Abstract Aim The aim of the study was to evaluate the effects of tooth wear, age and sex on facial height measurements based on soft tissue analysis. Methods One hundred and twelve subjects (45 males and 67 females), 19 to 80 years of age (mean 43 ± 0.9 years), which were divided into three age groups, met the inclusion criteria. Tooth wear was assessed using a 5‐point ordinal scale (0–4). Based on the tooth wear score, three groups were defined: mild, moderate and severe wear. Facial height...
Sat Nov 09, 2019 20:44
Abstract Background Movement of the hyoid and laryngeal complex is critical for preventing aspiration, as well as smooth bolus passage through the pharynx. We have developed a non‐invasive system for measuring laryngeal movement during swallowing with a bend sensor and have already reported the time‐coordination between the signal waveform from the sensor and hyoid movement. Objective The aim of this study was to clarify the quantitative association between the output value of the sensor...
Sat Nov 09, 2019 20:25
Abstract Purpose In the definition of an occlusal scheme, clinicians should choose between conventional and computerized methods based on a careful appraise of the advantages and limitations. This study aims to assess the correlation between the two approaches in a clinical setting. Methods 24 patients were included to compare different methods of occlusal contacts assessment on the posterior surfaces of flat mandibular appliances. In supine position, they were asked to clench with maximum...
Sat Nov 09, 2019 20:18
Cancers, Vol. 11, Pages 1769: Response to Lenvatinib Is Associated with Optimal RelativeDose Intensity in Hepatocellular Carcinoma: Experience in Clinical Settings Cancers doi: 10.3390/cancers11111769 Authors: Sasaki Fukushima Haraguchi Miuma Miyaaki Hidaka Eguchi Matsuo Tajima Matsuzaki Hashimoto Ooba Kugiyama Yatsuhashi Motoyoshi Shigeno Kinoshita Nakao Background: Lenvatinib is currently available as the first-line...
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Cancers, Vol. 11, Pages 1768: Antineoplastic Effect of a Combined Mitotane Treatment/Ionizing Radiation in Adrenocortical Carcinoma: A Preclinical Study Cancers doi: 10.3390/cancers11111768 Authors: Cerquetti Bucci Carpinelli Lardo Proietti Saporito Rindi Petrangeli Toscano Stigliano Mitotane (MTT) is an adrenolytic drug used in adjuvant and advanced treatments of adrenocortical carcinoma (ACC). Ionizing radiation (IR) is also used in adrenal cancer...
Sat Nov 09, 2019 02:00
Cancers, Vol. 11, Pages 1767: DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression Cancers doi: 10.3390/cancers11111767 Authors: Marta Jiménez-Martínez Cristina M. Ostalé Lennart R. van der Burg Javier Galán-Martínez James C. H. Hardwick Ricardo López-Pérez Lukas J. A. C. Hawinkels Konstantinos Stamatakis Manuel Fresno Cell contact inhibition (CCI) is deregulated in cancer. Colorectal cancer (CRC) is the third most...
Sat Nov 09, 2019 02:00
Cancers, Vol. 11, Pages 1765: PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target Cancers doi: 10.3390/cancers11111765 Authors: Lisa Salvatore Maria Alessandra Calegari Fotios Loupakis Matteo Fassan Brunella Di Stefano Maria Bensi Emilio Bria Giampaolo Tortora Molecular assessment of colorectal cancer (CRC) is receiving growing attention, beyond RAS and BRAF, because of its influence on prognosis and prediction in cancer treatment. PTEN...
Sat Nov 09, 2019 02:00
Cancers, Vol. 11, Pages 1764: Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide Cancers doi: 10.3390/cancers11111764 Authors: Anastasios I. Birmpilis Chrysoula-Evangelia Karachaliou Pinelopi Samara Kyriaki Ioannou Platon Selemenakis Ioannis V. Kostopoulos Nadia Kavrochorianou Hubert Kalbacher Evangelia Livaniou Sylva Haralambous Athanasios Kotsinas Farzin Farzaneh Ioannis P. Trougakos Wolfgang...
Sat Nov 09, 2019 02:00
Cancers, Vol. 11, Pages 1763: Antitumor Response and Immunomodulatory Effects of Sub-Microsecond Irreversible Electroporation and Its Combination with Calcium Electroporation Cancers doi: 10.3390/cancers11111763 Authors: Vitalij Novickij Robertas Čėsna Emilija Perminaitė Auksė Zinkevičienė Dainius Characiejus Jurij Novickij Saulius Šatkauskas Paulius Ruzgys Irutė Girkontaitė In this work, we have investigated the feasibility of sub-microsecond range irreversible...
Sat Nov 09, 2019 02:00
Cancers, Vol. 11, Pages 1766: Collagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1 Cancers doi: 10.3390/cancers11111766 Authors: Sook Ling Lai May Leng Tan Robert J. Hollows Max Robinson Maha Ibrahim Sandra Margielewska E. Kenneth Parkinson Anand Ramanathan Rosnah Binti Zain Hisham Mehanna Rachel J. Spruce Wenbin Wei Ivy Chung Paul G. Murray Lee Fah Yap Ian C. Paterson Head and neck...
Sat Nov 09, 2019 02:00
Publication date: Available online 9 November 2019Source: Clinical ImagingAuthor(s): Susie S. Kwon, J. Levi Chazen, Sirish Kishore, Behnum A. Habibi, Michelle Chi, Ethan Rand, Ryan Lowder, Jaspal Ricky SinghAbstractBackgroundGenicular nerve block and subsequent radiofrequency neurotomy (RFN) has emerged as a novel intervention and alternative for total knee arthroplasty in patients with refractory pain from knee osteoarthritis (OA). To our knowledge, there is no cited report correlating the accuracy...
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Publication date: Available online 9 November 2019Source: Clinical ImagingAuthor(s): Miguel Couto, Miguel Souto, Amparo Martínez, Alicia Maceira, Cecilia Vieira, José M. Pumar, Pierre CroisilleAbstractBackgroundCardiac magnetic resonance imaging (MRI) is an essential imaging method used to assess patients with diseases of the left and right ventricles. Cardiac MRI is the gold standard for right ventricular measurements; however, the most suitable method for volumetric analysis of the right ventricle...
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Publication date: Available online 9 November 2019Source: Clinical ImagingAuthor(s): Mnahi Bin Saeedan, Faisal Mohammad Alabdulkarim, Faisal Fahad Aloufi, Khalefa Ali Alghofaily, Nadeem Parkar, Subha GhoshAbstractMagnetic resonance imaging (MRI) of the abdomen may include lower chest findings which may be overlooked or misinterpreted due to their location outside the area of main exam focus or lack of familiarity with the image appearance of these findings. This article will review the utility of...
Sat Nov 09, 2019 15:45
Abstract Photobiomodulation therapy (PBMT) in the infrared spectrum exerts positive effects on glucose metabolism, but the use of PBMT at the red spectrum has not been assessed. Male Swiss albino mice were divided into low‐fat control (LFC) and high‐fat diet (HFD) for 12 weeks and were treated with red (630 nm) PBMT or no treatment (Sham) during weeks 9‐12. PBMT was delivered at 31.19 J/cm2, 60 J total dose per day for 20 days. In HFD‐fed mice, PBMT improved glucose tolerance, insulin resistance,...
Sat Nov 09, 2019 21:09
We aimed to evaluate the effectiveness nasopharyngeal cancer (NPC) screening by comprehensive clinical follow‐up and adjunctive Epstein‐Barr virus (EBV) testing. In a prospective cohort study, 524 individuals with a first‐degree family history of NPC were recruited at a university clinical center in Singapore. The cohort was evaluated at baseline and at 6‐monthly intervals, with a complete head and neck examination including nasopharyngeal endoscopy. Blood was taken at baseline and at yearly intervals...
Sat Nov 09, 2019 22:53
Abstract When future reproductive potential is threatened, for example following infection, the terminal investment hypothesis predicts that individuals will respond by investing preferentially in current reproduction. Terminal investment involves reallocating resources to current reproductive effort, so it is likely to be influenced by the quantity and quality of resources acquired through diet. Dietary protein specifically has been shown to impact both immunity and reproduction in a range of organisms,...
Sat Nov 09, 2019 20:28
Abstract Among‐population variance of phenotypic traits is of high relevance for understanding evolutionary mechanisms that operate in relatively short timescales, but various sources of non‐independence, such as common ancestry and gene flow can hamper the interpretations. In this comparative analysis of 138 dog breeds, we demonstrate how such confounders can independently shape the evolution of a behavioral trait (human‐directed play behavior from the Dog Mentality Assessment project). We combined...
Sat Nov 09, 2019 13:07
Abstract Response of endophytic fruit fly species (Tephritidae) to larval crowding is a form of scramble competition that may affect important life history traits of adults, such as survival and reproduction. Recent empirical evidence demonstrates large differences in adult life history traits, especially longevity, among Mediterranean fruit fly (Ceratitis capitata; "medfly") biotypes obtained from different regions of the world. However, whether the evolution of long lifespan is associated with...
Sat Nov 09, 2019 11:54
Abstract Thoracic myelocystocele are extremely rare, non-terminal, closed neural tube defects. Intraoperative neuromonitoring (IONM) is a mainstay of pediatric spinal surgery. However, in neonates and infants, incomplete myelination of the corticospinal tract presents unique challenges to successful use of IONM in this vulnerable patient population. Surgery can often be delayed until patients are older, but there are circumstances in which early intervention is necessary. We report...
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Abstract Moyamoya disease is a chronic cerebral vascular disease characterized by progressive occlusion of the cerebral arteries and resulting in the development of abnormal collateral circulation. We report a case of moyamoya disease in a 3-year-old Chinese girl with partly reversible white matter lesions. This case indicates that, in pediatric moyamoya disease, white matter lesions may be associated with cerebral ischemia, and they may be reversible after treatment.
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Abstract Background Modern neurosurgery is nowadays based on technological advances. Intra-operative image guidance systems are frequently utilized in the everyday neurosurgical practice. Frameless stereotactic procedures (FSPs) require a great deal of technical abilities and precautions. Frameless stereotaxy mandates a high degree of problem-solving attitude and on-the-spot neurosurgeon’s creativity. ...
Sat Nov 09, 2019 02:00
Abstract Purpose The objective of this study was to investigate and present the early results on the efficacy, safety, and quality of life of 225Ac-DOTATATE targeted alpha therapy (TAT) in patients with advanced, progressive, 177Lu-DOTATATE refractory, and somatostatin receptor (SSTR) expressing metastatic GEP-NETs. Methods In this prospective study, we recruited...
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Abstract The 2015 American Thyroid Association (ATA) guideline have suggested modifications in the risk stratification (RS) for differentiated thyroid cancer (DTC) patients, introduced the concept of dynamic risk stratification (DRS) and redefined the role of radioactive iodine (RAI) in treatment algorithm. The aim of this retrospective audit was to assess the practical implications of these modifications in management of DTC. ...
Sat Nov 09, 2019 02:00
Abstract Background The role of radioiodine treatment following total thyroidectomy for differentiated thyroid cancer is changing. The last major revision of the American Thyroid Association (ATA) Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer in 2015 changed treatment recommendations dramatically in comparison with the European Association of Nuclear Medicine (EANM) 2008 guidelines. We hypothesised...
Sat Nov 09, 2019 02:00
The increased prevalence of Klebsiella pneumoniae infections and resistance rates are a current cause for concern. However, data for resistance rates in K. pneumoniae strains from primary hospitals and the resist...
Sat Nov 09, 2019 02:00
Brucellosis is one of the most important infection of diseases. Due to its large period of treatment and survival ability of bacteria inside the macrophages, relapse of this disease is the main challenge, espe...
Sat Nov 09, 2019 02:00
Chronic primary musculoskeletal pain (CPMP) is one subcategory of the new classification of chronic primary pain for the upcoming ICD-11, defined as chronic pain in the muscles, bones, joints, or tendons that ...
Sat Nov 09, 2019 02:00
A major challenge in evolutionary biology has been to explain the variation in multicellularity across the many independently evolved multicellular lineages, from slime moulds to humans. Social evolution theory has highlighted the key role of relatedness in determining multicellular complexity and obligateness, however there is a need to extend this to a broader perspective incorporating the role of the environment. In this paper, we formally test Bonners 1998 hypothesis that the environment is crucial...
Sat Nov 09, 2019 02:00
Recently, Muhlemann et al. (2018) and Krause-Kyora et al. (2018) discovered 15 ancient Hepatitis B virus (aHBV) sequences dating back to the Neolithic age (NA) and the Bronze age (BA). Being published simultaneously, neither of these studies could include sequences from the other for analyses. In the present research, aHBV sequences from these studies were collective re-analysed with reference to a comprehensive database comprising extant HBV diversity to understand their relatedness and role in...
Sat Nov 09, 2019 02:00
Phylogeny estimation is an important part of much biological research, but large-scale tree estimation is infeasible using standard methods due to computational issues. Recently, an approach to large-scale phylogeny has been proposed that divides a set of species into disjoint subsets, computes trees on the subsets, and then merges the trees together using a computed matrix of pairwise distances between the species. The novel component of these approaches is the last step: Disjoint Tree Merger (DTM)...
Sat Nov 09, 2019 02:00
Enzymes can evolve new catalytic activity when their environments change to present them with novel substrates. Despite this seemingly straightforward relationship, factors other than the direct catalytic target can also impact enzyme adaptation. Here, we characterize the adaptive landscape separating an ancestral dihydrocoumarin hydrolase from a methyl parathion hydrolase descendant under eight different environments supplemented with alternative divalent metals. This variation shifts an evolutionary...
Sat Nov 09, 2019 02:00
Theory suggests speciation without geographic isolation is plausible if divergent natural selection is strong enough to counteract gene flow. Tropical mountains provide strong and temporally stable environmental gradients that can promote local adaptation and population genetic structure. Pairs of closely related species with adjacent but divergent elevational ranges are common in these environments, a pattern that suggests parapatric speciation (i.e., speciation with moderate gene flow), but evidence...
Sat Nov 09, 2019 02:00
The extent to which evolutionary transitions are shaped by developmental bias remains poorly understood. Classically, morphological variation is assumed to be abundant and continuous, but if morphogenesis biases how traits vary than evolutionary transitions might follow somewhat predictable steps. Compared to other anatomical structures, teeth have an exceptional fossil record which documents striking evolutionary trajectories toward complexity. Using computer simulations of tooth morphogenesis,...
Sat Nov 09, 2019 02:00
OBJECTIVE: The treatment of chronic pain frequently combines pharmacologic and non-pharmacological options, and analgesia after surgery is of major importance. Tapentadol is both µ-opioid receptor agonist (with a 40% agonism on these receptors) and noradrenaline reuptake inhibitor, with similar analgesic efficacy to strong opioids, but fewer adverse effects. For these reasons, tapentadol may represent a valuable first choice option in the treatment of chronic, neuropathic, and mixed pain.PATIENTS...
Fri Nov 08, 2019 11:03
OBJECTIVE: Low back pain (LBP) is a highly prevalent chronic pain condition with a neuropathic component of pain that limits the benefits of classical opioids. Tapentadol is an innovative drug for the treatment of chronic severe pain, with a dual mechanism of action combining µ-opioid receptors agonism and noradrenaline re-uptake inhibition (NRI). Its efficacy is equal to that of strong opioids, with a better tolerability profile and a consequently lower risk of treatment discontinuation. The aim...
Fri Nov 08, 2019 11:03
Musculoskeletal pain, encompassing back and osteoarthritis (OA) pain, represents the most frequent source of chronic pain in western countries, and it is particularly frequent in older adults. Remarkably, back and OA pain present, in most cases, both a nociceptive and a neuropathic component of pain. Treatment selection should, therefore, properly consider the ability of a drug to act on both components, reducing the possibility of plastic changes in the central nervous system, and consequently promoting...
Fri Nov 08, 2019 11:03
L'articolo Editorial – Musculoskeletal pain: which role for tapentadol? sembra essere il primo su European Review.
Fri Nov 08, 2019 11:03
OBJECTIVE: Chronic pain is frequently irreversible, representing a major health problem. A survey has shown that 19% of European adults experience chronic pain which is not adequately managed. Innovative interventional techniques for the treatment of chronic pain have been developed, as a further step beyond the three-layer WHO analgesic ladder. Among these techniques, continuous and pulsed radiofrequency (RF) are very effective in the management of radicular pain syndrome. Usually, these techniques...
Fri Nov 08, 2019 11:03
OBJECTIVE: The use of long-term opioids for the management of chronic musculoskeletal pain is a hot topic in the scientific community, especially when it concerns the elderly. This paper aimed at assessing the efficacy and tolerability of tapentadol prolonged release (PR), a molecule with a unique mechanism of action combining μ-opioid-receptor (MOR) agonism and noradrenaline reuptake inhibition (NRI), administered to patients aged ≥80 years with chronic persistent pain. The effect of this molecule...
Fri Nov 08, 2019 11:03
OBJECTIVE: Chronic pain is highly prevalent in the elderly, and the prolonged use of long-term opioids for the management of chronic musculoskeletal pain is controversial. Tapentadol, combining μ‐opioid receptor (MOR) agonism and noradrenaline reuptake inhibition (NRI) in a unique mechanism of action, may be a valid option for chronic pain management in the geriatric population. The aim of the study was to assess the efficacy and tolerability of tapentadol prolonged release (PR), administered to...
Fri Nov 08, 2019 11:03
We present the case of a 59-year-old woman with third-grade obesity and severe comorbidities including osteoporosis, dyslipidemia, diabetes mellitus, hypertension, night eating following bariatric biliary-intestinal bypass surgery, severe fibromyalgia, poly-arthrosis, lumbar disc herniation in L5S1, sleep disorders and sleep apnea syndrome, and emotional disorders with anxiety and depression, who suffered from chronic pain unresponsive to a combination of multiple analgesics. After a period of metabolic...
Fri Nov 08, 2019 11:03
OBJECTIVE: The incidence of chronic pain increases with age and comorbidities, a particularly relevant issue in the elderly over the age of 80 years. Thus, the choice of the best analgesic treatment is difficult to make. The therapeutic priority in elderly patients is to favor the least invasive route of administration, and the minimum effective dose, with a gradual and slow up-titration, if needed. Tapentadol with its dual mechanism of action, combining synergistically a reduced load (<40% that...
Fri Nov 08, 2019 11:03
Related ArticlesEffects of Er:YAG Laser Treatment on the Mineral Content and Morphology of Primary Tooth Enamel. Photomed Laser Surg. 2018 Dec;36(12):680-686 Authors: Kahvecioglu F, Kahraman K, Akman H, Tosun G Abstract Objective: The aim of this study was to evaluate the mineral content and morphology of primary tooth enamel prepared using an Er:YAG laser at different power settings. Materials and methods: The buccal surfaces of 45 noncarious primary...
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Related ArticlesEffects of Photobiomodulation and Ultrasound Applications on Orthodontically Induced Inflammatory Root Resorption; Transcriptional Alterations in OPG, RANKL, Cox-2: An Experimental Study in Rats. Photomed Laser Surg. 2018 Dec;36(12):653-659 Authors: Gul Amuk N, Kurt G, Guray E Abstract Objective: The aim of this study was to evaluate and compare the reparative and inhibitory effects of a light-emitting diode-mediated photobiomodulation...
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Related ArticlesLaser Photobiomodulation Over Teeth Subjected to Orthodontic Movement. Photomed Laser Surg. 2018 Dec;36(12):647-652 Authors: Cordeiro JM, Sahad MG, Cavalcanti MFXB, Marcos RL, Diomede F, Trubiani O, Maria DA, Leal-Junior ECP, Frigo L Abstract Background: Orthodontics of the 21st century requires aesthetic, painless, predictable, and quick treatments. This demand for faster results generated orthodontic movement acceleration protocols...
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Related ArticlesWhat Will It Take? Photomed Laser Surg. 2018 12;36(12):629-630 Authors: Hode L PMID: 31697635 [PubMed - in process]
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Abstract As the alternative treatment for heart failure, left ventricular assist devices (LVADs) have been widely applied to clinical practice. However, the effects of the support modes of LVADs on the biomechanical states of the aortic valve are still poorly understood. Hence, the present study investigates such effects and proposes a novel fluid–structure interaction (FSI) approach that combines the lattice Boltzmann method (LBM) and finite element (FE) method. Two support modes...
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Tumor cell repopulation after radiotherapy is a major cause for the tumor radioresistance and recurrence. This study aims to investigate the underlying mechanism of tumor repopulation after radiotherapy, with ...
Sat Nov 09, 2019 02:00
Authors: Elodie Portanier, Mathieu Garel, Sébastien Devillard, Jeanne Duhayer, Marie-Thérèse Poirel, Hélène Henri, Corinne Régis, Daniel Maillard, Elizabeth Redman, Christian Itty, Patricia Michel and Gilles Bourgoin.Parasite Vol. 26 , page 64Published online: 07/11/2019 Keywords: Ovis gmelini musimon × Ovis sp. ; Host-parasite co-structure ; Population genetics ; Nematode ; Mouflon ; Haemonchus contortus.
Thu Nov 07, 2019 02:00
Authors: Nadège Perier, Wilfried Lebon, Leon Meyer, Noua Lekouch, Nesrine Aouiche and Frédéric Beugnet.Parasite Vol. 26 , page 63Published online: 05/11/2019 Keywords: Phlebotomus perniciosus ; Sandfly ; Insecticide ; Afoxolaner ; NexGard® ; Dog.
Tue Nov 05, 2019 02:00
Angiopoietin-1 (Ang-1) and 2 (Ang-2), high mobility group box 1 (HMGB1), soluble receptor for advanced glycation endproducts (sRAGE), soluble triggering receptor expressed on myeloid cells 1 (sTREM1), and solu...
Fri Nov 08, 2019 02:00
Abstract Hematologic malignancies include several lymphoproliferative and myeloproliferative disorders, many of which are frequently encountered in current health care settings. These malignancies frequently affect the gastrointestinal (GI) tract, either by secondary extranodal or extramedullary extension to the GI tract, or as a primary process arising in the GI tract. In fact, the GI tract may represent the most common extranodal site of involvement in many of them, such as lymphoma....
Sat Nov 09, 2019 02:00
Abstract Chronic pancreatitis is a chronic fibro-inflammatory syndrome characterized by chronic pancreatic inflammation leading to fibrosis and scarring. Patients with this multifactorial debilitating illness often require endoscopic or surgical intervention for treatment. Radiologists play a crucial role in pre-therapeutic workup as well as post-treatment imaging of chronic pancreatitis. This review summarizes the most common surgical and endoscopic treatment options that are...
Sat Nov 09, 2019 02:00
Abstract Peribiliary glands are minute structures that are distributed along the intrahepatic large bile ducts, extrahepatic bile duct, and cystic duct. These glands regulate many physiological functions, such as enzyme secretion. Pancreatic exocrine tissues and enzymes are often observed in peribiliary glands; thus, peribiliary glands are involved in enzyme secretion. As such, these glands can be affected by conditions such as IgG4-related sclerosing cholangitis based on commonalities...
Sat Nov 09, 2019 02:00
Abstract Radiomics is a new field in medical imaging with the potential of changing medical practice. Radiomics is characterized by the extraction of several quantitative imaging features which are not visible to the naked eye from conventional imaging modalities, and its correlation with specific relevant clinical endpoints, such as pathology, therapeutic response, and survival. Several studies have evaluated the use of radiomics in patients with hepatocellular carcinoma (HCC)...
Sat Nov 09, 2019 02:00
Abstract Urothelial carcinoma of the upper urinary tract (UUT) is a relatively uncommon genitourinary malignancy, accounting for about 5–7% of urothelial tumors. The significant features of this tumor are multifocality and high rate of recurrence. Computed tomography urography (CTU) has replaced excretory urography (EU) and retrograde pyelography (RP) for imaging of upper tract urothelial carcinoma. While many studies have confirmed high sensitivity (88–100%) and specificity (93–100%)...
Sat Nov 09, 2019 02:00
Ectodermal dysplasia is a rare genetic disorder that affects ectodermally derived structures, including teeth, nails, hair, and sweat glands. Hypohidrotic ectodermal dysplasia is the most common type, with oli...
Fri Nov 08, 2019 02:00
Publication date: Available online 8 November 2019Source: European Journal of Surgical OncologyAuthor(s): Sara Hägg, Juulia JylhäväAbstractColorectal cancer (CRC) is a chronic disease of the old population with slow development progressing into clinical signs and symptoms. Biological aging is characterized by e.g. mitochondrial dysfunction and epigenetic alterations (e.g. methylation) - mechanisms that are also important in cancer development. For CRC, specific types of tumors are distinguishable...
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The aim of this review was to determine the effect of cortical perforations in bone regeneration considering the surgical technique. An electronic search in the PubMed (MEDLINE) and ScienceDirect databases and a hand search of the literature was conducted covering the period July 2008 to December 2018. Studies that specified the creation of perforations in the recipient area as a study variable associated with the regenerative technique were included. The quality of the randomized clinical trials...
Sat Nov 09, 2019 02:00
Submental intubation is a low-risk alternative to tracheostomy when nasotracheal or orotracheal intubation is not appropriate. To improve the selection of patients and clinical outcomes we have explored published papers on submental intubation in oral and maxillofacial surgery, and included a proposal for a decision pathway. Systematic searches of PubMed, Scopus, and Cochrane databases for papers published between 1986 and 2018 yielded 116 eligible articles (one randomised controlled trial, 61 case...
Sat Nov 09, 2019 02:00
Biomechanics are crucial for bony regeneration and survival of implants in functional maxillary and mandibular reconstructions. However, we know of no study that has included an analysis of biomechanics to guide the optimal position of a fibular graft in virtual surgery. This study was designed to evaluate the combination of biomechanics and accurate placement of implants for virtual surgery in reconstruction of the jaw using fibular grafts. Thirty-one patients had maxillary or mandibular reconstruction...
Sat Nov 09, 2019 02:00
We aimed to compare the postoperative stability of conventional bimaxillary surgery (with bilateral sagittal split osteotomy) with that of maxillary impaction surgery (with mandibular autorotation without bilateral sagittal split osteotomy) in patients with skeletal class II retrognathia. Patients were assigned to have conventional bimaxillary surgery (conventional group, n=6) or mandibular autorotation (experimental group, n=7). Measurements were made using serial lateral cephalometric radiographs...
Sat Nov 09, 2019 02:00
Oral biopsies are common diagnostic and therapeutic procedures in oral and maxillofacial surgical (OMFS) outpatient departments. The chalazion clamp is similar to a pair of forceps. One extension has a flat, solid, oval plate, the other, a ring-like structure that is used to clamp and retract soft tissues. We highlight the benefits of using this simple, widely-available tool during oral biopsies. We find that the clamp increases effectiveness and efficiency for the clinician and assistant. We recommend...
Sat Nov 09, 2019 02:00
The most complex and controversial area in head and neck reconstructive surgery is the management of tumours of the maxilla, midface, and skull base.1 Patients who develop a tumour in the orbital roof or from the nasal cavity usually develop a large defect that can extend into the anterior cranial fossa. This makes prosthodontic reconstruction with a facial prosthesis in this region challenging.
Sat Nov 09, 2019 02:00
Abstract Objective Burning mouth syndrome (BMS) is a chronic intraoral burning sensation with no identifiable causes. In this study, we aim to demonstrate the effectiveness of treatment strategy using ethyl loflazepate monotherapy or in combination with milnacipran or amitriptyline. Method A hospital‐based, retrospective study was conducted in 86 patients. The patients were divided into remission and non‐remission group. The remission group comprised patients who were satisfied with their...
Sat Nov 09, 2019 12:38
Abstract Objectives Examine the clinical and microbiological benefits of a dual‐strain Lactobacillus reuteri probiotic on the non‐surgical therapy of initial peri‐implantitis. Materials and methods This randomized, double‐blind study targeted patients with initial peri‐implantitis, i.e. peri‐implantitis with a maximum mean probing pocket depth of 6mm and maximum 3mm bone loss compared to loading. A full‐mouth prophylaxis was performed and the peri‐implantitis sites were debrided. Subsequently,...
Sat Nov 09, 2019 12:35
Abstract The microsporidian Nosema bombycis is an obligate intracellular parasitic fungus that causes devastating disease in sericulture. To date, no efficient biotechnological method to inhibit the proliferation of microspores has been established. Here, we developed a powerful genetic engineering technique involving microsporidia-inducible genome editing in transgenic silkworm that confers resistance to N. bombycis. This system includes an HSP70 promoter-induced expression of...
Sat Nov 09, 2019 02:00
Abstract Synthetic chemical pesticides have been used for many years to increase the yield of agricultural crops. However, in the future, this approach is likely to be limited due to negative impacts on human health and the environment. Therefore, studies of the secondary metabolites produced by agriculturally important microorganisms have an important role in improving the quality of the crops entering the human food chain. In this review, we have compiled information about the...
Sat Nov 09, 2019 02:00
Abstract Lignocellulosic biomass (LCB) is globally available and sustainable feedstock containing sugar-rich platform that can be converted to biofuels and specialty products through appropriate processing. This review focuses on the efforts required for the development of sustainable and economically viable lignocellulosic biorefinery to produce carbon neutral biofuels along with the specialty chemicals. Sustainable biomass processing is a global challenge that requires the fulfillment...
Sat Nov 09, 2019 02:00
Abstract Microbial metagenome analysis has proven its usefulness to investigate the microbiomes present in technical engineered ecosystems such as anaerobic digestion systems. The analysis of the total microbial genomic DNA allows the detailed determination of both the microbial community structure and its functionality. In addition, it enables to study the response of the microbiome to alterations in technical process parameters. Strategies of functional microbial networks to...
Sat Nov 09, 2019 02:00
The original version of this article was revised: After publication of this article, the publisher was notified that Michael Klocke has been listed as an author without his consent.
Sat Nov 09, 2019 02:00
Related ArticlesPerspective: Proposed Harmonized Nutrient Reference Values for Populations. Adv Nutr. 2019 Nov 08;: Authors: Allen LH, Carriquiry AL, Murphy SP Abstract Two core nutrient intake reference values (NRVs) are required for assessing the adequacy and safety of nutrient intakes for population groups: the average requirement (AR) and the tolerable upper level of intake (UL). Applications of such assessments include providing advice to improve...
Sat Nov 09, 2019 23:19
Abstract Objectives To investigate the effect of daily emollient treatment on infantile AD during the maintenance period. Methods A total of 309 children younger than 2 years with moderate AD (155 and 154 in the treatment and control groups, respectively) were enrolled in this multicentre, randomised, parallel controlled clinical trial. Subjects were topically treated with desonide cream and emollients in Prinsepia utilis Royle for 2‐4 weeks before entering the maintenance period and then...
Sat Nov 09, 2019 22:49
Abstract Psoriasis and pemphigus are clinically well‐characterized chronic, inflammatory skin diseases. Many case reports have described the coexistence of psoriasis and bullous pemphigoid. However, the present report is about a rare case of pemphigus vulgaris in a patient with psoriasis vulgaris. We had a 68‐year‐old male psoriatic patient who developed blisters lesions and erosions on the trunk and extremities. The histopathology of a blister lesion showed the intraepidermal blisters that contained...
Sat Nov 09, 2019 17:48
Abstract Paronychia has been described as a side effect in patients undergoing treatment with MEK (mitogen activated protein kinase enzyme) inhibitors. It is usually a recurrent condition that can have a significant impact in the quality of life. Topical beta blocker treatment has been described as an effective therapy in antineoplastic‐induced pyogenic granulomas and in antineoplastic‐induced paronychia. We describe the first case treated with topical timolol for a trametinib‐induced paronychia...
Fri Nov 08, 2019 18:48
Abstract BACKGROUND An appropriately designed cosmetic product and regimen of treatment can improve facial skin appearance and provide good tolerability. The aim of the study was to evaluate the effect of 0.3% and 0.5% retinol in liquid crystal formula, applied with sonophoresis, on mature skin. Serum with various concentrations of retinol was applied to the left and right sides of the face and treated with ultrasound. The treatments were performed once a week for a period of seven weeks. The...
Fri Nov 08, 2019 18:38
Fri Nov 08, 2019 18:24
ABSTRACT Mental retardation is a potential limitation to self‐administration of innovative biologic treatment, which are otherwise very effective for chronic devastating chronic inflammatory conditions, such as hidradenitis suppurativa. We report our successful experience in with a 34‐year‐old woman, who was genetically affected by Warkany syndrome, which causes intellectual disability. This patient was unable to maintain long‐term antibiotic regimen, and was disappointed by the limited results...
Fri Nov 08, 2019 18:14
Related ArticlesSomething for Everyone in Rhinology and Allergy. Am J Rhinol Allergy. 2019 Nov;33(6):621-623 Authors: McCoul E PMID: 31698940 [PubMed - in process]
Sat Nov 09, 2019 22:35
Related ArticlesEpidemiology and Trends of Hereditary Hemorrhagic Telangiectasia in the United States. Am J Rhinol Allergy. 2019 Nov 07;:1945892419886756 Authors: Ferry AM, Wright AE, Baillargeon G, Kuo YF, Chaaban MR PMID: 31698927 [PubMed - as supplied by publisher]
Sat Nov 09, 2019 22:35
Related ArticlescircEPSTI1 acts as a ceRNA to regulate the progression of osteosarcoma. Curr Cancer Drug Targets. 2019 Nov 07;: Authors: Tan X, Tan D, Li H, Lin Y, Wen Z, Zeng C Abstract BACKGROUND: Recent studies have reported the vital roles of circular RNAs (circRNAs) in tumor progression. However, the function and expression profile of most circRNAs in osteosarcoma remain unclear. METHOD: We examined the expression of circEPSTI1, a circRNA,...
Sat Nov 09, 2019 22:34
Related ArticlesCirc-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4120-4130 Authors: Du W, Li D, Guo X, Li P, Li X, Tong S, Tong J, Kuang L, Liang D Abstract Background: Gastric cancer (GC) is a global leading source of cancer-associated deaths. Circular RNAs (circRNAs) are a new type of non-coding RNA and promising biomarkers for diagnosis of multiple diseases...
Sat Nov 09, 2019 22:28
Related ArticlesSinomenine hydrochloride exerts antitumor outcome in ovarian cancer cells by inhibition of long non-coding RNA HOST2 expression. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4131-4138 Authors: Xu Y, Jiang T, Wang C, Wang F Abstract Background: Accumulating evidence displays that sinomenine hydrochloride (SH) are utilised to treat a variety of cancers. Nevertheless, the influences of SH on ovarian cancer stay blurry. We endeavoured to...
Sat Nov 09, 2019 22:28
Related ArticlesClinicopathological and prognostic significance of epithelial cell transforming sequence 2 expression in cancers: a systematic review and meta-analysis. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4139-4148 Authors: Li B, Lin JP, Li Z, Yin C, Yang JB, Meng YQ Abstract Numerous studies have investigated the prognostic significance of ECT2 (epithelial cell transforming sequence 2) expression in patients with cancer. Nevertheless, conflicting...
Sat Nov 09, 2019 22:28
Related ArticlesThe role of myeloid-derived suppressor cells in the pathogenesis of rheumatoid arthritis; anti- or pro-inflammatory cells? Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4149-4158 Authors: Rajabinejad M, Salari F, Gorgin Karaji A, Rezaiemanesh A Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of the immature myeloid cells that are derived from the myeloid progenitors with immunosuppressive functions. MDSCs...
Sat Nov 09, 2019 22:28
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