Abstract Background Patients initiating highly emetic chemotherapy (HEC) are at a 90% risk of chemotherapy-induced nausea and vomiting (CINV). Despite guideline-concordant antiemetic prescribing preventing CINV in up to 80% of patients, studies suggest that guideline-concordant antiemetic regimen use by patients initiating HEC is sub-optimal. However, these studies have been limited to single-site or single-cancer type with limited...
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Abstract Purpose This study aimed to assess whether prostate cancer survivors who received a behavioral intervention to urinary incontinence had experienced a significant mood improvement. Methods One hundred fifty-three prostate cancer survivors with persistent incontinence were included in this secondary data analysis. They were randomly assigned...
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Abstract Purpose There has yet to be a quantitative measurement of communicative resilience processes as outlined in the Communicative Theory of Resilience (CTR). This study aims to determine the structure, reliability, and validity of the Dyadic Communicative Resilience Scale (DCRS) in cancer patients and partners. Method The DCRS was administered...
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Abstract Growth traits are important for the profitability of buffalo breeding systems, since in general, these animals are raised both for meat and milk. In this study, the single-step genomic BLUP method was employed to prospect the genomic regions’ associated with weight at standard ages of 100, 210, 365, and 550 days in a buffalo population, aiming to identify genes with stronger expression for those characteristics. We found 6, 1, 2, and 5 SNPs significantly associated (p...
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Abstract Insulin-like growth factor 1 (IGF1) is pivotal in the regulation of animal growth. Highly polymorphic CA repeat microsatellites have been identified in the IGF1 promoter region of different breeds of pigs. Previous studies showed that CA repeat microsatellites are associated with circulating IGF1 level. However, the mechanisms by which CA repeat microsatellites regulate IGF1 expression remain unclear. This study aimed to detect the association of CA repeat microsatellites...
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Abstract Introduction Cushing’s disease (CD) is rare disorder that should be adequately managed to optimize long-term prognosis. Treatment of CD is multidisciplinary and often includes surgical resection, adjuvant stereotactic radiosurgery (SRS), and medical treatment. Here we review surgical and radiosurgical treatment strategies for ACTH producing pituitary adenomas. Methods...
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Future Oncology, Ahead of Print.
Thu Oct 31, 2019 13:49
Future Oncology, Ahead of Print.
Thu Oct 31, 2019 13:20
Future Oncology, Ahead of Print.
Thu Oct 31, 2019 12:52
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Thu Oct 31, 2019 09:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Thu Oct 31, 2019 09:00
In the original publication the last column of the table 2 is aligned incorrectly. The correct version of table 2 is given below.
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British Journal of Cancer, Published online: 01 November 2019; doi:10.1038/s41416-019-0610-7Phospholipase D2 in prostate cancer: protein expression changes with Gleason score
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British Journal of Cancer, Published online: 01 November 2019; doi:10.1038/s41416-019-0609-0Systematic chemical screening identifies disulfiram as a repurposed drug that enhances sensitivity to cisplatin in bladder cancer: a summary of preclinical studies
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British Journal of Cancer, Published online: 01 November 2019; doi:10.1038/s41416-019-0612-5Treatment patterns and survival in HER2-positive early breast cancer: a whole-of-population Australian cohort study (2007–2016)
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British Journal of Cancer, Published online: 01 November 2019; doi:10.1038/s41416-019-0617-0Hsp60 and IL-8 axis promotes apoptosis resistance in cancer
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British Journal of Cancer, Published online: 01 November 2019; doi:10.1038/s41416-019-0613-4Use of hydrochlorothiazide and risk of skin cancer: a nationwide Taiwanese case–control study
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The sodium iodide symporter (NIS) is required for iodide uptake which facilitates thyroid hormone biosynthesis. NIS has been exploited for over 75 years in ablative radioiodine (RAI) treatment of thyroid cancer where its ability to transport radioisotopes depends on its localization to the plasma membrane. The advent of NIS-based in vivo imaging and theranostic strategies in other malignancies and disease modalities has recently increased the clinical importance of NIS. However, NIS trafficking remains...
Thu Oct 31, 2019 16:43
Master regulators of the unfolded protein response (UPR) IRE1alpha and PERK promote adaptation or apoptosis depending on the level of endoplasmic reticulum (ER) stress. While the UPR is activated in many cancers, its effects on tumor growth remain unclear. Derived from endocrine cells, pancreatic neuroendocrine tumors (PanNETs) universally hypersecrete one or more peptide hormones, likely sensitizing these cells to high ER protein-folding stress. To assess whether targeting the UPR is a viable therapeutic...
Thu Oct 31, 2019 16:43
Natural Killer (NK) cells are cytotoxic lymphocytes targeting virus-infected cells and cancer cells. Specific pro- and anti-killing signals modulate the overall ability of NK cells to kill cancer cells, however, several immune-escape mechanisms can be enacted by cancer cells to avoid NK-mediated killing. Recently, increasing evidence has shown that extracellular vesicles (EVs) released by NK cells carry proteins and microRNAs (miRs) able to exert an anti-tumoral effect, even within a highly immune-suppressive...
Thu Oct 31, 2019 16:43
Relapsed neuroblastomas are enriched with activating mutations of the RAS-MAPK signaling pathway. The MEK1/2 inhibitor trametinib delays tumor growth but does not sustain regression in neuroblastoma preclinical models. Recent studies have implicated the Hippo pathway transcriptional coactivator protein YAP1 as an additional driver of relapsed neuroblastomas, as well as a mediator of trametinib resistance in other cancers. Here, we used a highly annotated set of high-risk neuroblastoma cellular models...
Thu Oct 31, 2019 16:43
Microbial carboxyl and catechol siderophores have been shown to have natural iron-chelating abilities, suggesting that hyaluronic acid (HA) and the catechol compound, gallic acid (GA), may have iron-coordinating activities. Here, a photoresponsive self-gelling hydrogel that was both injectable and could be applied to the skin was developed based on the abilities of HA and GA to form coordination bonds with ferric ions (Fe3+). The conjugate of HA and GA (HA-GA) instantly formed hydrogels in the presence...
Thu Oct 31, 2019 16:43
Purpose: The limited knowledge of the molecular alterations that characterize poorly differentiated neuroendocrine carcinomas has limited the clinical development of targeted agents directed to driver mutations. Here we aim to identify new molecular targets in colon neuroendocrine carcinomas (co-NEC) and proof the efficacy of matching drugs. Experimental Design: We performed a multiomic analysis of co-NEC to identify genetic or epigenetic alterations that could be exploited as effective drug targets....
Thu Oct 31, 2019 15:29
Purpose: Epidermal growth factor-like domain 7 (EGFL7) is a secreted protein and recently has been shown to play an important role in acute myeloid leukemia (AML); however, the underlying mechanism by which EGFL7 promotes leukemogenesis is largely unknown. Experimental Design: Using an antibody interaction-array we measured the ability of EGFL7 to bind directly ~400 proteins expressed by primary AML blasts. Primary patient samples were stimulated in vitro with recombinant EGFL7 (rEGFL7) or anti-EGFL7...
Thu Oct 31, 2019 15:29
Purpose: Pathologic response assessment of tumor specimens from patients receiving systemic treatment provide an early indication of therapeutic efficacy and predict long-term survival. Grading systems for pathologic response were first developed for chemotherapy in select tumor types. Immunotherapeutic agents have a mechanism of action distinct from chemotherapy and are being used across a broad array of tumor types. A standardized, universal scoring system for pathologic response that encompasses...
Thu Oct 31, 2019 15:29
The progression of multiple myeloma (MM), a hematologic malignancy characterized by unregulated plasma cell growth, is associated with increasing innate and adaptive immune system dysfunction, notably in the T-cell repertoire. Although treatment advances in MM have led to deeper and more durable clinical responses, the disease remains incurable for most patients. Therapeutic strategies aimed at overcoming the immunosuppressive tumor microenvironment and activating the host immune system have recently...
Thu Oct 31, 2019 15:29
Purpose: Ulocuplumab (BMS- 936564) is a first-in-class fully human IgG4 monoclonal anti-CXCR4 antibody that inhibits the binding of CXCR4 to CXCL12. Experimental design: This phase Ib/II study aimed to determine the safety and tolerability of ulocuplumab alone and in combination with lenalidomide and dexamethasone (Len-Dex, Arm A), or bortezomib and dexamethasone (Bor-Dex, Arm B), in patients with relapsed/refractory MM. Results: Forty-six patients were evaluated (median age, 60 years; range, 53-67)....
Thu Oct 31, 2019 15:29
Reliable approaches to predict residual disease prior to primary debulking surgery have been sought to further personalize surgical approaches. Reliance on molecular biomarkers alone in a complex clinical environment is challenging and algorithms that incorporate both molecular and clinical features may need to be considered.
Thu Oct 31, 2019 15:29
Although chemo- or radio-therapy is usually performed in colorectal cancer (CRC) patients, the response is highly variable in locally rectal cancer. Therefore, additional studies are needed on predictable markers and the molecular mechanisms of chemo- and radio-therapy. Y box binding protein 1 (YB1) is an oncoprotein that is aberrantly expressed in many cancers, including CRC. However, to date there are no targeting agents or strategies to inhibit YB1 expression. Here, we investigate the oncogenic...
Thu Oct 31, 2019 16:05
Glioblastoma is resistant to conventional treatments and has dismal prognosis. Despite promising in vitro data, molecular targeted agents have failed to improve outcomes in patients, indicating that conventional two-dimensional (2D) in vitro models of GBM do not recapitulate the clinical scenario. Responses of primary glioblastoma stem-like cells (GSC) to radiation in combination with EGFR, VEGF and Akt inhibition were investigated in conventional 2D cultures and a 3-dimensional (3D) in vitro model...
Thu Oct 31, 2019 16:05
Using RNA sequencing for individual pediatric cancer cases could more effectively target gene expression in tumors. (Source: CancerNetwork)
Thu Oct 31, 2019 05:00
A relatively enormous ‘protein scaffolding’ network that stabilizes and then fixes DNA damage was found to be a potential cause of cancer by a team of scientists in Denmark if the mechanism utilizing the proteins 53BP1 and RIF1 malfunctions. The resulting pathway could be the culprit behind some diseases, according t o the results reported in the journal Nature. (Source: CancerNetwork)
Thu Oct 31, 2019 05:00
Treatment with SY-1425 in combination with azacitidine induced a 62% complete response rate with incomplete blood count recovery rate among unfit patients with RARA-positive AML. (Source: CancerNetwork)
Thu Oct 31, 2019 05:00
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