A relatively enormous ‘protein scaffolding’ network that stabilizes and then fixes DNA damage was found to be a potential cause of cancer by a team of scientists in Denmark if the mechanism utilizing the proteins 53BP1 and RIF1 malfunctions. The resulting pathway could be the culprit behind some diseases, according t o the results reported in the journal Nature. (Source: CancerNetwork)
Thu Oct 31, 2019 05:00
Treatment with SY-1425 in combination with azacitidine induced a 62% complete response rate with incomplete blood count recovery rate among unfit patients with RARA-positive AML. (Source: CancerNetwork)
Thu Oct 31, 2019 05:00
In the original publication of this article,[1] the Funding section needs to be revised, and the corrected Funding section appears below.
Thu Oct 31, 2019 02:00
In the original publication of this article [1], there are mistakes in Fig. 3c and Fig. 3e.
Thu Oct 31, 2019 02:00
In the publication of our publication [1], we have noticed there is a wrong label in Fig. 1e, in which the position of “HCC” and “Adjacent” should be transposed.
Thu Oct 31, 2019 02:00
In the original publication of this article [1], the author would like to revise Figure 4.
Thu Oct 31, 2019 02:00
In the original publication of this article [1], there are mistakes in Fig. 4d. The corrected Fig. 4 should be:
Thu Oct 31, 2019 02:00
Abstract Purpose The importance of benign ovarian tumors as precursors or risk markers for ovarian cancer is not fully understood. Studies on the association between benign ovarian tumors and ovarian cancer have provided inconclusive results. We examined the overall and histological type-specific risk of ovarian cancer among 158,221 Danish women diagnosed with a benign ovarian tumor during 1978–2016. ...
Thu Oct 31, 2019 02:00
Abstract Purpose Circumscribed gliomas -pilocytic astrocytomas (PA), gangliogliomas (GG), ependymomas (EP)- are mostly low-grade tumours but may progress to anaplasia and sometimes surgery can be challenging due to deep anatomical localization. Because of the high frequency of MAPK-pathway alterations and availability of targeted therapies for FGFR1 and BRAF-mutated tumors, we investigated these mutational hotspots in a cohort of adult...
Thu Oct 31, 2019 02:00
Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Rosa Maria Leon-Salas Ordoñez, Beatriz E. Amendola, Paul F. Martinez, Aizik Wolf, Sammie R. Coy, Marco AmendolaAbstractPurposeWe present our results in the treatment of brain metastases (BM) from ovarian cancer using Gamma Knife Radiosurgery (GKRS) over the last 25 years in a single institution.BackgroundGamma Knife Radiosurgery has become increasingly important in the management...
Thu Oct 31, 2019 19:19
Publication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): E. Nobakht, N. FouladiAbstractAimThe feasibility of using 230 MeV proton cyclotrons in proton therapy centers as a spallation neutron source for Boron Neutron Capture Therapy (BNCT) was investigated.BackgroundBNCT is based on the neutron irradiation of a 10B-containing compound located selectively in tumor cells. Among various types of neutron generators, the spallation neutron...
Thu Oct 31, 2019 19:19
Tumor motion may compromise the accuracy of liver stereotactic radiotherapy. In order to carry out a precise planning, estimating liver tumor motion during radiotherapy has received a lot of attention. Previou...
Tue Oct 29, 2019 02:00
Abstract Purpose Single-session cardiac stereotactic body radiotherapy, called cardiac radiosurgery (CRS) or radioablation (RA), may offer a potential treatment option for patients with refractory ventricular tachycardia (VT) and electrical storm who are otherwise ineligible for catheter ablation. However, there is only limited clinical experience. We now present the first-in-patient treatment using (CRS/RA) for VT in Germany. ...
Thu Oct 31, 2019 02:00
Publication date: Available online 30 October 2019Source: Seminars in OncologyAuthor(s): David Cheng, Jaime Ramos-Cejudo, David Tuck, Danne Elbers, Mary Brophy, Nhan Do, Nathanael FillmoreAbstractBackground: There is wide interest in developing prognostic models in non–small-cell lung cancer (NSCLC) due to the heterogeneity of the disease. Models developed at other healthcare institutions may not be directly applicable for patients treated at the Department of Veterans Affairs (VA). External validation...
Thu Oct 31, 2019 18:02
Cancers, Vol. 11, Pages 1696: Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment Cancers doi: 10.3390/cancers11111696 Authors: Park Lee Sphingosylphosphorylcholine (SPC) is a unique type of lysosphingolipid found in some diseases, and has been studied in cardiovascular, neurological, and inflammatory phenomena. In particular, SPC's studies on cancer have been conducted mainly in terms of effects on cancer cells, and relatively little consideration has been given...
Thu Oct 31, 2019 02:00
Cancers, Vol. 11, Pages 1697: Roles for Autophagy in Esophageal Carcinogenesis: Implications for Improving Patient Outcomes Cancers doi: 10.3390/cancers11111697 Authors: Saxena Klochkova Murray Kabir Samad Beccari Gang Patel Hamilton Whelan Esophageal cancer is among the most aggressive forms of human malignancy with five-year survival rates of <20%. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged...
Thu Oct 31, 2019 02:00
Publication date: Available online 31 October 2019Source: Journal of Infection and ChemotherapyAuthor(s): Hiram Villanueva-Lozano, Gloria M. González, Jaime E. Espinosa-Mora, Byron A. Bodden-Mendoza, Angel Andrade, Michel F. Martínez-Reséndez, Rogelio de J. Treviño-RangelAbstractThe emergence of non-Aspergillus mold pathogens has increased notoriously in the last decades with serious health consequences. The options of treatment for these microorganisms often resistant to a wide variety of antifungals...
Thu Oct 31, 2019 17:56
Publication date: Available online 31 October 2019Source: Journal of Infection and ChemotherapyAuthor(s): Sachio Tsuchida, Syota Murata, Akiko Miyabe, Mamoru Satoh, Masaki Takiwaki, Kazuyuki Matsushita, Fumio NomuraAbstractMatrix-assisted laser desorption ionization–time-of-flight mass spectrometry (MALDI-TOF MS) is one of the most promising technologies for the identification of microbial pathogens directly from positive blood culture bottles. As blood culture bottle medium contains various nonbacterial...
Thu Oct 31, 2019 17:56
Publication date: Available online 30 October 2019Source: Journal of Infection and ChemotherapyAuthor(s): Tetsuya Horino, Seiji HoriAbstractStaphylococcus aureus causes various infections, including skin and soft tissue infections and pneumonia via both, community-associated and nosocomial infection. These infectious diseases can lead to bacteremia, and may subsequently result in metastatic infections in several cases. Metastatic infections are critical complications in patients with S. aureus bacteremia,...
Thu Oct 31, 2019 17:56
Publication date: Available online 30 October 2019Source: Cancer Treatment ReviewsAuthor(s): Andrew Y. Li, Michael G. McCusker, Alessandro Russo, Katherine A. Scilla, Allison Gittens, Katherine Arensmeyer, Ranee Mehra, Vincenzo Adamo, Christian RolfoAbstractThe RET proto-oncogene has been well-studied. RET is involved in many different physiological and developmental functions. When altered, RET mutations influence disease in a variety of organ systems from Hirschsprung’s disease and multiple endocrine...
Thu Oct 31, 2019 17:31
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Imke Satzger, Ulrike Leiter, Nikolai Gräger, Ulrike Keim, Claus Garbe, Ralf GutzmerAbstractBackgroundThe tumor burden within the sentinel lymph node (SLN) is not included in the 8th edition of the American Joint Committee of Cancer (AJCC) melanoma classification. Therefore, we analysed the prognostic relevance of the SLN tumor burden in the stage III subgroups.Patients and methodsA total of 736 patients with melanoma...
Thu Oct 31, 2019 17:23
Publication date: Available online 31 October 2019Source: European Journal of CancerAuthor(s): Shih-Wei Lai, Yu-Hung Kuo, Kuan-Fu Liao
Thu Oct 31, 2019 17:23
Mike Richards’s independent review of adult screening programmes in England is out and can be summarised as “nothing is too much.”1 Calling for financial incentives, increased uptake, reorganisation,...
Thu Oct 31, 2019 12:56
The national guidelines on research integrity have been updated to clarify the requirements for universities and enable sanctions to be enforced when research misconduct takes place.1The move follows...
Thu Oct 31, 2019 12:35
What are the long term health needs of women with a history of sexual trauma? This question isn’t well covered in guidelines, since they tend to focus on acute treatment after a sexual attack. Over a...
Thu Oct 31, 2019 12:25
Football for prostate cancerTwo hundred men with prostate cancer were randomised either to an offer of free football training at a local club or to usual treatment plus a recommendation to pursue an...
Thu Oct 31, 2019 12:16
Doctors specialising in general internal medicine are part of the acute medical care workforce. Their work involves diagnosing and treating a wide spectrum of diseases and conditions that present...
Thu Oct 31, 2019 12:11
This is pyoderma gangrenosum (fig 1) triggered by trauma from a tattoo.bmj;367/oct31_5/l5765/F1F1f1Fig 1The patient was a medically well 51 year old woman who developed painful studded pustules and...
Thu Oct 31, 2019 12:05
Cancers, Vol. 11, Pages 1695: Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation Cancers doi: 10.3390/cancers11111695 Authors: Ilaria Casari Alice Domenichini Simona Sestito Emily Capone Gianluca Sala Simona Rapposelli Marco Falasca Deregulation of different intracellular signaling pathways is a common feature in cancer. Numerous studies indicate that persistent activation of the phosphoinositide 3-kinase (PI3K) pathway...
Thu Oct 31, 2019 02:00
Abstract Alternative splicing of precursor mRNA is a key mediator of gene expression regulation leading to greater diversity of the proteome in complex organisms. Systematic sequencing of the human genome and transcriptome has led to our understanding of how alternative splicing of critical genes leads to multiple pathological conditions such as cancer. For many years, proteases were known only for their roles as proteolytic enzymes, acting to regulate/process proteins associated...
Thu Oct 31, 2019 02:00
Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Urvi H. Gala, Dave A. Miller, Robert O. WilliamsAbstractThe treatment of cancer is still a major challenge. But tremendous progress in anticancer drug discovery and development has occurred in the last few decades. However, this progress has resulted in few effective oncology products due to challenges associated with anticancer drug delivery. Oral administration is the most...
Thu Oct 31, 2019 13:27
Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s)
Publication date: Available online 30 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Joseph Carmicheal, Asish Patel, Vipin Dalal, Pranita Atri, Amaninder S. Dhaliwal, Uwe A. Wittel, Mokenge P. Malafa, Geoffrey Talmon, Benjamin J. Swanson, Shailender Singh, Maneesh Jain, Sukhwinder Kaur, Surinder K. BatraAbstractPancreatic ductal adenocarcinoma (PDAC) is an incredibly deadly disease with a 5-year survival rate of 6%. The presence of pancreatic cystic lesions...
Thu Oct 31, 2019 13:27
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου