BACKGROUND Clinical benefits of plasma as an adjunct for treatment of hemorrhagic shock (HS) have been well established. However, its use is not without risk. Little is understood regarding the clinical implications of plasma variability. We hypothesized there to be interdonor variability in plasma that would impact endothelial and organ function post injury. METHODS Pulmonary endothelial cells (EC) were incubated with plasma from 24 random donors and transendothelial electrical resistance...
Mon Oct 14, 2019 03:00
No abstract available
Mon Oct 14, 2019 03:00
No abstract available
Mon Oct 14, 2019 03:00
BACKGROUND There has been an unprecedented increase in critical care research recently and there is a need for an organized and systematic approach to surgical critical care research planning. The purpose of this paper was to establish a surgical critical care research agenda via a systematic review of the literature and needs assessment. METHODS A systematic review of the literature was performed to identify high-impact critical care articles since 1999 on the basis of citation data. Using...
Mon Oct 14, 2019 03:00
No abstract available
Mon Oct 14, 2019 03:00
No abstract available
Mon Oct 14, 2019 03:00
No abstract available
Mon Oct 14, 2019 03:00
BACKGROUND Trauma-induced coagulopathy seen on rotational thromboelastometry (ROTEM) is associated with poor outcomes in adults, however this relationship is poorly understood in the pediatric population. We sought to define thresholds for product-specific transfusion and evaluate the prognostic efficacy of ROTEM in injured children. METHODS Demographics, ROTEM, and clinical outcomes from severely injured children (age 84.5 sec (p=0.049), decreased EXTEM amplitude at 10 minutes (A10) 68.5...
Mon Oct 14, 2019 03:00
No abstract available
Mon Oct 14, 2019 03:00
Background Venous thromboembolism (VTE) continues to be a devastating source of morbidity and mortality in obese patients who suffer traumatic injuries or obese surgery patients. High incidence rates in VTE despite adherence to prevention protocols has stirred interest in new dosing regimens. The purpose of this study was to systematically review the literature and present the existing VTE chemoprophylaxis regimens for obese trauma and surgical patients in terms of efficacy and safety as measured...
Mon Oct 14, 2019 03:00
Background Platelet dysfunction (PD) is an independent predictor of mortality in patients with severe traumatic brain injury (sTBI). Platelet transfusions have been shown to be an effective treatment strategy to reverse platelet inhibition. Their use is contingent on availability and may be associated with increased cost and transfusion related complications making desmopressin (DDAVP) an attractive. We hypothesized that DDAVP would correct PD similarly to platelet transfusions in patients with...
Mon Oct 14, 2019 03:00
Microorganisms, Vol. 7, Pages 525: Distinct Microbial Community of Phyllosphere Associated with Five Tropical Plants on Yongxing Island, South China Sea Microorganisms doi: 10.3390/microorganisms7110525 Authors: Lijun Bao Wenyang Cai Xiaofen Zhang Jinhong Liu Hao Chen Yuansong Wei Xiuxiu Jia Zhihui Bai The surfaces of a leaf are unique and wide habitats for a microbial community. These microorganisms play a key role in plant growth and adaptation to adverse conditions,...
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Toxins, Vol. 11, Pages 641: Using Botulinum Toxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome—Possible Pathomechanisms and Practical Issues Toxins doi: 10.3390/toxins11110641 Authors: Jia-Fong Jhang Treatment for patients with interstitial cystitis/bladder pain syndrome (IC/BPS) is always challenging for urologists. The main mechanism of the botulinum toxin A (BoNT-A) is inhibition of muscle contraction, but the indirect sensory modulation and anti-inflammatory effect...
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Journal of International Medical Research, Ahead of Print.
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Background: The choice of general anesthesia (GA) or conscious sedation (CS) may impact neurological outcomes of patients undergoing endovascular therapy (EVT) for acute ischemic stroke (AIS). The aim of this survey was to describe the practice patterns of members of the Society for Neuroscience in Anesthesiology and Critical Care (SNACC) for anesthetic management of AIS. Methods: Following institutional review board approval, a 16-question online survey assessing anesthetic management of...
Wed Oct 23, 2019 03:00
JCM, Vol. 8, Pages 1866: Identification of Risk of QT Prolongation by Pharmacists When Conducting Medication Reviews in Residential Aged Care Settings: A Missed Opportunity? Journal of Clinical Medicine doi: 10.3390/jcm8111866 Authors: Louise Christensen J. Rick Turner Gregory M. Peterson Mark Naunton Jackson Thomas Kwang Choon Yee Sam Kosari QT interval prolongation is associated with torsade de pointes and sudden cardiac death. QT prolongation can be caused by many...
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JCM, Vol. 8, Pages 1867: Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm8111867 Authors: Daniele D’Arrigo Alice Roffi Magali Cucchiarini Matteo Moretti Christian Candrian Giuseppe Filardo Secretome and extracellular vesicles (EVs) are considered a promising option to exploit mesenchymal stem cells’ (MSCs) properties to address knee osteoarthritis (OA)....
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JCM, Vol. 8, Pages 1865: Osteoarthritis Severely Decreases the Elasticity and Hardness of Knee Joint Cartilage: A Nanoindentation Study Journal of Clinical Medicine doi: 10.3390/jcm8111865 Authors: Mieloch Richter Trzeciak Giersig Rybka The nanoindentation method was applied to determine the elastic modulus and hardness of knee articular cartilage. Cartilage samples from both high weight bearing (HWB) and low weight bearing (LWB) femoral condyles were collected from...
Sun Nov 03, 2019 02:00
JCM, Vol. 8, Pages 1862: Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project Journal of Clinical Medicine doi: 10.3390/jcm8111862 Authors: Acosta-Manzano Coll-Risco Van Poppel Segura-Jiménez Femia Romero-Gallardo Borges-Cosic Díaz-Castro Moreno-Fernández Ochoa-Herrera Aparicio The aim of the present study was to analyze the influence of a supervised...
Sun Nov 03, 2019 02:00
JCM, Vol. 8, Pages 1860: Lipid Profile Rather Than the LCAT Mutation Explains Renal Disease in Familial LCAT Deficiency Journal of Clinical Medicine doi: 10.3390/jcm8111860 Authors: Lamiquiz-Moneo Civeira Gómez-Coronado Blanco-Vaca Villafuerte-Ledesma Gil Amigó Mateo-Gallego Cenarro Renal complications are the major cause of morbidity and mortality in patients with familial lecithin–cholesterol acyltransferase (LCAT) deficiency (FLD). We report...
Sun Nov 03, 2019 02:00
JCM, Vol. 8, Pages 1863: Associations of Anti-Aquaporin 5 Autoantibodies with Serologic and Histopathological Features of Sjögren's Syndrome Journal of Clinical Medicine doi: 10.3390/jcm8111863 Authors: Jeon Lee Park Kim Choi Biomarkers to stratify the complex and heterogeneous phenotypes of Sjogren’s syndrome (SS) are needed. We aimed to validate the prevalence of anti-aquaporin 5 (AQP5) IgG in a non-Korean cohort and to optimize the method to screen the anti-AQP5...
Sun Nov 03, 2019 02:00
JCM, Vol. 8, Pages 1861: Hypovitaminosis D Influences the Clinical Presentation of Immune Thrombocytopenia in Children with Newly Diagnosed Disease Journal of Clinical Medicine doi: 10.3390/jcm8111861 Authors: Petrovic Benzon Batinic Culic Roganovic Markic Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia defined as platelet count in peripheral blood <100 × 109/L. Hypovitaminosis D is very...
Sun Nov 03, 2019 02:00
JCM, Vol. 8, Pages 1864: Positive Programmed Cell Death-Ligand 1 Expression Predicts Poor Treatment Outcomes in Esophageal Squamous Cell Carcinoma Patients Receiving Neoadjuvant Chemoradiotherapy Journal of Clinical Medicine doi: 10.3390/jcm8111864 Authors: Huang Lu Wang Chen Lo Lin Lan Tseng Li Background: Programmed cell death-ligand 1 (PD-L1) is present in a subgroup of cancer patients who may be favorable targets for immune checkpoint inhibitor therapies....
Sun Nov 03, 2019 02:00
Abstract Purpose Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. To uncover a possible relationship between VDR genotype and clinical conditions in TS patients, we investigated two functional VDR variants (Cdx-2 and FokI) for allele and genotype frequencies, as well as...
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Abstract A lectin gene (plectin) with a high level of expression was previously identified by comparative transcriptome analysis of Pleurotus ostreatus. In this study, we cloned a 733-bp DNA fragment from the start codon of the plectin gene. Sequence analysis showed that the plectin promoter (Plp) region contained several eukaryotic transcription factor binding motifs, such as the TATA-box, four possible CAAT-box, light responsiveness motifs and MeJA-responsiveness motifs. To determine...
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Abstract A strictly anaerobic bacterium, designated as strain KGMB-03357T, was isolated from the faeces of a healthy Korean selected by Bundang Seoul National University based on health status. Cells of strain KGMB03357T are Gram-stain-positive, non-motile, non-spore-forming, and observed as straight or curved rods. The isolate grew at 10–45°C (optimum temperature of 40°C) and a pH range of 5.1–10.5 (optimum pH of 6.8). Analysis of phylogenetic trees based on the 16S rRNA gene...
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Abstract One of the advantages for initial survival of inhaled fungal spores in the respiratory tract is the ability for iron acquisition via hemolytic factor-production. To examine the ability of indoor Aspergillus and Penicillium affecting hemolysis, the secreted factors during the growth of thirteen strains from eight species were characterized in vitro for their hemolytic activity (HA) and CAMP-like reaction. The hemolytic index of HA on human blood agar of Aspergillus micronesiensis,...
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Abstract Purpose Two-wheeled motor vehicles are dichotomized into mopeds and motorcycles (MCs) based on their engine capacity. While efforts have been made, mostly by European researchers, to evaluate the possible difference in the frequency/severity of riders’ traumatic brain injury (TBI) between the two categories, the results have been inconsistent. Methods ...
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Abstract Purpose To determine the effects of oral contraceptive (OC) use on salivary concentrations of testosterone, estrogen, progesterone, and its effects on the changes in indirect markers of muscle damage following eccentric cycling in women. Methods 10 oral contraceptive users at follicular phase (OC-FOL), 10 non-oral contraceptives users at follicular...
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Introducing Trek, Sonic’s newest Super Power and Ultra Power hearing instruments featuring the revolutionary SoundDNA platform. Join us to learn about the technology and features that make Trek a perfect choice for patients with severe to profound hearing loss.
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Η αφιέρωση υπερβολικού χρόνου μπροστά σε μια οθόνη έχει αρνητική επίδραση στη φαντασία των παιδιών, σύμφωνα με δημοσκόπηση σε νηπιαγωγούς την οποία επικαλείται η Independent. Τα παιδιά σήμερα ξοδεύουν πάρα πολύ χρόνο μπροστά σε οθόνες (smartphones, tablets, τηλεόραση). Αν και δεν είναι λίγοι αυτοί που υποστηρίζουν ότι η ενασχόληση με την τεχνολογία συμβάλλει στην ανάπτυξη των παιδιών, οι ειδικοί λένε ότι το να αφιερώνει ένα παιδί υπερβολικό χρόνο μπροστά σε μια οθόνη μπορεί να έχει κόστος στη φαντασία...
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Από τη Σύλβα Σαραφίδου, Ψυχολόγο, MSc, AKC, PhDc Η άνοια αποτελεί μία ευρεία κατηγορία παθήσεων του εγκεφάλου, με εκφυλιστικό και προοδευτικό χαρακτήρα. Η φύση των συμπτωμάτων οδηγεί στην πεποίθηση πως οι πάσχοντες ‘χάνουν τον εαυτό τους’, και βιώνουν ιδιαίτερα κακή καθημερινότητα και ζωή, γεγονός που έχει αντίκτυπο τόσο στην προσέγγιση των επαγγελματιών υγείας, όσο και των φροντιστών των ατόμων. Αυτό με την σειρά του επηρεάζει τα άτομα, οδηγώντας σε αρνητικές επιπτώσεις. Τις τελευταίες δεκαετίες,...
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