In patients with advanced or metastatic non–small-cell lung cancer (NSCLC) with mutations in the gene encoding epidermal growth factor receptor (EGFR) that are sensitive to tyrosine kinase inhibitors (TKIs) (exon 19 deletions or L858R point mutations), guidelines recommend treatment with an…
Thu Nov 21, 2019 02:00
The worm Caenorhabditis elegans is a simple yet powerful model organism that is useful in carrying out rapid genomewide genetic screens. There, high-throughput functional tests are designed to detect specific phenotypic (e.g. behavioral) deficits after the knockout of thousands of genes (resulting…
Thu Nov 21, 2019 02:00
Humans have always lived in intimate association with arthropods that transmit pathogens between humans or from animals to humans. About 700,000 deaths due to vectorborne diseases occur globally each year, according to World Health Organization estimates. In the summer and fall of 2019, nine U.S.…
Thu Nov 21, 2019 02:00
Presentation of Case. Dr. Pierre O. Ankomah (Medicine): A 34-year-old man with asthma was admitted to this hospital during the winter because of dyspnea. Three months before admission, odynophagia developed, and the patient noted white plaques in his mouth. He presented to an urgent care clinic,…
Thu Nov 21, 2019 02:00
Mr. P. a 53-year-old black man with schizoaffective disorder, post-traumatic stress disorder, and substance use disorder, had been a patient at a community mental health clinic in Los Angeles County for 3 years. At first, he had trouble being around other people, who he believed were always talking…
Thu Nov 21, 2019 02:00
Americans have ranked "taking action to lower prescription drug prices" as their top priority for Congress this year. Policymakers seem to be listening. Proposals have emanated from Senate and House committees, the Trump administration, and several Democratic presidential candidates. Though the…
Wed Nov 20, 2019 02:00
Dengue is a pandemic-prone viral disease, the incidence of which has increased by a factor of 30 over the past 50 years. Nearly half of the world’s population lives in dengue-endemic areas in more than 100 countries worldwide, where approximately 390 million cases of dengue virus infection are…
Thu Nov 21, 2019 02:00
New England Journal of Medicine, Ahead of Print.
Wed Nov 20, 2019 12:01
New England Journal of Medicine, Volume 381, Issue 21, Page 1992-1993, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, Page 2052-2061, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, Page 2067-2069, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, Page 2072-2075, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, Page 1985-1989, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, Page 2075-2077, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Ahead of Print.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, Page 2051-2051, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Volume 381, Issue 21, Page 1989-1992, November 2019.
Wed Nov 20, 2019 12:00
New England Journal of Medicine, Ahead of Print.
Wed Nov 20, 2019 12:00
In 2015, empagliflozin, an inhibitor of sodium–glucose cotransporter 2 (SGLT2), lowered the composite cardiovascular end point in the EMPA-REG trial involving patients with type 2 diabetes mellitus who were at increased cardiovascular risk. What was remarkable in that finding was that the benefit…
Thu Nov 21, 2019 02:00
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