Related ArticlesImmune checkpoint inhibitor-induced sarcoidosis-like granulomas. Int J Clin Oncol. 2019 Oct;24(10):1171-1181 Authors: Rambhia PH, Reichert B, Scott JF, Feneran AN, Kazakov JA, Honda K, Koon H, Gerstenblith MR Abstract Immune checkpoint inhibitors targeting the cytotoxic T lymphocyte-associated antigen-4 and programmed cell death-1 receptors have transformed the treatment of melanoma and other cancers. These therapies are associated with...
Tue Nov 19, 2019 13:34
Related ArticlesCyclin D1 regulates osteoarthritis chondrocyte apoptosis via WNT3/β-catenin signalling. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1971-1977 Authors: Chen YY, Chen Y, Wang WC, Tang Q, Wu R, Zhu WH, Li D, Liao LL Abstract Objective: Cyclin D1 was an important molecular involved in the pathological process of osteoarthritis (OA). The purpose of this study was to identify the effect and potential mechanism of Cyclin D1 for the proliferation...
Tue Nov 19, 2019 13:34
Related ArticlesOverexpression of miR-335 inhibits the migration and invasion of osteosarcoma by targeting SNIP1. Int J Biol Macromol. 2019 Jul 15;133:137-147 Authors: Xie Y, Deng H, Wei R, Sun W, Qi Y, Yao S, Cai L, Wang Y, Deng Z Abstract MicroRNAs (miRNAs) are key regulators in the development and progression of osteosarcoma (OS). Based on our previous microarray data, we found that miR-335 expression was downregulated in OS tissue relative to normal...
Tue Nov 19, 2019 13:34
Related ArticlesLncRNA DCST1-AS1 functions as a competing endogenous RNA to regulate FAIM2 expression by sponging miR-1254 in hepatocellular carcinoma. Clin Sci (Lond). 2019 01 31;133(2):367-379 Authors: Chen J, Wu D, Zhang Y, Yang Y, Duan Y, An Y Abstract Long non-coding RNAs (lncRNAs) play important roles in a variety of tumours; however, their biological function and clinical significance in hepatocellular carcinoma (HCC) are still unclear. In the...
Tue Nov 19, 2019 13:34
Related ArticlesLabeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[18F]Fluoronicotinate Resulting in High Tumor-to-Kidney Ratios. Mol Pharm. 2019 01 07;16(1):214-226 Authors: Zhou Z, McDougald D, Devoogdt N, Zalutsky MR, Vaidyanathan G Abstract ImmunoPET agents are being investigated to assess the status of epidermal growth factor receptor 2 (HER2) in breast cancer patients with the goal of selecting those...
Tue Nov 19, 2019 13:34
Related Articles6-MOMIPP, a novel brain-penetrant anti-mitotic indolyl-chalcone, inhibits glioblastoma growth and viability. Cancer Chemother Pharmacol. 2019 02;83(2):237-254 Authors: Du S, Sarver JG, Trabbic CJ, Erhardt PW, Schroering A, Maltese WA Abstract PURPOSE: 3-(6-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one (6-MOMIPP) is a novel indole-based chalcone that disrupts microtubules. The present study aims to define the mechanism...
Tue Nov 19, 2019 13:34
Related ArticlesRole of IL-17RA in the proliferative priming of hepatocytes in liver regeneration. Cell Cycle. 2018;17(21-22):2423-2435 Authors: Piobbico D, Bartoli D, Pieroni S, De Luca A, Castelli M, Romani L, Servillo G, Della-Fazia MA Abstract A tight link has been established between inflammation and cancer. Liver regeneration is a widely used model to study the correlation between inflammation and proliferation. IL-6 is essentially involved in...
Tue Nov 19, 2019 13:34
Related ArticlesResveratrol as an adjuvant for normal tissues protection and tumor sensitization. Curr Cancer Drug Targets. 2019 Oct 19;: Authors: Mortezaee K, Najafi M, Farhood B, Ahmadi A, Shabeeb D, Musa AE Abstract Cancer is one of the most complicated diseases in present day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for treatment of cancer with low side effects are...
Tue Nov 19, 2019 16:29
Related ArticlesEffects of Intermittent Hypoxia on Expression of Glucose Metabolism Genes in MCF7 Breast Cancer Cell line. Curr Cancer Drug Targets. 2019 Nov 15;: Authors: Jarrar Y, Zihlif M, Bawab A, Sharab A Abstract BACKGROUND: Hypoxic condition induces molecular alterations which affect the survival rate and chemo-resistant phenotype of cancer cells. OBJECTIVE: This study aimed to investigate the influence of intermittent hypoxic condition...
Tue Nov 19, 2019 16:29
Related ArticlesNovel mechanistic insights into the anti-cancer mode of arsenic trioxide. Curr Cancer Drug Targets. 2019 Oct 21;: Authors: Wahiduzzaman M, Ota A, Hosokawa Y Abstract Arsenic, a naturally-occurring toxic element, and a traditionally-used drug, has caught a great deal of attention from worldwide people due to its curable anti-cancer effect in patients with acute promyelocytic leukemia (APL). Among the arsenicals, arsenic trioxide (ATO)...
Tue Nov 19, 2019 16:29
Related ArticlesWell-defined graphene oxide as a potential component in lung cancer therapy. Curr Cancer Drug Targets. 2019 Oct 21;: Authors: Zuchowska A, Jastrzebska E, Mazurkiewicz-Pawlicka M, Malolepszy A, Stobinski L, Trzaskowski M, Brzozka Z Abstract BACKGROUND: Graphene oxide (GO) has unique physical and chemical properties that can be used in anticancer therapy - especially as a drug carrier. Graphene oxide due to the presence of several hybrid...
Tue Nov 19, 2019 16:29
Related ArticlesUltrastructural study of adult Haemonchus contortus exposed to polyphenol-rich materials under in vivo conditions in goats. Parasite. 2019;26:65 Authors: Martínez-Ortiz-de-Montellano C, Torres-Acosta JFJ, Fourquaux I, Sandoval-Castro CA, Hoste H Abstract This study assessed the ultrastructural changes caused in adult Haemonchus contortus obtained from goats fed fodder based on polyphenol-rich plants Lysiloma latisiliquum or Onobrychis...
Tue Nov 19, 2019 17:35
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Front Oncol"[jour] These pubmed results were generated on 2019/11/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Nov 19, 2019 13:29
Related ArticlesThe Nerve to Thyrohyoid Muscle as a Novel Donor Nerve for Laryngeal Reinnervation. Ann Otol Rhinol Laryngol. 2019 Nov 18;:3489419888956 Authors: Graham ME, Smith ME Abstract OBJECTIVES: Recurrent laryngeal nerve (RLN) injury may be a consequence of surgical procedures of the skull base, neck, and chest, with adverse consequences to function and quality of life. Laryngeal reinnervation offers a potentially stable improvement in vocal fold...
Tue Nov 19, 2019 13:29
Related ArticlesIdentifying Disadvantaged Groups for Cochlear Implantation: Demographics from a Large Cochlear Implant Program. Ann Otol Rhinol Laryngol. 2019 Nov 18;:3489419888232 Authors: Tolisano AM, Schauwecker N, Baumgart B, Whitson J, Kutz JW, Isaacson B, Hunter JB Abstract OBJECTIVE: To identify demographic predictors of patients undergoing cochlear implantation evaluation and surgery. METHODS: Consecutive adult patients between 2009...
Tue Nov 19, 2019 13:29
Related ArticlesDifferential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes. Drug Chem Toxicol. 2019 Nov 17;:1-6 Authors: Chen GW, Chen TY, Yang PM Abstract In recent years, herbal tea consumption becomes popular because of the potential health benefits and attractive flavors. However, there is also a growing concern that herbal supplements contribute to the drug-drug/drug-herb...
Tue Nov 19, 2019 15:32
Related ArticlesPrognostic and predictive factors on overall survival and surgical outcomes in pancreatic neuroendocrine tumors: recent advances and controversies. Expert Rev Anticancer Ther. 2019 Nov 18;: Authors: Lee L, Ito T, Jensen RT Abstract Introduction: Recent advances in diagnostic modalities and therapeutic agents have raised the importance of prognostic factors in predicting overall survival, as well as predictive factors for surgical outcomes,...
Tue Nov 19, 2019 16:25
Related ArticlesParent report of children's sleep disordered breathing symptoms and limited academic progress in reading, writing, and math. Sleep Med. 2019 Aug 02;65:105-112 Authors: Harding R, Haszard JJ, Schaughency E, Drummond B, Galland B Abstract OBJECTIVES: To estimate via questionnaire within a population sample of New Zealand (NZ) children aged 6-to-10 years, the prevalence of sleep disordered breathing (SDB) and those struggling academically,...
Tue Nov 19, 2019 15:20
Related ArticlesPrognostic value of lymph node ratio in non-small-cell lung cancer: a meta-analysis. Jpn J Clin Oncol. 2019 Nov 18;: Authors: Zhou J, Lin Z, Lyu M, Chen N, Liao H, Wang Z, Hao J, Yan C, Liu L Abstract BACKGROUND: This meta-analysis aimed to investigate the prognostic value of lymph node ratio in non-small-cell lung cancer. METHODS: We searched systematically for eligible studies in PubMed, Web of Science, Medline (via Ovid) and...
Tue Nov 19, 2019 13:23
Related ArticlesA comparison of liquid-based and conventional cytology using data for cervical cancer screening from the Japan Cancer Society. Jpn J Clin Oncol. 2019 Nov 18;: Authors: Ito K, Kimura R, Konishi H, Ozawa N, Yaegashi N, Ohashi Y, Suzuki M, Kakizoe T Abstract OBJECTIVE: Liquid-based cytology has replaced conventional cytology in cervical cancer screening in many countries. However, a detailed comparison of liquid-based cytology with conventional...
Tue Nov 19, 2019 13:23
Related ArticlesIn Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages. J Vis Exp. 2019 Nov 01;(153): Authors: Zhang Y, Rayner BS, Jensen M, Hawkins CL Abstract The release of extracellular traps (ETs) by neutrophils has been identified as a contributing factor to the development of diseases related to chronic inflammation. Neutrophil ETs (NETs) consist of a mesh of DNA, histone proteins,...
Tue Nov 19, 2019 14:22
Related ArticlesLabeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin. J Vis Exp. 2019 Nov 01;(153): Authors: Maiti P, Plemmons A, Bowers Z, Weaver C, Dunbar G Abstract Deposition of amyloid beta protein (Aβ) in extra- and intracellular spaces is one of the hallmark pathologies of Alzheimer's disease (AD). Therefore, detection of the presence of Aβ in AD brain tissue is a valuable tool for developing new treatments...
Tue Nov 19, 2019 14:22
Related ArticlesMurine Cervical Aortic Transplantation Model using a Modified Non-Suture Cuff Technique. J Vis Exp. 2019 Nov 02;(153): Authors: Ryll M, Bucher J, Drefs M, Bösch F, Kumaraswami K, Schiergens T, Niess H, Schoenberg M, Jacob S, Rentsch M, Guba M, Werner J, Andrassy J, Thomas MN Abstract With the introduction of powerful immunosuppressive protocols, distinct advances are possible in the prevention and therapy of acute rejection episodes....
Tue Nov 19, 2019 14:22
Related ArticlesHemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors. J Vis Exp. 2019 Nov 04;(153): Authors: Silvério-Alves R, Gomes AM, Kurochkin I, Moore KA, Pereira CF Abstract The cellular and molecular mechanisms underlying specification of human hematopoietic stem cells (HSCs) remain elusive. Strategies to recapitulate human HSC emergence in vitro are required to overcome limitations in studying this complex...
Tue Nov 19, 2019 14:22
Related ArticlesGenetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit. J Vis Exp. 2019 Oct 31;(152): Authors: Gale GAR, Schiavon Osorio AA, Puzorjov A, Wang B, McCormick AJ Abstract Cyanobacteria are a diverse group of prokaryotic photosynthetic organisms that can be genetically modified for the renewable production of useful industrial commodities. Recent advances in synthetic biology have led to development...
Tue Nov 19, 2019 14:22
Related ArticlesA Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development. J Vis Exp. 2019 Oct 29;(152): Authors: Khaliullin RN, Hendel JM, Gerson-Gurwitz A, Wang S, Ochoa SD, Zhao Z, Desai A, Oegema K, Green RA Abstract C. elegans is the premier system for the systematic analysis of cell fate specification and morphogenetic events during embryonic development. One challenge is that embryogenesis...
Tue Nov 19, 2019 14:22
Related ArticlesMeasuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry. J Vis Exp. 2019 Oct 30;(152): Authors: Wong V, Arumugam P, Wrenshall LE Abstract The ability of a cell to proliferate is integral to the normal function of most cells, and dysregulation of proliferation is at the heart of many disease processes. For these reasons, measuring proliferation is a common tool used to assess cell function. Cell proliferation can...
Tue Nov 19, 2019 14:22
Related ArticlesCustomizing a Cryolite Glass Prosthetic Eye. J Vis Exp. 2019 Oct 31;(152): Authors: Rokohl AC, Trester M, Mor JM, Loreck N, Koch KR, Heindl LM Abstract In Germany, Austria, and Switzerland, over 90% of ocularists still manufacture customized prostheses using cryolite glass from Thuringia. The present manuscript demonstrates this long-forgotten technique in detail. This manuscript shows some major advantages of manufacturing prosthetic...
Tue Nov 19, 2019 14:22
Related ArticlesThree-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization. J Vis Exp. 2019 Oct 29;(152): Authors: Bratton BP, Barton B, Morgenstein RM Abstract The shape of a bacterium is important for its physiology. Many aspects of cell physiology such as cell motility, predation, and biofilm production can be affected by cell shape. Bacterial cells are three-dimensional (3D) objects, although...
Tue Nov 19, 2019 14:22
Related ArticlesProspecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation. J Vis Exp. 2019 Oct 31;(152): Authors: Villela HDM, Vilela CLS, Assis JM, Varona N, Burke C, Coil DA, Eisen JA, Peixoto RS Abstract Pollution affects all biomes. Marine environments have been particularly impacted, especially coral reefs, one of the most sensitive ecosystems on Earth. Globally, 4.5 billion people are...
Tue Nov 19, 2019 14:22
Related ArticlesUsing Flight Mills to Measure Flight Propensity and Performance of Western Corn Rootworm, Diabrotica virgifera virgifera (LeConte). J Vis Exp. 2019 Oct 29;(152): Authors: Yu EY, Gassmann AJ, Sappington TW Abstract The western corn rootworm, Diabrotica virgifera virgifera (LeConte) (Coleoptera: Chrysomelidae), is an economically important pest of corn in the northern United States. Some populations have developed resistance to management...
Tue Nov 19, 2019 14:22
Related ArticlesStatistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms. J Vis Exp. 2019 Nov 01;(153): Authors: Keogh C, Pini G, Gemo I, Tropea D Abstract Non-invasive electrophysiological recordings are useful for the evaluation of nervous system function. These techniques are inexpensive, fast, replicable, and less resource-intensive than imaging. Further, the functional data produced have excellent temporal resolution,...
Tue Nov 19, 2019 14:22
Related ArticlesA Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice. J Vis Exp. 2019 Nov 02;(153): Authors: Wiinholt A, Jørgensen MG, Bučan A, Dalaei F, Sørensen JA Abstract Animal models are of paramount importance in the research of lymphedema in order to understand the pathophysiology of the disease but also to explore potential treatment options. This mouse model allows researchers to induce significant lymphedema lasting at...
Tue Nov 19, 2019 14:22
Related ArticlesPreparation of Binary and Ternary Deep Eutectic Systems. J Vis Exp. 2019 Oct 31;(152): Authors: Meneses L, Santos F, Gameiro AR, Paiva A, Duarte ARC Abstract The preparation of deep eutectic systems (DES) is a priori a simple procedure. By definition, two or more components are mixed together at a given molar ratio to form a DES. However, from our experience in the laboratory, there is a need to standardize the procedure to prepare, characterize...
Tue Nov 19, 2019 14:22
Related ArticlesIntrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System. J Vis Exp. 2019 Oct 29;(152): Authors: Chen Y, Mazur C, Luo Y, Sun L, Zhang M, McCampbell A, Tomassy GS Abstract The blood brain barrier (BBB) is an important defense against the entrance of potentially toxic or pathogenic agents from the blood into the central nervous system (CNS). However, its existence also dramatically lowers the accessibility of...
Tue Nov 19, 2019 14:22
Related ArticlesAnalysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze. J Vis Exp. 2019 Oct 29;(152): Authors: Tian H, Ding N, Guo M, Wang S, Wang Z, Liu H, Yang J, Li Y, Ren J, Jiang J, Li Z Abstract A Morris water maze (MWM) experiment forces experimental animals to swim and learn to find a platform hidden in the water. It is widely used in scientific research to assess the learning and memory of animals....
Tue Nov 19, 2019 14:22
Related ArticlesIsolation and Characterization of Extracellular Vesicles Produced by Iron-limited Mycobacteria. J Vis Exp. 2019 Oct 31;(152): Authors: Gupta S, Marcela Rodriguez G Abstract Mycobacteria, including Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, naturally release extracellular vesicles (EVs) containing immunologically active molecules. Knowledge regarding the molecular mechanisms of vesicle biogenesis, the...
Tue Nov 19, 2019 14:22
Related ArticlesA Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model. J Vis Exp. 2019 Oct 30;(152): Authors: Jones B, Hitchcock S, Loza M, Malaviya R, Ort T, Shen F Abstract Profiling molecular changes in local tissues is crucial to understand the mechanism(s) of action of therapeutic candidates in vivo. In the field of arthritis research, many studies are...
Tue Nov 19, 2019 14:22
Related ArticlesPalatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents. J Vis Exp. 2019 Nov 01;(153): Authors: Leigh SJ, Kendig MD, Morris MJ Abstract Obesity is rapidly increasing in incidence in developed and developing countries and is known to induce or exacerbate many diseases. The health burden of obesity and its comorbid conditions highlight the need for better understanding of its pathogenesis,...
Tue Nov 19, 2019 14:22
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