Related ArticlesEffects of chemical and mechanical stimulation on laryngeal motion during alfaxalone, thiopentone or propofol anaesthesia in healthy dogs. Vet Anaesth Analg. 2019 Jul;46(4):435-442 Authors: Labuscagne S, Zeiler GE, Dzikiti BT Abstract OBJECTIVE: To compare the effect of chemical and mechanical stimulation on arytenoid cartilage motion during anaesthetic induction with alfaxalone, thiopentone or propofol. STUDY DESIGN: Masked,...
Thu Nov 21, 2019 13:27
Related ArticlesInterleukin-17 Regulates Neuron-Glial Communications, Synaptic Transmission, and Neuropathic Pain after Chemotherapy. Cell Rep. 2019 Nov 19;29(8):2384-2397.e5 Authors: Luo H, Liu HZ, Zhang WW, Matsuda M, Lv N, Chen G, Xu ZZ, Zhang YQ Abstract The proinflammatory cytokine interleukin-17 (IL-17) is implicated in pain regulation. However, the synaptic mechanisms by which IL-17 regulates pain transmission are unknown. Here, we report that...
Thu Nov 21, 2019 15:24
Related ArticlesGenotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence. Mol Psychiatry. 2019 Nov 19;: Authors: Meng W, Sjöholm LK, Kononenko O, Tay N, Zhang D, Sarkisyan D, Geske JR, Ing A, Qiu W, Watanabe H, Almamoun R, Frieling H, Bleich S, Cui D, Biernacka JM, Mayfield RD, Dang Y, Karpyak VM, Schumann G, IMAGEN Consortium, Bakalkin G, Ekström TJ, Rüegg J, Liu Y Abstract Alcohol misuse is a major public health problem originating...
Thu Nov 21, 2019 13:24
Related ArticlesCDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β-catenin Signaling. Curr Cancer Drug Targets. 2019 Nov 17;: Authors: Peng F, Yang C, Kong Y, Huang X, Chen Y, Zhou Y, Xie X, Liu P Abstract BACKGROUND: CDK12 is a promising therapeutic target in breast cancer with effective cancer cell stemness maintainess ability. OBJECTIVE: We aim to investigate the mechanism of CDK12 in maintaining breast...
Thu Nov 21, 2019 13:17
Related ArticlesCardiac remodeling in obesity and after bariatric and metabolic surgery; is there a role for gastro-intestinal hormones? Expert Rev Cardiovasc Ther. 2019 Nov 20;:1-20 Authors: Sanches E, Timmermans M, Topal B, Celik A, Sundbom M, Ribeiro R, Parmar C, Ugale S, Proczko M, Stepaniak PS, Pujol Rafols J, Mahawar K, Buise MP, Neimark A, Severin R, Pouwels S Abstract Introduction: Obesity is associated with various diseases such as type 2 diabetes,...
Thu Nov 21, 2019 14:47
Related ArticlesTongue peak pressure: a tool to aid in the identification of obstruction sites in patients with obstructive sleep apnea/hypopnea syndrome. Sleep Breath. 2019 Nov 19;: Authors: O'Connor-Reina C, Plaza G, Garcia-Iriarte MT, Ignacio-Garcia JM, Baptista P, Casado-Morente JC, De Vicente E Abstract Purpose of this study was to evaluate whether tongue peak pressure measured using the Iowa Oral Performance Instrument is correlated with the topographic...
Thu Nov 21, 2019 13:17
Related ArticlesErratum: Synthesis of In37P20(O2CR)51 Clusters and Their Conversion to InP Quantum Dots. J Vis Exp. 2019 Nov 20;(153): Authors: Abstract An erratum was issued for: Synthesis of In37P20(O2CR)51 Clusters and Their Conversion to InP Quantum Dots. The Representative Results were updated. The fifth sentence in the second paragraph of the Representative Results was updated from: The 31P NMR spectrum of myristate-capped InP clusters shows 11...
Thu Nov 21, 2019 15:22
Related ArticlesEarly economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy. PLoS One. 2019;14(11):e0224571 Authors: Widjaja E, Papastavros T, Sander B, Snead C, Pechlivanoglou P Abstract BACKGROUND: MRI-guided laser interstitial thermal therapy (MRgLITT) is a new minimally invasive treatment for temporal lobe epilepsy (TLE), with limited effectiveness data. It is unknown...
Thu Nov 21, 2019 15:08
Related ArticlesMobile and Web-Based Apps That Support Self-Management and Transition in Young People With Chronic Illness: Systematic Review. J Med Internet Res. 2019 Nov 20;21(11):e13579 Authors: Virella Pérez YI, Medlow S, Ho J, Steinbeck K Abstract BACKGROUND: More adolescents with chronic physical illness are living into adulthood, and they require the development of proficient self-management skills to maintain optimal physical health as they transition...
Thu Nov 21, 2019 15:08
Circulating microRNAs as potential biomarkers for Genetic Generalized Epilepsies: a three MiR panel.
Related ArticlesCirculating microRNAs as potential biomarkers for Genetic Generalized Epilepsies: a three MiR panel. Eur J Neurol. 2019 Nov 20;: Authors: Martins-Ferreira R, Chaves J, Carvalho C, Bettencourt A, Chorão R, Freitas J, Samões R, Boleixa D, Lopes J, Ramalheira J, da Silva BM, Martins da Silva A, Costa PP, Leal B Abstract BACKGROUND: Genetic Generalized Epilepsies (GGEs) encompass a group of syndromes of mainly genetic causes, characterized...
Thu Nov 21, 2019 15:08
Related ArticlesPolyamines: The possible missing link between mental disorders and epilepsy (Review). Int J Mol Med. 2019 Nov 11;: Authors: Baroli G, Sanchez JR, Agostinelli E, Mariottini P, Cervelli M Abstract Polyamines are small positively charged alkylamines that are essential in a number of crucial eukaryotic processes, like normal cell growth and development. In normal physiological conditions, intracellular polyamine content is tightly regulated...
Thu Nov 21, 2019 15:08
Related ArticlesClinical report and biochemical analysis of a patient with fumarate hydratase deficiency. Am J Med Genet A. 2019 Nov 20;: Authors: Grocott O, Phanor SK, Fung F, Thibert RL, Berkmen MB Abstract Fumarate hydratase deficiency (FHD) is a rare metabolic disease caused by two defective copies of the FH gene, which encodes the Krebs cycle enzyme fumarase. FHD is associated with brain and developmental abnormalities, seizures, and high childhood...
Thu Nov 21, 2019 13:13
Related ArticlesPotassium citrate and metabolic acidosis in children with epilepsy on the ketogenic diet: a prospective controlled study. Dev Med Child Neurol. 2019 Nov 19;: Authors: Bjurulf B, Magnus P, Hallböök T, Strømme P Abstract AIM: To investigate if potassium citrate, a mild alkaline compound, can prevent metabolic acidosis in children with epilepsy treated with the ketogenic diet without reducing antiepileptic efficacy. METHOD: In this...
Thu Nov 21, 2019 13:13
Related ArticlesFirst add-on perampanel for focal-onset seizures: an open-label, prospective study. Acta Neurol Scand. 2019 Nov 20;: Authors: Kim JH, Kim DW, Lee SK, Seo DW, Lee JW, Park HJ, Lee SA Abstract OBJECTIVES: This study aimed to determine the efficacy and safety of perampanel added to monotherapy in patients with focal-onset seizures, with or without secondarily generalised tonic-clonic seizures. MATERIALS & METHODS: In this multicentre,...
Thu Nov 21, 2019 13:13
Related ArticlesAdult neurogenesis in epileptogenesis: An update for preclinical finding and potential clinical translation. Curr Neuropharmacol. 2019 Nov 18;: Authors: Chen L, Wang Y, Chen Z Abstract Epileptogenesis refers to the process in which a normal brain becomes epileptic, and is characterized by hypersynchronous spontaneous recurrent seizures involving a complex epileptogenic network. Current available pharmacological treatment of epilepsy is...
Thu Nov 21, 2019 13:13
Related ArticlesTeratogenic potential of third-generation antiepileptic drugs: Current status and research needs. Pharmacol Rep. 2019 Jun;71(3):491-502 Authors: Singh KP, Verma N Abstract The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs) considering their clinical implications and to highlight for further research need in the interest of the diseased population...
Thu Nov 21, 2019 13:13
Related ArticlesAssociation of BMI and lipid profiles with axillary osmidrosis: a retrospective case-control study. J Dermatolog Treat. 2019 Nov 20;:1-4 Authors: Dong Z, Tan Z, Chen Z Abstract Background: Axillary osmidrosis (AO) is a common disease. There are no safely effective therapies for AO.Objective: The objective of our study was to establish whether increased BMI and lipid profiles affects the prevalence of AO.Methods: Our research was a retrospective...
Thu Nov 21, 2019 15:14
Related ArticlesMeta-analysis of photobiomodulation for the treatment of androgenetic alopecia. J Dermatolog Treat. 2019 Nov 20;:1-5 Authors: Gupta AK, Carviel JL Abstract Background: Androgenetic alopecia (AGA) is a condition that affects most people at some point in their life, yet few treatments are available. Use of photobiomodulation is ideal due to the safety profile and lack of serious adverse effects. Therefore, the efficacy of photobiomodulation...
Thu Nov 21, 2019 15:14
Related ArticlesCannabinoids: a possible treatment for chronic cutaneous wounds. J Dermatolog Treat. 2019 Nov 20;:1-2 Authors: Mansouri K, Norooznezhad AH PMID: 31746244 [PubMed - as supplied by publisher]
Thu Nov 21, 2019 15:14
Related ArticlesVietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma. J Basic Clin Physiol Pharmacol. 2019 Nov 20;: Authors: Devi Khwairakpam A, Monisha J, Roy NK, Bordoloi D, Padmavathi G, Banik K, Khatoon E, Kunnumakkara AB Abstract Background According to GLOBOCAN 2018, oral cancer was reported as the second highest cancer prevalent in India. Despite the several...
Thu Nov 21, 2019 15:06
Related ArticlesIdentifying fates of cancer cells exposed to mitotic inhibitors by quantitative phase imaging. Analyst. 2019 Nov 20;: Authors: Huang D, Roy IJ, Murray GF, Reed J, Zangle TA, Teitell MA Abstract Cell cycle deregulation is a cancer hallmark that has stimulated the development of mitotic inhibitors with differing mechanisms of action. Quantitative phase imaging (QPI) is an emerging approach for determining cancer cell sensitivities to chemotherapies...
Thu Nov 21, 2019 15:06
Related ArticlesIn vitro evaluation of electroporated gold nanoparticles and extremely-low frequency electromagnetic field anticancer activity against Hep-2 laryngeal cancer cells. Folia Histochem Cytobiol. 2019 Nov 20;: Authors: Alshehri MA, Wierzbicki PM, Kaboo HF, Nasr MSM, Amer ME, Abuamara TMM, Badr DA, Saleh KA, Fazary AE, Mohamed AF Abstract INTRODUCTION: The extremely-low frequency electromagnetic field (ELFEMF) has been proposed for use in cancer...
Thu Nov 21, 2019 15:06
Related ArticlesiTRAQ‑based proteomics analysis of the therapeutic effects of combined anticancer bioactive peptides and oxaliplatin on gastric cancer cells. Oncol Rep. 2019 Nov 11;: Authors: Xu Y, Li X, Su X Abstract The combination of chemotherapeutic modalities may be more effective in treating gastric cancer compared with any modality alone. Previous studies have demonstrated that the combination of anticancer bioactive peptides (ACBP) and oxaliplatin (OXA)...
Thu Nov 21, 2019 15:06
Related ArticlesCircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling. Biosci Rep. 2019 Nov 20;: Authors: Zhang WY, Liu QH, Wang TJ, Zhao J, Cheng XH, Wang JS Abstract Circular RNAs (circRNAs) have been identified as crucial regulators of gene expression in human cancer biology. CircZFR is a novel identified circRNA and its effect in bladder cancer remains unclearly. In this study, we aimed to...
Thu Nov 21, 2019 15:06
Related ArticlesmiR-4319 suppresses the growth of esophageal squamous cell carcinoma via targeting NLRC5. Curr Mol Pharmacol. 2019 Nov 18;: Authors: Hu X, Wang M, Cao L, Cong L, Gao Y, Lu J, Feng J, Shen B, Liu D Abstract BACKGROUND: The functions of microRNAs (miRNAs) in cancer progression have been recognized in recent years. However, the role of miR-4319 in esophageal squamous cell carcinoma (ESCC) remains unclear. OBJECTIVE: We aimed to...
Thu Nov 21, 2019 15:06
Related ArticlesTargeting senescent cells in translational medicine. EMBO Mol Med. 2019 Nov 19;:e10234 Authors: Paez-Ribes M, González-Gualda E, Doherty GJ, Muñoz-Espín D Abstract Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a hallmark of ageing. Senescent...
Thu Nov 21, 2019 13:11
Related ArticlesTranscriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2019 Nov 20;: Authors: Kim MJ, Kim CH, Seo YJ, An MJ, Lee JH, Shin GS, Hwang JY, Park J, Kim JY, Hwang SY, Rhee S, Kim JW Abstract Methylparaben is most frequently used as an antimicrobial preservative in pharmaceuticals and foods. Methylparaben has been subjected to toxicological...
Thu Nov 21, 2019 13:11
Related ArticlesModulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. Nat Commun. 2019 Nov 19;10(1):5232 Authors: Kaoud TS, Johnson WH, Ebelt ND, Piserchio A, Zamora-Olivares D, Van Ravenstein SX, Pridgen JR, Edupuganti R, Sammons R, Cano M, Warthaka M, Harger M, Tavares CDJ, Park J, Radwan MF, Ren P, Anslyn EV, Tsai KY, Ghose R, Dalby KN Abstract Recently, the targeting of ERK with ATP-competitive inhibitors...
Thu Nov 21, 2019 13:11
Related ArticlesInhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway. Cell Death Dis. 2019 Nov 19;10(12):874 Authors: Xu Q, Wu N, Li X, Guo C, Li C, Jiang B, Wang H, Shi D Abstract Pancreatic cancer is a highly malignant cancer and lacks effective therapeutic targets. Protein-tyrosine phosphatase 1B (PTP1B), a validated therapeutic target for diabetes and obesity, also plays a critical positive or negative...
Thu Nov 21, 2019 13:11
Related ArticlesMetformin inhibits cell proliferation in SKM-1 cells via AMPK-mediated cell cycle arrest. J Pharmacol Sci. 2019 Nov 02;: Authors: Zhou X, Kuang Y, Liang S, Wang L Abstract Metformin, a widely used antidiabetic drug, has previously been demonstrated to exert anti-cancer effects in certain hematological malignancies, but its effects on the transformation of myelodysplastic syndromes to acute myeloid leukemia (AML-MDS) remain unclear. The...
Thu Nov 21, 2019 13:11
Related ArticlesExposure to etoxazole induces mitochondria-mediated apoptosis in porcine trophectoderm and uterine luminal epithelial cells. Environ Pollut. 2019 Nov 09;:113480 Authors: Park W, Lim W, Park S, Whang KY, Song G Abstract Etoxazole is an organofluorine insecticide widely used in agriculture. Exposure to insecticides is a serious environmental problem owing to their cytotoxic effects in humans and animals. Reproductive toxicity of various...
Thu Nov 21, 2019 13:11
Related ArticlesCatching HPV in the Homologous Recombination Cookie Jar. Trends Microbiol. 2019 Nov 16;: Authors: Wallace NA Abstract To replicate, the human papillomaviruses (HPVs) that cause anogenital and oropharyngeal malignancies must simultaneously activate DNA repair pathways and avoid the cell cycle arrest that normally accompanies DNA repair. For years it seemed that HPV oncogenes activated the homologous recombination pathway to facilitate...
Thu Nov 21, 2019 13:11
Related ArticlesBiological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents. Pharmaceuticals (Basel). 2019 Nov 17;12(4): Authors: Nascimento da Cruz AC, Brondani DJ, I Talo de Santana T, Oliveira da Silva L, da Oliveira Borba EF, de Faria AR, Ferreira Cavalcanti de Albuquerque J, Piessard S, Matos Ximenes R, Baratte B, Bach S, Ruchaud S, Bezerra Mendonça Junior FJ, Bazin MA, Montenegro Rabello M, Hernandes MZ, Marchand P, Gonçalves da Silva T...
Thu Nov 21, 2019 13:11
Related ArticlesHPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes. Aging (Albany NY). 2018 12 30;11(1):33-47 Authors: Villota C, Varas-Godoy M, Jeldes E, Campos A, Villegas J, Borgna V, Burzio LO, Burzio VA Abstract Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal...
Thu Nov 21, 2019 13:11
Related ArticlesPredictors of eustachian tube dysfunction improvement and normalization after endoscopic sinus surgery. Laryngoscope. 2019 Nov 20;: Authors: Higgins TS, Cappello ZJ, Wu AW, Ting JY, Sindwani R Abstract OBJECTIVE: Studies have demonstrated improvement in Eustachian tube dysfunction (ETD) symptomatology after functional endoscopic sinus surgery (FESS); however, factors associated with ETD symptom alteration have not been elucidated. This...
Thu Nov 21, 2019 15:09
Related ArticlesCT and MRI features of calvarium and skull base osteosarcoma (CSBO). Br J Radiol. 2019 Nov 20;:20190653 Authors: Luo Z, Chen W, Shen X, Qin G, Yuan J, Hu B, Lyu J, Pan D Abstract OBJECTIVE: This study aims to assess the computed tomography (CT) and magnetic resonance imaging (MRI) features of calvarium and skull base osteosarcoma (CSBO). METHODS: The CT and MRI features and pathological characteristics of 12 cases of pathologically...
Thu Nov 21, 2019 15:09
Related ArticlesThe endoscopic endonasal approach or microscopic transcranial approach for anterior skull base meningiomas-it is all about right indication rather than superiority. Acta Neurochir (Wien). 2019 Nov 19;: Authors: Muskens IS, Zamanipoor Najafabadi AH, Broekman MLD PMID: 31745623 [PubMed - as supplied by publisher]
Thu Nov 21, 2019 13:07
Related ArticlesUltrasound Ablation in Neurosurgery: Current Clinical Applications and Future Perspectives. Neurosurgery. 2019 Nov 20;: Authors: Franzini A, Moosa S, Prada F, Elias WJ Abstract The concept of focusing high-intensity ultrasound beams for the purpose of cerebral ablation has interested neurosurgeons for more than 70 yr. However, the need for a craniectomy or a cranial acoustic window hindered the clinical diffusion of this technique. Recent...
Thu Nov 21, 2019 13:07
Related ArticlesQuantitative analysis of the surgical exposure and surgical freedom between transcranial and transorbital endoscopic anterior petrosectomies to the posterior fossa. J Neurosurg. 2018 08 03;131(2):569-577 Authors: Noiphithak R, Yanez-Siller JC, Revuelta Barbero JM, Otto BA, Carrau RL, Prevedello DM Abstract OBJECT: This study proposes a variation of the transorbital endoscopic approach (TOEA) that uses the lateral orbit as the primary...
Thu Nov 21, 2019 13:07
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