS) to determine differentially expressed genes using HTG EdgeSeq Oncology Biomarker panel. Ingenuity Pathway Analysis (IPA) was used to identify functional significance of altered genes. The conformational studies for assessing the expression of key regulators and genes were conducted by Western blot and qPCR. IPA identified several...
Thu Oct 31, 2019 15:41
ConclusionStrengthening alcohol policies is a promising prevention strategy for alcohol-related cancer. (Source: Chemico Biological Interactions)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Thu Oct 31, 2019 15:41
ConclusionsPt coated Au NP caused NO-dependent mitochondrial dysfunction and autophagy. Mode of cell death due to NP was much different from ROS-inducing cisplatin.General significancePt coated Au NP offer promising opportunity in cancer therapeutic and warrants advanced study in vivo models of cancer.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Thu Oct 31, 2019 15:41
Publication date: Available online 30 October 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Valéria Barbosa de Souza, Daniel Fábio KawanoBackgroundAurora kinases are essential enzymes for the control of cell cycle. The specific role of aurora kinase A (AURKA) is the regulation of spindle assembly and stability by promoting centrosome maturation and separation. Because AURKA is an essential protein for the normal occurrence of the cycle, mutations and deregulations in...
Thu Oct 31, 2019 15:41
In this study, a set of 40 independent molecular dynamics (MD) simulations of Pgp embedded in cholesterol-rich lipid bilayers are reported, totaling 8 μs, enabling extensive sampling of cholesterol-protein interactions in Pgp. Clustering analyses of the ensemble of cholesterol molecules (∼ 5,740) sampled around Pgp in these simulations reveal specific and asymmetric cholesterol-binding regions formed by the transmembrane (TM) helices TM1-6 and TM8. Notably, not all the putative cholesterol binding...
Thu Oct 31, 2019 15:41
Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Zahra Vaezi, Annalisa Bortolotti, Vincenzo Luca, Giulia Perilli, Maria Luisa Mangoni, Roya Khosravi-Far, Sara Bobone, Lorenzo StellaAbstractHost defense peptides selectively kill bacterial and cancer cells (including those that are drug-resistant) by perturbing the permeability of their membranes, without being significantly toxic to the host. Coulombic interactions between these...
Thu Oct 31, 2019 15:41
Publication date: Available online 30 October 2019Source: Reactive and Functional PolymersAuthor(s): Seyed Jamal Tabatabaei Rezaei, Elnaz Sarijloo, Hamid Rashidzadeh, Sahar Zamani, Ali Ramazani, Ali Hesami, Elham MohammadiAbstractA novel copolymers based on glycidyl azide polymer (GAP) and polyethylene glycol (PEG) with comb-linear-comb architecture were synthesized via atom transfer radical polymerization (ATRP) and then linear GAP segment modified to generate polymers with pendant thiol groups....
Thu Oct 31, 2019 15:39
New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ02990G, PaperXin Fu, Hua-qing Zhang, Jun Zhao, Lu-lu Yu, Qing-rong Liang, Yu Zhang, Xiu-Guang Yi, Yong-xiu Li, Ji-long Hu, Yuan-qiao He, Qun Tang Rare earth arsenite colloids, acting as arsenic trioxide nanoparticle prodrugs, effectively arrested cancer growth in a patient-derived colorectal xenograft model. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society...
Thu Oct 31, 2019 15:38
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