Related ArticlesMicroRNA-542-3p regulates P-glycoprotein expression in rat epilepsy via the toll-like receptor 4/Nuclear factor-kappa B signaling pathway. Curr Neurovasc Res. 2019 Oct 23;: Authors: Yan Y, Xia H, Hu J, Zhang B Abstract BACKGROUND: Function of microRNA-542-3p (miR-542-3p) in rat epilepsy is still unclear. METHODS: The levels of miR-542-3p and toll-like receptor 4 (TLR4) were determined through quantitative real-time PCR. The protein...
Sat Nov 09, 2019 22:26
Related ArticlesA Randomized, Single-dose, Two-sequence, Two-period, Crossover Study to assess the Bioequivalence between Two Formulations of Clonazepam Tablet in Healthy Subjects. Drug Dev Ind Pharm. 2019 Nov 08;:1-18 Authors: Davanço MG, Meulman J, Guzmán MRP, Palomino DMH, Tuiran CMG, Duarte FG, Campos DR Abstract Clonazepam is a benzodiazepine commonly prescribed to treat panic disorder, epilepsy, anxiety, depression and certain types of seizures....
Sat Nov 09, 2019 22:26
Related Articles[Altered expressions of SphK1 and S1PR2 in hippocampus of epileptic rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 Jul 28;35(4):308-311 Authors: Dong YY, Wang L, Chu X, Cui S, Kong QX Abstract OBJECTIVE: To observe the expressions of sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate receptor 2 (S1PR2) in hippocampus of epileptic rats and to investigate the pathogenesis of SphK1 and S1PR2 in epilepsy. METHODS: One...
Sat Nov 09, 2019 22:26
Related ArticlesNon-epileptic Seizures versus Frontal Lobe Epilepsy in an Adolescent: A Case Report. Cureus. 2019 Sep 23;11(9):e5732 Authors: Gaur S Abstract Multiple inpatient psychiatric hospitalizations can be due to system issues, patient complexity, family dynamics, and misdiagnoses to name a few. This study highlights a diagnostically challenging case and how that, in itself, contributed to hospital admissions. Although 18 months elapsed from the...
Sat Nov 09, 2019 22:26
Related ArticlesWomen with Epilepsy: Anti-epileptic Drugs and Perinatal Outcomes. Cureus. 2019 Sep 13;11(9):e5642 Authors: Kashif T, Fathima N, Usman N, Qaseem A, Jayaraj JS Abstract Epilepsy is a chronic neurological condition that requires treatment throughout the pregnancy. Seizures should be well controlled before conception with a specific type of anti-epileptic drug (AED) for each epileptic syndrome. The selection of AED is crucial in women with...
Sat Nov 09, 2019 22:26
Related ArticlesPresurgical epilepsy evaluation and epilepsy surgery. F1000Res. 2019;8: Authors: Baumgartner C, Koren JP, Britto-Arias M, Zoche L, Pirker S Abstract With a prevalence of 0.8 to 1.2%, epilepsy represents one of the most frequent chronic neurological disorders; 30 to 40% of patients suffer from drug-resistant epilepsy (that is, seizures cannot be controlled adequately with antiepileptic drugs). Epilepsy surgery represents a valuable treatment...
Sat Nov 09, 2019 22:26
Related ArticlesTreatment response and predictors in patients with newly diagnosed epilepsy in Ethiopia: a retrospective cohort study. Sci Rep. 2019 Nov 07;9(1):16254 Authors: Gidey K, Chelkeba L, Gemechu TD, Daba FB Abstract Epilepsy is a chronic neurological disease with a variable therapeutic response. To design effective treatment strategies for epilepsy, it is important to understand treatment responses and predictive factors. However, limited data...
Sat Nov 09, 2019 22:26
Related ArticlesEndothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis. J Exp Med. 2019 Nov 07;: Authors: Liu XX, Yang L, Shao LX, He Y, Wu G, Bao YH, Lu NN, Gong DM, Lu YP, Cui TT, Sun NH, Chen DY, Shi WX, Fukunaga K, Chen HS, Chen Z, Han F, Lu YM Abstract Blood-brain barrier (BBB) dysfunction has been suggested to play an important role in epilepsy. However, the mechanism mediating...
Sat Nov 09, 2019 22:26
Related ArticlesDiazepam buccal film for the treatment of acute seizures. Epilepsy Behav. 2019 Nov 05;:106537 Authors: Rogawski MA, Heller AH Abstract Benzodiazepines, including diazepam and midazolam, are the mainstay of treatment for seizure emergencies, including acute repetitive seizures. Nonparenteral dosage forms are used when parenteral (intravenous or intramuscular) dosing is not feasible. Currently available nonparenteral dosage forms have limitations...
Sat Nov 09, 2019 22:26
Related ArticlesSustained Effort Network for treatment of Status Epilepticus (SENSE) - A multicenter prospective observational registry. Epilepsy Behav. 2019 Nov 04;:106553 Authors: Kellinghaus C, Rossetti AO, Trinka E, Lang N, May TW, Unterberger I, Rüegg S, Sutter R, Strzelczyk A, Tilz C, Uzelac Z, Rosenow F Abstract Status epilepticus (SE) is an important neurological emergency lacking adequate evidence for efficacy and safety of treatment beyond...
Sat Nov 09, 2019 22:26
Related ArticlesOriginal ArticleIL-1β-31/IL1-RA genetic markers association with idiopathic generalized epilepsy and treatment response in a cohort of Egyptian population. Int J Neurosci. 2019 Nov 07;:1-7 Authors: Barseem NF, Khattab ESAEH, Mahasab MM Abstract Background: Neuroinflammation is an important feature of epileptogenesis.Objectives: To investigate the association of Interleukin-1beta-31 (IL-1β-31) and Interleukin-1 receptor antagonist (IL1-RA)...
Sat Nov 09, 2019 22:26
Related ArticlesFabrication and evaluation of novel quercetin-conjugated Fe3O4-β-cyclodextrin nanoparticles for potential use in epilepsy disorder. Int J Nanomedicine. 2019;14:6481-6495 Authors: Hashemian M, Ghasemi-Kasman M, Ghasemi S, Akbari A, Moalem-Banhangi M, Zare L, Ahmadian SR Abstract Background: Despite the numerous pharmacological activities of quercetin, its biomedical application has been hampered, because of poor water solubility and low...
Sat Nov 09, 2019 22:26
Related ArticlesNeural basis of episodic memory in the intermediate term after medial temporal lobe resection. J Neurosurg. 2018 10 26;131(3):790-798 Authors: Jeong W, Lee H, Kim JS, Chung CK Abstract OBJECTIVE: How the brain supports intermediate-term preservation of memory in patients who have undergone unilateral medial temporal lobe resection (MTLR) has not yet been demonstrated. To understand the neural basis of episodic memory in the intermediate...
Sat Nov 09, 2019 22:26
Related ArticlesUtility and safety of depth electrodes within the supratemporal plane for intracranial EEG. J Neurosurg. 2018 09 07;131(3):772-780 Authors: Nagahama Y, Schmitt AJ, Dlouhy BJ, Vesole AS, Gander PE, Kovach CK, Nakagawa D, Granner MA, Howard MA, Kawasaki H Abstract OBJECTIVE: The epileptogenic zones in some patients with temporal lobe epilepsy (TLE) involve regions outside the typical extent of anterior temporal lobectomy (i.e., "temporal...
Sat Nov 09, 2019 22:26
Related ArticlesRecurrent meningitis in children: etiologies, outcome, and lessons to learn. Childs Nerv Syst. 2018 08;34(8):1541-1547 Authors: Masri A, Alassaf A, Khuri-Bulos N, Zaq I, Hadidy A, Bakri FG Abstract PURPOSE: Recurrent meningitis in children is a rare condition. However, its early recognition is important in order to prevent serious complications. This study aims to review cases of recurrent meningitis in children. METHODS: This...
Sat Nov 09, 2019 22:26
Related ArticlesPatients with primary aldosteronism respond to unilateral adrenalectomy with long-term reduction in salt intake. J Clin Endocrinol Metab. 2019 Nov 08;: Authors: Adolf C, Heinrich DA, Holler F, Lechner B, Nirschl N, Sturm L, Görge V, Riester A, Williams TA, Treitl M, Ladurner R, Beuschlein F, Reincke M Abstract CONTEXT: High dietary salt intake is known to aggravate arterial hypertension. This effect could be of particular relevance in...
Sat Nov 09, 2019 22:26
Related ArticlesSkeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study. J Clin Endocrinol Metab. 2019 Nov 08;: Authors: Gonzalez Rodriguez E, Stuber M, Del Giovane C, Feller M, Collet TH, Löwe AL, Blum MR, van Vliet NA, van Heemst D, Kearney PM, Gussekloo J, Mooijaart S, Westendorp RGJ, Stott DJ, Aeberli D, Bauer DC, Hans D, Rodondi N Abstract CONTEXT: Both thyroid dysfunction and levothyroxine...
Sat Nov 09, 2019 22:26
Related ArticlesThe molecular basis of congenital hypopituitarism and related disorders. J Clin Endocrinol Metab. 2019 Nov 08;: Authors: Gregory LC, Dattani MT Abstract CONTEXT: Congenital hypopituitarism (CH) is characterized by the presence of deficiencies in one or more of the six anterior pituitary (AP) hormones secreted from the five different specialized cell types of the AP. During human embryogenesis, hypothalamo-pituitary (HP) development is...
Sat Nov 09, 2019 22:26
Related ArticlesLong-term outcomes of treatments for central precocious puberty or early and fast puberty in Chinese girls. J Clin Endocrinol Metab. 2019 Nov 08;: Authors: Fu J, Zhang J, Chen R, Ma X, Wang C, Chen L, Liang Y, Luo X, Yang Y, Xiong F, Su Z, Wu J, Yao H, Xu J, Wu D, Ni Y Abstract CONTEXT: Gonadotropin-releasing hormone analogues (GnRHa) and recombinant human growth hormone (rhGH) have been widely used to treat idiopathic central precocious...
Sat Nov 09, 2019 22:26
Related ArticlesDissecting the role of thyrotropin in the DNA damage response in human thyrocytes after 131I, γ radiation and H2O2. J Clin Endocrinol Metab. 2019 Nov 08;: Authors: Kyrilli A, Gacquer D, Detours V, Lefort A, Libert F, Twyffels L, Van den Eeckhaute L, Strickaert A, Maenhaut C, De Deken X, Dumont JE, Miot F, Corvilain B Abstract BACKGROUND: The early molecular events in human thyrocytes after 131I exposure have not yet been unravelled. Therefore,...
Sat Nov 09, 2019 22:26
Related ArticlesBiochemical control in acromegaly with multimodality therapies: outcomes from a pituitary center and changes over time. J Clin Endocrinol Metab. 2019 Nov 08;: Authors: Ghajar A, Jones P, Guarda FJ, Faje A, Tritos NA, Miller KK, Swearingen B, Nachtigall LB Abstract PURPOSE: To determine the prevalence of IGF-1 normalization with long-term multimodality therapy in a pituitary center, and to assess changes over time. METHODS: Patients...
Sat Nov 09, 2019 22:26
Related ArticlesHtra1 is a Novel Transcriptional Target of RUNX2 That Promotes Osteogenic Differentiation. Cell Physiol Biochem. 2019;53(5):832-850 Authors: Iyyanar PPR, Thangaraj MP, Eames BF, Nazarali AJ Abstract BACKGROUND/AIMS: Runt-related transcription factor 2 (Runx2) is a master regulator of osteogenic differentiation, but most of the direct downstream targets of RUNX2 during osteogenesis are unknown. Likewise, High-temperature requirement factor...
Sat Nov 09, 2019 22:23
Related ArticlesClinical Evidence on the Interaction Between MLK4, KRAS and Microsatellite Instability to Determine the Prognosis of Early-Stage Colorectal Carcinoma. Cell Physiol Biochem. 2019;53(5):820-831 Authors: Brandl L, Horst D, Grünewald TGP, Mayerle J, Sendelhofert A, Neumann J, Kirchner T, De Toni EN Abstract BACKGROUND/AIMS: MLK4 (KIAA1804) is the second most frequently mutated kinase in microsatellite stable (MSS) colorectal carcinomas (CRC)....
Sat Nov 09, 2019 22:23
43 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2019/11/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 09, 2019 22:19
Related ArticlesContributions of the Women's Health Initiative to understanding associations between sleep duration, insomnia symptoms, and sleep-disordered breathing across a range of health outcomes in postmenopausal women. Sleep Health. 2019 Nov 04;: Authors: Beverly Hery CM, Hale L, Naughton MJ Abstract The Women's Health Initiative (WHI), a longitudinal study of more than 161,000 postmenopausal women across the United States, provides an opportunity...
Sat Nov 09, 2019 22:19
Related ArticlesObstructive sleep apnea risk and subclinical atherosclerosis in South Asians living in the United States. Sleep Health. 2019 Nov 04;: Authors: Deol R, Lee KA, Kanaya AM, Kandula NR Abstract OBJECTIVES: The objective of this study was to examine the association between high risk of obstructive sleep apnea (OSA) and subclinical atherosclerosis among South Asians in the United States. DESIGN: A secondary analysis of cross-sectional...
Sat Nov 09, 2019 22:19
Related ArticlesRhinologic signs associated with snuff taking. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Nov 04;: Authors: Hounkpatin SHR, Flatin MC, Bouraima AF, Amegan HN, Toukourou Adios MAF, Adjibabi W Abstract OBJECTIVE: To study rhinologic signs associated with nasal tobacco (snuff) intake in Parakou, northern Benin. MATERIALS AND METHODS: A cross-sectional descriptive comparative study included 300 tobacco snuff takers and 300 subjects...
Sat Nov 09, 2019 22:19
Related ArticlesThird international conference "Bioinformatics: from Algorithms to Applications" (BiATA 2019) : Saint Petersburg, Russia. 20-22 June 2019. BMC Bioinformatics. 2019 Nov 08;20(Suppl 17):516 Authors: PMID: 31699023 [PubMed - in process]
Sat Nov 09, 2019 22:18
Related ArticlesThe DAGs of war. Proc Natl Acad Sci U S A. 2019 Nov 07;: Authors: Fisman D, Tuite A PMID: 31699821 [PubMed - as supplied by publisher]
Sat Nov 09, 2019 22:14
Related ArticlesHow collective asperity detachments nucleate slip at frictional interfaces. Proc Natl Acad Sci U S A. 2019 Nov 07;: Authors: de Geus TWJ, Popović M, Ji W, Rosso A, Wyart M Abstract Sliding at a quasi-statically loaded frictional interface can occur via macroscopic slip events, which nucleate locally before propagating as rupture fronts very similar to fracture. We introduce a microscopic model of a frictional interface that includes asperity-level...
Sat Nov 09, 2019 22:14
Related ArticlesTrisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity. Proc Natl Acad Sci U S A. 2019 Nov 07;: Authors: Araya P, Waugh KA, Sullivan KD, Núñez NG, Roselli E, Smith KP, Granrath RE, Rachubinski AL, Enriquez Estrada B, Butcher ET, Minter R, Tuttle KD, Bruno TC, Maccioni M, Espinosa JM Abstract Trisomy 21 (T21) causes Down syndrome (DS), a condition characterized by high prevalence...
Sat Nov 09, 2019 22:14
Related ArticlesaPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions. Proc Natl Acad Sci U S A. 2019 Nov 07;: Authors: Villeneuve C, Lagoutte E, de Plater L, Mathieu S, Manneville JB, Maître JL, Chavrier P, Rossé C Abstract Metastasis is the main cause of cancer-related deaths. How a single oncogenic cell evolves within highly organized epithelium is still unknown. Here,...
Sat Nov 09, 2019 22:14
Related ArticlesGenetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. Proc Natl Acad Sci U S A. 2019 Nov 07;: Authors: Notomi S, Ishihara K, Efstathiou NE, Lee JJ, Hisatomi T, Tachibana T, Konstantinou EK, Ueta T, Murakami Y, Maidana DE, Ikeda Y, Kume S, Terasaki H, Sonoda S, Blanz J, Young L, Sakamoto T, Sonoda KH, Saftig P, Ishibashi T, Miller JW, Kroemer G, Vavvas DG Abstract The early stages of...
Sat Nov 09, 2019 22:14
Related ArticlesCrack engineering for the construction of arbitrary hierarchical architectures. Proc Natl Acad Sci U S A. 2019 Nov 07;: Authors: Li W, Yu M, Sun J, Mochizuki K, Chen S, Zheng H, Li J, Yao S, Wu H, Ong BS, Kawata S, Wang Z, Ren K Abstract Three-dimensional hierarchical morphologies widely exist in natural and biomimetic materials, which impart preferential functions including liquid and mass transport, energy conversion, and signal transmission...
Sat Nov 09, 2019 22:14
Related ArticlesLasting coastal hazards from past greenhouse gas emissions. Proc Natl Acad Sci U S A. 2019 Nov 07;: Authors: Wong TE PMID: 31699815 [PubMed - as supplied by publisher]
Sat Nov 09, 2019 22:14
Related ArticlesNeutrophils promote VLA-4-dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation. Proc Natl Acad Sci U S A. 2019 Nov 07;: Authors: Parker Harp CR, Archambault AS, Cheung M, Williams JW, Czepielewski RS, Duncker PC, Kilgore AJ, Miller AT, Segal BM, Kim AHJ, Randolph GJ, Wu GF Abstract The success of B cell depletion therapies and identification of leptomeningeal ectopic lymphoid tissue (ELT)...
Sat Nov 09, 2019 22:14
Related Articles[Treatment of head and neck squamous cell carcinoma recurrences and distant metastases : Highlights of the 2019 ASCO Meeting]. HNO. 2019 Nov 07;: Authors: Zech HB, Laban S, Schafhausen P, Bussmann L, Betz C, Busch CJ Abstract BACKGROUND: The contributions presented at this year's ASCO conference on treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC) focused on systemic therapies, as in recent years....
Sat Nov 09, 2019 22:14
Related Articles[Update on HPV-associated head and neck cancer-highlights from the 2019 ASCO Annual Meeting]. HNO. 2019 Nov 07;: Authors: Tribius S, Würdemann N, Laban S, Hoffmann TK, Sharma SJ, Klussmann JP Abstract At this year's Annual Meeting of the American Society for Clinical Oncology (ASCO), the keyword search "HPV-associated head and neck cancer" resulted in 920 hits-74% of the hits on human papillomavirus (HPV). This underlines the relevance...
Sat Nov 09, 2019 22:14
Related ArticlesRADON, THORON AND THEIR PROGENY DISTRIBUTION AND ESTIMATION OF ANNUAL EFFECTIVE DOSE AND EXCESS LIFETIME CANCER RISK IN PANATHADY, KASARAGOD DISTRICT, KERALA. Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Mahamood KN, Prakash V Abstract Radon and thoron are natural radioactive gases that tend to accumulate in the indoor environment and one of their major health implications is the ability to cause lung cancer. Present study comprises...
Sat Nov 09, 2019 22:10
Related ArticlesASSOCIATION OF 210Po CONTENT IN URINE WITH CONCENTRATION OF 222Rn IN DWELLINGS. Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Valdezová P, Hölgye Z, Fojtíková I, Kotík L Abstract Effect of indoor radon concentrations higher than 500 Bq m-3 in dwellings on excretion of 210Po was studied in 28 volunteers. The study was further augmented by following eight individuals from the group for 5 months at 1-month intervals. Association between...
Sat Nov 09, 2019 22:10
Related ArticlesEXPOSURE OF THE BIOGAS STATION OPERATORS WORKING WITH CONTAMINATED BIOMASS. Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Škrkal J, Možnar R, Kajan M, Fantínová K Abstract The article deals with evaluation of irradiation of an operator of a 1 MW biogas station (BGS), processing silage plant biomass contaminated by 137Cs and 134Cs. External irradiation and internal irradiation by the means of aerosol particles inhalation were considered....
Sat Nov 09, 2019 22:10
PRE-ANTHROPIC AND PRESENT OUTDOOR GAMMA EQUIVALENT DOSE RATE OF THE HISTORIC CENTER OF ROME (ITALY).
Related ArticlesPRE-ANTHROPIC AND PRESENT OUTDOOR GAMMA EQUIVALENT DOSE RATE OF THE HISTORIC CENTER OF ROME (ITALY). Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Daniela G, Carloni S, Voltaggio M, Di Lisa GA Abstract The outdoor gamma background of the historic center of Rome was studied by in situ measurements and average values of the outcropping geological formations. The survey resulted in two maps of dose equivalent rate, related to pre-anthropic...
Sat Nov 09, 2019 22:10
Related ArticlesA NEW TL-DOS NEUTRON DOSEMETER FOR MEASUREMENTS OF THE PERSONAL DOSE EQUIVALENT HP(10). Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Heiny M, Busch F, Kröninger K, Theinert R, Walbersloh J Abstract A new thermoluminescence albedo dosemeter with improved properties is developed as part of the TL-DOS project. The dosemeter measures the neutron and photon whole-body dose of radiation workers. The TL-DOS neutron dosemeter is presented and...
Sat Nov 09, 2019 22:10
Related ArticlesLOW FREQUENCY MAGNETIC FIELDS INSIDE CARS. Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Pääkkönen R, Korpinen L Abstract Magnetic fields were compared inside passenger seats of electric, petrol and hybrid cars. While driving about 5 km in an urban environment, values were recorded and compared between car types. The magnetic flux densities of the cars were less than 2.6 μT. The magnitudes of the magnetic fields of petrol cars and hybrid...
Sat Nov 09, 2019 22:10
Related ArticlesANGULAR DEPENDENCE OF TRACK-ETCH DETECTOR HARZLAS TD-1. Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Ambrožová I, Pachnerová Brabcová K, Shurshakov VA, Tolochek RV, Kodaira S Abstract Track-etched detectors are commonly used also for radiation monitoring onboard International Space Station. To be registered in track-etched detectors, the particle needs to meet several criteria-it must have linear energy transfer above the detection threshold...
Sat Nov 09, 2019 22:10
Related ArticlesEMERGENCY PREPAREDNESS OF GAMMA SPECTROMETRY LABORATORIES. Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Sloboda M, Malá H, Rulík P, Bečková V Abstract Currently, the territorial Radiation Monitoring Network (RMN) of the Czech Republic consists of seven laboratories equipped with gamma spectrometry High Purity Germanium (HPGe) detectors. From 2007 to 2018, five emergency exercises were carried out to test the sample throughput of these...
Sat Nov 09, 2019 22:10
Related ArticlesNEUTRON DOSE ASSESSMENT USING SAMPLES OF HUMAN BLOOD AND HAIR. Radiat Prot Dosimetry. 2019 Nov 07;: Authors: Ekendahl D, Rubovič P, Žlebčík P, Hupka I, Huml O, Bečková V, Malá H Abstract The unique feature of nuclear accidents with neutron exposure is the induced radioactivity in body tissues. For dosimetry purposes, the most important stable isotopes occurring in human body, which can be activated by neutrons, are 23 Na and 32 S. The...
Sat Nov 09, 2019 22:10
Related ArticlesPTK7 expression is associated with lymph node metastasis, ALK and EGFR mutations in lung adenocarcinomas. Histol Histopathol. 2019 Nov 08;:18183 Authors: Jiang W, He J, Lv B, Xi X, He G, He J Abstract Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death worldwide. Lung adenocarcinoma is the main tumor type of NSCLC. Recent advances in the molecular characterization and personalized therapies have improved NSCLC...
Sat Nov 09, 2019 22:09
Related ArticlesTraining the next generation of Africa's doctors: why medical schools should embrace the team-based learning pedagogy. BMC Med Educ. 2019 Nov 04;19(1):403 Authors: Odongo CO, Talbert-Slagle K Abstract BACKGROUND: As far back as 1995, the Cape Town Declaration on training Africa's future doctor recognized the need for medical schools to adopt active-learning strategies in order to nurture holistic development of the doctor. However, medical...
Sat Nov 09, 2019 22:04
Related ArticlesOncoSim and OncoWiki: an authentic learning approach to teaching cancer genomics. BMC Med Educ. 2019 Nov 07;19(1):407 Authors: Schoenborn P, Osborne R, Toms N, Johnstone K, Milsom C, Muneer R, Jarvis MA, Belshaw R Abstract BACKGROUND: Personalised medicine is rapidly changing the clinical environment, especially in regard to the management of cancer. However, for the large part, methods used to educate undergraduate students as future...
Sat Nov 09, 2019 22:04
Related ArticlesCan e-learning improve the performance of undergraduate medical students in Clinical Microbiology examinations? BMC Med Educ. 2019 Nov 07;19(1):408 Authors: Stevens NT, Holmes K, Grainger RJ, Connolly R, Prior AR, Fitzpatrick F, O'Neill E, Boland F, Pawlikowska T, Humphreys H Abstract BACKGROUND: Clinical Microbiology is a core subject in medical undergraduate curricula. However, students struggle to cover the content and clinically contextualise...
Sat Nov 09, 2019 22:04
Abstract The biliary tree and the pancreatic ducts originate from different buds of the primitive foregut. A plethora of anatomical variants and congenital anomalies have been described for both the biliary and the pancreatic duct systems, although they are usually asymptomatic. However, in some cases, these abnormalities can lead to serious clinical scenarios, especially when involving the biliopancreatic junction, with consequent mixing and reflux of the two different juices....
Sat Nov 09, 2019 02:00
Abstract Purpose Understanding anatomical variations of the facial artery and its branches is important for dental and medical practitioners. Methods Routine cadaveric dissection of the head and neck was performed to demonstrate the origin and branches of the facial artery. Results ...
Sat Nov 09, 2019 02:00
Related ArticlesEsophageal Position Affects Short-Term Outcomes After Minimally Invasive Esophagectomy: A Retrospective Multicenter Study. World J Surg. 2019 Nov 07;: Authors: Uchihara T, Yoshida N, Baba Y, Nakashima Y, Kimura Y, Saeki H, Takeno S, Sadanaga N, Ikebe M, Morita M, Toh Y, Nanashima A, Maehara Y, Baba H Abstract BACKGROUND: Anatomical esophageal position may affect the short-term outcomes after minimally invasive esophagectomy (MIE). A previous...
Sat Nov 09, 2019 21:56
Abstract Circulating tumor cell (CTC) and cell‐free (cf) DNA‐based genomic alterations are increasingly being used for clinical decision‐making in oncology. However, the concordance and discordance between paired CTC and cfDNA genomic profiles remain largely unknown. We performed comparative genomic hybridization (CGH) on CTCs and cfDNA, and low‐pass whole genome sequencing (lpWGS) on cfDNA to characterize genomic alterations (CNA) and tumor content in two independent prospective studies of 93 men...
Sat Nov 09, 2019 17:45
Abstract Precursor B cell phenotype Burkitt lymphoma/leukemia with IGH‐MYC is a rare subtype of Burkitt lymphoma (BL). BL and B lymphoblastic leukemia/lymphoma (B‐ALL/LBL) differ as regards treatment and the distinction between these two entities is crucial. Patients demonstrating a terminal deoxynucleotidyl transferase (TdT)‐positive precursor B cell phenotype with IGH‐MYC rearrangement have been reported to be molecularly distinct from BL and closer to B‐ALL/LBL. We investigated the molecular...
Sat Nov 09, 2019 17:42
Publication date: March 2020Source: Radiotherapy and Oncology, Volume 144Author(s): Tobias Finazzi, Miguel A. Palacios, Cornelis J.A. Haasbeek, Marjan A. Admiraal, Femke O.B. Spoelstra, Anna M.E. Bruynzeel, Berend J. Slotman, Frank J. Lagerwaard, Suresh SenanAbstractBackground and purposeWe studied the benefits of using stereotactic MR-guided adaptive radiation therapy (SMART) for delivery of SABR in peripherally located lung tumors.Methods and materialsTwenty-three patients (25 peripheral lung tumors)...
Sat Nov 09, 2019 21:45
Publication date: March 2020Source: Radiotherapy and Oncology, Volume 144Author(s): Weiwei Wang, Zhijie Huang, Yinxiangzi Sheng, Jingfang Zhao, Kambiz Shahnazi, Qing Zhang, Guoliang JiangAbstractBackground and purposeThe aim of this study was to establish curves for the conversion of RBE-weighted doses for targets and organs at risk (OARs) from the microdosimetric kinetic model (MKM) calculation to that of the local effect model I (LEM) for carbon ion radiotherapy (CIRT) for prostate carcinoma (PCA).Materials...
Sat Nov 09, 2019 21:45
Publication date: March 2020Source: Radiotherapy and Oncology, Volume 144Author(s): An-Sofie Verrijssen, José Guillem, Rodrigo Perez, Krzysztof Bujko, Nathalie Guedj, Angelita Habr-Gama, Ruud Houben, Danny Goudkade, Jarno Melenhorst, Jeroen Buijsen, Ben Vanneste, Heike I. Grabsch, Murillo Bellezzo, Gabriel Paiva Fonseca, Frank Verhaegen, Maaike Berbee, Evert J. Van LimbergenAbstractObjectiveIn selected rectal cancer patients with residual local disease following neoadjuvant chemoradiation (CRT) and...
Sat Nov 09, 2019 21:45
Publication date: March 2020Source: Radiotherapy and Oncology, Volume 144Author(s): Aman Sharma, Sarah Baker, Marloes Duijm, Esther Oomen-de Hoop, Robin Cornelissen, Cornelis Verhoef, Mischa Hoogeman, Joost Jan NuyttensAbstractPurposeThe study aimed to evaluate overall survival and local control, and to identify factors independently associated with overall survival (OS) and local control (LC).Materials and methodsThis retrospective study examined 118 patients with primary colorectal cancer, in whom...
Sat Nov 09, 2019 21:45
Publication date: March 2020Source: Radiotherapy and Oncology, Volume 144Author(s): Michael Jones, George Hruby, Catherine Coolens, Brandon Driscoll, Peter Stanwell, Mahesh Kumar, Anne Capp, Swetha Sridharan, Jameen Arm, Sarah Gallagher, Carl Holder, Christopher Oldmeadow, Jarad MartinAbstractBackground and purposeTo investigate the role of multi-parametric magnetic resonance imaging (MP-MRI) as a biomarker for squamous cell carcinoma of the anal canal (SCCAC).Materials and methodsFrom January 2013...
Sat Nov 09, 2019 21:45
Publication date: March 2020Source: Radiotherapy and Oncology, Volume 144Author(s): Joanna Socha, Lucyna Kępka, Wojciech Michalski, Karol Paciorek, Krzysztof BujkoAbstractBackgroundThe watch-and-wait (w&w) strategy is associated with frequent local regrowth (LR). Distant metastases (DM) occur more often in the patients with LR than in those without. However, it is unknown whether omitting immediate surgery results in the additional risk of DM.Materials/methodsA systematic review and meta-analysis...
Sat Nov 09, 2019 21:45
Publication date: March 2020Source: Radiotherapy and Oncology, Volume 144Author(s): Shao Hui Huang, Brian O'Sullivan, Jie Su, Eric Bartlett, John Kim, John N. Waldron, Jolie Ringash, John R. de Almeida, Scott Bratman, Aaron Hansen, Andrew Bayley, John Cho, Meredith Giuliani, Andrew Hope, Ali Hosni, Anna Spreafico, Lillian Siu, Douglas Chepeha, Lt Tong, Wei XuAbstractPurposeThis study examines outcome heterogeneity and potential to refine the TNM-8 cN-classification using radiologic extranodal extension...
Sat Nov 09, 2019 21:45
Abstract Introduction Procollagen type I N-terminal propeptide (P1NP), a bone formation marker, reportedly predicts bone mineral density (BMD) response to teriparatide treatment in treatment-naive patients with osteoporosis. Results from a randomized, phase 3, open-label, active-controlled trial— STRUCTURE—showed that in patients previously treated with bisphosphonates, romosozumab led to gains in hip BMD, which were not observed with...
Sat Nov 09, 2019 02:00
Related ArticlesThe side door and front door to the upper retroclival region: a comparative analysis of the open pretemporal and the endoscopic endonasal transcavernous approaches. J Neurosurg. 2019 Nov 08;:1-13 Authors: Labib MA, Borba Moreira L, Zhao X, Gandhi S, Cavallo C, Tayebi Meybodi A, Youssef AS, Little AS, Nakaji P, Preul MC, Lawton MT Abstract OBJECTIVE: The pretemporal transcavernous approach (PTA) and the endoscopic endonasal transcavernous...
Sat Nov 09, 2019 21:31
Related Articles[Diagnosis and treatment of glomus tumors of the skull base and neck]. Radiologe. 2019 Nov 07;: Authors: Reith W, Kettner M Abstract Glomus tumors (paragangliomas) are rare, usually benign, neuroendocrine tumors that arise from nonchromaffin cells and can be multifocal or familial. They grow slowly, often infiltratively and rarely form metastases. A distinction is made between carotid, jugular, tympanicum and vagal tumors. Depending on...
Sat Nov 09, 2019 21:31
Related ArticlesGreater Occipital Nerve Block as a Tool to Diagnose Spontaneous Intracranial Hypotension Before Epidural Blood Patch: A Case Report. A A Pract. 2019 Nov 06;: Authors: Bortolato A, Simonato D, Garrì F, Gabrieli JD, Cester G, Causin F, Feltracco P Abstract Spontaneous intracranial hypotension (SIH) has been increasingly characterized in recent years. A definitive diagnostic algorithm remains controversial because several symptoms are often...
Sat Nov 09, 2019 21:31
Related ArticlesA rare case of concomitant pneumocephalus and pneumorachis after lumbar spine surgery with late presenting dural leak. Spinal Cord Ser Cases. 2019;5:86 Authors: Gupta M, Kumar Varma KK, Singh Chhabra H Abstract Introduction: We report a case of pneumocephalus and pneumorachis i.e., air in the cranial cavity and the spinal canal, which are rarely associated with a primary spinal cause. Their concomitant occurrence and association with...
Sat Nov 09, 2019 21:31
Related ArticlesEpidemiology and outcome of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) infections in cardiac surgery patients: a brief narrative review. J Chemother. 2019 Nov 08;:1-8 Authors: Del Puente F, Giacobbe DR, Salsano A, Maraolo AE, Ong DSY, Yusuf E, Tutino S, Marchese A, Santini F, Viscoli C Abstract Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-KP) is a difficult-to-treat pathogen...
Sat Nov 09, 2019 21:30
31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/11/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 09, 2019 21:28
Related ArticlesIdentification of Dual negative allosteric modulators of Group I mGluR family: A shape based screening, ADME Prediction, Induced Fit Docking and Molecular Dynamics approach against Neurodegenerative Diseases. Curr Top Med Chem. 2019 Nov 04;: Authors: Prabhu SV, Singh SK Abstract BACKGROUND: Glutamate is principal neurotransmitter in human brain that exerts its effects through iGlu and mGlu receptors. The mGluRs are the class C GPCRs play...
Sat Nov 09, 2019 21:21
Related ArticlesWhether The Validation Of The Predictive Potential Of Toxicity Models Is Solved Task? Curr Top Med Chem. 2019 Nov 04;: Authors: Toropova AP, Toropov AA Abstract BACKGROUND: Different kinds of biological activity are defined by complex biochemical interactions, i.e. are a "mathematical function" not only of the molecular structure but also some unclear addition circumstances, such as physicochemical conditions, interactions via energy...
Sat Nov 09, 2019 21:21
Related ArticlesSpiro-Lactams as Novel Antimicrobial Agents. Curr Top Med Chem. 2019 Nov 04;: Authors: Alves AJS, Alves NG, Caratão CC, I M Esteves M, Fontinha D, Bártolo I, Soares MIL, Lopes SMM, Prudêncio M, Taveira N, Pinho E Melo TMVD Abstract AIMS: To extend our previous studies on spirocyclic-β-lactams with anti-HIV and antiplasmodial properties to new spirocyclic-lactams in order to further explore structure-activity relationships. BACKGROUND:...
Sat Nov 09, 2019 21:21
Related ArticlesCytotoxicity of Anchusa arvensis against HepG-2 cell lines: Mechanistic and computational approaches. Curr Top Med Chem. 2019 Nov 04;: Authors: Hussain S, Ullah F, Sadiq A, Ayaz M, Shah AA, Ali Shah SA, Shah SM, Nadhman A, Ullah F, Wadood A, El-Shazly M Abstract BACKGROUND: Liver cancer, a devastating cancer with increasing incidence and mortality rates worldwide. Plants possess numerous therapeutic properties, therefore the search for...
Sat Nov 09, 2019 21:21
Related ArticlesIn-silico subtractive proteomic analysis approach for therapeutic targets in MDR Salmonella enterica sub sp. Enterica serovar Typhi str. CT18. Curr Top Med Chem. 2019 Nov 04;: Authors: Rahman N, Muhammad I, Nayab GE, Khan H, Filosa R, Xiao J, Hassan STS Abstract AIMS: In the present study, an attempt has been made for subtractive proteomic analysis approach for novel drug targets in Salmonella enterica subsp. Enterica serover Typhi str.CT18...
Sat Nov 09, 2019 21:21
Related ArticlesSynthesis, biological evaluation and molecular docking studies of novel di-hydropyridine analogs as potent antioxidants. Curr Top Med Chem. 2019 Nov 04;: Authors: Saddala MS, Pradeepkiran JA Abstract AIMS: The aim of the present study to synthesis and biological evaluation of 3-ethyl 5-methyl 2-(2-aminoethoxy)-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate derivatives. Dihydropyridine (DHP) is an important class of calcium antagonist...
Sat Nov 09, 2019 21:21
CO2 transformations are conducted in a one-pot two-step procedure for the synthesis of complex molecules. The selective 4 e- reduction of CO2 with a hydroborane reductant affords a reactive and versatile bis(boryl)acetal intermediate which is subsequently involved in condensation reaction or carbene-mediated C-C coupling generation.
Sat Nov 09, 2019 21:00
Delignified densified wood represents a new promising lightweight, high-performance and bio-based material with great potential to partially substitute natural fiber reinforced- or glass fiber reinforced composites in the future. We here present two versatile fabrication routes and demonstrate the possibility to create complex composite parts.
Sat Nov 09, 2019 21:00
Macrophages, especially primary macrophages, are challenging to transfect as they specialize in detecting molecules of non-self origin. We describe a protocol that allows highly efficient transfection of primary macrophages with mRNA generated from DNA templates such as plasmids.
Sat Nov 09, 2019 20:00
We present a protocol and a feasibility study for applying transcranial direct current stimulation (tDCS) and neuroimaging assessment in online gamers.
Sat Nov 09, 2019 20:00
Hematopoietic stem progenitor cells (HSPCs) transition from a quiescent state to a differentiation state due to their metabolic plasticity during blood formation. Here, we present an optimized method for measuring mitochondrial respiration and glycolysis of HSPCs.
Sat Nov 09, 2019 19:00
A protocol for the study of desensitization and sensitivity recovery of crayfish photoreceptors as a function of circadian time is presented.
Sat Nov 09, 2019 19:00
Related ArticlesCritical Issues in Dental and Medical Management of Obstructive Sleep Apnea. J Dent Res. 2019 Nov 08;:22034519885644 Authors: Lavigne GJ, Herrero Babiloni A, Beetz G, Dal Fabbro C, Sutherland K, Huynh N, Cistulli PA Abstract This critical review focuses on obstructive sleep apnea (OSA) and its management from a dental medicine perspective. OSA is characterized by ≥10-s cessation of breathing (apnea) or reduction in airflow (hypopnea)...
Sat Nov 09, 2019 21:16
Related ArticlesEffects of bone marrow‑derived mesenchymal stem cell transplantation on chronic obstructive pulmonary disease/obstructive sleep apnea overlap syndrome in rats. Mol Med Rep. 2019 Sep 30;: Authors: Chen M, Huang Z, Bi H, Pan X, He J, He L, He X, Du J, Zhou K, Wang L, Wang Q, Guo X, Jin Z Abstract Bone marrow‑derived mesenchymal stem cells (BMSCs) possess potential therapeutic properties for treating patients with chronic obstructive pulmonary...
Sat Nov 09, 2019 21:16
Related ArticlesStatistical uncertainty of the apnea-hypopnea index is another reason to question the utility of this metric. Sleep Med. 2019 Jul 24;: Authors: Joosten SA, Landry SA, Terrill PI PMID: 31699470 [PubMed - as supplied by publisher]
Sat Nov 09, 2019 21:16
Related ArticlesHypoglossal Nerve (Cranial Nerve XII) Stimulation. Otolaryngol Clin North Am. 2019 Nov 04;: Authors: Yu JL, Thaler ER Abstract Hypoglossal nerve stimulation is a novel strategy for the treatment of obstructive sleep apnea (OSA). Its anatomy allows for easy surgical access, and its function as a motor nerve allows for tolerable neurostimulation. It has shown success as a therapy for the treatment of OSA with a greater than 80% success...
Sat Nov 09, 2019 21:16
Related ArticlesThe inverted-L ramus osteotomy versus sagittal split ramus osteotomy in maxillomandibular advancement for the treatment of obstructive sleep apnea patients: A retrospective study. J Craniomaxillofac Surg. 2019 Oct 23;: Authors: Wu Q, Wang Y, Wang P, Xiang Z, Ye B, Li J Abstract This study aimed to compare the effectiveness and feasibility of inverted-L osteotomy (ILO) and sagittal split ramus osteotomy (SSRO) on obstructive sleep apnea...
Sat Nov 09, 2019 21:16
Related ArticlesAn 82-Year-Old Man With Sleep-Onset Insomnia, Breathing Arrest, and Heart Failure. Chest. 2019 Nov;156(5):e95-e98 Authors: de la Motte T, Schwab M, Schultze T, Witte OW, Rupprecht S Abstract CASE PRESENTATION: An 82-year-old man presented with 6 months of difficulties of falling asleep. He described a feeling of fading breath culminating in breathing arrest when he becomes drowsy. These recurrent events prevented him from falling asleep....
Sat Nov 09, 2019 21:16
Related ArticlesExcessive Daytime Sleepiness, Depression and Sleep-Disordered Breathing in Patients With Cardiovascular Disease - Reply. Circ J. 2019 02 25;83(3):693 Authors: Ohashi M, Kohno T, Fukuda K PMID: 30674754 [PubMed - indexed for MEDLINE]
Sat Nov 09, 2019 21:16
Related ArticlesExcessive Daytime Sleepiness, Depression and Sleep-Disordered Breathing in Patients With Cardiovascular Disease. Circ J. 2019 02 25;83(3):692 Authors: Kawada T PMID: 30674753 [PubMed - indexed for MEDLINE]
Sat Nov 09, 2019 21:16
Related ArticlesSchlafapnoe beeinträchtigt oft gar nicht. MMW Fortschr Med. 2017 05;159(9):39 Authors: Füeßl HS PMID: 28509027 [PubMed - indexed for MEDLINE]
Sat Nov 09, 2019 21:16
135 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/11/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 09, 2019 21:14
103 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/11/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Nov 09, 2019 21:13
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