The purpose of this study was to develop an effective management algorithm for lesions of third or fourth branchial sinuses.
Mon Nov 11, 2019 02:00
Abstract Sordariomycetes is one of the largest classes of Ascomycota that comprises a highly diverse range of fungi mainly characterized by perithecial ascomata and inoperculate unitunicate asci. Freshwater Sordariomycetes play an important role in ecosystems and some of them have the potential to produce bioactive compounds. This study documents and reviews the freshwater Sordariomycetes, which is one of the largest and important groups of fungi in aquatic habitats. Based on...
Mon Nov 11, 2019 02:00
SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in <i>Drosophila</i>
by Yongbo Xue, Joanna C. Chiu, Yong Zhang Circadian rhythms are generated by endogenous pacemakers that rely on transcriptional-translational feedback mechanisms conserved among species. In Drosophila, the stability of a key pacemaker protein PERIOD (PER) is tightly controlled by changes in phosphorylation status. A number of molecular players have been implicated in PER destabilization by promoting PER progressive phosphorylation. On the other hand, there have been few reports describing mechanisms...
Mon Nov 11, 2019 21:27
by Jessica A. Lee, Siavash Riazi, Shahla Nemati, Jannell V. Bazurto, Andreas E. Vasdekis, Benjamin J. Ridenhour, Christopher H. Remien, Christopher J. Marx While microbiologists often make the simplifying assumption that genotype determines phenotype in a given environment, it is becoming increasingly apparent that phenotypic heterogeneity (in which one genotype generates multiple phenotypes simultaneously even in a uniform environment) is common in many microbial populations. The importance...
Mon Nov 11, 2019 21:27
by Megan A. Sloan, Karen Brooks, Thomas D. Otto, Mandy J. Sanders, James A. Cotton, Petros Ligoxygakis Trypanosomatid parasites are causative agents of important human and animal diseases such as sleeping sickness and leishmaniasis. Most trypanosomatids are transmitted to their mammalian hosts by insects, often belonging to Diptera (or true flies). These are called dixenous trypanosomatids since they infect two different hosts, in contrast to those that infect just insects (monoxenous). However,...
Mon Nov 11, 2019 21:27
The authors reported a case of extensive maxillary osteoradionecrosis. The maxilla was resected and reconstructed with fibula musculocutaneous flap. It was the first reported that the osteoradionecrotic maxilla was reconstructed with free vascularized bone. The musculocutaneous flap might be a better choice of maxillary osteoradionecrosis reconstruction instead of the simple soft-tissue flap. Address correspondence and reprint requests to Yue He, PhD, Department of Oral Maxillofacial—Head and Neck...
Fri Nov 08, 2019 02:00
No abstract available
Fri Nov 08, 2019 02:00
Large skull bone defects of the cranial vault can result from various reasons. Reconstruction of these defects is performed for protective and aesthetic reasons but is also required for adequate intracranial homeostasis. Computer-aided-design/computer-aided-manufacturing (CAD/CAM) patient-specific skull implants have become the most valuable alternative to the traditional methods of reconstruction and a growing number of publications is dealing with this topic in adults. Literature related to the...
Fri Nov 08, 2019 02:00
The authors report a patient with masticator space abscess due to an ascending infection following a wisdom tooth extraction. They administered antibiotics and did an incision and drainage; however, osteomyelitis of the mandible and compartment syndrome of the temporal muscle complicated the course. The authors suggest a physiopathology and discuss the management of this study. Address correspondence and reprint requests to Gian Battista Bottini, MD, DMD, Department of Oral and Maxillofacial Surgery,...
Fri Nov 08, 2019 02:00
In the era of genomics and precision medicine, patients deserve a definitive diagnosis before the mention of cancer, argues oncologist Don Dizon.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Mon Nov 11, 2019 18:03
The appropriate timing of radiotherapy (RT) for patients after radical prostatectomy (RP) with adverse pathological features (APFs) remains controversial. This systematic review was conducted to compare the ef... (Source: Radiation Oncology)
Sat Nov 09, 2019 01:00
Oncogene, Published online: 11 November 2019; doi:10.1038/s41388-019-1096-8Correction: VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (Source: Oncogene)
Mon Nov 11, 2019 00:00
Abstract Background Nowadays, we have to face the fact that the Web represents one of the most important sources of information for patients. Postbariatric patients in particular are usually very motivated, and they are enthusiastic users of the Web as a source of information on the different types of surgery they could undergo after their weight loss in order to reshape and remodel their body thus regaining physical and functional wellness...
Mon Nov 11, 2019 02:00
by Soham Gupta, Päivi Ylä-Anttila, Tatyana Sandalova, Renhua Sun, Adnane Achour, Maria G. Masucci The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase encoded in the N-terminus of the Epstein-Barr virus (EBV) large tegument protein BPLF1 harnesses 14-3-3...
Mon Nov 11, 2019 20:47
by Christopher M. Ziegler, Loan Dang, Philip Eisenhauer, Jamie A. Kelly, Benjamin R. King, Joseph P. Klaus, Inessa Manuelyan, Ethan B. Mattice, David J. Shirley, Marion E. Weir, Emily A. Bruce, Bryan A. Ballif, Jason Botten Viral late domains are used by many viruses to recruit the cellular endosomal sorting complex required for transport (ESCRT) to mediate membrane scission during viral budding. Unlike the P(S/T)AP and YPX(1–3)L late domains, which interact directly with the ESCRT proteins...
Mon Nov 11, 2019 20:47
by James Weger-Lucarelli, Lucia Carrau, Laura I. Levi, Veronica Rezelj, Thomas Vallet, Hervé Blanc, Jérémy Boussier, Daniela Megrian, Sheryl Coutermarsh-Ott, Tanya LeRoith, Marco Vignuzzi Malnourishment, specifically overweight/obesity and undernourishment, affects more than 2.5 billion people worldwide, with the number affected ever-increasing. Concurrently, emerging viral diseases, particularly those that are mosquito-borne, have spread dramatically in the past several decades, culminating...
Mon Nov 11, 2019 20:47
Palmoplantar epidermoid cysts can range in clinical presentation from an asymptomatic slowly enlarging mass to a painful nodule. We report two cases: an epidermoid cyst on the sole and another on the palm. This article reviews the possible etiology, diagnosis, and prognosis of palmoplantar epidermoid cysts.
Fri Nov 08, 2019 02:00
The University of California, Davis, School of Medicine, Department of Dermatology, is recruiting for a PediatricDermatologist in the Clinical X series or Health Sciences Clinical Professor (HSCP) series at the Assistant/Associate/FullProfessor level based on experience and qualifications. The appointment may be made up to 100%.Basic Qualifications: Candidates must possess an MD or MD/PhD, can be board eligible, but must be board-certified in dermatology at the time ofstarting employment and must...
Fri Nov 08, 2019 02:00
Hydroxyurea is a chemotherapeutic agent that is used in the treatment of various hematological diseases including chronic myelogenous leukemia, polycythemia vera, and sickle cell anemia. Hydroxyurea is also used to treat psoriasis. Drug-induced hyperpigmentation is a known cutaneous side effect of hydroxyurea along with xerosis, dermal ulcers, and dermatomyositis-like eruptions. Hyperpigmentation has been observed in the oral mucosa, nails, and in a generalized or a diffuse pattern. The mechanism...
Fri Nov 08, 2019 02:00
Apocrine hidrocystoma is a rare, benign, cystic tumor of the apocrine sweat glands. They are most commonly located around the eyes and may also be found on the scalp and neck. However, despite the fact that the nipple and areola contain numerous apocrine sweet glands, apocrine hydrocystomas have not been described previously in this area to the best of our knowledge. We report the first case of this cyst in this unsual location.
Fri Nov 08, 2019 02:00
Organizing pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. The pathological pattern of organizing pneumonia may be idiopathic or related to a determined cause, termed secondary organizing pneumonia. We report a 68-year-old woman with a longstanding history of chronic plaque psoriasis, treated with the tumor necrosis factor (TNF) inhibitor, adalimumab. After 8 years of treatment, she developed a gradual-onset,...
Fri Nov 08, 2019 02:00
Immune checkpoint inhibitors are used to treat numerous malignancies but may be associated with severe adverse events. Bullous dermatoses, chiefly bullous pemphigoid (BP), are potentially progressive adverse events that cause blistering skin lesions and may involve a significant body surface area. Herein, we report an 87-year-old man with urothelial cell carcinoma undergoing atezolizumab treatment who presented with an acute-onset blistering eruption. Biopsy revealed a subepidermal bulla, direct...
Fri Nov 08, 2019 02:00
Unusual distributions of contact dermatitis often lead to identification of the offending agent. We present a case of unilateral dermatitis of the chest developing in a patient with a history of allergy to metal. A name tag attached magnetically to his work uniform was identified as the cause of the eruption. Unilateral eruption of the chest can be a manifestation of allergic contact dermatitis to metal objects in breast pockets or attached to clothing.
Fri Nov 08, 2019 02:00
Follicular spicules are a very rare but highly characteristic cutaneous manifestation of multiple myeloma. The spicules typically appear as hyperkeratotic horns in the follicular openings of the face, most commonly on or around the nose and forehead. The pathophysiology of this condition has not been fully elucidated and remains an active area of research and debate. Herein we describe a patient who presented with follicular spicules in the context of unintentional weight loss, anemia, and elevated...
Fri Nov 08, 2019 02:00
Reactivation of hepatitis B virus (HBV) following the use of TNF antagonists has been reported and is a contraindication to use of these medications. Although the risk of reactivation of HBV during use of ustekinumab and secukinumab is low in patients with only HBV core antibody positivity, the risk is substantial in patients with chronic HBV infection. Less information is available regarding the use of pure IL-23 antagonists. Herein we discuss the successful treatment with guselkumab of a patient...
Fri Nov 08, 2019 02:00
Checkpoint inhibitor immunotherapy, including ipilimumab and nivolumab, is associated with numerous immune-related adverse events including dermatitis, pruritus, hepatitis, diarrhea, and hypophysitis. As the number of patients undergoing immunotherapy treatment increases, however, rare and unusual immune-related adverse events are observed. Many of these resemble known autoimmune phenomenon, such as subacute lupus erythematosus and myositis. Herein, we report a patient with metastatic serous ovarian...
Fri Nov 08, 2019 02:00
Porokeratosis ptychotropica is a rare and commonly misdiagnosed subtype of porokeratosis involving the body folds. We present a 53-year-old man with systemic mastocytosis who presented with a pruritic, verrucous plaque in the gluteal fold that showed multiple cornoid lamellae on histopathologic evaluation, diagnostic of porokeratosis ptychotropica. Various treatments have been reported, including topical corticosteroids, retinoids, vitamin D analogs, calcineurin inhibitors, imiquimod, phototherapy,...
Fri Nov 08, 2019 02:00
Unilateral linear capillaritis (ULC) is a rare variant of pigmented purpuric dermatoses (PPD) that is characterized by a linear or pseudo-dermatomal eruption on a single extremity. Although clinically distinct from the other PPD, it shares histopathologic features with this group. Herein, we present a man in his 50s who presented with asymptomatic macules and scaly papules on the left lower extremity in a linear distribution. The eruption persisted despite treatment with topical triamcinolone 0.1%...
Fri Nov 08, 2019 02:00
Cutaneous metastases are rarely the initial manifestation of a previously undiagnosed malignancy and keratoacanthoma-like lesions are a notoriously unusual presentation pattern of cutaneous dissemination of a primary tumor. Herein, we report a 40-year-old woman presenting to our dermatology department with multiple keratoacanthoma-like scalp nodules. Subsequent investigation determined it to be the first manifestation of a disseminated endometrial epithelioid trophoblastic tumor, eventually causing...
Fri Nov 08, 2019 02:00
We report a patient with penile sarcomatoid squamous cell carcinoma (SCC) initially misdiagnosed as condyloma acuminatum. Sarcomatoid SCC is a rare, aggressive, biphasic cancer that often presents a diagnostic challenge and carries a poor prognosis, especially after a delay in diagnosis. Although sarcomatoid SCC may exhibit a broad range of clinical features, the expression of p63 and keratin 34?E12 is a common finding. Our case highlights the importance of accurate clinicopathologic correlation...
Fri Nov 08, 2019 02:00
Background: Mobile medical applications (apps) for clinical management of medical conditions are increasing in prevalence. Our aim was to identify features and overall quality of acne apps that could facilitate clinical management. Methods: We established 10 pertinent features (6 essential and 4 desirable) for an acne app through literature search and nominal group discussion. Searches were then conducted in the Apple App Store and Google Play Store. Apps which assisted with clinical management of...
Thu Nov 07, 2019 02:00
Melasma is an acquired hyperpigmentation disorder most commonly affecting females with darker skin types. It is triggered by several factors including sun exposure, genetic influences, and female sex hormones. The pathology of melasma extends beyond melanocytes and recent literature points to interactions between keratinocytes, mast cells, gene regulation abnormalities, neovascularization, and disruption of basement membrane. This complex pathogenesis makes melasma difficult to target and likely...
Thu Nov 07, 2019 02:00
Subscription skin care services are a rising niche of direct-to-consumer telehealth models. The explosion of such services may be a reflection of the increasing demand by patients to have accessible, affordable dermatological care. These models come with both benefits and risks to patients. A thorough understanding of how subscription skin care services work may benefit dermatologists in addressing patients' questions regarding alternative care options.
Thu Nov 07, 2019 02:00
Background: Medical scribe integration into academic dermatology practices results in decreased attending documentation time, improved physician efficiency, and positive patient satisfaction. However, scribes' impact on dermatology education has not been explored. Methods: We conducted a cross-sectional survey at the Brigham and Women's Hospital Dermatology Department and its associated residency program assessing trainee and attending perceptions of scribe impact on documentation time, teaching...
Thu Nov 07, 2019 02:00
The interplay between psychiatric and dermatologic conditions has been recognized for decades as evidenced by the widely accepted classification system of psychocutaneous disorders: (1) primary dermatologic disorder with psychiatric sequelae, (2) primary dermatologic disorder exacerbated by stress, (3) primary psychiatric disorder with dermatologic sequelae, and (4) miscellaneous. However, there is minimal literature regarding dermatologic patients who demonstrate a preoccupation with a more severe...
Thu Nov 07, 2019 02:00
Publication date: Available online 10 November 2019Source: Gait & PostureAuthor(s): Florêncio Diniz-Sousa, Lucas Veras, José Carlos Ribeiro, Giorjines Boppre, Vítor Devezas, Hugo Santos-Sousa, John Preto, Leandro Machado, João Paulo Vilas-Boas, José Oliveira, Hélder FonsecaAbstractBackgroundAlmost all accelerometer calibration studies were developed for non-obese people, which hampers an accurate prediction of energy expenditure (EE) and induces a misclassification of sedentary activity (SA)...
Mon Nov 11, 2019 20:41
Publication date: Available online 10 November 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): M.H.J. Hollander, J. Schortinghuis, A. Vissink, J. Jansma, R.H. SchepersAbstractAlthough upper blepharoplasty is a common cosmetic surgical intervention, a better scientific understanding of the aesthetic results and the preferred surgical technique to achieve the best aesthetic results is still needed. A systematic search using four search engines (PubMed, Embase, CINAHL,...
Mon Nov 11, 2019 20:37
425 εκατ. ενήλικες σε όλο τον κόσμο πάσχουν από ΣΔ 693 εκατ. ενήλικες εκτιμάται ο αριθμός (2045) «Ανακάλυψε, Πρόλαβε, Διαχειρίσου το Διαβήτη» – «Εμπόδισε την εμφάνιση του στην δική σου Οικογένεια», είναι για 2η χρονιά το μήνυμα της ενημερωτικής εκστρατείας κατά του ΣΔ της Ελληνικής Διαβητολογικής Εταιρείας (ΕΔΕ), στο πλαίσιο της Παγκόσμιας Ημέρας Διαβήτη (14 Νοεμβρίου). Στόχος της εκστρατείας είναι η ευαισθητοποίηση του κοινού για τις επιπτώσεις του Σακχαρώδη Διαβήτη (ΣΔ) καθώς και η ανάδειξη...
Mon Nov 11, 2019 20:18
Την πρώτη φορητή συσκευή που αξιολογεί στην αληθινή ζωή την κινητικότητα των ασθενών με νόσο Πάρκινσον ανέπτυξαν Ισπανοί επιστήμονες. Με τη βοήθειά της ο γιατρός μπορεί να παρακολουθεί ακόμα και εξ αποστάσεως την πορεία της νόσου και να προσαρμόζει τη θεραπεία σε κάθε ασθενή ξεχωριστά. Οι επιστήμονες από το Πολυτεχνικό Πανεπιστήμιο της Καταλονίας (UPC) παρουσίασαν την πρωτοποριακή συσκευή τους στο ετήσιο συνέδριο της International Parkinson and Movement Disorder Society (MDS), που πραγματοποιήθηκε...
Mon Nov 11, 2019 20:07
Αν σας έχει τύχει ποτέ να εμφανίσετε πέτρα στα νεφρά και να την απορρίψει από μόνος του ο οργανισμός σας, γνωρίζετε πολύ καλά ότι πρόκειται για μια από τις πλέον επίπονες εμπειρίες. «Οι πέτρες στα νεφρά είναι πιο συχνές στους άντρες παρά στις γυναίκες και περίπου στο 50% των ανθρώπων που εμφανίζουν πέτρες αυτές ξαναεμφανίζονται μέσα σε 2-5 χρόνια αν δεν ληφθούν τα απαραίτητα προληπτικά μέτρα» αναφέρει ο χειρουργός ουρολόγος Δρ. Στυλιανός Κοντός, μέλος της Πανευρωπαϊκής ενδο-Ουρολογικής Εταιρείας...
Mon Nov 11, 2019 20:03
Τον μήνα Οκτώβριο η δράση προληπτικής Ιατρικής/Οδοντιατρικής «ΙΠΠΟΚΡΑΤΗΣ» του Οργανισμού «Το Χαμόγελο του Παιδιού» επισκέφτηκε την Περιφέρεια Κρήτης και τον Δήμο Άρτας. Το εγχείρημα του Οργανισμού στήριξαν εθελοντές Ιατροί και Οδοντίατροι μέλη των τοπικών Ιατρικών και Οδοντιατρικών Συλλόγων. Οι δύο Κινητές Μονάδες Πρόληψης, το Νέο Κινητό Πολυϊατρείο για παιδιά και η Κινητή Οδοντιατρική/Ιατρική Μονάδα του Οργανισμού για ακόμα μία φορά, υπήρξαν το σημείο συνάντησης για εκατοντάδες παιδιά με στόχο...
Mon Nov 11, 2019 19:53
Η Φαρμακευτική Εταιρεία GALENICA πραγματοποίησε Επιστημονική Εκδήλωση με θέμα: «Τα Οφέλη του Ύπνου», το Σάββατο 9 Νοεμβρίου 2019, στη Θεσσαλονίκη, υπό την Αιγίδα της Ελληνικής Εταιρείας Υπνολογίας, με προσκεκλημένους Επαγγελματίες Υγείας από τη Θεσσαλονίκη. Ομιλητές της Επιστημονικής Εκδήλωσης ήταν ο κύριος Δημήτριος Δικαίος, Πρόεδρος της Ελληνικής Εταιρείας Υπνολογίας & Καθηγητής Ψυχιατρικής στο Πανεπιστήμιο Αθηνών, και ο κύριος Παναγιώτης Παναγιωτίδης, Ψυχίατρος. Ο κύριος Δημήτριος...
Mon Nov 11, 2019 19:46
Για ακόμα μια χρονιά η ελληνική φαρμακοβιομηχανία επιβεβαίωσε τη θέση της ως σημαντική εξαγωγική δύναμη στη διεθνή έκθεση CPhI, που πραγματοποιήθηκε από τις 5 έως τις 7 Nοεμβρίου 2019 στη Φρανκφούρτη. Η έκθεση CPhI αποτελεί τη μεγαλύτερη διεθνή διοργάνωση στο χώρο του φαρμάκου, η οποία πραγματοποιείται εδώ και περισσότερα από 30 χρόνια, συγκεντρώνοντας το ενδιαφέρον του παγκόσμιου φαρμακευτικού επιχειρείν, των εταιρειών που αναπτύσσουν φαρμακευτικά προϊόντα, των παραγωγών, των διανομέων, και των...
Mon Nov 11, 2019 19:43
Stem Cells and Development, Ahead of Print.
Mon Nov 11, 2019 10:00
Stem Cells and Development, Ahead of Print.
Mon Nov 11, 2019 10:00
Affinity-based sensors are electrochemical devices that can detect a large variety of disease biomarkers. They typically have enzyme-coated electrodes onto which chemical biomarkers can stick, in the process changing the electrical characteristics of the device, something that can be accurately measured. Although they’re extremely sensitive, when used in practice with whole blood, they quickly become fouled by all sort of compounds. This causes them to quickly lose their effectiveness, making affinity-based...
Mon Nov 11, 2019 19:53
Stem cells hold a great deal of promise in treating a huge variety of human diseases. Although much hyped to the general public some years ago, it turned out to be very difficult to safely use stem cells to generate replacement tissues without inadvertently introducing tumors or other maladies. Knowing how stem cells differentiate, and whether they turn into healthy cells, is key to overcoming a major hurdle for stem cell therapies. Now, a team at Rutgers University has developed a platform and accompanying...
Mon Nov 11, 2019 18:58
Researchers at Lawrence Berkeley National Laboratory have developed synthetic peptide-coated magnetic beads that can be used to detect the presence of misfolded proteins in blood samples. Misfolded proteins are a factor in a number of diseases, including prion diseases, Alzheimer’s, and Parkinson’s. To date it has been difficult to detect such proteins in patient blood samples, often because they are present in very small quantities and closely resemble their correctly folded cousins. The new beads...
Mon Nov 11, 2019 16:36
Abstract Leprosy is a chronic infectious disease of the skin and peripheral nerves that presents a strong link with the host genetic background. Different approaches in genetic studies have been applied to leprosy and today leprosy is among the infectious diseases with the greatest number of genetic risk variants identified. Several leprosy genes have been implicated in host immune response to pathogens and point to specific pathways that are relevant for host defense to infection....
Mon Nov 11, 2019 02:00
Abstract Mutation accumulation has been proposed as a cause of senescence. During this process, age-related genetic and epigenetic mutations steadily accumulate. Cascading deleterious effects of mutations might initiate a steady “accumulation of deficits” in cells, despite the existence of repair mechanisms, leading to cellular senescence and functional decline of tissues and organs, which ultimately manifest as frailty and disease. Here, we investigate several of these aspects...
Mon Nov 11, 2019 02:00
BackgroundPowered, two-wheeled transportation devices like electric bicycles (E-bikes) and scooters are increasingly popular, but little is known about their relative injury risk compared to pedal operated bicycles.MethodsDescriptive and comparative analysis of injury patterns and trends associated with E-bikes, powered scooters and pedal bicycles from 2000 to 2017 using the US National Electronic Injury Surveillance System.ResultsWhile persons injured using E-bikes were more likely to suffer internal...
Mon Nov 11, 2019 19:00
H καρδιακή ανακοπή είναι πιο θανατηφόρα όταν συμβαίνει το Σαββατοκύριακο, σύμφωνα με νέα έρευνα που θα παρουσιαστεί στο ετήσιο Συνέδριο της Αμερικανικής Καρδιολογικής Ένωσης το οποίο θα διεξαχθεί στη Φιλαδέλφεια 16- 8 Νοεμβρίου 2019. Οι ερευνητές είπαν ότι η επιβίωση από τέτοια περιστατικά το Σαββατοκύριακο μπορεί να μειώνεται επειδή είναι πιθανό να μην υπάρχει κοντά Αυτόματος Εξωτερικός Απινιδωτής. Αυτοί που θα υποστούν καρδιακή ανακοπή κατά τη διάρκεια του Σαββατοκύριακου είναι λιγότερο πιθανό...
Mon Nov 11, 2019 19:34
Οι άνδρες που περπατάνε τουλάχιστον 30 λεπτά την ημέρα μετά από το καρδιακό έμφραγμα ζουν περισσότερο συγκριτικά με εκείνους που δεν ασκούνται, σύμφωνα με έρευνα που θα παρουσιαστεί στο ετήσιο Συνέδριο της Αμερικανικής Καρδιολογικής Ένωσης που θα λάβει χώρα από τις 16 έως τις 18 Νοεμβρίου 2019 στη Φιλαδέλφεια. Οι ερευνητές ανέλυσαν στοιχεία για τα επίπεδα σωματικής άσκησης 1.500 ατόμων πριν και μετά από μια καρδιακή προσβολή. Κατά τη διάρκεια 14 ετών παρακολούθησης διαπιστώθηκε ότι: Οι άνδρες...
Mon Nov 11, 2019 19:14
Είναι γνωστό το πρόβλημα των ενδονοσοκομειακών λοιμώξεων παγκοσμίως. Στις ΗΠΑ πρόκειται για την όγδοη αιτία θανάτου. Στην Ελλάδα, ένας στους 10 Έλληνες (9,6%) που νοσηλεύονται σε νοσοκομείο παρουσιάζει λοίμωξη από ανθεκτικά μικρόβια. Τώρα, μια νέα μελέτη διαπίστωσε ότι οι νοσοκομειακές κλίνες χαλκού στη Μονάδα Εντατικής Θεραπείας (ΜΕΘ) είχαν κατά μέσο όρο 95% λιγότερα βακτήρια από τα συμβατικά νοσοκομειακά κρεβάτια και διατήρησαν αυτά τα επίπεδα χαμηλού κινδύνου καθόλη τη διάρκεια παραμονής των...
Mon Nov 11, 2019 15:20
Εκτιμάται ότι το 6% των ανθρώπων στις ΗΠΑ και το Ηνωμένο Βασίλειο πάσχουν από ανεπάρκεια βιταμίνης Β12. Η κατάσταση αναγνωρίζεται από τον Παγκόσμιο Οργανισμό Υγείας ως παγκόσμιο πρόβλημα υγείας που μπορεί να έχει αντίκτυπο σε εκατομμύρια ζωές. Η ανεπάρκεια της βιταμίνης Β12 τυπικά χαρακτηρίζεται από συμπτώματα όπως υπερβολική κόπωση, έλλειψη ενέργειας, μυϊκή αδυναμία και ακόμη και προβλήματα μνήμης. Όχι μόνο αυτό, αλλά μπορεί να προκαλέσει μια σειρά από σοβαρά προβλήματα υγείας, όπως μη αναστρέψιμη...
Mon Nov 11, 2019 14:30
Μια πλύση εγκεφάλου -κυριολεκτικά- δεχόμαστε κάθε βράδυ που κοιμόμαστε. Μάλιστα, οι νευροεπιστήμονες έχουν δημιουργήσει ένα βίντεο που δείχνει αυτή τη νυκτερινή διαδικασία εν δράση. Κύματα του εγκεφαλονωτιαίου υγρού (CSF: cerebrospinal fluid) ρέουν στο μυαλό μας. Αυτό γίνεται ρυθμικά ενώ παίρνουμε έναν υπνάκο και ταυτόχρονα γίνεται εκκαθάριση τοξινών που δεν πρέπει να μαζεύονται μέσα στα κεφάλια μας. Η έρευνα δημοσιεύθηκε στο περιοδικό Science. Η επιστημονική ομάδα πίσω από αυτές τις νέες ιδέες...
Mon Nov 11, 2019 12:37
Η DEMO ΑΒΕΕ με τη Mylan Ελλάδας ανακοινώνουν τη στρατηγική συνεργασία τους, όσον αφορά την αποκλειστική κυκλοφορία και διανομή στην Ελλάδα από την DEMO ΑΒΕΕ, του βιοομοειδούς της τραστουζουμάμπης της Mylan για όλες τις εγκεκριμένες ενδείξεις. Η εν λόγω συνεργασία θα ενισχύσει τη θέση αμφότερων των εταιρειών στο πεδίο της ογκολογίας. Το νέο σκεύασμα έρχεται να προστεθεί και να εμπλουτίσει το ήδη υπάρχον χαρτοφυλάκιο βιοομοειδών φαρμάκων που διανέμονται από τη DEMO ΑΒΕΕ στην Ελλάδα. H τραστουζουμάμπη...
Mon Nov 11, 2019 09:48
In the context of a concerning increase in rates of syphilis and congenital syphilis in the United States, this Viewpoint discusses the importance of improving screening programs and diagnostics, and it argues for legislation, media coverage, and activism by patient advocacy groups and policy makers to remove the stigma of this resurgent sexually transmitted infection (STI).
Mon Nov 11, 2019 02:00
A 40-year-old woman with Graves disease presented with abdominal pain and constipation. Thyroid-stimulating hormone was undetectable and physical examination revealed a tender midline abdominal mass. Three months earlier she was evaluated for 3 to 4 months of amenorrhea, and a urine human chorionic gonadotropin test was negative for pregnancy. What would you do next?
Mon Nov 11, 2019 02:00
Environmental Science & Technology LettersDOI: 10.1021/acs.estlett.9b00621
Mon Nov 11, 2019 07:00
Environmental Science & Technology LettersDOI: 10.1021/acs.estlett.9b00626
Mon Nov 11, 2019 07:00
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01485
Mon Nov 11, 2019 07:00
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Source: Reuters - HealthThousands of people with mental health conditions are held in chains in institutions across Nigeria, Human Rights Watch said in a report published on Monday in which it urged the government to ban the practice.
Mon Nov 11, 2019 18:12
Source: BBC News - Science and EnvironmentCutting the speed of ships by 20% can benefit health, protect whales and limit warming, say campaigners.
Mon Nov 11, 2019 18:12
Είσαι θολωμένη κι εγώ σου δίνω την ψύχραιμη οπτική!
Mon Nov 11, 2019 18:00
Abstract Purpose This study aimed to compare lung perfusion scan with single photon emission computed tomography/computed tomography (SPECT/CT) for the evaluation of lung function and to elucidate the most appropriate modality for the prediction of postoperative lung function in patients with lung cancer. Methods A total of 181 patients underwent Tc-99m macroaggregated...
Mon Nov 11, 2019 02:00
Publication date: Available online 10 November 2019Source: Revue des Maladies RespiratoiresAuthor(s):
Mon Nov 11, 2019 19:07
Biomedicines, Vol. 7, Pages 89: Use of Platelet Rich Fibrin (PRF)-Based Autologous Membranes for…Biomedicines, Vol. 7, Pages 89: Use of Platelet Rich Fibrin (PRF)-Based Autologous Membranes for Tooth Extraction in Patients under Bisphosphonate Therapy: A Case ReportBiomedicines, Vol. 7, Pages 89: Use of Platelet Rich Fibrin (PRF)-Based Autologous Membranes for Tooth Extraction in Patients under Bisphosphonate Therapy: A Case Report Biomedicines doi: 10.3390/biomedicines7040089 Authors: Alberto Pispero...
Mon Nov 11, 2019 10:03
Thyroid, Ahead of Print.
Mon Nov 11, 2019 10:00
Abstract Purpose In bilateral sagittal split osteotomy (BSSO), the risk of lesion of the inferior alveolar nerve (IAN) is important. The aim of this study was to investigate the situation of the IAN in the area of the BSSO in preoperative 158 CBCT. Methods The situation of the mandibular canal (MC) has been studied in six coronal sections (one section each...
Mon Nov 11, 2019 02:00
Abstract The radial artery usually passes on the radial side of the wrist lateral to the wrist to enter the anatomical snuff box and dorsum of the hand. If the radial artery passes anterior to the wrist, it usually enters the carpal tunnel, and in such cases, it may lead to the compression of the median nerve within the carpal tunnel. During the routine dissection, we found a case of the unusual radial arterial branch that passed anterior to the wrist yet outside the carpal tunnel....
Mon Nov 11, 2019 02:00
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Tiere sind 'in' - in den Herzen der Menschen, in den Medien, im Alltag, aber auch in den Wissenschaften. Die unterschiedlichen Vorstellungen wissenschaftlicher Bearbeitung des Mensch-Tier-Verhältnisses werden in vielfältiger Weise im wissenschaftlichen Diskurs sichtbar: als philosophisch-ethische Reflexion des Mensch-Tier-Verhältnisses, als naturwissenschaftlich geprägte Verhaltensforschung, als geistes- und sozialwissenschaftliche Analyse kultureller Bedeutungen, als ökonomische Berechnung des Nähr-...
Mon Nov 11, 2019 17:08
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Mon Nov 11, 2019 16:27
This thesis describes historical configurations of a rural health system, concepts and practices of development. Based on archival studies and interviews in Tanzania and Switzerland it contributes to the local history of south central Tanzania, to transnational mission and church history, and to global histories of medicine and development in the context of colonialism, late colonial politics and decolonization. It describes the role of mission health institutions (the case of the Catholic Swiss...
Mon Nov 11, 2019 16:04
Intelligent computing is rapidly reshaping healthcare. In light of the global burden of population aging and neurological disorders, dementia and elderly care are among the healthcare sectors that are most likely to benefit from this technological revolution. Trends in artificial intelligence, robotics, ubiquitous computing, neurotechnology and other branches of biomedical engineering are progressively enabling novel opportunities for technology-enhanced care. These Intelligent Assistive Technologies...
Mon Nov 11, 2019 15:20
With the growing demand for a therapeutic drug monitoring (TDM) in clinical laboratories the development of appropriate and improved analytical methods to monitor drug concentrations and optimize patient care has become imperative. This dissertation contributes in this regard by developing sensitive, specific, and reliable GC-MS and LC-MS/MS methods to measure drug concentrations and validating them according to the FDA Guidance for Industry. The methods are performed based on the example of the...
Mon Nov 11, 2019 14:45
Liquid mass density and viscosity are fundamental characteristics of fluids. Their quantification by means of classical viscosity and density meters has several drawbacks: (i) the liquid-density and the viscosity cannot be measured simultaneously, (ii) sample volumes in the mL-range are consumed, (iii) the measurements cannot be multiplexed, and, (iv) the quantifications are time-consuming (minutes). Nano-mechanical transducers promise to overcome these limitations. We use fully clamped, gold coated...
Mon Nov 11, 2019 14:36
Epigenetic changes are a hallmark of short- and long-term transcriptional regulation, and hence instrumental in the control of cellular identity and plasticity. Epigenetic mechanisms leading to changes in chromatin structure, accessibility for recruitment of transcriptional complexes, and interaction of enhancers and promoters all contribute to acute and chronic adaptations of cells, tissues and organs to internal and external perturbations. Similarly, the peroxisome proliferator-activated receptor...
Mon Nov 11, 2019 13:23
Die wissenschaftspolitischen Empfehlungen rund um die Förderung von Reallaboren, die das Begleitforschungsvorhaben der Universität Basel zu den Baden-Württembergischen Reallaboren vorlegt, zielen in erster Linie darauf, das Format Reallabor als Förderformat voranzubringen. Die Empfehlungen des 'BF-Teams Basel' rücken daher die Perspektive von Fördergebern in den Vordergrund. Entsprechend fokussieren sie nicht darauf, die Rahmenbedingungen für die Arbeit in Reallaboren zu optimieren, die Qualität...
Mon Nov 11, 2019 13:03
BACKGROUND & AIMS: Wilson disease (WD) is a rare disorder of copper metabolism. The objective of this systematic review is to determine the comparative effectiveness and safety of common treatments of WD. METHODS: We included WD patients of any age or stage and the study drugs D-penicillamine, zinc salts, trientine, and tetrathiomolybdate. The control could be placebo, no treatment, or any other treatment. We included prospective, retrospective, randomized, and non-randomized studies. We searched...
Mon Nov 11, 2019 12:26
Bartonella is a genus of facultative-intracellular bacteria causing a long-lasting intra-erythrocytic bacteremia in their mammalian reservoir hosts. Clearance of the bacteremia has been described to be mediated by antibodies. The exact clearance mechanism, however, has not been investigated so far. In this work, several aspects related to the immune response against Bartonella have been studied in more detail, with an emphasis on the host’s protective antibody response. For the manuscript "Neutralizing...
Mon Nov 11, 2019 11:34
Mon Nov 11, 2019 11:25
Sialic acids constitute a large family of monosaccharides that is characterized by a nine- carbon backbone and predominantly found as terminal moieties on glycans. These glycans are linked to glycoproteins, glycolipids, or proteoglycans located on the outer membrane of cells. The glycan layer on cell surfaces is called glycocalyx. Recognition of these endogenous glycans by their glycan-binding protein counterparts plays a key role in the immune system to discriminate between self and non-self. One...
Mon Nov 11, 2019 11:16
We compare the cost complexities of two approximation schemes for functions that live on the product domain Ω1×Ω2"> Ω_ 1 × Ω _ 2 of sufficiently smooth domains Ω1⊂Rn1"> Ω Ω1×Ω2"> _ 1 ⊂ ℝ^{ n_ 1} and Ω2⊂Rn2"> Ω Ω1×Ω2"> _ 2 ⊂ ℝ^{ n_ 2} , namely the singular value / Karhunen-Lòeve decomposition and the sparse grid representation. We assume that appropriate finite element methods with associated orders r1"> r Ω1×Ω2"> _ 1 and r2"> r Ω1×Ω2"> _ 2 of accuracy are given on the...
Mon Nov 11, 2019 10:32
Efficient multisensory integration is often influenced by other cognitive processes including, but not limited to, semantic congruency and focused endogenous attention. Semantic congruency can re-allocate processing resources to the location of a congruent stimulus, while attention can prioritize the integration of multi-sensory stimuli under focus. Here, we explore the robustness of this phenomenon in the context of three stimuli, two of which are in the focus of endogenous attention. Participants...
Mon Nov 11, 2019 10:21
Psychological models of value-based decision-making describe how subjective values are formed and mapped to single choices. Recently, additional efforts have been made to describe the temporal dynamics of these processes by adopting sequential sampling models from the perceptual decision-making tradition, such as the diffusion decision model (DDM). These models, when applied to value-based decision-making, allow mapping of subjective values not only to choices but also to response times. However,...
Mon Nov 11, 2019 10:20
A key goal of model-based cognitive neuroscience is to estimate the trial-by-trial fluctuations of cognitive model parameters in order to link these fluctuations to brain signals. However, previously developed methods are limited by being difficult to implement, time-consuming, or model-specific. Here, we propose an easy, efficient and general approach to estimating trial-wise changes in parameters: Leave-One-Trial-Out (LOTO). The rationale behind LOTO is that the difference between parameter estimates...
Mon Nov 11, 2019 10:18
The clinical course of Campylobacter infection varies in symptoms and severity depending on host factors, virulence of the pathogen and initiated therapy. The type VI secretion system (T6SS) has been identified as a novel virulence factor, which mediates contact-dependent injection of enzymes and toxins into competing bacteria or host cells and facilitates the colonisation of a host organism. We aimed to compare the clinical course of Campylobacter infection caused by strains with and without the...
Mon Nov 11, 2019 10:17
The Type VI secretion system (T6SS) is important for bacterial competition as well as virulence in many Gram-negative bacteria and its dynamics and regulation varies significantly between species. To gain insights into the mechanisms regulating T6SS assembly, we apply targeted proteomics to determine the abundance of the key T6SS components in Vibrio cholerae, Pseudomonas aeruginosa and Acinetobacter baylyi. We show that while there are species specific exceptions, the abundance of most components...
Mon Nov 11, 2019 10:14
Nosocomial infections with; Acinetobacter baumannii; are a global problem in intensive care units with high mortality rates. Increasing resistance to first- and second-line antibiotics has forced the use of colistin as last-resort treatment, and increasing development of colistin resistance in; A. baumannii; has been reported. We evaluated the transcriptional regulator PmrA as potential drug target to restore colistin efficacy in; A. baumannii; Deletion of; pmrA; restored colistin susceptibility...
Mon Nov 11, 2019 10:09
Efflux pumps mediate antimicrobial resistance in several WHO critical priority bacterial pathogens. However, most available data come from laboratory strains. The quantitative relevance of efflux in more relevant clinical isolates remains largely unknown.; We developed a versatile method for genetic engineering in multi-drug resistant (MDR) bacteria, and used this method to delete tolC and specific antibiotic-resistance genes in 18 representative MDR clinical E. coli isolates. We determined efflux...
Mon Nov 11, 2019 10:08
Hepatitis C virus (HCV) is common in men who have sex with men (MSM) with HIV. The Swiss HCVree Trial targeted a micro-elimination by using a treat and counsel strategy. Self-reported condomless anal intercourse with non-steady partners was used as the selection criterion for participation in a counselling intervention designed to prevent HCV re-infection. The purpose of this study was to assess the ability of this criterion to identify men who engaged in other sexual risk behaviours associated with...
Mon Nov 11, 2019 09:55
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