Related ArticlesTargeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas. Cell Rep. 2019 Nov 19;29(8):2321-2337.e7 Authors: Yamagishi M, Hori M, Fujikawa D, Ohsugi T, Honma D, Adachi N, Katano H, Hishima T, Kobayashi S, Nakano K, Nakashima M, Iwanaga M, Utsunomiya A, Tanaka Y, Okada S, Tsukasaki K, Tobinai K, Araki K, Watanabe T, Uchimaru K Abstract Although global H3K27me3 reprogramming...
Thu Nov 21, 2019 15:10
Related ArticlesNationwide Survey of Patients' Perspectives Regarding Their Radiation and Multidisciplinary Cancer Treatment Experiences. J Oncol Pract. 2019 Nov 20;:JOP1900376 Authors: Shaverdian N, Yeboa DN, Gardner L, Harari PM, Liao K, McCloskey S, Tuli R, Vapiwala N, Jagsi R Abstract PURPOSE: The perspectives of patients with cancer about their treatment can inform interventions to improve the approaches of treating oncologists and experiences of...
Thu Nov 21, 2019 15:10
Related ArticlesCirculating microRNAs as biomarkers for early diagnosis of cutaneous melanoma. Expert Rev Mol Diagn. 2019 Nov 20;: Authors: Carpi S, Polini B, Fogli S, Podestà A, Ylösmäki E, Cerullo V, Romanini A, Nieri P Abstract Introduction: Cutaneous melanoma is the deadliest form of skin cancer, with a dramatic increase in the incidence rate worldwide over the past decade. Early detection has been shown to improve the outcome of melanoma patients....
Thu Nov 21, 2019 15:10
Related ArticlesRecent Advances in Microfluidic Platforms Applied in Cancer Metastasis: Circulating Tumor Cells' (CTCs) Isolation and Tumor-On-A-Chip. Small. 2019 Nov 20;:e1903899 Authors: Lin Z, Luo G, Du W, Kong T, Liu C, Liu Z Abstract Cancer remains the leading cause of death worldwide despite the enormous efforts that are made in the development of cancer biology and anticancer therapeutic treatment. Furthermore, recent studies in oncology have...
Thu Nov 21, 2019 15:10
Related ArticlesIncidence and survival trends for appendiceal mucinous adenocarcinoma: an analysis of 3237 patients in the Surveillance, Epidemiology, and End Results database. Future Oncol. 2019 Nov 20;: Authors: Yan Q, Zheng W, Luo H, Wang B, Zhang X, Wang X Abstract Aim: To characterize the epidemiology of appendiceal mucinous adenocarcinoma. Methods: Prognostic factors were evaluated with univariate and multivariate analyses. The results were used...
Thu Nov 21, 2019 15:10
Related ArticlesRadiation-induced intestinal damage: latest molecular and clinical developments. Future Oncol. 2019 Nov 20;: Authors: Lu L, Li W, Chen L, Su Q, Wang Y, Guo Z, Lu Y, Liu B, Qin S Abstract Aim: To systematically review the prophylactic and therapeutic interventions for reducing the incidence or severity of intestinal symptoms among cancer patients receiving radiotherapy. Materials & methods: A literature search was conducted in the...
Thu Nov 21, 2019 15:10
Related ArticlesThe effect of marital status on endometrial cancer-related diagnosis and prognosis: a Surveillance Epidemiology and End Results database analysis. Future Oncol. 2019 Nov 20;: Authors: Dong J, Dai Q, Zhang F Abstract Aim: Marital status has been proved a significant prognostic factor for diagnosis and prognosis in various cancers, but the effect in endometrial cancer (EMC) is controversial. The research was designed to clarify the relationship...
Thu Nov 21, 2019 15:10
Related ArticlesRegorafenib in patients with refractory metastatic pancreatic cancer: a Phase II study (RESOUND). Future Oncol. 2019 Nov 20;: Authors: Bozzarelli S, Rimassa L, Giordano L, Sala S, Tronconi MC, Pressiani T, Smiroldo V, Prete MG, Spaggiari P, Personeni N, Santoro A Abstract Aim: Regorafenib may be active in different cancer types. This Phase II trial included patients with various refractory cancer types treated with regorafenib. Here,...
Thu Nov 21, 2019 15:10
Related ArticlesBevacizumab use in the frontline, maintenance and recurrent settings for ovarian cancer. Future Oncol. 2019 Nov 20;: Authors: Haunschild CE, Tewari KS Abstract On 13 June 2018, Genentech, Inc. issued a press release announcing that the US FDA had approved the antiangiogenesis drug, bevacizumab, in combination with chemotherapy for frontline and maintenance therapy for women with newly diagnosed ovarian cancer. Regulatory approval was...
Thu Nov 21, 2019 15:10
Related ArticlesBrachytherapy with surgical resection as salvage treatment for recurrent high-grade meningiomas: a matched cohort study. J Neurooncol. 2019 Nov 19;: Authors: Mooney MA, Bi WL, Cantalino JM, Wu KC, Harris TC, Possatti LL, Juvekar P, Hsu L, Dunn IF, Al-Mefty O, Devlin PM Abstract PURPOSE: To evaluate surgical resection with brachytherapy placement as a salvage treatment in patients with recurrent high-grade meningioma who exhausted prior...
Thu Nov 21, 2019 13:06
Related ArticlesTranscriptome analysis reveals overlap in fusion genes in a phase I clinical cohort of TNBC and HGSOC patients treated with buparlisib and olaparib. J Cancer Res Clin Oncol. 2019 Nov 19;: Authors: Eismann J, Heng YJ, Waldschmidt JM, Vlachos IS, Gray KP, Matulonis UA, Konstantinopoulos PA, Murphy CJ, Nabavi S, Wulf GM Abstract PURPOSE: Fusion genes can be therapeutically relevant if they result in constitutive activation of oncogenes or...
Thu Nov 21, 2019 13:06
Related ArticlesResponse to Immunotherapy in Combination With Mitotane in Patients With Metastatic Adrenocortical Cancer. J Endocr Soc. 2019 Dec 01;3(12):2295-2304 Authors: Head L, Kiseljak-Vassiliades K, Clark TJ, Somerset H, King J, Raeburn C, Albuja-Cruz M, Weyant M, Cleveland J, Wierman ME, Leong S Abstract Adrenocortical carcinoma (ACC) is a rare orphan disease with a dismal prognosis. Surgery remains the first-line treatment, but most patients...
Thu Nov 21, 2019 13:06
Related ArticlesContribution of high body mass index and alcohol use to liver cancer-related mortality: A study based on 195 countries or territories. Dig Liver Dis. 2019 Nov 16;: Authors: Zhang G, Cao F, Shi L, Ma T, Zhang L Abstract BACKGROUND: High body mass index (BMI) and alcohol use are well-defined risk factors for liver cancer. AIMS: We aim to describe the contribution of high BMI and alcohol use to liver-cancer-related death at the...
Thu Nov 21, 2019 13:06
Related ArticlesGeographic Differences in Phenotype and Treatment of Children with Sickle Cell Anemia from the Multinational DOVE Study. J Clin Med. 2019 Nov 17;8(11): Authors: Inusa BPD, Colombatti R, Rees DC, Heeney MM, Hoppe CC, Ogutu B, Hassab HM, Zhou C, Yao S, Brown PB, Heath LE, Jakubowski JA, Abboud MR Abstract BACKGROUND: DOVE (Determining Effects of Platelet Inhibition on Vaso-Occlusive Events) was a Phase 3, randomized, double-blind, placebo-controlled...
Thu Nov 21, 2019 13:06
Approximately 50% of patients with metastatic melanoma harbor an activating BRAF mutation. Tumors with activating mutation BRAF gene proliferate excessively and can be treated with targeted BRAF-inhibitors in combination with MEK inhibitors. The most common BRAF mutation occurs at amino acid position 600. Other BRAF mutations are rare and their predictive value for treatment response to BRAF/MEK inhibition is low. Here, we report on a patient with a BRAF A598_T599insV mutated melanoma, a mutation...
Thu Nov 21, 2019 11:36
Adenosquamous carcinoma is a rare type of non-small cell lung cancer associated with advanced disease and poor prognosis. There is limited data for the management of mixed histology disease in elderly or frail patients. A 79-year-old woman with no smoking history presented with a right upper lobe lung mass on chest x-ray. Biopsy of the mass demonstrated an EGFR-amplified, PD-L1 positive adenosquamous lung cancer. The mass was surgically resected but the patient was not a candidate for adjuvant chemotherapy....
Thu Nov 21, 2019 11:35
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