Abstract Allogeneic hematopoietic stem cell transplantation (allo-SCT) has been considered as a potentially curative treatment option for refractory or relapsed diffuse large B cell lymphoma (DLBCL) patients. However, there is little information available, especially for Japanese patients and in cord blood transplantation (CBT). We aimed to determine treatment outcomes of allo-SCT for DLBCL in the Kyoto Stem Cell Transplantation Group, a multi-institutional joint research group....
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Σε συναγερμό έχουν τεθεί οι υγειονομικές υπηρεσίες προκειμένου να προετοιμάσουν τουλάχιστον τα μεγάλα δημόσια νοσοκομεία... HealthReport.gr
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Journal of International Medical Research, Ahead of Print.
Mon Nov 11, 2019 09:23
Journal of International Medical Research, Ahead of Print.
Mon Nov 11, 2019 09:20
Future Oncology, Ahead of Print.
Mon Nov 11, 2019 14:38
Future Oncology, Ahead of Print.
Mon Nov 11, 2019 13:24
Future Oncology, Ahead of Print.
Mon Nov 11, 2019 12:02
Volume 52, Issue 4, December 2019, Page 184-205.
Mon Nov 11, 2019 11:21
Telemedicine and e-Health, Ahead of Print.
Mon Nov 11, 2019 10:00
Journal of medicinal chemistry
Sun Nov 10, 2019 22:10
Sun Nov 10, 2019 22:09
Science (New York, N.Y.)
Sun Nov 10, 2019 22:08
Seminars in cell & developmental biology
Sun Nov 10, 2019 22:06
Systematic Reviews
Sun Nov 10, 2019 00:12
Sun Nov 10, 2019 00:09
Abstract In the analysis of current life science datasets, we often encounter scenarios in which the application of asymptotic theory to hypothesis testing can be problematic. Besides improved asymptotic results, permutation/simulation‐based tests are a general approach to address this issue. However, these randomized tests can impose a massive computational burden, for example, in scenarios in which large numbers of statistical tests are computed, and the specified significance level is very small....
Mon Nov 11, 2019 17:25
Brain Sciences, Vol. 9, Pages 320: C-Fiber Assays in the Cornea vs. Skin Brain Sciences doi: 10.3390/brainsci9110320 Authors: Eric A. Moulton David Borsook C-fibers are unmyelinated nerve fibers that transmit high threshold mechanical, thermal, and chemical signals that are associated with pain sensations. This review examines current literature on measuring altered peripheral nerve morphology and discusses the most relevant aspects of corneal microscopy, especially whether corneal...
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Background and Objectives Widespread applications of supercontinuum (SC) source lead to the possibility of ocular damages. However, the corneal damage effects induced by SC have not been explored before. The objectives of this study are to determine the rabbit corneal injury threshold for SC radiation and to examine whether the existing safety guidelines and standards are suitable for the hazard evaluation of this new kind of light source. Study Design/Materials and Methods A series of experiments...
Mon Nov 11, 2019 18:19
Background and Objective Keratosis pilaris (KP) is a common follicular disorder for which various topical agents and energy‐based devices have been used with some efficacy. To evaluate the efficacy of a novel 1064‐nm Nd:YAG laser for the reduction of skin roughness, erythema, and hyperpigmentation in KP subjects. Study Design/Materials and Methods Twenty‐three subjects with untreated KP on the upper outer arms participated in a randomized, single‐blind fashion. One arm of each subject was...
Mon Nov 11, 2019 18:19
Abstract In the Amazon and Orinoco basins, mercury has been released from artisanal and industrial gold mining since the Colonial time, as well as a result of deforestation and burning of primary forest, that release natural deposits of methyl mercury, affecting the local aquatic vertebrate fauna. This study reports the presence of mercury in river dolphins’ genera Inia and Sotalia. Mercury concentrations were analysed in muscle tissue samples collected from 46 individuals at the...
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Surgical Infections, Ahead of Print.
Mon Nov 11, 2019 10:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01715A, PaperMuhammad Ali Tahir, Xinlian Zhang, Hanyun Cheng, Dong Xu, Yiqing Feng, Guodong Sui, Hongbo Fu, Ventsislav Valev, Liwu Zhang, JM ChenDetecting atmospheric bioaerosol in a quantitative way is highly desirable for public health and safety. This work demonstrates that Surface-enhanced Raman Spectroscopy (SERS) is a simple and rapid analytical technique...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN02226K, CommunicationXiaojun He, Chuchu Xu, Wei Xiong, Yuna Qian, Jinyi Fan, Feng Ding, Hui Deng, Hong Chen, Jianliang ShenThis work shown a novel chemosensor, SPTPA, which exhibited fluorescent and colorimetric dual sensing of hypochlorite with ICT ON strategy. Additionally, the chemosensor has successfully detected and imaged endogenous hypochlorite...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN02000D, PaperLin Xu, Bingying Jiang, Wenjiao Zhou, Ruo Yuan, Yun XiangDetecting aberrant ATP concentration with high sensitivity and selectivity is of critical importance for monitoring many biological processes and disease stages. By coupling extension/excision amplification with target recycling, we have...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01962F, CommunicationAshwini Gajarushi, Sandeep Surya, Mrinalini Walawalkar, Mangalampalli Ravikanth, Ramgopal Rao, Chandramouli SubramaniamThe high energy density (4.2 MJ/kg) and low vapor pressure (7.2 x 10-9 atm) of chemical explosives such as TNT (2,4,6-Trinitrotoluene) poses grave security risk demanding immediate attention. Detection of...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C8AN00615F, PaperElnaz Tavakkoli, Hamid Abdollahi, Paul J GemperlineData sets produced by hyphenated chemical analysis methods like GC/MS, LC/MS, or HPLC with UV/Vis diode array detection are often presumed to have “trilinear” structure if the profile for each...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Nov 11, 2019 02:00
Analyst, 2019, Advance ArticleDOI: 10.1039/C9AN01364D, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sebastian Tassoti, Martin Walenta, Alexander Pöcheim, Kathrin Buchberger, Olaf Kunert, Klaus ZanggerWe present a simple and broadly applicable method to determine the protonation state of heteroatoms in organic compounds.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c)...
Mon Nov 11, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01725A, PaperQingsong Mei, Cuilan Zhang, Xiao Ling, Hongbo He, Shengsong Deng, Yong ZhangSensitive and on-site detection of sulfur dioxide (SO2) is in great demand in fields of food safety and environmental protection. Here we developed a novel upconversion nanoprobe based on luminescence...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Nov 11, 2019 02:00
Shiraia bambusicola is a rare medicinal fungus found in China that causes bamboo plants to decay and die with severe infection. Hypocrellin, its main active ingredient, is widely used in several fields, such as medicine, agriculture, and food industry. In this study, to clarify the genomic components, taxonomic status, pathogenic genes, secondary metabolite synthesis pathways, and regulatory mechanisms of S. bambusicola, whole-genome sequencing, assembly, and functional annotation were performed...
Mon Nov 11, 2019 22:48
Different Musa species, subspecies, and cultivars are currently investigated to reveal their genomic diversity. Here, we compare the genome sequence of one of the commercially most important cultivars, Musa acuminata Dwarf Cavendish, against the Pahang reference genome assembly. Numerous small sequence variants were detected and the ploidy of the cultivar presented here was determined as triploid based on sequence variant frequencies. Illumina sequence data also revealed a duplication of a large...
Mon Nov 11, 2019 22:48
The relationship of genotypes to phenotypes can be modified by environmental inputs. Such crucial environmental inputs include metabolic cues derived from microbes living together with animals. Thus, the analysis of genetic effects on animals' physiology can be confounded by variations in the metabolic profile of microbes. Caenorhabditis elegans exposed to distinct bacterial strains and species exhibit phenotypes different at cellular, developmental, and behavioral levels. Here we reported metabolomic...
Mon Nov 11, 2019 22:48
Abstract Background Simulation-based training has been considered as the most promising curriculum for neurosurgical education to finally improve surgical skills with the greatest efficiency and safety. However, most of the simulators including physical models and virtual reality systems are relatively expensive, which limits their promotion. In this study, the authors tried to develop a realistic, low-cost, and reusable simulator for...
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Can you dedicate a few minutes a day to your own mental health? Self-care for clinicians and other stressed professionals begins with slowing down for some deep breaths.
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I can tell, from the look on my patient’s face, that I am the last person he wants to see. Unfortunately, he has little choice.
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Conventional wisdom tell us that there are “no atheists in foxholes.” But new research makes us ask: Is that really true?
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Punishing a child who hits doesn't stop the hitting. It just increases the child's fear, making future hitting more likely.
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Anxious? Try sleep. New research shows a direct causal link between restricted deep sleep and anxiety. If you're feeling anxious, some "Vitamin Z" might help. Parents, take note.
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The fact that sex can be boring comes as astonishing to some and as a statement of all too familiar hopelessness to others.
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Why are there more men in STEM fields?
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Our homeless veterans face high rates of PTSD and suicide risk. These are some resources and ways to help support them.
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A new study published in the Journal of Neurology Neurosurgery & Psychiatry asserts the efficacy of anti-inflammatories in treating major depression.
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While divorce is always painful, divorcing police officers and other emergency responders brings up unique considerations, especially if there is PTSD involved.
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Did you know veterans face many challenges transitioning back to civilian life and many never regain the quality of life they once knew? They deserve better. We can help.
Mon Nov 11, 2019 23:42
If your children only knew one or two stories about your life, what stories would you want those to be and why?
Mon Nov 11, 2019 22:12
Successful business deals require a contract. Delivering and receiving honest feedback requires a psychological contract – a stated agreement about boundaries. Here's how to do it.
Mon Nov 11, 2019 22:00
Instead of rushing to Ritalin, parents can try these no-risk non-drug treatments for ADHD kids.
Mon Nov 11, 2019 21:04
The blurring of the lines of age could prove to be baby boomers’ most enduring contribution to society as we enter a new age of cultural “agelessness.”
Mon Nov 11, 2019 21:02
New research explores the personality types that respond best to confusion.
Mon Nov 11, 2019 20:56
Many don't know how to stand up for ourselves without attacking or folding to the demands of others. Find the healthy middle ground by being assertive.
Mon Nov 11, 2019 20:36
Do you get annoyed with friends or family who never initiate contact? Keeping score in relationship can distract you from working on your own maturity.
Mon Nov 11, 2019 20:31
Navigating a breakup and hoping to be “just friends" afterward?" Wondering how soon is too soon? In Part Two of a four-part series.
Mon Nov 11, 2019 19:57
The problem with change is that it makes most people anxious or worse - afraid. It’s fear of the unknown that does this.
Mon Nov 11, 2019 18:11
Even if you have the best intentions, helping someone with anxiety can be touchy. Here are four things you’ll want to avoid saying or doing.
Mon Nov 11, 2019 18:02
Remind yourself how it's in your own best interest to admit fault and move on. It takes a strong person to admit fault, and it puts us in a stronger position with others.
Mon Nov 11, 2019 17:31
Machado's canny insight is that she doesn't overestimate empathy. She uses formal experimentation to extend it into moral and political territory.
Mon Nov 11, 2019 17:11
Part Two: If you don't love acting on the environment and still feel guilt and shame, this perspective may change your mind.
Mon Nov 11, 2019 17:02
Why should anyone expect that marijuana would affect cortical thickness? The answer is related to the potential influence cannabis has on brain development and growth.
Mon Nov 11, 2019 16:51
Gut organisms impact the ability to extinguish fear
Mon Nov 11, 2019 16:26
Writers often listen to music to boost their creativity, but new research shows this trick may backfire.
Mon Nov 11, 2019 16:14
Have you forgotten the value of your own company?
Mon Nov 11, 2019 16:04
When getting to know someone, you might have heard that “flattery will get you everywhere.” But responses to flattery might determine where you want to go with the relationship.
Mon Nov 11, 2019 16:04
Women tell different truths, ones that cause us to revise our standard wisdom. How do we learn from them?
Mon Nov 11, 2019 14:53
The nuts and bolts of making a living on your own.
Mon Nov 11, 2019 09:43
Recently, we saw the breakthroughs in drug development for Alzheimer disease. The Chinese regulatory authority (NMPA) approved GV-971 (Oligomannate) for the treatment of mild and moderate Alzheimer’s disease. GV-971 is the first drug approved anywhere in the world for Alzheimer’s disease since 2003. While other Alzheimer’s drugs are developed based on the beta-amyloid theory, GV-971 targets a different mechanism. Based on the pre-clinical studies, GV-971 remodeled the gut microbiome in a way that...
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Key PointsChronic EtOH consumption alters the existing memory T cell compartment.EtOH-induced changes in existing memory T cells increase susceptibility to IAV.Chronic EtOH alters memory T cell–mediated killing and recruitment into the lungs.
Mon Nov 11, 2019 18:48
Key PointsDiet-induced obese mice exhibit reduced αβ and IEL persistence within 7 wk.Obese mice are more susceptible to dextran sulfate sodium–induced colitis.Diet-induced weight loss restores IEL number and improves outcome in colitis.
Mon Nov 11, 2019 18:48
Rationale: Lymphatic tracers can help visualize the lymphatic drainage patterns and sentinel nodes of individual prostate cancer patients. To determine the role of nuclear medicine, in particular the positional guidance of a SPECT/CT-based 3D imaging roadmap, in this process we studied to which extend fluorescence-guidance underestimated the number of target lesions. Methods: SPECT/CT imaging was performed after intraprostatic tracer administration of either ICG-99mTc-nanocolloid (hybrid tracer...
Mon Nov 11, 2019 22:55
18F-PI-2620 is a positron emission tomography (PET) tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer’s disease (AD) and other neurodegenerative disorders. Preclinically, 18F-PI-2620 binds to both, 3R and 4R tau isoforms. The purpose of this first-in-human study was to evaluate the ability of 18F-PI-2620 to detect tau pathology in AD patients using PET imaging, as well as to assess its safety and tolerability of this new tau PET tracer. Methods: Participants...
Mon Nov 11, 2019 22:55
By contributing to non-invasive molecular imaging and radioguided surgery, nuclear medicine has been instrumental in the realization of precision medicine. During the last decade it has also became apparent that nuclear medicine (e.g., in the form of bimodal/hybrid tracers) can help empower fluorescence guided surgery. More specifically, when using hybrid tracers, lesions can be non-invasively identified and localized with a high sensitively and precision (guided by the radioisotope) and ultimately...
Mon Nov 11, 2019 22:55
18F-PI-2620 is a next generation tau positron emission tomography (PET)-tracer that has demonstrated ability to image the spatial distribution of suspected tau pathology. The objective of this study was to assess the tracer biodistribution, dosimetry and quantitative methods of 18F-PI-2620 in the human brain. Full kinetic modelling approaches to quantify tau load were investigated. Non-invasive kinetic modeling approaches and semi-quantitative methods were evaluated against the full tracer kinetics....
Mon Nov 11, 2019 22:55
Striated muscle is activated by myosin- and actin-linked processes, with the latter being regulated through changes in the position of tropomyosin relative to the actin surface. The C-terminal region of cardiac troponin T (TnT), a tropomyosin-associated protein, is required for full TnT inactivation at low Ca2+ and for limiting its activation at saturating Ca2+. Here, we investigated whether basic residues in this TnT region are involved in these activities, whether the TnT C terminus undergoes Ca2+-dependent...
Mon Nov 11, 2019 22:30
Bone morphogenetic protein 10 (BMP10) is a cardiac peptide growth factor, belonging to the transforming growth factor beta (TGFβ) superfamily, that critically controls cardiovascular development, growth, and maturation. It has been shown that BMP10 elicits its intracellular signaling through a receptor complex of activin receptor–like kinase 1 (ALK1) with morphogenetic protein receptor type II (BMPR2A) or activin receptor type-2A (ActR2A). Previously, we generated and characterized a transgenic mouse...
Mon Nov 11, 2019 22:30
The reverse transcriptases (RTs) encoded by mobile group II introns and other non-LTR-retroelements differ from retroviral RTs in being able to template switch efficiently from the 5' end of one template to the 3' end of another with little or no complementarity between the donor and acceptor templates. Here, to establish a complete kinetic framework for the reaction and identify conditions that more efficiently capture acceptor RNAs or DNAs, we used a thermostable group II intron RT (TGIRT; GsI-IIC...
Mon Nov 11, 2019 20:30
Successes and challenges in simulating the folding of large proteins [Protein Structure and Folding]
Computational simulations of protein folding can be used to interpret experimental folding results, to design new folding experiments and to test the effects of mutations and small molecules on folding. However, while major experimental and computational progress has been made in understanding how small proteins fold, research on larger, multi-domain proteins, which comprise the majority of proteins, is less advanced. Specifically, large proteins often fold via long-lived partially folded intermediates,...
Mon Nov 11, 2019 20:30
The ferric iron uptake (Fiu) transporter from Escherichia coli functions in the transport of iron–catecholate complexes across the bacterial outer membrane, providing the bacterium with iron, which is essential for growth. Recently, it has become clear that Fiu also represents a liability for E. coli because its activity allows the import of antimicrobial compounds that mimic catecholate. This inadvertent import suggests the potential utility of antimicrobial catechol-siderophore mimetics in managing...
Mon Nov 11, 2019 17:30
The tnaC regulatory gene from the tna operon of Escherichia coli controls the transcription of its own operon through an attenuation mechanism relying on the accumulation of arrested ribosomes during inhibition of its own translation termination. This free L-Trp dependent mechanism of inhibition of translation termination remains unclear. Here, we analyzed the inhibitory effects of L-Trp on the function of two known E. coli translation termination factors, RF1 and RF2. Using a series of reporter...
Mon Nov 11, 2019 16:30
In cancer, aberrant growth factor receptor signaling reprograms cellular metabolism and global gene transcription to drive aggressive growth, but the underlying mechanisms are not well understood. Here we show that in the highly lethal brain tumor glioblastoma (GBM), mechanistic target of rapamycin complex 2 (mTORC2), a critical core component of the growth factor signaling system, couples acetyl-CoA production with nuclear translocation of histone-modifying enzymes including pyruvate dehydrogenase...
Mon Nov 11, 2019 16:30
Due to a single error in the annual cost of sarilumab the following needs to be corrected in the article.
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Abstract Pelodiscus sinensis is the most common turtle species raised in East and Southeast Asia. The Japanese strain and the Qingxi black strain are important aquatic breeds of P. sinensis in China with unique characteristics in terms of production performance and appearance, including skin color. In this study, melanin content measure and histological analysis on skin samples of these two strains were carried out to compare their color characteristics. The results showed that...
Mon Nov 11, 2019 02:00
Abstract Objectives To determine glucose transporter 1 (GLUT1) and runt‐related transcription factor 2 (RUNX2) expression during reparative dentinogenesis after pulpotomy with mineral trioxide aggregate (MTA) capping. Subjects and Methods Eight‐week‐old male Wistar rats were used. Pulp of the upper left first molar was exposed and capped with MTA. The upper right first molar of the same animal was used as a control. After collecting molars at various time points, GLUT1, RUNX2, and mammalian...
Mon Nov 11, 2019 21:19
Abstract Objective We determined the bacterial community structure of the buccal mucosa in patients with oral lichen planus (OLP) and evaluated the potential association of Fusobacterium nucleatum with OLP. Subjects And Methods We collected buccal mucosa swab samples of patients with OLP (n = 20) and healthy controls (n = 10) and performed 16S rRNA gene sequencing and real‐time PCR to determine potentially different bacteria. Damaged and adjacent nondamaged mucosal swab samples of 25 OLP...
Mon Nov 11, 2019 20:54
Mucosal Immunology, Published online: 11 November 2019; doi:10.1038/s41385-019-0220-ySingle-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1− T-bet+ intraepithelial lymphocyte precursors
Mon Nov 11, 2019 02:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03173
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03728
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02443
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04088
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03763
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04552
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03291
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02117
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04268
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03731
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04422
Mon Nov 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04966
Mon Nov 11, 2019 07:00
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Range Variability in CMR Feature Tracking Multilayer Strain across Different Stages of Heart Failure
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