by Sahand Khakabimamaghani, Dujian Ding, Oliver Snow, Martin Ester Cancer is driven by genetic mutations that dysregulate pathways important for proper cell function. Therefore, discovering these cancer pathways and their dysregulation order is key to understanding and treating cancer. However, the heterogeneity of mutations between different individuals makes th is challenging and requires that cancer progression is studied in a subtype-specific way. To address this challenge, we provide a mathematical...
Mon Nov 11, 2019 00:00
Chronic Respiratory Disease, Volume 16, Issue , January-December 2019. We investigated whether the differences in exercise limitation between patients with chronic obstructive pulmonary disease (COPD) or chronic heart failure (CHF) affect the repeatability or responsiveness of incremental exercise tests. Patients with COPD (Medical Research Council dyspnoea grade 2–5) and patients with CHF (New York Heart Association class II–IV) performed two incremental shuttle walk tests (ISWT) following familiarisation...
05:06
Nature Reviews Clinical Oncology, Published online: 11 November 2019; doi:10.1038/s41571-019-0284-3Systemic hormone therapies and chemotherapy are the cornerstones of treatment for patients with de novo metastatic prostate cancer, with a currently limited role for local treatments. Herein, the authors outline the pathobiological and immunological rationale for local cytoreductive treatment of the primary tumour and/or metastases in patients with this disease. They also review the preclinical and...
Mon Nov 11, 2019 02:00
Publication date: Available online 10 November 2019Source: Advances in Life Course ResearchAuthor(s): Anneli Miettinen, Marika JalovaaraAbstractThis study investigates how unemployment is associated with the transition to parenthood among men and women in times of increased instability in the labour market. We provide novel insights into how education and life stage might modify the link between unemployment and fertility. We focus on a Nordic welfare state, Finland, and apply event history models...
Mon Nov 11, 2019 18:38
AbstractFire or combustion occurring during laparotomy is an uncommon and potentially hazardous event that can be precipitated by the use of surgical energy devices in the presence of enteric gases or exogenous materials present in the abdomen such as alcohol. Oxygen necessary for a combustive event can be increased in the setting of a proximal enteric injury and with higher concentrations of inspired oxygen during anaesthesia. We report on a case of combustion on entry to the abdomen using monopolar...
Mon Nov 11, 2019 02:00
AbstractFibroepithelial polyps (FP) of the ureter are rare and benign mesodermal tumors frequently mistaken for transitional cell carcinoma. We hereby report a rare case of a 19-year-old patient with two FPs, originating from the distal left ureter that were successfully treated with ureteroscopy. One of these polyps was completely protruding outside the bladder through the urethra, which makes this case unique in the literature. Ureteroscopy is currently the best method available for identification,...
Mon Nov 11, 2019 02:00
AbstractWe present an interesting case of a 66-year-old male who had acute testicular infarction following a right common femoral artery to left profunda femoris artery bypass with advanced symptoms of claudication. Angiography in the preoperative period demonstrated the extent of peripheral arterial disease present, revealing a calcified aorta, partially occluded left hypogastric artery, occluded left external iliac, common femoral and superficial femoral arteries and an occluded right hypogastric...
Mon Nov 11, 2019 02:00
Fracture of a popliteal nitinol stent and pseudoaneurysm: a case report and review of the literature
AbstractThere is a lack of reports onr stent fracture with pseudoaneurysm formation in the femoropopliteal artery, which can cause restenosis or occlusion of the treated arterial segment. We present a case of a large pseudoaneurysm of the popliteal artery that was observed 18 months after popliteal stenting using a self-expandable nitinol stent. We describe an endovascular approach to overcome this severe complication. Stent fractures are an often overlooked complication of femoropopliteal stenting...
Mon Nov 11, 2019 02:00
AbstractAlthough it rather became a routine procedure to evaluate and use a cadaveric horseshoe kidney, using one from a living donor is quite rare. In this paper, we present methods we used during such a case which may benefit the procedures in the future. A 29-year-old female patient was considered for transplant and only viable living donor was her 59-year-old mother. Dynamic computed tomography revealed horseshoe anomaly with one renal artery and one renal vein for each side, a long but thin...
Mon Nov 11, 2019 02:00
AbstractThe role of cytoreductive nephrectomy for metastatic renal cell carcinoma (RCC) is currently debated, with the advancements in target therapy development. The aim of our work was to present an interesting case report with mini review to describe the important role of cytoreductive nephrectomy for kidney cancer control that failed to respond well to Sutent, in spite of good response for all metastases. Medline review of related English publication was conducted and included to the study. RCC...
Mon Nov 11, 2019 02:00
Nature Reviews Neurology, Published online: 11 November 2019; doi:10.1038/s41582-019-0289-7A high-salt diet leads to the development of hallmark Alzheimer disease (AD) pathology and cognitive impairment in mice, according to new research published in Nature. The study reveals previously unknown molecular mechanisms that could have therapeutic implications.
Mon Nov 11, 2019 02:00
Test your Memory (Free + 5 minutes): https://practicalpie.com/free-memory-test/ Learn more about working memory, including the phonological loop, visuospatial sketchpad, and the episodic buffer: https://practicalpie.com/working-memory/ --- Invest in yourself & help me out --- ❤️ Psychology of Attraction: https://practicalpie.com/POA ⏰ Psychology of Productivity: https://practicalpie.com/psychology-of-productivity/ 💵 Psychology of Selling: https://practicalpie.com/psychology-of-selling/ 💸...
Mon Nov 11, 2019 17:45
Nature Neuroscience, Published online: 11 November 2019; doi:10.1038/s41593-019-0523-zQasim et al. describe neurons in the human entorhinal cortex that activate near the locations in space that a person is cued to recall during a memory task. These results show one way in which the cognitive map shifts according to memory demands.
Mon Nov 11, 2019 02:00
Nature Neuroscience, Published online: 11 November 2019; doi:10.1038/s41593-019-0528-7Hartley et al. report the bidirectional remodeling of a basolateral amygdala-to-central amygdala neural circuit, where input onto corticotropin-releasing factor (CRF)-expressing and CRF-negative neurons is shaped by the acquisition and extinction of fear memory.
Mon Nov 11, 2019 02:00
Publication date: Available online 10 November 2019Source: Journal of NeuroradiologyAuthor(s): Yeonah Kang, Kuo-Chen Wei, Cheng Hong TohAbstractPurpose: To evaluate the potential of quantitative dynamic susceptibility contrast (DSC) perfusion MR imaging parameters as imaging biomarkers for predicting intraoperative blood loss in meningioma.Methods: Fifty-one non-embolized meningioma patients who had undergone preoperative DSC perfusion MR imaging were retrospectively included. The corrected relative...
Mon Nov 11, 2019 18:19
I grew up in the 1980s, so I couldn’t help but know who Dr. Ruth was. Her popularity exploded and she was absolutely everywhere. I heard her on the radio. I saw her in the movies and on talk shows—she was even on MTV. However, I didn’t fully understand or appreciate how revolutionary the work she was doing truly was back then. For a long time, all I really knew was that she was a short woman who talked a lot about this thing called “sex,” something else I didn’t fully understand in the 80s, either. On...
Mon Nov 11, 2019 17:00
The main aim of this study was to assess the Magnitude of intestinal parasitic infections and associated factors among food handlers working at Woldia University Student’s cafeteria, Northeastern Ethiopia. Ins...
Fri Nov 08, 2019 02:00
Nature Chemistry, Published online: 11 November 2019; doi:10.1038/s41557-019-0354-2A solution-processing step has been used to prepare quantum-well structures that comprise a thin layer of perovskite sandwiched between two layers of conjugated oligothiophene derivatives. The band gap of the resulting 2D hybrid perovskites can be fine-tuned by functionalizing the organic component, which also improves the stability of the system.
Mon Nov 11, 2019 02:00
SPONSORED POST By CATALYST @ HEALTH 2.0 According to the U.S. Census Bureau, the number of American seniors will grow to over 71 million by 2030. To address critical problems that the growing elder population faces, GuideWell is hosting a health and wellness accelerator program for companies and innovators focused on senior care. GuideWell’s Scale Up Accelerator: Aging in Place is seeking solutions that provide affordable, accessible health care or holistic solutions for diverse...
Mon Nov 11, 2019 17:23
Thyroid, Ahead of Print.
Mon Nov 11, 2019 10:00
73o Σεμινάριο ALSO, Σέρρες 25 – 26 Ιανουαρίου 2020 (Advanced Life Support in Obstetrics) που θα διεξαχθεί στις Σέρρες, στο Αμφιθέατρο Νοσοκομείου Σερρών από 25 ως 26 Ιανουαρίου 2020. Το Ελληνικό πρόγραμμα ALSO (Advanced Life Support of Obstetrics) παρέχει από το 2002 εκπαίδευση στην Ελλάδα και την Κύπρο σε μαιευτικά επείγοντα περιστατικά και έχει δύο κύριους στόχους: την αντιμετώπιση των επειγόντων περιστατικών με εξειδικευμένους χειρισμούς και την αποφυγή περιττών παρεμβάσεων. Για το Πρόγραμμα: Πρόγραμμα...
Mon Nov 11, 2019 16:46
Το ΟΚΙΒΕΕ σε συνεργασία με τη Γ΄ Πανεπιστημιακή Παθολογική Κλινική του Νοσοκομείου «Σωτηρία» προαναγγέλλουν τη διεξαγωγή του Πανελληνίου Συνεδρίου «Ημέρες Παθολογίας 2020 – 29ο Έτος» το οποίο θα διεξαχθεί στην Αθήνα 02-04 Απριλίου 2020, στο Ξενοδοχείο Crowne Plaza. Το Συνέδριο, με κεντρικό θέμα: «Διλήμματα στην Κλινική Παθολογία» απευθύνεται στους Έλληνες Ιατρούς, κυρίως Παθολόγους και Γενικούς Ιατρούς καθώς και στους ειδικευόμενους, τους φοιτητές της ιατρικής αλλά και τους υπόλοιπους επαγγελματίες...
Mon Nov 11, 2019 16:22
Η Επιστημονική Εταιρεία «Καρκίνος: Εκπαίδευση, Έρευνα και Κλινική Πράξη» εναρμονιζόμενη με τις σύγχρονες ανάγκες της διαδικτυακής εκπαίδευσης (web based) διοργανώνει έναν κύκλο Web Congresses «21ος αιώνας: η ογκολογία στην ακμή της» τα οποία βασίζονται στην τεχνολογία web. Το επόμενο Web Congress με θέμα «Η χρυσή εποχή της ανοσοθεραπείας» θα προβληθεί την Τρίτη 12 Νοεμβρίου 2019 και ώρα 19:00-20:30. Για την παρακολούθηση παρακαλούμε ακολουθήστε την παρακάτω διαδικασία: Link: https://bit.ly/2CycNU7...
Mon Nov 11, 2019 15:35
Μηνιαία Ενημέρωση Ελληνικής Εταιρείας Λιπιδιολογίας, Αθηροσκλήρωσης και Αγγειακής Νόσου: Οκτώβριος 2019. Για το Δελτίο Τύπου: Δελτίο Τύπου The post Ελληνική Εταιρεία Λιπιδιολογίας, Αθηροσκλήρωσης και Αγγειακής Νόσου: Ενημερωτικό Δελτίο Οκτώβριος 2019 appeared first on Ιατρικός Σύλλογος Πάτρας.
Mon Nov 11, 2019 15:27
Τετάρτη 13 Νοεμβρίου 2019 ώρα 18:00-20:30 Ξενοδοχείο Astir – Πάτρα Πρόσκληση SCORE_invitation Πρόγραμμα SCORE_program The post Ημερίδα: «Μετανάστες/πρόσφυγες στην ελληνική κοινωνία. Το έργο SCORE», Πάτρα 13 Νοεμβρίου 2019 appeared first on Ιατρικός Σύλλογος Πάτρας.
Mon Nov 11, 2019 14:23
Πατήστε στον παρακάτω σύνδεσμο για να δείτε το σχετικό έγγραφο: ΔΩΡΕΑΝ ΣΕΜΙΝΑΡΙΑ ΕΠΕΙΓΟΝΤΩΝ 2019-Αράχωβα 15-11, Καρπενήσι 6-12, Λίμνη Πλαστήρα 12-12 The post Κλινικό Φροντιστήριο Αντιμετώπισης Επειγόντων – Interactive Rapid Response Workshop (IRRW) 2019 appeared first on Ιατρικός Σύλλογος Πάτρας.
Mon Nov 11, 2019 14:08
Πατήστε στον παρακάτω σύνδεσμο για να δείτε το ΦΕΚ:ΦΕΚ 3417_9-9-2019 τΒ Σύσταση ειδικών επιτροπών στον ΕΟΠΥΥ για έγκριση ειδικών εξετάσεων The post ΦΕΚ 3417/9-9-2019/τ. Β΄: Σύσταση στο Ανώτατο Υγειονομικό Συμβούλιο του ΕΟΠΥΥ, ειδικών μη αμειβόμενων Επιτροπών, που αφορούν στην έγκριση για διενέργεια εξετάσεων ειδικών θεραπειών και ειδικών επεμβάσεων ασθενών. appeared first on Ιατρικός Σύλλογος Πάτρας.
Mon Nov 11, 2019 13:27
Με αφορμή την Παγκόσμια Ημέρα Ατόμων με Αναπηρία οι «Μαχητές» διοργανώνουν τριήμερο εκδηλώσεων 18, 20 & 21 Νοέμβρη, εστιασμένο στην ανάδειξη της μοναδικότητας και της διαφορετικότητας των νέων με νοητική υστέρηση. Σκοπός των εκδηλώσεων είναι η ενημέρωση, εξοικείωση και ευαισθητοποίηση των πολιτών, η εξάλειψη στερεότυπων αντιλήψεων και συμπεριφορών και η δημιουργία συνθηκών ισότιμης πρόσβασης στον κοινωνικοοικονομικό βίο. ΔΕΛΤΙΟ ΤΥΠΟΥ – ΑΝΑΛΥΤΙΚΟ ΠΡΟΓΡΑΜΜΑ ΑΦΙΣΑ ΤΕΛΙΚΗ Δευτέρα 18 Νοέμβρη Επιστημονική...
Mon Nov 11, 2019 11:27
Το Ινστιτούτο Μοριακής Ιατρικής & Βιοϊατρικής Έρευνας σε συνεργασία με το Ογκολογικό Τμήμα Πανεπιστημιακού Γενικού Νοσοκομείου Πατρών διοργανώνουν το17ο Μετεκπαιδευτικό Συνέδριο – Εξελίξεις στην Ογκολογία, το οποίο θα πραγματοποιηθεί στις 13-14 Δεκεμβρίου 2019 στο Συνεδριακό & Πολιτιστικό Κέντρο, στην Πανεπιστημιούπολη Πατρών. Παρακαλώ βρείτε εδώ το Save the Date του Συνεδρίου προς ενημέρωσή σας Ο Πρόεδρος της Οργανωτικής ΕπιτροπήςΧαράλαμπος Καλόφωνος Πληροφορίες:E.T.S. Events &...
Mon Nov 11, 2019 11:16
Η Pop Queen Ελένη Φουρέιρα τραγουδά για το «Make-A-Wish» («Κάνε-Μια-Ευχή Ελλάδος»)
Mon Nov 11, 2019 17:13
SHINE A LIGHT WORLD TOUR
Mon Nov 11, 2019 13:49
«Δύσκολοι οι χωρισμοί από αυτούς που αγαπάς. Καλό Παράδεισο.», έγραψε ο Ντάνος
Mon Nov 11, 2019 12:01
Ο Leo μας έχει σήμερα γενέθλια και υπάρχουν κάποια quotes του που μας γεμίζουν ασιοδοξία…
Mon Nov 11, 2019 16:45
AbstractBackgroundBacterial translocation in HIV is associated with inflammation and metabolic complications; few data exist on the role of fungal translocation.MethodsA5260s was a substudy of A5257, a prospective open label randomized trial in which treatment-naïve people with HIV (PWH) were randomized to tenofovir-emtricitabine (TDF/FTC) plus atazanavir-ritonavir (ATV/r), darunavir-ritonavir (DRV/r), or raltegravir (RAL) over 96 weeks. Baseline was assessed, and changes in β-D-glucan (BDG) were...
Mon Nov 11, 2019 02:00
AbstractCryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report successful maintenance phase treatment with isavuconazole, a novel triazole, following fluconazole-induced prolonged QT syndrome.
Wed Oct 23, 2019 03:00
AbstractBackgroundProsthetic hip and knee joint infections (PJIs) are challenging to eradicate despite prosthesis removal and antibiotic therapy. There is a need to understand risk factors for PJI treatment failure in the setting of prosthesis removal.MethodsA retrospective cohort of individuals who underwent prosthesis removal for a PJI at 5 hospitals in Toronto, Canada, from 2010 to 2014 was created. Treatment failure was defined as recurrent PJI, amputation, death, or chronic antibiotic suppression....
Mon Oct 21, 2019 03:00
AbstractBackgroundTreatment of rheumatoid arthritis (RA) often involves immune-suppressive therapies. Concern for recurrent prosthetic joint infection (PJI) in RA patients might be high and could reduce use of joint implantation in these patients. We aimed to evaluate the risk of recurrence of PJI in RA patients compared with osteoarthritis (OA) patients by utilizing a large health care system.MethodsWe conducted a retrospective cohort study of all patients admitted for a Staphylococcus aureus PJI...
Sat Oct 19, 2019 03:00
Publication date: Available online 10 November 2019Source: Annales de PaléontologieAuthor(s): Hervé Monchot, Marjan Mashkour, Fereidoun Biglari, Kamyar AbdiAbstractWhile bears (Ursidae) are well represented in Western Europe and the Caucasus during the Pleistocene, bear remains from this period are rare in Southwest Asia. Only a limited number of sites, both natural and archaeological, have yielded evidence of brown bear (Ursus arctos Linnaeus, 1758). Skeletal remains for this species are often represented...
Mon Nov 11, 2019 17:41
Publication date: Available online 11 November 2019Source: Journal of Surgical EducationAuthor(s): Lauren V. Huckaby, Anthony R. Cyr, Kenneth Lee, Jennifer G. SteimanObjectiveExtrinsic burdens, including new personal and professional responsibilities, may distract from early career success. We sought to assess resident preparedness in nonclinical topics and to utilize this data to design a curriculum to address these content areas.DesignAll residents were surveyed to ascertain their self-reported...
Mon Nov 11, 2019 17:35
Swedish environmental activist, Greta Thunberg and her speech sent shockwaves across the globe. Her message made people get out of their comfort zone and start doing their part to save... The post...
Mon Nov 11, 2019 17:11
Το Bullying έχει ταυτιστεί με τον σχολικό εκφοβισμό. Όμως στην πραγματικότητα, δεν είναι ένα φαινόμενο που ξεκινά στο σχολείο, αλλά μια κατάσταση που το άτομο βιώνει ήδη στο σπίτι του συχνά από τους γονείς αλλά και από τα αδέρφια του με την σιωπηρή ή και ξεκάθαρη συναίνεση των γονιών του.
Sat Nov 09, 2019 14:44
Publication date: Available online 10 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Peter B. BarelaAbstractBackgroundZebrafish are a popular animal model for investigations into the neurobiological mechanisms of learning. However, there remains a need for a standardized set of behavioral methods for use with this species.New methodThe goldfish conditioned withdrawal preparation was upgraded and its efficacy for use with zebrafish tested. The upgrades consisted of, 1) automating the...
Mon Nov 11, 2019 17:15
Mon Nov 11, 2019 04:03
Publication date: Available online 10 November 2019Source: Hearing ResearchAuthor(s): Donald A. Godfrey, Nikki L. Mikesell, Timothy G. Godfrey, James A. KaltenbachAbstractThe mountain beaver and pocket gopher are two rodents that live mostly underground in tunnel systems. Previous studies have suggested that their cochlear nucleus structure, particularly that of the dorsal cochlear nucleus (DCN), differs significantly from that of other mammals, that the hearing ability of the pocket gopher is deficient...
Mon Nov 11, 2019 17:09
Publication date: Available online 10 November 2019Source: Brain Research BulletinAuthor(s): Lu-Lu Xue, Fang Wang, Liu-Lin Xiong, Ruo-Lan Du, Hao-Li Zhou, Yu Zou, Ma-Xiu Wu, Ming-An Yang, Jing Dai, Man-Xi He, Ting-Hua WangAbstractSingle-nucleotide polymorphism (SNP) and Alternative splicing (AS) were found to be implicated in certain diseases, nevertheless, the contributions of mRNA SNPs and AS to pathogenesis in developing rat brains with hypoxic-ischemic encephalopathy (HIE) remained largely vague....
Mon Nov 11, 2019 17:06
Publication date: Available online 10 November 2019Source: Brain Research BulletinAuthor(s): Anjyu Ikeda, Akari Muroki, Chie Suzuki, Yoshihito Shimazu, Mamoru TakedaAbstract7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid (resolvin D1 [RvD1]) is biosynthesized from docosahexaenoic acid (DHA), and belongs to a novel family of lipid mediators showing remarkable anti-inflammatory effects; however, the effect of RvD1 on inflammation-induced hyperexcitability of nociceptive neurons under...
Mon Nov 11, 2019 17:06
Publication date: Available online 10 November 2019Source: Brain Research BulletinAuthor(s): Di Luan, Yuanxiang Zhang, Lili Yuan, Zhaohu Chu, Lingsong Ma, Yang Xu, Shoucai ZhaoAbstractMST4 limits peripheral, macrophage-dependent inflammatory responses through direct phosphorylation of the adaptor TRAF6; though its role in neuro-inflammation is unclear. We investigated microglia expression of MST4 and whether is attenuates neuro-inflammatory response after cerebral ischemia-reperfusion injury in mice....
Mon Nov 11, 2019 17:06
Publication date: Available online 11 November 2019Source: Food ControlAuthor(s): Ilaria Benucci, Maria Chiara Caso, Teodora Bavaro, Stefania Masci, Milda Keršienė, Marco EstiAbstractThe recently growing demand of gluten-reduced beer is leading to the development of diverse approaches to be applied in brewing. The current work focuses on the development of an innovative and sustainable biocatalytic tool for the continuous production of gluten-reduced beer, based on the application of immobilized...
Mon Nov 11, 2019 16:54
“Influenza (type A) virus fingerprints were studied by Raman before and after its inoculation into Madin‐Darby canine kidney cells. The vibrational features clearly reflected host cell/virus interactions and linked to viral assembly and cell metabolic reactions.” Abstract Raman spectroscopy was applied with a high spectral resolution to a structural study of Influenza (type A) virus before and after its inoculation into Madin–Darby canine kidney cells. This study exploits the fact that the major...
Mon Nov 11, 2019 12:30
MiR‐150‐5p inhibition ameliorated high glucose‐induced cardiac fibroblasts injury via inactivation of TGF‐β1/Smad‐induced cardiac fibrosis and NF‐κB‐related cardiac inflammation via targeting Smad7, which suggests that miR‐150‐5p may be a potential therapeutic target for diabetic cardiomyopathy. Abstract Hyperglycemia‐induced cardiac fibrosis is a prominent characteristic of diabetic cardiomyopathy. Changes in proinflammatory cytokines have been shown to lead to cardiac fibrosis in patients with...
Mon Nov 11, 2019 12:29
Published on: 11 November 2019 The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of flavouring substances from subgroup 3.2 of FGE.19 in the Flavouring Group Evaluation 215, Revision 1 (FGE.215Rev1). In FGE.215, the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids concluded that the concern for genotoxicity could not be ruled out and requested in vivo data for the two representative substances...
Mon Nov 11, 2019 16:38
Published on: 11 November 2019 Soybean MON 87751 × MON 87701 × MON 87708 × MON 89788 (four‐event stack soybean) was produced by conventional crossing to combine four single events: MON 87751, MON 87701, MON 87708 and MON 89788. The GMO Panel previously assessed the four single events and did not identify safety concerns. No new data on the single events have been identified that would lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis...
Mon Nov 11, 2019 16:38
Published on: 11 November 2019 Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on heat‐killed Mycobacterium setense manresensis as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is an encapsulated ingredient composed of 200 mg mannitol and ≤ 105 heat‐killed, freeze‐dried M. setense manresensis. The information provided on the efficacy of the heat inactivation process demonstrates that...
Mon Nov 11, 2019 16:38
Published on: 11 November 2019 Prior to being applied to the new bisphenol A (BPA) re‐evaluation, the study appraisal methodology described in the 2017 BPA hazard assessment protocol, i.e. the so‐called ‘2017 methodology’, was tested on a selection of studies that had been previously appraised by EFSA in the context of its 2015 and 2016 assessments of BPA. This report describes this testing phase, its outcome and the resulting refinement of the 2017 methodology. The goals of this testing phase were...
Mon Nov 11, 2019 14:38
A meta‐analysis of blood flow rate and arterial radius for seven major cephalic arteries provides normal values for adult humans. The relationships reveal that mean flow rate scales with radius to the power of approximately 2 and that wall shear stress scales with radius to approximately −1. The hypothetical exponents would be 3 and 0, respectively, if wall shear stress were constant, according to Murray’s Law. Thus the flow regimen is more consistent with da Vinci’s Rule. Abstract Blood flow rate...
Mon Nov 11, 2019 16:34
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/11/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Nov 11, 2019 16:03
Biosensors, Vol. 9, Pages 132: Optical Biosensors for Therapeutic Drug Monitoring Biosensors doi: 10.3390/bios9040132 Authors: Vivian Garzón Daniel G. Pinacho Rosa-Helena Bustos Gustavo Garzón Sandra Bustamante Therapeutic drug monitoring (TDM) is a fundamental tool when administering drugs that have a limited dosage or high toxicity, which could endanger the lives of patients. To carry out this monitoring, one can use different biological fluids, including blood, plasma,...
Mon Nov 11, 2019 02:00
Introduction: Platycodin D (PD), a triterpenoid saponin isolated from Platycodon grandiflorum, has a well-known anti-tumor effect in multiple human cancers, including gastric cancer (GC). miR-34a plays an important role in the progression of GC. However, the relationship between miR-34a and the susceptibility of GC cells to PD is still unclear. The aim of our research was to investigate the functions of miR-34a in mediating the susceptibility of GC to PD. Methods: qPCR was performed to detect the...
Mon Nov 11, 2019 15:20
Abstract Acetylcholine (ACh) is best known as a neurotransmitter and was the first such molecule identified1. ACh signaling in the neuronal cholinergic system has long been known to regulate numerous biological processes (reviewed by Beckmann and Lips2). In actuality, ACh is a ubiquitous signaling molecule that is produced by numerous non‐neuronal cell types and even by some single‐celled organisms3,4. Within multicellular organisms, a non‐neuronal cholinergic system that includes the...
Mon Nov 11, 2019 15:29
Photochem. Photobiol. Sci., 2019, Accepted ManuscriptDOI: 10.1039/C9PP00242A, PaperShujuan Yao, Shanshan Zhou, Jie Wang, Wenzhi Li, Zhihui LiA multifunctional SnO2/TiO2/RGO nanocomposites with enhanced photocatalytic degradation and antibacterial activity has been successfully synthesized by a facile one-pot environmentally-friendly green hydrothermal route using titanium tetrabutoxide (TBOT), Na2SnO3 and graphene...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Nov 11, 2019 02:00
Abstract Verruciform xanthoma is a benign, wart‐like lesion that can clinically mimic squamous cell carcinoma. We describe two teenage patients with severe genodermatoses, recessive dystrophic epidermolysis bullosa (RDEB), and keratitis‐ichthyosis‐deafness (KID) syndrome, respectively, each found to have plaques suspicious for malignancy, later demonstrated on histopathologic examination to be verruciform xanthoma. We discuss the connection between these severe genodermatoses and the suspected pathophysiology...
Mon Nov 11, 2019 15:00
1729 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/11/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Nov 11, 2019 15:21
Publication date: Available online 10 November 2019Source: Journal of Functional FoodsAuthor(s): Rui Han, Daorui Pang, Lingrong Wen, Lijun You, Riming Huang, Viktoryia KulikouskayaAbstractThe study explored the changes of a sulfated polysaccharide (SP) from Gracilaria Lemaneiformis during simulated human digestive system. The results showed SP was scarcely degraded without significant difference. Moreover, the results of fermentation in vitro indicated 53.7% of SP were utilized by gut microbiota...
Mon Nov 11, 2019 15:17
Publication date: Available online 10 November 2019Source: Journal of Functional FoodsAuthor(s): Zhe Zhang, Xi Liang, Youyou Lv, Huaxi Yi, Yujie Chen, Lu Bai, Hui Zhou, Tongjie Liu, Rui Li, Lanwei ZhangAbstractThis study was to screen strains which had effects on insulin resistance in vitro and explore the possible mechanism. These strains were tested the ability of colonization, hormone release, lipid accumulation, glucose uptake and immunomodulatory. Three strains of Lactobacillus paracasei 1F-20,...
Mon Nov 11, 2019 15:17
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/11/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Nov 11, 2019 15:15
Cells, Vol. 8, Pages 1418: Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation Cells doi: 10.3390/cells8111418 Authors: Sardar Sindhu Reeby Thomas Shihab Kochumon Ajit Wilson Mohamed Abu-Farha Abdullah Bennakhi Fahd Al-Mulla Rasheed Ahmad Interferon regulatory factor (IRF)-5 is known to be involved in M1 macrophage polarization, however, changes in the adipose expression of IRF5 in obesity...
Mon Nov 11, 2019 02:00
Cells, Vol. 8, Pages 1419: TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019 Cells doi: 10.3390/cells8111419 Authors: Dewidar Meyer Dooley Meindl-Beinker Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and current treatment is mainly the removal of the causative factor. Transforming growth factor (TGF)-β is...
Mon Nov 11, 2019 02:00
Cells, Vol. 8, Pages 1420: The Effect of Sertoli Cells on Xenotransplantation and Allotransplantation of Ventral Mesencephalic Tissue in a Rat Model of Parkinson’s Disease Cells doi: 10.3390/cells8111420 Authors: Yun-Ting Jhao Chuang-Hsin Chiu Chien-Fu F. Chen Ta-Kai Chou Yi-Wen Lin Yu-Ten Ju Shinn-Chih Wu Ruoh-Fang Yan Chyng-Yann Shiue Sheau-Huei Chueh Christer Halldin Cheng-Yi Cheng Kuo-Hsing Ma Intra-striatal transplantation of fetal ventral mesencephalic...
Mon Nov 11, 2019 02:00
AbstractGlioblastoma (GBM, WHO grade-IV) being the most malignant and aggressive form of glioma remains a major clinical challenge, with an overall 5-year survival rate of only 9.8%. Till recently, glioma diagnosis and grading were solely dependent on the phenotypic and histological features. However, with the advancement in the understanding of the molecular biology of glioma several molecules have been identified. The importance of these molecular/genotypic features of the tumor became evident...
Mon Nov 11, 2019 02:00
AbstractBACKGROUNDSDespite recent limelight of precision medicine in oncology, effective targeted drugs and diagnostics for molecular markers have not been developed or approved for glioblastoma (GBM) yet. Notably, there remain multiple issues in MGMT testing, including determination of optimal assays and cutoff for methylation status, and its value as “companion diagnostics.” We compared two of MGMT assays, qualitative standard MSP and pyrosequencing, in light of compatibility, predictability, and...
Mon Nov 11, 2019 02:00
AbstractBACKGROUNDMeningiomas can be classified into six genomic subgroups based on mutations in NF2, SMARCB1, KLF4, POLR2A, or activating variants in the PI3K or Hedgehog signaling pathways. Previous work has identified specific associations of driver events with clinical and molecular features, such as tumor location. However, their utility in predicting post-operative patient outcomes is not well-explored. Similar to recently described epigenetic signatures, underlying genomic subgroup may provide...
Mon Nov 11, 2019 02:00
AbstractBACKGROUNDApplication of deep learning to neuro-oncology has shown promising clinically relevant results for tumor classification, localization, and segmentation. Hardware limitations, typically memory size of graphics cards, prevent magnetic resonance imaging (MRI) volumes from being processed as a whole, and hence they are divided into smaller, overlapping tiles. Deep learning algorithms (e.g., U-Net) can then be trained and applied for predictions on such tiles, followed by their combination/stitching...
Mon Nov 11, 2019 02:00
AbstractBACKGROUNDVestibular schwannomas (VS) are tumors arising from cranial nerve Schwann cells and show variable outcomes after treatment, including oscillation in size for many years after radiosurgery. To understand the unique biology of VS, we performed multiplatform molecular profiling to develop a single cell atlas of VS and reveal that VS exists on a molecular axis defined by neural crest and immune genes. METHODSSixty-six sporadic VS with available tissue for molecular profiling from 59...
Mon Nov 11, 2019 02:00
AbstractGlioblastoma (GBM) is characterized by widespread genetic and transcriptional heterogeneity. Cystic GBM (cGBM) as a rare type, yet the cause of cyst formation and their bioinformatics about the role of the epigenome in disease progression are still unknown. We believe that there are certain factors that cause the entity of tumor to dissolve, leading to the formation of cavities inside the tumor. Exploring the is mechanism and key gene targets may become important strategies for future treatment....
Mon Nov 11, 2019 02:00
AbstractPrognosis of patients diagnosed with IDHwt glioblastoma is influenced by known clinical and demographic factors, and likely by physiological characteristics. Our goal is to determine tumor-intrinsic gene expression signatures associated with aggressive tumor growth in patient-derived xenografts (PDXs). Cancer stem cell (CSC) lines established from 10 IDHwt glioblastoma tumors were implanted orthotopically in cohorts of 10 to 15 nude mice (3x10E5 viable cells/mouse), for development of PDX...
Mon Nov 11, 2019 02:00
AbstractPURPOSECombined surgical strategy with both trans-cranial surgery and trans-sphenoid surgery is necessary for selected giant pituitary adenoma with both intra-cranial and intra-sphenoidal invasion. Cases of staged surgery were reviewed retrospectively to deeply investigate this treatment strategy. METHODSAdult cases received staged surgery were reviewed. Data regarding clinical presentation, laboratory tests, image examination, surgery details, and outcome were analyzed. The size and invasion...
Mon Nov 11, 2019 02:00
AbstractGlioblastoma (GBM) is the most common and malignant adult brain tumor. Despite years of research, few advancements have been made in its management. One promising avenue of research has been treatment with BRD4 inhibitors, which decrease oncogene expression in GBM cells. However, resistance to these inhibitors is rapidly acquired. Kinome reprogramming is thought to underlie this resistance, suggesting a need for combination therapy with kinase inhibitors. The goal of this study is to determine...
Mon Nov 11, 2019 02:00
AbstractGlioblastoma (GBM), the deadliest and most common adult brain malignancy, is molecularly and clinically heterogeneous. The most common subtype (both primary and recurrent), mesenchymal (MES)-GBM, has the worst prognosis and highest treatment resistance. MES-GBM exhibits hyperactive transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo tumor suppressive pathway effector whose expression in GBMs predicts short survival. Yet, how Hippo-TAZ dysregulation might drive GBM MES transition...
Mon Nov 11, 2019 02:00
AbstractLow-grade gliomas (LGGs), which include grade II astrocytoma and grade II oligodendroglioma, inevitably recur despite aggressive treatment with surgery, and sometimes, with radiation and the chemotherapeutic agent temozolomide (TMZ). The clinical benefit of TMZ in LGG is unclear, and a subset of TMZ-treated LGGs recur with hypermutation in association with malignant progression to high-grade tumors. It is currently unknown why some TMZ-treated LGGs recur with hypermutation while others do...
Mon Nov 11, 2019 02:00
AbstractINTRODUCTIONImmunotherapy with engineered CAR T cells is a promising new therapy for glioblastoma, for which predictive and prognostic biomarkers are needed to inform effective intervention. Recently, our group analyzed standard-of-care (SOC) MRI images of long-term and short-term glioblastoma survivors and identified six intratumoral “habitats” of which “Habitat 6” was correlated with survival at diagnosis in high-grade glioma. Based on the MRI characteristics of “Habitat 6”, viz. high enhancement...
Mon Nov 11, 2019 02:00
AbstractGlioblastoma (GBM) is the most aggressive primary brain tumor with a median survival of only 15 months with standard of care treatment. Lacunarity, a quantitative morphological measure of how shapes fill space, and fractal dimension, another morphological measure of the complexity of pixel arrangement, of segmented necrotic regions on gadolinium-enhanced T1 weighted (T1gd) MRI have previously been shown to distinguish both overall survival (OS) and progression free survival (PFS) in GBM (n...
Mon Nov 11, 2019 02:00
AbstractBACKGROUNDCerebral radiation necrosis (RN) is a critical complication of radiotherapy for brain tumors. Treatment with corticosteroids provides suboptimal symptom relief, and may have considerable side effects. Small-scale studies support the use of bevacizumab, but systematic data from clinical practice on its efficacy and toxicity remain scarce. METHODSIn this retrospective cohort study, we included consecutive patients with symptomatic RN that underwent treatment with bevacizumab in our...
Mon Nov 11, 2019 02:00
AbstractAnywhere from 30–70% of osseous metastatic disease occurs in the spine across many different tumor types. These metastases lead to debilitating pain and neurologic dysfunction significantly reducing patients’ quality of life. Unfortunately, the cause of preferential metastatic growth to the spine is not understood. The purpose of this study was to identify the role of NCOR1 and NCOR2/SMRT, genes included in Cancer Gene Census (https://cancer.sanger.ac.uk/cosmic), in the promotion of metastatic...
Mon Nov 11, 2019 02:00
AbstractBACKGROUNDGlioblastoma (GBM) patient survival and therapy response is greatly hindered by the presence of invasive glioma stem cells (GSC) and the blood-brain barrier (BBB) which limits effective drug delivery. WNT/beta-catenin signaling is important in the development and maintenance of the BBB by mediating transcription of growth factors, multidrug resistance proteins, and junctional proteins. In WNT-subtype medulloblastoma, activating mutations of beta-catenin lead to reciprocal secretion...
Mon Nov 11, 2019 02:00
AbstractAtypical teratoid/rhabdoid tumors (AT/RTs) are rare pediatric brain tumors affecting mainly infants and young children. However, AT/RTs encompass almost 10% of death caused by pediatric brain tumors, and the 2-year overall survival for these children remains below 20%. For this reason, AT/RT ranks among the deadliest pediatric brain tumors. Therefore, it is clear we need to find out new therapeutic options for these children. Delta-24-RGD oncolytic adenovirus has already demonstrated its...
Mon Nov 11, 2019 02:00
AbstractWhile diffuse gliomas are notorious for their histopathological, genetic and transcriptional spatial heterogeneity, little is known about their epigenetic spatial heterogeneity. The result of spatial (epi)genetic analysis is strongly influenced by the proportion of cancer cells in a sample, so called tumor purity. However, a gold standard for assessment of tumor purity is lacking. We set out to analyze tumor purity using different measurement modalities and explore tumor purity-corrected...
Mon Nov 11, 2019 02:00
AbstractBACKGROUNDWomen ages 35–44 have three-fold higher risk of meningioma compared to men. Epidemiologic studies have implicated exogenous hormone use, but endogenous hormonal factors are inconsistently associated. Elevated body mass index (BMI) is consistently associated with meningioma risk in both men and women, and personal history of breast cancer has also been associated with meningioma risk. Recent genome-wide association studies (GWAS) have identified a meningioma risk locus on chromosome...
Mon Nov 11, 2019 02:00
AbstractBACKGROUND & SIGNIFICANCECancer is a disease in 3-dimensions and there is a desperate need for infrastructure and models to study immuno-oncology treatment strategies in 3D. A new culture system for long-duration maturation of patient derived microtumors has been developed. This system enables in situconfocal imaging and movies of T-cells and tumor model interactions, including measurements of T-cell migration, infiltration, and killing. HYPOTHESIS: Biofabrication of 3D microtumors using...
Mon Nov 11, 2019 02:00
AbstractEmbryonal tumors with multi-layered rosettes (ETMR) are aggressive brain cancers with characteristic C19MC oncomiR amplification and enrichment of pluripotency factor LIN28A. Here we investigated C19MC oncogenic mechanisms and discovered a potent C19MC-LIN28A-MYCN circuitry driven by multiple regulatory loops and super-enhancers resulting from long-range MYCN DNA interactions and C19MC gene fusions. C19MC and LIN28A targets respectively converge on critical cell cycle tumor suppressors and...
Mon Nov 11, 2019 02:00
AbstractINTRODUCTIONWhile immunotherapy through anti-PD1 checkpoint inhibition has demonstrated impressive clinical efficacy against a number of tumor types, its application has been ineffective against glioblastomas. METHODSWe wished to determine whether high intensity focused ultrasound (HIFU) augment the efficacy of anti-PD1 checkpoint inhibition against glioblastomas. HIFU can be surgically administered through low-duty cycle to induce subcellular fragmentation without causing temperature elevation...
Mon Nov 11, 2019 02:00
AbstractINTRODUCTIONThe new understanding of molecular pathways in cancer is paving the way towards personalized cancer medicine, especially in refractory disease. High-grade gliomas (HGG) are common pediatric brain tumors that tend to recur, with no available standard therapy upon recurrence. HGG are challenging tumors with illusive biology and poor outcome. We report here the molecular testing of 27 pediatric HGG patients. MATERIALS AND METHODSAn analysis of pediatric patients with HGG treated...
Mon Nov 11, 2019 02:00
AbstractBACKGROUNDHigh grade glioma patients are prone to lapses in treatment due to the complexities related to coordination of care, the timing of adjuvant treatment, and insurance barriers. The purpose of this study was to determine the impact of an institutional multidisciplinary protocol on transitions of care after surgery for high grade gliomas between 2015 and 2018. METHODSA retrospective cohort study was conducted using CPT codes for enrolled glioma patients between 2015–2018 with unplanned...
Mon Nov 11, 2019 02:00
AbstractOBJECTIVENeuronavigation systems with magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging (methionine [MET], fluorothymidine [FLT], and fluoromisonidazole [FMISO]) are routinely used in glioblastoma surgery. Residual tumor identified using intraoperative MRI (IoMRI) or 5-aminolevulinic acid (5-ALA) fluorescence is removed. Neoadjuvant bevacizumab therapy is offered to patients with low Karnovsky performance status (KPS) or with tumors in eloquent regions. We evaluated...
Mon Nov 11, 2019 02:00
AbstractGlioblastoma treatment options remain limited due to its aggressive and invasive nature. It is increasingly appreciated that molecular heterogeneity between tumors and within tumors likely contributes to the lack of therapeutic advances. To maintain the inherent heterogeneity of glioblastoma, we employed a novel method to rapidly culture glioblastoma organoids (GBOs) directly from neurosurgical resection. GBOs are routinely generated around two weeks following initial resection. Comprehensive...
Mon Nov 11, 2019 02:00
AbstractDiffusely infiltrating gliomas feature loss-of-function mutations in the chromatin remodeler gene ATRX as defining molecular alterations delineating major adult and pediatric disease subtypes. We recently reported that Atrx deficiency drives glioma-relevant phenotypes, such as increased motility and astrocytic differentiation profiles, by directly modulating epigenomic landscapes and the corresponding transcriptional profiles in glioma cells of origin. In particular, Atrx deficiency was associated...
Mon Nov 11, 2019 02:00
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