Related ArticlesAuditory cortex responses to interaural time differences in the envelope of low-frequency sound, recorded with MEG in young and older listeners. Hear Res. 2018 12;370:22-39 Authors: Ross B Abstract Interaural time and intensity differences (ITD and IID) are important cues in binaural hearing and allow for sound localization, improving speech understanding in noise and reverberation, and integrating sound sources in the auditory scene....
Tue Nov 19, 2019 13:59
Related ArticlesNeural envelope encoding predicts speech perception performance for normal-hearing and hearing-impaired adults. Hear Res. 2018 12;370:189-200 Authors: Goossens T, Vercammen C, Wouters J, van Wieringen A Abstract Peripheral hearing impairment cannot fully account for speech perception difficulties that emerge with advancing age. As the fluctuating speech envelope bears crucial information for speech perception, changes in temporal envelope...
Tue Nov 19, 2019 13:59
Related ArticlesNew therapeutic targets in pancreatic cancer. Cancer Treat Rev. 2019 Nov 11;81:101926 Authors: Lai E, Puzzoni M, Ziranu P, Pretta A, Impera V, Mariani S, Liscia N, Soro P, Musio F, Persano M, Donisi C, Tolu S, Balconi F, Pireddu A, Demurtas L, Pusceddu V, Camera S, Sclafani F, Scartozzi M Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with poor survival. Of all newly diagnosed patients, only about 20% can benefit from...
Tue Nov 19, 2019 14:53
Related ArticlesPerformance comparison of prediction filters for respiratory motion tracking in radiotherapy. Med Phys. 2019 Nov 18;: Authors: Jöhl A, Ehrbar S, Guckenberger M, Klöck S, Meboldt M, Zeilinger M, Tanadini-Lang S, Schmid Daners M Abstract PURPOSE: In precision radiotherapy, the intrafractional motion causes substantial uncertainty. Traditionally, the target volume is expanded to cover the tumor in all positions. Alternative approaches are...
Tue Nov 19, 2019 14:53
Related ArticlesMULTIOMIC patterns in body fluids: Technological challenge with a great potential to implement the advanced paradigm of 3P medicine. Mass Spectrom Rev. 2019 Nov 18;: Authors: Gerner C, Costigliola V, Golubnitschaja O Abstract Liquid biopsy (LB) is defined as a sample of any of body fluids (blood, saliva, tear fluid, urine, sweat, amniotic, cerebrospinal and pleural fluids, cervicovaginal secretion, and wound efflux, amongst others), which...
Tue Nov 19, 2019 14:53
Related ArticlesCorrelation between cribriform/intraductal prostatic adenocarcinoma and percent Gleason pattern 4 to a 22-gene genomic classifier. Prostate. 2019 Nov 18;: Authors: Taylor AS, Morgan TM, Wallington DG, Chinnaiyan AM, Spratt DE, Mehra R Abstract BACKGROUND: The Decipher test measures expression of 22 RNA biomarkers associated with aggressive prostate cancer used to improve risk stratification of patients to help guide management. To date,...
Tue Nov 19, 2019 14:53
Related ArticlesMulti-Modality Treatment for Patients With Metastatic Gastric Cancer: A Real-World Study in China. Front Oncol. 2019;9:1155 Authors: Zhao L, Li J, Bai C, Nie Y, Lin G Abstract Introduction: People with metastatic gastric cancer (GC) have a poor prognosis. The study aims to investigate the efficacy of multi-modality treatment for patients with metastatic GC. Methods: We retrospectively identified 267 patients with stage IV gastric cancer...
Tue Nov 19, 2019 14:53
Related ArticlesSerum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study. Front Oncol. 2019;9:1095 Authors: Kessler A, Sollie S, Karagiannis SN, Walldius G, Hammar N, Van Hemelrijck M Abstract Background: Relatively little is known about the role of the humoral immune system in melanoma. Tumor infiltrating B cells in melanoma patients have been associated with increased T cell activation in tumors as well as improved patient survival....
Tue Nov 19, 2019 14:53
Related ArticlesLMO4 promotes the invasion and proliferation of gastric cancer by activating PI3K-Akt-mTOR signaling. Am J Transl Res. 2019;11(10):6534-6543 Authors: Wang N, Dong Q, Zhou XN Abstract This study assessed the biological functions of LIM-domain-only 4 (LMO4) in gastric cancer (GC) and investigated the underlying molecular mechanisms. It was found that the expression of LMO4 was significantly upregulated in GC tissues and closely associated...
Tue Nov 19, 2019 14:53
Related ArticlesWhat Is Karyotype Coding and Why Is Genomic Topology Important for Cancer and Evolution? Front Genet. 2019;10:1082 Authors: Ye CJ, Stilgenbauer L, Moy A, Liu G, Heng HH Abstract While the importance of chromosomal/nuclear variations vs. gene mutations in diseases is becoming more appreciated, less is known about its genomic basis. Traditionally, chromosomes are considered the carriers of genes, and genes define bio-inheritance. In recent...
Tue Nov 19, 2019 14:53
Related ArticlesWhat Do Neighbors Tell About You: The Local Context of Cis-Regulatory Modules Complicates Prediction of Regulatory Variants. Front Genet. 2019;10:1078 Authors: Penzar DD, Zinkevich AO, Vorontsov IE, Sitnik VV, Favorov AV, Makeev VJ, Kulakovskiy IV Abstract Many problems of modern genetics and functional genomics require the assessment of functional effects of sequence variants, including gene expression changes. Machine learning is considered...
Tue Nov 19, 2019 14:53
Related ArticlesThe Utility of PET/Computed Tomography for Radiation Oncology Planning, Surveillance, and Prognosis Prediction of Gastrointestinal Tumors. PET Clin. 2020 Jan;15(1):77-87 Authors: Rice SR, Chuong M, Koroulakis A, Siddiqui OM, Sharma AM, Simone CB, Molitoris JK, Kaiser A Abstract At present, the strongest evidence for the use of PET/computed tomography (CT) in gastrointestinal (GI) malignancies is to rule out distant metastatic disease...
Tue Nov 19, 2019 13:53
Related ArticlesThe Role of Positron Emission Tomography Imaging in Radiotherapy Target Delineation. PET Clin. 2020 Jan;15(1):45-53 Authors: Menon H, Guo C, Verma V, Simone CB Abstract Positron emission tomography (PET) is an advanced functional imaging modality in oncology care for the diagnosis, staging, prognostication, and surveillance of numerous malignancies. PET can also offer considerable advantages for target volume delineation as part of radiation...
Tue Nov 19, 2019 13:53
Related ArticlesAdherence to Home-Based Rehabilitation in Older Adults With Diabetes After Hip Fracture. Nurs Res. 2019 Sep/Oct;68(5):383-389 Authors: Kuo WY, Shyu YL, Wang JS, Chen MC, Wu CC, Chen ML Abstract BACKGROUND: Adherence to rehabilitation is beneficial to patients with hip fracture. However, the relationships between different levels of adherence and postoperative recovery among older adults after hip fracture have not been addressed thoroughly...
Tue Nov 19, 2019 13:53
Related ArticlesRelationship between intestinal microorganisms and T lymphocytes in colorectal cancer. Future Oncol. 2019 May;15(14):1655-1666 Authors: Shuwen H, Xi Y, Quan Q, Yuefen P, Miao D, Qing Z Abstract Colorectal cancer (CRC) is a common type of malignant cancer worldwide. Recent studies have identified the gut microbiota as the origin of CRC, and T lymphocyte-mediated immune functions have been shown to play an important role in this disease....
Tue Nov 19, 2019 13:53
Related ArticlesAssessment of the response of hepatocellular carcinoma to interventional radiology treatments. Future Oncol. 2019 May;15(15):1791-1804 Authors: Patella F, Pesapane F, Fumarola E, Zannoni S, Brambillasca P, Emili I, Costa G, Anderson V, Levy EB, Carrafiello G, Wood BJ Abstract According to Barcelona Clinic Liver Cancer (BCLC) guidelines, interventional radiology procedures are valuable treatment options for many hepatocellular carcinomas...
Tue Nov 19, 2019 13:53
Related ArticlesRelationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews. Prostaglandins Leukot Essent Fatty Acids. 2019 Oct 11;151:14-36 Authors: Hibbeln CJR, Spiller P, Brenna JT, Golding J, Holub BJ, Harris WS, Kris-Etherton P, Lands B, Connor SL, Myers G, Strain JJ, Crawford MA, Carlson SE Abstract Abundant data are now available to evaluate relationships between seafood consumption...
Tue Nov 19, 2019 15:49
Related ArticlesComplications of craniofacial surgery using the ultrasonic-assisted pinned resorbable system: A prospective report with a minimum follow-up of 30 months. J Plast Reconstr Aesthet Surg. 2019 Oct 11;: Authors: Nakajima Y, Sakamoto Y, Miwa T, Yoshida K, Kishi K Abstract Several resorbable fixation systems are used for osteosynthesis in craniofacial surgery. Recently, ultrasonic-assisted pinned resorbable systems have been introduced; however,...
Tue Nov 19, 2019 13:52
Related ArticlesStatement of Retraction. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4273 Authors: PMID: 31738581 [PubMed - in process]
Tue Nov 19, 2019 15:49
Related ArticlesKRas-ERK signalling promotes the onset and maintenance of uveal melanoma through regulating JMJD6-mediated H2A.X phosphorylation at tyrosine 39. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4257-4265 Authors: Li Y, Yu P, Zou Y, Cai W, Sun W, Han N Abstract Since DNA damage is a first incident occurred during a tumour attack, it is rational that histone H2A.X phosphorylation on tyrosine 39 (H2A.XY39ph) may act as a tumour-relevant factor....
Tue Nov 19, 2019 15:49
Related ArticlesDynamic pituitary-adrenal interactions in the critically ill after cardiac surgery. J Clin Endocrinol Metab. 2019 Nov 18;: Authors: Gibbison B, Keenan DM, Roelfsema F, Evans J, Phillips K, Rogers CA, Angelini GD, Lightman SL Abstract CONTEXT: Patients with critical illness are thought to be at risk of adrenal insufficiency. There are no models of dynamic hypothalamic-pituitary-adrenal (HPA) axis function in this group of patients and...
Tue Nov 19, 2019 15:52
Related ArticlesOutcomes of patients with Nelson's syndrome after primary treatment: a multicenter study from 13 UK Pituitary centers. J Clin Endocrinol Metab. 2019 Nov 18;: Authors: Fountas A, Lim ES, Drake WM, Powlson AS, Gurnell M, Martin NM, Seejore K, Murray RD, MacFarlane J, Ahluwalia R, Swords F, Ashraf M, Pal A, Chong Z, Freel M, Balafshan T, Purewal TS, Speak RG, Newell-Price J, Higham CE, Hussein Z, Baldeweg SE, Dales J, Reddy N, Levy MJ, Karavitaki N ...
Tue Nov 19, 2019 13:48
Related ArticlesNovel Therapeutic Strategy Using Interventional Radiology (IVR) for Hepatitis C Virus (HCV)-Related Decompensated Liver Cirrhosis: A Case Report. Am J Case Rep. 2019 Nov 18;20:1699-1704 Authors: Iwamoto T, Saeki I, Hidaka I, Ishikawa T, Takami T, Sakaida I Abstract BACKGROUND The appearance of direct acting antivirals (DAAs) has produced a major paradigm shift in hepatitis C virus (HCV) infection treatment, and virus elimination has become...
Tue Nov 19, 2019 15:45
Related ArticlesPort-Site Implantation Diagnosed by Iodine-131 Post-Ablation Single-Photon Emission Tomography-Computed Tomography After Robotic Thyroidectomy: A Case Report. Am J Case Rep. 2019 Nov 18;20:1695-1698 Authors: Kim MR, Jo S, Shim HK Abstract BACKGROUND Robotic thyroidectomy using remote access approaches is currently regarded as the optimal surgical protocol for highly selected patients. This approach has excellent cosmetic outcomes compared...
Tue Nov 19, 2019 13:47
Related ArticlesTreating Clinically Node-Negative Insular Thyroid Carcinoma without Prophylactic Central Compartment Neck Dissection Is Associated with Decreased Survival Regardless of T Staging and Administration of Radioactive Iodine Therapy: The First Evidence. Int J Endocrinol. 2019;2019:3078012 Authors: Yu PC, Shi X, Ma B, Li CW, Tan LC, Hu WP, Wang Y, Wei WJ, Wang YL, Ji QH Abstract For the rare but aggressive insular thyroid carcinoma (ITC), there's...
Tue Nov 19, 2019 15:49
Related ArticlesRadiofrequency Coblation-Assisted Resection of Skull Base Neoplasms Using an Endoscopic Endonasal Approach. ORL J Otorhinolaryngol Relat Spec. 2019 Nov 18;:1-9 Authors: Zhang L, Shi H, Li D, Ye H, Zhang W, Yin S Abstract OBJECTIVES: We describe our early experiences with resecting skull base tumors using a radiofrequency ablation-assisted endoscopic endonasal approach. Ninety-seven patients with skull base tumors who were admitted to...
Tue Nov 19, 2019 15:42
Related ArticlesThe Relationship Between the Pneumatization Patterns of the Frontal Sinus, Crista Galli and Nasal Septum: A Tomography Study. Turk Neurosurg. 2019 Jul 12;: Authors: Acar G, Cicekcibasi AE, Koplay M, Kelesoglu KS Abstract AIM: From a surgical point of view, the pneumatization patterns of the frontal sinus, crista galli and nasal septum are crucial as they are in close localization and the communication between them can cause dissemination...
Tue Nov 19, 2019 13:41
Related ArticlesTreatment of Traumatic Depressed Compound Skull Fractures. J Craniofac Surg. 2019 Oct;30(7):2239-2244 Authors: Shao X, Wang Q, Shen J, Liu J, Chen S, Jiang X Abstract BACKGROUND: A skull fracture widely occurs in patients with traumatic brain injury, leading to intracranial hematoma, brain contusion, and intracranial infection. It also influences the prognosis and death of patients. This study aimed to discuss cases of patients with...
Tue Nov 19, 2019 13:41
Related ArticlesSynthesis and in vitro cytotoxicity evaluation of star-shaped polymethacrylic conjugates with methotrexate or acitretin as potential antipsoriatic prodrugs. Eur J Pharmacol. 2019 Nov 15;:172804 Authors: Mielanczyk A, Mrowiec K, Kupczak M, Mielanczyk Ł, Scieglinska D, Gogler-Piglowska A, Michalski M, Gabriel A, Neugebauer D, Skonieczna M Abstract Water-soluble polymer-drug conjugates were obtained and analyzed towards their potential use...
Tue Nov 19, 2019 14:32
Related ArticlesUpregulation of microRNA-143-3p induces apoptosis and suppresses proliferation, invasion, and migration of papillary thyroid carcinoma cells by targeting MSI2. Exp Mol Pathol. 2019 Nov 15;:104342 Authors: Wang ZL, Wang C, Liu W, Ai ZL Abstract As a tumor-associated biological molecule, microRNA-143-3p (miR-143-3p) is implicated in the progression of papillary thyroid carcinoma (PTC). We conducted this study to elucidate the effects of...
Tue Nov 19, 2019 14:32
Related ArticlesPopulation-specific metabolic alterations in professional antigen-presenting cells contribute to sepsis-associated immunosuppression. Shock. 2019 Feb 26;: Authors: Schenz J, Tamulyte S, Nusshag C, Brenner T, Poschet G, Weigand MA, Uhle F Abstract Sepsis is a complex host response triggered by an infection, with the patient's immune system between hyper- and hypo-responsiveness being the main reason for the syndromes' development and propagation....
Tue Nov 19, 2019 14:32
Related ArticlesHistone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers. Adv Biomed Res. 2019;8:63 Authors: Sanaei M, Kavoosi F Abstract Epigenetic modifications such as histone modification play an important role in tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key role in cancer induction and progression by histone deacetylation. Besides, histone acetylation is...
Tue Nov 19, 2019 14:32
Related ArticlesMicroRNA-181 inhibits the proliferation, drug sensitivity and invasion of human glioma cells by targeting Selenoprotein K (SELK). Am J Transl Res. 2019;11(10):6632-6640 Authors: Xu CH, Xiao LM, Zeng EM, Chen LK, Zheng SY, Li DH, Liu Y Abstract Gliomas are aggressive type of brain tumors and cause significant human mortality world over. The frequent relapses, development of drug resistance, the adverse effects of the chemotherapy and dearth...
Tue Nov 19, 2019 14:32
Related ArticlesAngiopoietin-like protein 2 is an important facilitator of tumor proliferation, metastasis, angiogenesis and glycolysis in osteosarcoma. Am J Transl Res. 2019;11(10):6341-6355 Authors: Wang X, Hu Z, Wang Z, Cui Y, Cui X Abstract Background: Solid tumors are often exposed to hypoxia. Hypoxia inducible factor (HIF-1α) upregulates numerous target genes associated with the malignant behavior of hypoxic cancer cells. Angiopoietin-like protein...
Tue Nov 19, 2019 14:32
Related ArticlesMatrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response. Oxid Med Cell Longev. 2019;2019:1045345 Authors: You L, Yang C, Du Y, Liu Y, Chen G, Sai N, Dong X, Yin X, Ni J Abstract Matrine, an alkaloid isolated from Sophora flavescens, possesses a wide range of pharmacological properties. However, the use of matrine in clinical practice is limited due to...
Tue Nov 19, 2019 14:32
Related ArticlesOncogenic Wnt3a: A Candidate Specific Marker and Novel Molecular Target for Hepatocellular Carcinoma. J Cancer. 2019;10(23):5862-5873 Authors: Zheng W, Yao M, Fang M, Pan L, Wang L, Yang J, Dong Z, Yao D Abstract Background and aim: It is of the utmost importance for the specific diagnosis and effective therapy of hepatocellular carcinoma (HCC). Abnormality of oncogenic Wingless-type MMTV integration site family member 3a (Wnt3a) has...
Tue Nov 19, 2019 14:32
Related ArticlesAberrant Scinderin Expression Correlates With Liver Metastasis and Poor Prognosis in Colorectal Cancer. Front Pharmacol. 2019;10:1183 Authors: Lin Q, Li J, Zhu D, Niu Z, Pan X, Xu P, Ji M, Wei Y, Xu J Abstract Many genes and mutations have been reported for colorectal cancer (CRC); however, very few have been associated with colorectal cancer liver metastasis (CRLM). We performed gene expression profiling experiments to identify genetic...
Tue Nov 19, 2019 14:32
Related ArticlesOnoseriolide, from Hedyosmum racemosum, induces cytotoxicity and apoptosis in human colon cancer cells. Nat Prod Res. 2019 Nov 18;:1-5 Authors: Guamán-Ortiz LM, Bailon-Moscoso N, Morocho V, Vega-Ojeda D, Gordillo F, Suárez AI Abstract The number of colon cancer patients is increasing, and new alternatives for treatment are important. We focused on the sesquiterpene lactone onoseriolide from Hedyosmum racemosum, which is widely used in...
Tue Nov 19, 2019 14:32
Related ArticlesDownregulation of oncogenic gene TGFβR2 by miRNA-107 suppresses non-small cell lung cancer. Pathol Res Pract. 2019 Oct 12;:152690 Authors: Wu Z, Yuan Q, Yang C, Zhang X, Qi P, Huang H, Ma Z Abstract Non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancer cases with a low 5-year survival rate. MicroRNA may be targeted in the clinical treatment of the disease. In this study, miR-107 showed low expression in NSCLC serum...
Tue Nov 19, 2019 13:34
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