Abstract Purpose of Review This chapter focuses on limb apraxia, a cognitive-motor disorder of learned skilled movement, and the nature of the spatiotemporal errors that disrupt movement sequences. Recent Findings A cognitive model that attempts to reconcile conceptual and preparatory aspects of the motor program with perceptual and kinematic...
02:00
Environmental Science & TechnologyDOI: 10.1021/acs.est.9b03697
Mon Nov 11, 2019 07:00
Environmental Science & TechnologyDOI: 10.1021/acs.est.9b03607
Mon Nov 11, 2019 07:00
Environmental Science & TechnologyDOI: 10.1021/acs.est.9b04347
Mon Nov 11, 2019 07:00
Environmental Science & TechnologyDOI: 10.1021/acs.est.9b04191
Mon Nov 11, 2019 07:00
Ο Αbraham Η. Maslow γεννήθηκε την 1η Απριλίου του 1908 στο Μπρούκλιν της Νέας Υόρκης. Οι γονείς του ήταν Ρωσο-Εβραίοι μετανάστες. Ο πατέρας του ήταν βαρελοποιός και είχε μεταναστεύσει στις Ηνωμένες Πολιτείες όταν ήταν νέος. Όταν τακτοποιήθηκε, έγραψε σε μια εξαδέλφη του στη Ρωσία, ζητώντας της να έρθει στις ΗΠΑ και να τον παντρευτεί. Εκείνη το έκανε. Ο Μaslow ήταν το πρώτο από τα επτά τους παιδιά. Ήταν ένας εξαιρετικά ντροπαλός, νευρωσικός νέος, καταθλιπτικός, τρομερά δυστυχισμένος, μοναχικός, γεμάτος...
00:02
Planta MedDOI: 10.1055/a-1035-5183Kava, the extract of the roots of Piper methysticum, has been traditionally consumed in the South Pacific islands for its natural relaxing property. Epidemiological data suggests that kava consumption may reduce human cancer risk, and in vitro and in vivo models suggest chemopreventive potential against carcinogen-induced tumorigenesis. Therefore, knowledge about its molecular mechanisms and responsible ingredient(s) for these beneficial properties will better guide...
Mon Nov 11, 2019 01:00
Peroxisomes share extensive metabolic connections with other cell organelles. Membrane contact sites (MCSs) establish and maintain such interactions, and they are vital for organelle positioning and motility. In the past few years peroxisome interactions and MCSs with other cellular organelles have been explored extensively, resulting in the identification of new MCSs, the tethering molecules involved, and their functional characterization. Defective tethering and compartmental communication can...
Mon Nov 11, 2019 02:00
Spermatogenesis is supported by intricate crosstalk between Sertoli cells and germ cells including spermatogonia, spermatocytes, haploid spermatids, and spermatozoa, which takes place in the epithelium of seminiferous tubules. Sertoli cells, also known as ‘mother’ or ‘nurse’ cells, provide nutrients, paracrine factors, cytokines, and other biomolecules to support germ cell development. Sertoli cells facilitate the generation of several biologically active peptides, which include F5-, noncollagenous...
Mon Nov 11, 2019 02:00
Mitochondrial diseases are a heterogeneous group of inherited or acquired devastating disorders that affect the energy metabolism of the body. Many strategies have been investigated, but currently there is no FDA-approved drug that can alleviate disease symptoms or slow disease progression. This review analyzes to what extent growing knowledge over the past two decades about the etiology and pathogenesis of mitochondrial diseases is reflected in the design and development of new experimental drugs...
Mon Nov 11, 2019 02:00
Doctors treating a teenager in the UK for severe lung failure say it was likely caused by an allergic reaction to e-cigarettes
01:30
White researchers are nearly 59 per cent more likely to receive funding for their studies than ethnic minority researchers, according to data from seven UK research councils
Mon Nov 11, 2019 18:57
The silver-backed chevrotain – or Vietnam mouse-deer - hasn't been seen for 30 years, but conservationists have tracked some down
Mon Nov 11, 2019 18:00
Social media campaigning and a strategic voting alliance have helped the yellow-eyed penguin beat fierce competition to become New Zealand’s bird of the year
Mon Nov 11, 2019 16:41
Social media campaigning and a strategic voting alliance have helped the yellow-eyed penguin beat fierce competition to become New Zealand’s bird of the year
Mon Nov 11, 2019 16:41
Paul Rudd's character's quest to find a perfect version of himself in Netflix's Living With Yourself - with the help of a dodgy DNA hacking service - explores the dark side of our drive for perfection
Wed Nov 06, 2019 20:00
Artificial intelligence can predict a person’s chances of dying within a year by looking at heart test results, but doctors can't work out what patterns it’s picking up
Mon Nov 11, 2019 12:00
Rabies -- PakistanAnother young man is awaiting death in an isolation ward of the Jinnah Postgraduate Medical Centre (JPMC) after developing full-blown rabies, as he was bitten by a rabid dog some 3 months ago but was not administered the rabies vaccine, officials said on Saturday [9 Nov 2019]."18-year-old Z.K., a resident of Jeva Khan Goth in the Nooriabad area of District Jamshoro, has been brought to the casualty ward of the JPMC with full-blown rabies," Dr Seemin Jamali, the hospital's executive
02:21
Ebola -- DR Congo
00:02
African Swine Fever -- Indonesia
Mon Nov 11, 2019 19:30
Abstract Objectives We investigated retinal change and its relationship with neurodegeneration markers in a prodromal Parkinson cohort. Methods A total of 30 patients with idiopathic rapid eye movement sleep behavior disorder were recruited. Participants underwent olfactory testing, macular optical coherence tomography, microperimetry, contrast sensitivity test, and brain N‐(3‐[18F]fluoropropyl)‐2‐carbomethoxy‐3‐(4‐iodophenyl) nortropane positron emission tomography. We measured the ganglion...
Mon Nov 11, 2019 17:06
Mon Nov 11, 2019 17:03
Mon Nov 11, 2019 17:01
Abstract Background Impulse control disorders related to alterations in the mesocorticolimbic dopamine network occur in Parkinson's disease (PD). Our objective was to investigate the functional neural substrates of reward processing and inhibitory control in these patients. Methods Eighteen PD patients with impulse control disorders, 17 without this complication, and 18 healthy controls performed a version of the Iowa Gambling Task during functional magnetic resonance scanning under 3 conditions:...
Mon Nov 11, 2019 15:42
Mon Nov 11, 2019 15:30
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative clinically heterogeneous disorder, formal diagnosis being based on postmortem histological brain examination. Objective We aimed to perform a precise in vivo staging of neurodegeneration in PSP using quantitative multimodal MRI. The ability of MRI biomarkers to differentiate PSP from PD was also evaluated. Methods Eleven PSP patients were compared to 26 age‐matched healthy controls and 51 PD patients....
Mon Nov 11, 2019 15:22
Abstract Background Long‐term population‐representative data on motor fluctuations and levodopa‐induced dyskinesias in Parkinson's disease is lacking. Methods The Cambridgeshire Parkinson's Incidence from GP to Neurologist (CamPaIGN) cohort comprises incident PD cases followed for up to 13 years (n = 141). Cumulative incidence of motor fluctuations and levodopa‐induced dyskinesias and risk factors were assessed using Kaplan‐Meyer and Cox regression analyses. Results Cumulative incidence...
Mon Nov 11, 2019 14:59
Nature, Published online: 12 November 2019; doi:10.1038/s41586-019-1756-4Author Correction: Forearc carbon sink reduces long-term volatile recycling into the mantle
02:00
Nature, Published online: 12 November 2019; doi:10.1038/s41586-019-1755-5Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03487-3Phill Cassey outlines one proactive step to support diversity in his workplace.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03467-7Camera traps have recorded the first images of the silver-backed chevrotain in the wild.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03480-wThe trouble with megaconstellations like SpaceX’s Starlinks, how to put your code in the cloud and about Russia’s raid on a top physics institute.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03438-yAnalysis finds female-led papers are more likely to be rejected, and less likely to be cited, than those with male corresponding authors.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03349-yAs universities shut down, researchers are demonstrating — and meeting with lawmakers to figure out if science can help solve socio-economic inequality.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03446-yResearchers fear that plans to send tens of thousands of communications satellites into orbit will disrupt scientific observations of the Universe.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03416-4The ability of birds to learn a song depends not on their genes alone, but also on whether their genetic make-up is well matched to that of their singing teacher. This discovery sheds light on how gene–environment interactions affect learning.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03460-0Noam Shomron includes antiques and his own paintings of wildlife in the decor for his genomics lab.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03392-9The ultimate goal of genome editing is to be able to make any specific change to the blueprint of life. A ‘search-and-replace’ method for genome editing takes us a giant leap closer to this ambitious goal.
Mon Nov 11, 2019 02:00
Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03479-3New gene-editing documentary showcases biology’s hottest tool — up to the point when things went awry. By Amy Maxmen
Mon Nov 11, 2019 02:00
Are Institutions Obligated to Authentically Display Contemporary Artwork? In 1977, a visitor to the Guggenheim Museum in New York complained that the display of Eva Hesse’s Expanded Expansion (1969) was inaccurate because certain elements of the artwork were not displayed as expected. In her reply, the assistant curator - Linda Shearer - explained that the artwork was designed to be changeable: “it can be stretched to its full capacity or compressed, like an accordion”.Such interactions...
02:00
It did not take Herminia Palacio long to accept the role of President and Chief Executive Officer of the Guttmacher Institute in New York City, USA, steering its mission to advance sexual and reproductive health and rights (SRHR) in the USA and globally. “I felt like this was the moment to take up a key leadership role in this field, and bring my expertise in responding to rapidly changing environments into the work of this essential organisation”, she says. Palacio, who took the helm at Guttmacher...
01:30
Resmetirom treatment resulted in significant reduction in hepatic fat after 12 weeks and 36 weeks of treatment in patients with NASH. Further studies of resmetirom will allow assessment of safety and effectiveness of resmetirom in a larger number of patients with NASH with the possibility of documenting associations between histological effects and changes in non-invasive markers and imaging.
Mon Nov 11, 2019 22:30
There have been major advances in many areas of rheumatology over the past 20 years, with better and earlier use of traditional disease modifying anti-rheumatic drugs and an increased availability of biological and targeted synthetic disease modifying anti-rheumatic drugs. During this time, the understanding of the pathophysiology of osteoarthritis has markedly increased; however, this increased understanding has not yet translated into improved treatment.1 In fact, there are still few available...
Mon Nov 11, 2019 18:00
Treatment with 10 mg prednisolone for 6 weeks is efficacious and safe for the treatment of patients with painful hand osteoarthritis and signs of inflammation. The results of our study provide clinicians with a new short-term treatment option for patients with hand osteoarthritis who report a flare-up of their disease.
Mon Nov 11, 2019 18:00
This erratum provides the link to the software implementation of the algorithm and the examples presented in [1], which was omitted by mistake in the published version of the manuscript. The algorithm was implemented in Matlab and is available online on Code Ocean [2].
Fri Nov 01, 2019 00:00
Background: Ambient ultrafine particles (UFPs,
Wed Nov 06, 2019 02:00
Introduction To evaluate scalp hair steroid concentrations as a monitoring tool for androgen control in adults with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH). Methods Scalp hair 17-hydroxyprogesterone (17-OHP), androstenedione, testosterone, cortisol, cortisone, progesterone, prednisolone and prednisone concentrations were measured by means of LC-MS/MS in women (N=27) and men (N=15) with CAH and controls (37 women, 42 men). Results In CAH men and women, 17-OHP...
01:00
Introduction: 18-Fluorodeoxyglucose (18F-FDG) PET avidity in neuroendocrine neoplasms (NENs) has been associated with higher grade disease. 18F-FDG avidity and high SUVmax have been demonstrated to predict poor outcome. Quantitative metrics of 18F-FDG PET, specifically metabolic tumour volume (MTV) and total lesion glycolysis (TLG), have been shown to be prognostic factors in other malignancies, but these have not been investigated to date in NENs. Methods: Patients with NEN undergoing 18F-FDG...
01:00
Enzalutamide showed activity as a second-line novel androgen receptor pathway inhibitor, whereas abiraterone acetate did not, leading to a longer time to second PSA progression for the sequence of abiraterone followed by enzalutamide than with the opposite treatment sequence. Our data suggest that using a sequencing strategy of abiraterone acetate followed by enzalutamide provides the greatest clinical benefit.
01:30
Mon Nov 11, 2019 20:30
What is the correct orientation for the X-axis belt? I first thought to place the smooth side down to match the tensioner bearing, but then changed it to match the motor pulley.
01:07
I've installed the an LV8729 on a kossel, configured with SKR 1.3 and marlin 2.0 with all the jumpers configured in the same way for 16 micro steps for X Y Z axis. Everthing seems fine the printer running well. I notice when I print, some tests prints, the dimension of a cube doesn't seems right, the on Z axis its perfect the the X Y I'm not getting the right dimension. Every driver have configured with the same vref value. Checking in the LCD configuration every driver axis had the same steps...
Mon Nov 11, 2019 15:13
So I just got the ender 3 and have been trying to print out a part. However, I noticed the printer is trying to print the part, which should be centered in the bed, on the left side. I performed the auto home, leveling procedures, prior to execution, but it still wants to print it on the left side. I checked the values it thinks it has for X, but they are about 60 mm to high (i.e. from the control/move axis menu, I move it towards the zero position and when it touches the switch, it still thinks...
Mon Nov 11, 2019 09:14
I just order myself an Ender 3 Pro which will come by the end of the week. Before it arrives I want to be ready to flash a bootloader onto it. I was wondering what other options there are to flashing except using an Arduino? I have a bunch of ESP8266/ESP32 and a USB to TTL. Would it be possible to use these somehow instead of an Arduino to flash a bootloader to the Ender 3? Or should I just go buy an Arduino?
Mon Nov 11, 2019 11:22
Objectives To evaluate the long‐term audiometric outcomes, sound localization abilities, binaural benefits, and tinnitus assessment of subjects with cochlear implant (CI) after a diagnosis of unilateral severe‐to‐profound hearing loss. Method The study group consisted of 60 (mean age 52 years, range 19–84) subjects with profound hearing loss in one ear and normal to near‐normal hearing in the other ear who underwent CI. Data analysis included pre‐ and postoperative Consonant‐Nucleus‐Consonant...
Mon Nov 11, 2019 20:10
Objectives/Hypothesis Human papillomavirus (HPV) is a DNA virus that causes cancer in multiple sites. Although sexual activity is the primary means of oropharyngeal HPV acquisition, studies suggest HPV transmission through occupational exposure from medical instruments and surgical fumes. We assess if aerosolization of HPV16 DNA via electrocautery places otolaryngologists at risk for exposure. Study Design Animal and human laboratory model. Methods Plasmid (pLXSN16E6E7) expressing HPV...
Mon Nov 11, 2019 20:10
Objectives/Hypothesis To evaluate the incidence of chronic cerebrospinal venous insufficiency in Menière's disease patients and the effect of bilateral percutaneous transluminal angioplasty of the jugular/azygos veins compared to medical therapy. Study Design Prospective case–control study. Methods Five hundred fourteen subjects were included in the study, 412 affected by definite Menière's disease, and 102 healthy controls. All patients underwent audiovestibular and vascular examination....
Mon Nov 11, 2019 20:07
Literature describing neodymium:yttrium‐aluminum‐garnet (Nd:YAG) photocoagulation and sclerotherapy for laryngeal venous malformations (VMs) is sparse. Here we present a case in which an extensive laryngeal VM in a 28‐year‐old female was managed through a combination of four serial Nd:YAG laser photocoagulation sessions and four bleomycin injections over the course of 2 years. The treatment plan resulted in resulted in noticeable lesion ablation, mucosalization, and significant improvement in symptoms....
Mon Nov 11, 2019 20:06
Even if you have the best intentions, helping someone with anxiety can be touchy. Here are four things you’ll want to avoid saying or doing.
Mon Nov 11, 2019 18:02
Writers often listen to music to boost their creativity, but new research shows this trick may backfire.
Mon Nov 11, 2019 16:14
In this study we propose a new tool for the perceptual assessment of voice quality. For its design, we have adapted the Simplified Vocal Profile Analysis so that the new tool features two main characteristics: (1) the ordinal scalar degrees of the original protocol are turned into a visual analog scale; and (2) the original paper-based version of the protocol is now a computer-based implementation. In order to assess the reliability of the new tool, five phoneticians listened to 12 different speakers...
Mon Nov 11, 2019 02:00
Traditionally, it has been widely assumed that patients with mental illness start smoking to self-medicate. However, a novel study suggests the reverse — that smoking may actually raise the risk of mental illness. Medscape Medical News
Mon Nov 11, 2019 23:35
PAN's new communications associate on the ground in Iowa, with a view of the challenges and opportunities ahead. Learn more Slideshow Category: Flex Slider
Mon Nov 11, 2019 23:17
Abstract Purpose Intraoperative molecular imaging with tumor-targeting fluorophores offers real-time detection of neoplastic tissue. The second window indocyanine green (SWIG) technique relies on passive accumulation of indocyanine green (ICG), a near-infrared fluorophore, in neoplastic tissues. In this study, we explore the ability of SWIG to detect neoplastic tissue and to predict postoperative magnetic resonance imaging (MRI) findings...
Mon Nov 11, 2019 02:00
Pediatric Research, Published online: 11 November 2019; doi:10.1038/s41390-019-0667-2Pitfalls of using IQ short forms in neurodevelopmental disorders: a study in patients with congenital heart disease
Mon Nov 11, 2019 02:00
Pediatric Research, Published online: 11 November 2019; doi:10.1038/s41390-019-0620-4Editor’s Focus
Mon Nov 11, 2019 02:00
Pediatric Research, Published online: 11 November 2019; doi:10.1038/s41390-019-0672-5Ventilator-associated pneumonia in the NICU: time to boost diagnostics?
Mon Nov 11, 2019 02:00
Pediatric Research, Published online: 11 November 2019; doi:10.1038/s41390-019-0668-1Shock and unresponsiveness to repeated courses of intravenous immunoglobulin in Kawasaki disease: a nationwide database study
Mon Nov 11, 2019 02:00
Pediatric Research, Published online: 11 November 2019; doi:10.1038/s41390-019-0666-3Microbial invasion of the amniotic cavity is associated with impaired cognitive and motor function at school age in preterm children
Mon Nov 11, 2019 02:00
Pediatric Research, Published online: 11 November 2019; doi:10.1038/s41390-019-0674-3Insights Image for “Rate of rise of total serum bilirubin in very low birth weight preterm infants”
Mon Nov 11, 2019 02:00
Lymphangioma of the tongue is a rare lymphatic malformation, and various authors have reported the successful use of sirolimus for its treatment. However, the safety of sirolimus in children needs further evaluation so that those who do not respond are not necessarily exposed to its potential adverse effects. We hypothesised that assessment of lymphangiogenesis can be used to predict whether the patient will respond to sirolimus, so we organised a prospective study after ethics committee approval...
Mon Nov 11, 2019 02:00
Idiopathic hemipalatal hypoplasia is rare and leads to speech problems and the regurgitation of fluids, and the reconstruction of asymmetrical velopharyngeal incompetence is a challenge to the cleft surgeon. We present a case in a 5-year-old boy, and introduce the one-stage surgical technique that we used to resolve it.
Mon Nov 11, 2019 02:00
CAMBRIDGE, Mass.--(BUSINESS WIRE)-- November 8, 2019 -- AVEO Oncology (AVEO) and Biodesix, Inc. today announced the initiation of the CyFi-2 study, a randomized Phase 2 clinical study evaluating ficlatuzumab, AVEO’s potent hepatocyte...
Mon Nov 11, 2019 21:11
SDG&E Wants More Money From Customers Who Don’t Buy Much Electricity. A Lot More. San Diego Gas & Electric's proposal to charge households a minimum of $38.40 a month would hurt rooftop solar and disproportionately burden low-income customers. The skyline of San Diego, where the local utility wants to raise most residential customers' minimum bills...
Mon Nov 11, 2019 22:45
Objectives: To determine the validity and reliability of the Brazilian Portuguese version of the Pediatric Confusion Assessment Method for the ICU for diagnosing delirium in patients with chronological and developmental ages from 5 to 17 years in Brazilian PICUs. Design: Prospective, cross-sectional study. Settings: Eight Brazilian PICUs (seven in Rio de Janeiro and one in São Paulo). Patients: One-hundred sixteen patients, 5–17 years old, without developmental delay, submitted...
Fri Nov 08, 2019 02:00
ACS Infectious DiseasesDOI: 10.1021/acsinfecdis.9b00307
Mon Nov 11, 2019 07:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου