ACS Pharmacology & Translational ScienceDOI: 10.1021/acsptsci.9b00064
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ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00335
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BiomacromoleculesDOI: 10.1021/acs.biomac.9b01143
BiomacromoleculesDOI: 10.1021/acs.biomac.9b01278
BiomacromoleculesDOI: 10.1021/acs.biomac.9b01446
BiomacromoleculesDOI: 10.1021/acs.biomac.9b01049
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Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00358
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00118
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00228
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00350
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Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00523
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00210
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00283
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00690
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Abstract The market of probiotics is growing dynamically for the food and supplements, which provides better health to an individual. Probiotics are used as dietary management for diseases, but it varies between regions and persons. Systems biology can help in resolving the strain specificity of probiotics by studying their genome level organization. In this review, we have compiled facets of systems biology and next-generation omics methods such as metagenomics, proteomics and...
Abstract In this work, we statistically improved culture media for rPOXA 1B laccase production, expressed in Pichia pastoris containing pGAPZαA-LaccPost-Stop construct and assayed at 10 L bioreactor production scale (6 L effective work volume). The concentrated enzyme was evaluated for temperature and pH stability and kinetic parameter, characterized by monitoring oxidation of different ABTS [2, 20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] substrate concentrations. Plackett–Burman...
Abstract The current study aims to enhance glycerol production using UV-mutagenesis of the marine yeast Wickerhamomyces anomalus HH16 isolated from marine sediment collected from South Sinai Governorate, Egypt. Besides optimization of the culture conditions and analyzing the kinetic parameters of growth and glycerol biosynthesis by the mutant strain were studied. The marine yeast isolate HH16 was selected as the front runner glycerol-producer among all tested isolates, with glycerol...
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Abstract In patients with acute pancreatitis (AP), diagnostic imaging is performed for various reasons, including the detection of the etiology (e.g., biliary obstruction caused by gallstones), diagnosis of pancreatitis in an unclear clinical setting, assessment of the severity of the process, and evaluation of its complications. In spite of the potential benefits of these imaging studies in the setting of AP, especially economic consequences but also medical risks are associated...
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Abstract The use of DNA extracted from skeletonized human remains is a common challenge for those working in human identification. Thermal age and chemical compromise should be considered prior to performing DNA testing on skeletonized remains. Both heat and chemical contamination may cause damage to the DNA present in the osseous materials and a subsequent increase in both the difficulty and expense of DNA testing. For this study, three World War II era mass fatality events involving...
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Abstract Aluminum phosphide (ALP) has been extensively used as an economical and effective insecticide, rodenticide, and fumigant. The active ingredient of ALP is phosphine (PH3), the use of which can lead to accidental inhalation and mass poisoning with high mortality. Exposure to PH3 will give rise to global damage in the human body. This study reviewed 4 fatal accidents including 8 children with PH3 poisoning and aimed to determine the pathological changes that resulted from...
Abstract We report here the first ever global study on genetic polymorphism using a Verifiler PlusTM autosomal STR multiplex system. The study evaluated genetic characteristics of 23 autosomal STRs in 200 unrelated residents of Guna district of Madhya Pradesh, India. Allele frequencies and forensic parameters are reported. Population comparison analysis was also performed using NJ tree and PCA plot. Penta E marker showed highest power of discrimination (0.938) among all 23 studied...
Abstract Crossbows are ancient distance weapons, which in modern times have been largely replaced by guns. Nowadays, they are used for target shooting and in some countries also for hunting. Bolts/arrows fired from a crossbow have a rather low initial velocity but a high penetration capacity comparable to bullets shot from firearms. A considerable number of homicidal, suicidal, and accidental crossbow injuries have been reported up to the present day both under clinical and medicolegal...
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Abstract Multiple approaches such as mathematical deconvolution and mechanistic oral absorption models have been used to predict in vivo drug dissolution in the gastrointestinal (GI) tract. However, these approaches are often validated by plasma pharmacokinetic profiles, but not by in vivo drug dissolution due to the limited data available regarding the local GI environment. It is also challenging to predict and validate in vivo dissolution in different regions of the GI tract...
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MacromoleculesDOI: 10.1021/acs.macromol.9b01785
MacromoleculesDOI: 10.1021/acs.macromol.9b01716
MacromoleculesDOI: 10.1021/acs.macromol.9b01994
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Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00757
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00430
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00840
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b01050
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EXPRESSION OF MUC2 GLYCOPROTEIN ANTIBODY AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN BARRETT'S MUCOSA.
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SONOELASTOGRAPHIC FEATURES OF HIGH-RISK BREAST LESIONS AND DUCTAL CARCINOMA IN SITU - A PILOT STUDY.
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Publication date: Available online 10 November 2019Source: Forensic Science International: GeneticsAuthor(s): Kimberly Sturk-Andreaggi, Walther Parson, Marie Allen, Charla MarshallAbstractAdvancements in sequencing technologies allow for rapid and efficient analysis of mitochondrial DNA (mtDNA) in forensic laboratories, which is particularly beneficial for specimens with limited nuclear DNA. Next generation sequencing (NGS) offers higher throughput and sensitivity over traditional Sanger-type sequencing...
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