BACKGROUND:Self-harm is increasing among adolescents, and because of changing behaviours, current data are needed on the consequences of self-harm. We sought to investigate the trends related to hospital presentation, readmission, patient outcome and medical costs in adolescents who presented with self-harm to the emergency department. METHODS:We used administrative data on 403 805 adolescents aged 13–17 years presenting to Ontario emergency departments in 2011–2013. Adolescents with self-harm visits...
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Cells, Vol. 8, Pages 1383: The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease Cells doi: 10.3390/cells8111383 Authors: John Papaconstantinou The ASK1-signalosome→p38 MAPK and SAPK/JNK signaling networks promote senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to oxidative stress and inflammation. These networks contribute to the promotion of age-associated...
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Cells, Vol. 8, Pages 1382: Cooperative and Escaping Mechanisms between Circulating Tumor Cells and Blood Constituents Cells doi: 10.3390/cells8111382 Authors: Garrido-Navas de Miguel-Perez Exposito-Hernandez Bayarri Amezcua Ortigosa Valdivia Guerrero Garcia Puche Lorente Serrano Metastasis is the leading cause of cancer-related deaths and despite measurable progress in the field, underlying mechanisms are still not fully understood. Circulating...
Sun Nov 03, 2019 02:00
Προφητείες, θρύλοι και διηγήσεις που ζωντανεύουν στις μνήμες μας τον μαρμαρωμένο βασιλιά συνδέονται άρρηκτα με θαύματα και γεγονότα που σχετίζονται με τον Άγιο βασιλιά Ιωάννη Βατάτζη! Ξετυλίγοντας το κουβάρι του θαυμαστού βίου του θα διαπιστώσουμε ότι ο ευσεβής βασιλέας Ιωάννης ο Βατάτζης, είχε θέσει προτεραιότητα στη ζωή του την ελεημοσύνη! Με βάση το έλεος και την αγάπη αντιμετώπισε με τη βοήθεια του Θεού ακανθώδη ζητήματα της εποχής του. Το χριστιανικό ...
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Geneva, Switzerland and Boston, MA – October 31, 2019 – ObsEva SA (NASDAQ: OBSV / SIX: OBSN), a clinical-stage biopharmaceutical company focused on the development and commercialization of novel therapeutics for serious...
Thu Oct 31, 2019 05:11
Tenax Therapeutics Provides Update on Phase 2 Pulmonary Hypertension Clinical Trial for Levosimendan
October 31, 2019 -- Tenax Therapeutics, Inc. (Nasdaq: TENX), a specialty pharmaceutical company focused on identifying, developing and commercializing products that address cardiovascular and pulmonary diseases with high unmet medical need, today...
Thu Oct 31, 2019 05:11
LEXINGTON, Mass. and AMSTERDAM, the Netherlands, Oct. 31, 2019 (GLOBE NEWSWIRE) -- uniQure N.V. (NASDAQ: QURE), a leading gene therapy company advancing transformative therapies for patients with severe unmet medical needs, today announced...
Thu Oct 31, 2019 05:11
DUBLIN--(BUSINESS WIRE)--Oct. 31, 2019-- Horizon Therapeutics plc (Nasdaq: HZNP) today announced integrated, pooled efficacy data from the Phase 2 and Phase 3 clinical trials of teprotumumab for the treatment of active thyroid eye disease...
Thu Oct 31, 2019 05:10
AbstractBefore 2016, human papillomavirus (HPV) vaccination was recommended in a three-dose schedule; however, many vaccine-eligible U.S. females received <3 doses, providing an opportunity to evaluate real-world vaccine effectiveness (VE) of 1, 2, and 3 doses. We analyzed data on cervical intraepithelial neoplasia grades 2–3 and adenocarcinoma in situ (CIN2+) from the HPV Vaccine Impact Monitoring Project (HPV-IMPACT), 2008–2014. Archived tissue from CIN2+ lesions was tested for 37 HPV types....
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Abstract High-level cognitive capacities that serve communication, reasoning, and calculation are essential for finding our way in the world. But whether and to what extent these complex behaviors share the same neuronal substrate are still unresolved questions. The present study separated the aspects of logic from language and numerosity—mental faculties whose distinctness has been debated for centuries—and identified a new cytoarchitectonic area as correlate for an operation...
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Abstract Objectives To examine the association between listening and disruptive behaviors and the association between disruptive behavior and the wellbeing of the nurse. To test whether constructive and destructive listening has an incremental validity. Methods A structured questionnaire survey that measured the (constructive & destructive)...
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Abstract Purpose Micro fractional anisotropy (μFA) is more accurate than conventional fractional anisotropy (FA) for assessing microscopic tissue properties and can overcome limitations related to crossing white matter fibres. We compared μFA and FA for evaluating white matter changes in patients with Parkinson’s disease (PD). Methods We compared FA and μFA...
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Abstract Purpose Kearns Sayre syndrome (KSS) is a mitochondrial disorder characterized by development of visual impairment. Electroretinogram (ERG) and visual evoked potentials are not able to provide topographical information of optic damage. The purpose of this study was to explore retrochiasmatic optic pathway alteration in KSS with diffusion tractographic analysis and to compare it with different tracts. ...
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Abstract Background Infertility is a major challenge for couples globally. Due to low income levels and the high cost of other assisted reproductive techniques, pharmacotherapy remain the major first line treatment option for infertility in Sub-Saharan Africa. Objective The aim of this study was to assess the prevalence of infertility as well...
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In recent years, laparoscopic surgery has been widely used for rectal cancer. In laparoscopic rectal surgery, a double-stapling technique (DST) anastomosis using a stapling device is considered a relatively di...
Sat Nov 02, 2019 02:00
Inflammation plays a critical role in the development and progression of cancers. The advanced lung cancer inflammation index (ALI) is thought to be able to reflect systemic inflammation better than current bi...
Sat Nov 02, 2019 02:00
Robotic latissimus dorsi-flap reconstruction (RLDFR) after skin-sparing mastectomy (SSM) for breast cancer (BC) has been performed through a single nipple incision. We report results of SSM with RLDFR, mainly ...
Sat Nov 02, 2019 02:00
Oculocerebrorenal syndrome of Lowe is an X-linked disorder with very low prevalence in the general population. The OCRL gene encodes the protein phosphatidylinositol 4,5-bisphosphate-5-phosphatase, a lipid phosph...
Sat Nov 02, 2019 02:00
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01383
Sun Nov 03, 2019 06:00
Fri Nov 01, 2019 02:00
BACKGROUND Females are hypercoagulable and have survival benefit in trauma-induced coagulopathy (TIC). The mechanism for this sex-specific hypercoagulability is unknown. Platelets and platelet function are central in providing hemostatic potential and are the largest contributor to clot strength. Ligands (adenosine diphosphate [ADP] and platelet-activating factor [PAF]) bind distinct platelet receptors to potentiate activation and aggregation. We hypothesize that female platelets have a differential...
Fri Nov 01, 2019 02:00
Publication date: Available online 2 November 2019Source: Medical Image AnalysisAuthor(s): Fabio Carrillo, Simon Roner, Marco von Atzigen, Andreas Schweizer, Ladislav Nagy, Lazaros Vlachopoulos, Jess G. Snedeker, Philipp FürnstahlAbstractThree-dimensional (3D) computer-assisted corrective osteotomy has become the state-of-the-art for surgical treatment of complex bone deformities. Despite available technologies, the automatic generation of clinically acceptable, ready-to-use preoperative planning...
Sun Nov 03, 2019 20:24
Here, we present a protocol describing isolation and culturing of cartilage explants from bovine knees. This method provides an easy and accessible tool to describe tissue changes in response to biological stimuli or novel therapeutics targeting the joint.
Sun Nov 03, 2019 20:00
AbstractA 7-year-old child of Turkish origin presented with headache and vomiting in the context of prolonged fever of unknown source. At examination, oral candidiasis and chronic onychomycosis were noted. A Candida meningoencephalitis was diagnosed and intravenous Amphotericin B liposomal was given during 6 months relayed by oral Fluconazole after regression of CNS lesions was observed on MRI. A complete immune evaluation was performed, and genetic analysis detected homozygous CARD9 mutation. CARD9...
Sun Nov 03, 2019 02:00
AbstractWith an increasing number of antimicrobial stewardship–related articles published each year, attempting to stay current is challenging. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship–related peer-reviewed literature that detailed an actionable intervention for 2018. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs...
Tue Oct 15, 2019 03:00
AbstractBackgroundTimely strain typing of group A Streptococci (GAS) is necessary to guide outbreak recognition and investigation. We evaluated the use of (matrix-assisted laser desorption ionization time-of-flight mass spectrometry) combined with cluster analysis software to rapidly distinguish between related and unrelated GAS isolates in real-time.MethodsWe developed and validated a typing model using 177 GAS isolates with known emm types. The typing model was created using 43 isolates, which...
Fri Oct 11, 2019 03:00
European Journal of Cardiovascular Nursing, Ahead of Print. Background:Delirium is a common postoperative complication after cardiac surgery. The relationship between delirium and cardiac function has not been fully elucidated.Aims:The aim of this study was to identify the association between preoperative cardiac function and delirium among patients after cardiac surgery.Methods:We prospectively recruited 635 cardiac surgery patients with a planned cardiac intensive care unit admission. Postoperative...
Fri Nov 01, 2019 14:51
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