Congenital heart disease (CHD) may cause a significant comorbidity in patients with Turner syndrome. The commonly reported CHD in these patients includes bicuspid aortic valve and coarctation of the aorta. Left ventricular noncompaction (LVNC) is a rare form of cardiomyopathy that has been reported in literature only three times in adult patients with Turner syndrome. We report the first case of a 6-year-old asymptomatic female with Turner syndrome who was referred for cardiac evaluation after her...
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British Journal of Cancer, Published online: 11 November 2019; doi:10.1038/s41416-019-0615-2Engaging chromatin: PRC2 structure meets function
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British Journal of Cancer, Published online: 11 November 2019; doi:10.1038/s41416-019-0602-7Human papillomavirus as a driver of head and neck cancers
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Anti-inflammatory cytokine interleukin-4 (IL-4) promotes glucose tolerance and insulin sensitivity while reduces lipid deposits. However, the effects of IL-4 on energy metabolism in muscle, the largest insulin-targeting organ, remain obscure. The study aimed at addressing the roles of IL-4 in myocyte differentiation (myogenesis) and energy metabolism of muscle cells. Effects of IL-4 on myogenesis, and interaction between IL-4 and insulin on glucose metabolism of C2C12 myoblasts and the terminal differentiated...
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Background. High levels of branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) were associated with an increased risk of hyperglycemia and the onset of diabetes. This study is aimed at assessing circulating valine concentrations in subjects with type 2 diabetes (T2D) and in T2D patients and high-fat diet- (HFD-) fed mice treated with the hypoglycemic agent sitagliptin (Sit) and analyzing the association of valine concentrations with metabolic parameters. Methods. Metabolomics in HFD-fed...
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Lung cancer is one of the deadliest and most common malignancies in the world, representing one of the greatest challenges in cancer treatment. Immunotherapy is rapidly changing standard treatment schedule and outcomes for patients with advanced malignancies. However, several ongoing studies are still attempting to elucidate the biomarkers that could predict treatment response as well as the new strategies to improve antitumor immune system response ameliorating immunotherapy efficacy. The complex...
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We previously reported that acute necrotizing pancreatitis (ANP) after normal or high-fat diet is associated with a decreased number of Paneth cells in ileal crypts. Here, we ablated Paneth cells in a rat model of ANP after normal and high-fat diet to investigate the effects on disease symptoms. Adult male Sprague-Dawley rats received standard rat chow or a high-fat diet for 2 weeks, after which they were treated with dithizone to deplete Paneth cells. Six hours later, ANP was established by retrograde...
02:07
Scientists have a relatively precise idea about where whales and their closest terrestrial relatives evolved more than 50 million years ago (early Eocene), thanks to the discovery of ancient cetacean fossils in India and Pakistan. Around 45 million years ago, four-legged whales (protocetids) gradually dispersed out of Asia, westward towards Africa and then reached the east coast of North America more than 41 million years ago.
Sat Nov 09, 2019 00:16
A team of researchers has uncovered the basis of stem rust pathogen Ug99's wide virulence, attacking a direct threat to the world wheat supply.
Thu Nov 07, 2019 23:06
Introduction. Mucormycosis following hematopoietic stem cell transplant (HSCT) carries a very high mortality rate. Pulmonary mucormycosis often leads to systemic dissemination and eventual death. It is imperative for transplant providers to have a high level of suspicion for mucormycosis and initiate early treatment. Here, we present a 64-year-old woman who died of disseminated mucormycosis 13 days following her allogeneic HSCT. Case Presentation. A 64-year-old female with a history of acute myeloid...
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Scombroid poisoning is a predominantly self-limited illness associated with ingestion of poorly handled fish. It is not frequently associated with bacteremia and has never been described with Brevundimonas septicemia. We describe a case of a man who presented in shock with histamine poisoning after ingesting sushi. Blood cultures grew an uncommon pathogen, Brevundimonas vesicularis. This case demonstrates systemic bacterial infection in the setting of histamine poisoning, which is an atypical presentation...
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Dysphagia is an expressive symptom, described by an individual as “difficulty in swallowing.” Dysphagia due to esophageal compression from an aberrant right subclavian artery is rare, and it is termed as “dysphagia lusoria.” We present a rare case of co-occurrence of dysphagia lusoria with esophageal eosinophilia in a patient with cognitive disability which portends a case with diagnostic challenge and treatment dilemma. A 31-year-old man with intellectual disability, cerebral palsy, previous history...
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The post intensive care syndrome (PICS) gathers various disabilities, associated with a substantial healthcare use. However, patients’ comorbidities and active medical conditions prior to intensive care unit (...
Sat Nov 09, 2019 02:00
Abstract Context: Palliative care encompasses an interdisciplinary team, including mental health care professionals, to address psychological distress of cancer patients. Objectives: To present the implementation of an outreach counseling program via videoconferencing or telephone to patients receiving care in an outpatient palliative care clinic and to compare patients using this service to those who only received psychological counseling in our outpatient clinic. Methods: We conducted a retrospective...
Sun Nov 10, 2019 12:23
We explore sequence determinants of enzyme activity and specificity in a major enzyme family of terpene synthases. Most enzymes in this family catalyze reactions that produce cyclic terpenes - complex hydrocarbons widely used by plants and insects in diverse biological processes such as defense, communication, and symbiosis. To analyze the molecular mechanisms of emergence of terpene cyclization, we have carried out in-depth examination of mutational space around (E)-{beta}-farnesene synthase, an...
Sun Nov 10, 2019 02:00
Neutral genetic diversity across the genome is determined by the complex interplay of mutation, demographic history, and natural selection. While the direct action of natural selection is limited to functional loci across the genome, its impact can have effects on nearby neutral loci due to genetic linkage. These effects of selection at linked sites, referred to as genetic hitchhiking and background selection (BGS), are pervasive across natural populations. However, only recently has there been a...
Sun Nov 10, 2019 02:00
Species tree estimation is a basic part of much biological research, but can be challenging because of gene duplication and loss (GDL), which results in genes that can appear more than once in a given genome. To construct species trees from gene families, biologists typically pick one copy of each gene in each species (based on estimations of orthology), but orthology detection is not yet reliably accurate, and incorrect orthology inferences can result in incorrect species trees. Restricting datasets...
Sun Nov 10, 2019 02:00
The past century has seen substantial theoretical and empirical progress on the genetic basis of adaptation. Over this same period a pressing need to prevent the evolution of drug resistance has uncovered much about the potential genetic basis of persistence in declining populations. However, we have little theory to predict and generalize how persistence -- by sufficiently rapid adaptation -- might be realized in this explicitly demographic scenario. Here we use Fisher's geometric model with absolute...
Sun Nov 10, 2019 02:00
Two previous studies on interspecific body size variation of anurans found that the key drivers of variation are the species’ lifestyles and the environments that they live in. To examine whether those finding...
Sat Nov 09, 2019 02:00
Although upper blepharoplasty is a common cosmetic surgical intervention, a better scientific understanding of the aesthetic results and the preferred surgical technique to achieve the best aesthetic results is still needed. A systematic search using four search engines (PubMed, Embase, CINAHL, and Cochrane) was performed to identify any study on the aesthetic outcome of a solitary upper blepharoplasty; these were subjected to quality assessment for possible inclusion. Eligible studies were randomized...
Sun Nov 10, 2019 02:00
The nasal soft triangles are extremely vulnerable subunits of the nose that are prone to severe unaesthetic deformities. A technique to overcome these problems, comprising an effective simple modification of the shield graft, is presented. Using this technique, many existing soft triangle deformities, notches, and defects are easily restored. It may also be applied effectively in susceptible cases in order to avoid these complications. This article presents technical details and the cases of two...
Sun Nov 10, 2019 02:00
The aim of this study was to establish a link between a large televised sporting event and the incidence of patients presenting to the emergency department with oral and maxillofacial injuries. When compared with daily attendances throughout the year, the mean (SD) number rose from 2.53 (1.69) to 4.00 (1.53) (p=0.005) between 1 November 2017 and 31 July 2018 on the day after an England fixture, an increase of 58%. These data show the need for workforce planning during large-scale national sporting...
Sun Nov 10, 2019 02:00
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Hemodialysis machines are equipped with a blood leak detector/alarm to prevent loss of blood following rupture of semipermeable membrane; the blood leak alarms could also be triggered by sensor malfunction or presence of air bubbles in the system. Hydroxocobalamin is a Food and Drug Administration–approved rapid-acting antidote to cyanide poisoning that converts cyanide to nontoxic cyanocobalamin....
Fri Nov 08, 2019 03:22
Publication date: Available online 9 November 2019Source: Medical Image AnalysisAuthor(s): Cian M. Scannell, Amedeo Chiribiri, Adriana D.M. Villaa, Marcel Breeuwer, Jack LeeAbstractMyocardial blood flow can be quantified from dynamic contrast-enhanced magnetic resonance (MR) images through the fitting of tracer-kinetic models to the observed imaging data. The use of multi-compartment exchange models is desirable as they are physiologically motivated and resolve directly for both blood flow and microvascular...
Sun Nov 10, 2019 22:43
Publication date: Available online 9 November 2019Source: Medical Image AnalysisAuthor(s): Jieyu Li, Jayaram K. Udupa, Yubing Tong, Lisheng Wang, Drew A. TorigianAbstractNumerous algorithms are available for segmenting medical images. Empirical discrepancy metrics are commonly used in measuring the similarity or difference between segmentations by algorithms and “true” segmentations. However, one issue with the commonly used metrics is that the same metric value often represents different levels...
Sun Nov 10, 2019 22:43
Publication date: Available online 9 November 2019Source: NeuroImageAuthor(s): Raihaan Patel, Christopher J. Steele, Anthony Chen, Sejal Patel, Gabriel A. Devenyi, Jürgen Germann, Christine L. Tardif, M. Mallar ChakravartyAbstractIn this work we use non-negative matrix factorization to identify patterns of microstructural variance in the human hippocampus. We utilize high-resolution structural and diffusion magnetic resonance imaging data from the Human Connectome Project to query hippocampus microstructure...
Sun Nov 10, 2019 20:16
Publication date: Available online 10 November 2019Source: Gait & PostureAuthor(s): L.A.F. de Jong, R.B. van Dijsseldonk, N.L.W. Keijsers, B.E. GroenAbstractBackgroundImprovement of balance control is an important rehabilitation goal for patients with motor and sensory impairments. To quantify balance control during walking, various stability outcome measures have described differences between healthy controls and patient groups with balance problems. To be useful for the evaluation of interventions...
Sun Nov 10, 2019 20:07
Publication date: Available online 9 November 2019Source: Gait & PostureAuthor(s): Djordje Slijepcevic, Matthias Zeppelzauer, Caterine Schwab, Anna-Maria Raberger, Christian Breiteneder, Brian HorsakAbstractBackgroundQuantitative gait analysis produces a vast amount of data, which can be difficult to analyze. Automated gait classification based on machine learning techniques bear the potential to support clinicians in comprehending these complex data. Even though these techniques are already...
Sun Nov 10, 2019 20:07
Publication date: Available online 9 November 2019Source: Gait & PostureAuthor(s): KL Paterson, L Sosdian, KL Bennell, BR Metcalf, TV Wrigley, J Kasza, MM Dowsey, PF Choong, RS HinmanAbstractBACKGROUNDSex and obesity may influence knee biomechanics associated with poor outcomes following primary total knee arthroplasty (TKA) however their long-term impact has not been investigated.RESEARCH QUESTIONDoes sex and/or pre-operative obesity influence change in gait biomechanics from pre-TKA to two-years...
Sun Nov 10, 2019 20:07
Publication date: Available online 9 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Jussi M. Kärkkäinen, Emanuel R. Tenorio, Niku Oksala, Thanila A. Macedo, Indrani Sen, Bernardo C. Mendes, Randall R. DeMartino, Michael J. Jacobs, Barend Mees, Gustavo S. OderichObjectiveTo investigate the association between psoas muscle area (PMA) and density (PMD) with survival and quality of life (QoL) after fenestrated-branched endovascular aortic repair (F-BEVAR).MethodsThe...
Sun Nov 10, 2019 17:58
Publication date: Available online 9 November 2019Source: International ImmunopharmacologyAuthor(s): Shan Feng, Erhong Duan, Xiaojuan Shi, Huiran Zhang, Haitao Li, Yunxia Zhao, Lingshan Chao, Xiaoqian Zhong, Weiwei Zhang, Rongqin Li, Xixin YanAbstractBackgroundAmbient fine particulate matter (PM2.5) could induce lung injury. Aryl hydrocarbon receptor (AhR) is involved in the molecular mechanisms of prooxidative and pro-inflammatory effect of PM2.5. Molecular hydrogen has antioxidant properties. The...
Sun Nov 10, 2019 17:42
Publication date: Available online 9 November 2019Source: Academic RadiologyAuthor(s): Nicole E. Curci
Sun Nov 10, 2019 17:42
Publication date: Available online 9 November 2019Source: Magnetic Resonance ImagingAuthor(s): Ryota Sato, Toru Shirai, Yoshihisa Soutome, Yoshitaka Bito, Hisaaki OchiAbstractWe propose a novel processing method for reducing shading artifacts in quantitative susceptibility mapping (QSM) for prostate imaging. In the conventional method, calculation errors in the boundary regions between water and fat cause shading artifacts that degrade the image quality for QSM. In the proposed method, water and...
Sun Nov 10, 2019 17:41
Publication date: Available online 9 November 2019Source: Magnetic Resonance ImagingAuthor(s): Mona Salehi Ravesh, Matthias Eden, Patrick Langguth, Tim-Christian Piesch, Johanna Karolin Lehmann, Annett Lebenatus, David Hauttemann, Joachim Graessner, Norbert Frey, Olav Jansen, Marcus BothAbstractPurposeThe aim of this study was to investigate the diagnostic value of myocardial deformation analysis based on the 17-segment heart model using non-contrast enhanced (CE) 2D tissue feature tracking (2D-FT)...
Sun Nov 10, 2019 17:41
In Ethiopia, the majority of married women practice predominantly short-acting contraceptive methods. Therefore this study aims to assess intention to use LAPMs and its determinants among short-acting users in...
Sat Nov 09, 2019 02:00
We previously reported the identification of monocarboxylate transporter 4 (MCT4) and glypican-3 (GPC3) as prognostic factors for hepatocellular carcinoma (HCC), which are now considered significant poor progn...
Sat Nov 09, 2019 02:00
Physicochemical approach such as strong ion difference provides a novel concept in understanding and managing acid–base disturbance in patients. However, its application in pediatrics is limited. This study ai...
Sat Nov 09, 2019 02:00
Carbapenem-resistant Enterobacteriaceae (CRE) are among the most severe threats to public and clinical health because of their high levels of resistance to various antibiotics. We assessed the efficacy of combina...
Sat Nov 09, 2019 02:00
Low back pain (LBP) is a common medical problem worldwide. The aim of this study is to evaluate the association between serum concentration of 25-hydroxivitamin D3 and functional disability in patients sufferi...
Fri Nov 08, 2019 02:00
Publication date: Available online 9 November 2019Source: Archives of Oral BiologyAuthor(s): Salvador García-López, Rosina E. Villanueva, Felipe Massó-Rojas, Araceli Páez-Arenas, Murray C. MeikleAbstractObjetiveIt has been claimed that micro-pulse vibration can accelerate the rate of tooth movement during orthodontic treatment; however, the underlying cellular mechanism has yet to be elucidated. The purpose of this study was to understand the mechanisms underlying tooth movement acceleration by measuring...
Sun Nov 10, 2019 17:33
Publication date: Available online 9 November 2019Source: Archives of Oral BiologyAuthor(s): Naile Dame-Teixeira, Jéssica Alves de Cena, Débora Azevedo Côrtes, Aline Belmok, Luiz Gustavo dos Anjos Borges, Letícia Marconatto, Adriana Giongo, Cynthia Maria KyawAbstractObjectiveAlthough the prevalence and functions associated with members of Bacteria are well known in dental caries, the role of Archaea in cariogenic biofilms has not been studied yet.DesignTo detect the presence of Archaea in dental...
Sun Nov 10, 2019 17:33
Publication date: Available online 9 November 2019Source: Archives of Oral BiologyAuthor(s): Vanja Stojić, Branislav Glišić, Ljiljana Djukić, Bogomir Prokić, Aleksa Janović, Zorana Stamenković, Sanja Milutinović-Smiljanić, Vesna Danilović, Božidar Brković, Jelena RoganovićAbstractObjectiveWe aimed to investigate alteration in cellular signaling mediated by vascular endothelial growth factor (VEGF) and parameters of oxidative stress/nitric oxide generation, superoxide dismutase (SOD) and neuronal...
Sun Nov 10, 2019 17:33
Publication date: Available online 9 November 2019Source: Archives of Oral BiologyAuthor(s): Yijia Wang, Wenyan Kang, Lingling Shang, Aimei Song, Shaohua GeAbstractObjectiveThe neuronal wiskott-aldrich syndrome protein (N-WASP) is a member of the wiskott-aldrich syndrome protein (WASP) family. N-WASP plays a vital role in promoting cell migration, receptor signaling and immune inflammatory responses. This study aimed to observe the changes in the expression of inflammatory factors and involving pathways...
Sun Nov 10, 2019 17:33
Publication date: Available online 9 November 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Santiago Ortega-Gutierrez, Andrea Holcombe, Nazan Aksan, Biyue Dai, Amir Shaban, Lara Lazarre, Binbin Zheng-Lin, Lauren Sager, Sudeepta Dandapat, Fazeel M. Siddiqui, Nicholas M. MohrAbstractOBJECTIVESCerebral venous sinus thrombosis (CVST) is a rare subtype of stroke that most commonly affects younger women. While most patients treated with anticoagulation therapy have good outcomes, a significant...
Sun Nov 10, 2019 17:19
Publication date: Available online 9 November 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Houjuan Zuo, Yan Zhang, Fei Ma, Rui Li, Yan Wang, Chenze Li, Hong Wang, Dao Wen WangAbstractBoth ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM) are characterized by left ventricular (LV) dysfunction and dilation. Differentiation between ICM and NICM using non-invasive image modalities is a clinical challenge. This study compared the myocardial deformation patterns of ICM...
Sun Nov 10, 2019 17:15
Publication date: Available online 10 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): N. Miller, A. Kearns, A. Bartram, R. BanksAbstractThe aim of this study was to establish a link between a large televised sporting event and the incidence of patients presenting to the emergency department with oral and maxillofacial injuries. When compared with daily attendances throughout the year, the mean (SD) number rose from 2.53 (1.69) to 4.00 (1.53) (p = 0.005) between 1...
Sun Nov 10, 2019 17:03
Publication date: January 2020Source: Brain and Language, Volume 200Author(s): Peiyun Zhou, Chantel Prat, Brianna L. Yamasaki, Andrea StoccoAbstractDeviations of attention from the task at hand are often associated with worse reading performance (Schooler, Reichle, & Halpern, 2004). Ironically, current methods for detecting these shifts of attention typically generate task interruptions and further disrupt performance. In the current study, we developed a method to (1) track shifts of attention...
Sun Nov 10, 2019 17:03
Publication date: Available online 10 November 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): B. Bohluli, S.C. Bagheri, E. Consky, F. KhabirAbstractThe nasal soft triangles are extremely vulnerable subunits of the nose that are prone to severe unaesthetic deformities. A technique to overcome these problems, comprising an effective simple modification of the shield graft, is presented. Using this technique, many existing soft triangle deformities, notches, and defects...
Sun Nov 10, 2019 16:56
Publication date: Available online 9 November 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): J. Alvira-González, L. De StavolaAbstractThe aim of this review was to determine the effect of cortical perforations in bone regeneration considering the surgical technique. An electronic search in the PubMed (MEDLINE) and ScienceDirect databases and a hand search of the literature was conducted covering the period July 2008 to December 2018. Studies that specified the creation...
Sun Nov 10, 2019 16:56
Publication date: Available online 10 November 2019Source: Brain Research BulletinAuthor(s): Lee Yoon-Hyung, Lee Seong-RyongAbstractN-acetylcysteine (NAC) is known to serve many biological functions including acting as an antioxidant, and electing antiinflammatory effects. Previous reports have revealed that NAC may have neuroprotective effects against the deleterious effects of brain ischemia. Despite of this, the mechanism by which NAC prevents neuronal damage after brain ischemia remains unclear....
Sun Nov 10, 2019 16:55
Publication date: Available online 9 November 2019Source: Brain Research BulletinAuthor(s): Sevket Evran, Fatih Calis, Enes Akkaya, Oguz Baran, Serdar Cevik, Salim Katar, Ebru Gurel Gurevin, Hakan Hanimoglu, Mustafa Aziz Hatiboglu, Elif Ilkay Armutak, Ersin Karatas, Abdurrahim Kocyigit, Mehmet Yasar KaynarAbstractTraumatic brain injury (TBI) is one of the important reason of morbidity and mortality. While the primary injury due to mechanical impact is unavoidable, the secondary injury which is formed...
Sun Nov 10, 2019 16:55
Publication date: Available online 9 November 2019Source: Brain Research BulletinAuthor(s): Mahdiye Saadi, Ahmad Karkhah, Fereshteh Pourabdolhossein, Amin Ataie, Mastura Monif, Hamid Reza NouriAbstractInflammatory response through interleukin-1β (IL-1β) plays a key role in the pathogenesis of Alzheimer’s disease (AD). However, the molecular mechanism of pro-IL-1β processing in AD is not clearly defined. The current study was designed to investigate which of the inflammasome complexes are critical...
Sun Nov 10, 2019 16:55
Publication date: Available online 9 November 2019Source: Brain Research BulletinAuthor(s): Xuan Gao, Xiangjian Zhang, Lili Cui, Rong Chen, Cong Zhang, Jing Xue, Lan Zhang, Weiliang He, Jiamin Li, Shanshan Wei, Mengmeng Wei, Hemei CuiAbstractThe central nervous system (CNS) has a poor self-repairing capability after injury because of the inhibition of axonal regeneration by many myelin-associated inhibitory factors. Therefore, ischemic stroke usually leads to disability. Previous studies reported...
Sun Nov 10, 2019 16:55
Publication date: Available online 9 November 2019Source: Brain Research BulletinAuthor(s): Shengxiang Liang, Jiayong Zhang, Qingqing Zhang, Le Li, Yuhao Zhang, Tingting Jin, Bingxue Zhang, Xiaojun He, Lewen Chen, Jing Tao, Zuanfang Li, Weilin Liu, Lidian ChenAbstractBrain ischemia leads to insufficient oxygen supply or hypoxia and thus to ischemic stroke or chronic hypoperfusion, which results in neuronal death and white matter damage is irreversible or partially recoverable under the interruption...
Sun Nov 10, 2019 16:55
Publication date: Available online 9 November 2019Source: Brain Research BulletinAuthor(s): Intissar Grissa, Jaber ElGhoul, Rhizlaine Mrimi, Lassaad El Mir, Hassen Ben Cheikh, Patricia HorcajadaAbstractTitanium dioxide nanoparticles were widely used in food as dietary supplements, in drugs, in toothpaste, ect. Few numbers of studies were interested to the neurotoxicity of TiO2 NPs through oral pathway. The present study aims firstly to understand the connection between the physicochemical properties...
Sun Nov 10, 2019 16:55
Publication date: Available online 9 November 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Phillip W. Clapp, David B. Peden, Ilona Jaspers
Sun Nov 10, 2019 16:33
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Takuya Nakamura, Toshihiro Ogiwara, Tetsuya Goto, Yu Fujii, Yoshinari Miyaoka, Yoshiki Hanaoka, Tetsuyoshi Horiuchi, Kazuhiro HongoAbstractBACKGROUNDWhen the medical devices and equipment in an operating room are connected to a network, vast amounts of data concerning the progress of the operation and the patient’s condition can be comprehensively processed to improve the precision and safety of the surgical procedure....
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Rasmus Holmboe Dahl, Vagn Eskesen, Goetz BenndorfAbstractBackgroundArteriovenous fistulas (AVFs) involving the cavernous sinus usually become clinically apparent due to eye symptoms. Although rare, the same symptoms can be associated with AVFs located remote from the cavernous sinus when the shunt drains into its tributaries. We report the unusual case of a dural AVF where such communication was not immediately...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Asfand Baig Mirza, Melika Akhbari, Jose Lavrador, Eleni C. MaratosAbstractBackgroundCauda Equina Syndrome (CES) is a neurosurgical emergency warranting urgent surgical decompression. Treatment delay may precipitate permanent adverse neurological sequelae. CES is a clinical diagnosis, corroborated by radiological findings. Atypical presentations should be acknowledged to avoid inappropriately rejected diagnoses.Case...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Abhidha Shah, Sukhdeep Singh Jhawar, Maximilliano Nunez, Aimee Goel Foundation, Atul GoelAbstractObjectiveA focused dissection of the brainstem was performed to study the various fiber bundles and gray matter nuclei of the brainstem and to decipher the intricate anatomy.MethodsTen formalin-fixed cadaveric human brains were procured.The fiber dissection techniques described by Klingler were then adopted to study...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Aysegul OZDEMIR OVALIOGLU, Talat Cem OVALIOGLU, Sema ARSLAN, Gokhan CANAZ, Aysegul ESEN AYDIN, Mehmet SAR, Erhan EMELAbstractObjectiveErythrosine (E127), a synthetic food dye containing iodine and sodium, has been commonly used inside the packaged foods and beverages both in Turkey and in many countries. We aimed to evaluate the effects of Erythrosine on neural tube development in the early stage chicken embryos.MethodsThe...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Werner Surbeck, Holger Joswig, Gerhard Hildebrandt
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Anastasia Tasiou, Christos Tzerefos, Cargill H. Alleyne, Edoardo Boccardi, Bengt Karlsson, Neil Kitchen, Robert F. Spetzler, Christos M. Tolias, Kostas N. FountasAbstractObjectiveArteriovenous malformations (AVMs) have been thought to be congenital in nature. An increasing number of de novo AVM cases, however, has questioned this doctrine.MethodsA consensus meeting of international experts, attempted to establish...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Yin Lun Edward Chu, Anderson Chun-on Tsang, Frederick Chun-Pong Tsang, Raymand Lee, Wai Man Lui
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Nader Delavari, Monica C. Mureb, Amanda Yaun, Jeffrey H. Wisoff, David H. Harter, E. Teresa HidalgoAbstractBackgroundVentriculoatrial shunts can be afflicted with distal malfunctions due to thrombus formation at the distal tip. Distal tip thrombus formation may occur more commonly in oncologic patients who are predisposed to hypercoagulability.Case DescriptionA patient who had a ventriculo-atrial shunt placed for...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Hayri Ogul
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Ioannis Christodoulides, José Pedro Lavrador, Istvan Bodi, Ross Laxton, Richard Gullan, Ranjeev Bhangoo, Francesco Vergani, Keyoumars AshkanAbstractIn the management of meningiomas, single-fraction stereotactic radiosurgery (SRS) is an established alternative treatment to surgical resection (1). However, its effects on tumorigenesis and malignant transformation are still uncertain (2). In this report, a grade-II...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Fabio Torregrossa, Giovanni Grasso
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Maria A. Bustillo, Ibrahim Hussain, Michael S. Virk, Kai-Ming Fu, Jacques H. ScharounAbstractBackgroundPatients with single ventricle congenital heart disease may present for scoliosis correction. These patients undergo a series of cardiac operations which create a novel circulation that has significant impact on the management of their spinal surgery.Case descriptionA 21-year-old man with severe scoliosis presented...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Pei-jie Luo, Yong-chao Tang, Teng-peng Zhou, Hui-zhi Guo, Dan-qing Guo, Guo-ye Mo, Yan-huai Ma, Pan-jie Liu, Shun-cong Zhang, De LiangAbstractObjectiveThis study aimed to evaluate the risk factors for adjacent vertebral compression fractures following lumbar spinal fusion with instrumentation.MethodsA total of 669 patients who received lumbar instrumented spinal fusion between January 2012 and December 2015 were...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Lin Xie, Hongli Wang, Jianyuan JiangAbstractObjectiveTo investigate the outcomes of radiotherapy with or without surgery during treatment of patients with solitary plasmacytoma of bone (SBP) of the spine.MethodsPatients diagnosed with SBP of the spine who are treated with radiotherapy with or without surgery were identified and extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Christof Wutte, Johannes Becker, Barbara Klein, Orpheus Mach, Stephanie Panzer, Fabian Maria Stuby, Martin Strowitzki, Doris Maier, Claudius Thomé, Lukas GrassnerAbstractObjectThere is accumulating evidence of a potential beneficial effect of early surgical intervention after acute cervical spinal cord injury (SCI). However, around one third of all SCI affect the thoracic spine. This cohort has not been extensively...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Abhinandan Reddy Mallepally, Vikas tandon, Harvinder Singh ChhabraAbstractIntroductionVertebral osteomyelitis presenting as a compression fracture misdiagnosed in the setting of steroid-induced or senile osteoporosis is very rare, though they are prone to infection or reactivation as their immune system is exhausted. Spondylodiscitis occurring at levels adjacent to that of the initial operation is a rare phenomenon....
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Marc Sindou, Chloé DumotAbstractBackgroundBecause damages or sacrifices of venous drainages during supratentorial basal cistern and skull base approaches may have severe and harmful consequences, all methods to identify pre-operatively “veins at risk” are of paramount importance. Among those a codified assessment with a venous topogram revealed helpful, with practical implications.MethodsThis article describes...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Garrett T. Venable, Pooja Dave, William E. Gordon, Brittany D. Fraser, David A. Wallace, William Mangham, Douglas R. Taylor, Nickalus R. Khan, L. Madison Michael, Brandy N. Vaughn, Paul KlimoAbstractIntroductionThe Preventable Shunt Revision Rate (PSRR) was recently introduced in pediatric hydrocephalus as a quality metric for shunt surgery. We sought to implement the PSRR in an adult hydrocephalus population.MethodsAll...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: World NeurosurgeryAuthor(s): Zhiqiang Zhou, Zhigao Jin, Peng Zhang, Bingchen Shan, Zhentao Zhou, Yingzi Zhang, Yekun Deng, Xiaozhong ZhouAbstractObjectiveTo assess the dynamic change of the dural sac size in patients with lumbar spinal stenosis (LSS) from supine to standing position and their correlations with clinical symptoms.MethodsA final of 110 patients with LSS were prospectively enrolled to undergo both supine (0°) and standing (78°)...
Sun Nov 10, 2019 16:18
Publication date: Available online 9 November 2019Source: European Journal of CancerAuthor(s): Lion Shahab, Samuel G. Smith
Sun Nov 10, 2019 14:53
Publication date: Available online 9 November 2019Source: Behavioural Brain ResearchAuthor(s): Samirah Hussain, Susie Villarreal, Nayeli Ramirez, Anjum Hussain, Isabel C. SumayaAbstractIt has been well established that the striatal dopaminergic system is compromised with aging, namely D2 receptor function. Also well documented is the age related decline of the neurohormone, melatonin, in both humans and nonhuman animals. What has not been well studied is the possible interaction between the D2 receptor...
Sun Nov 10, 2019 14:24
Abstract Endocannabinoids are produced within the gastrointestinal (GI) tract and modulate energy homeostasis and food intake, at least in part, via vagally‐dependent actions. The recent paper by Christie et al., [Christie, et al. J Physiol, 2019] demonstrate, for the first time, that cannabinoids exert biphasic effects on the mechanosensitivity of tension‐sensitive gastric vagal afferents. At higher concentrations, anandamide increased vagal afferent sensitivity in a CB1 and TRPV1 receptor dependent...
Sun Nov 10, 2019 12:48
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Sun Nov 10, 2019 13:05
Publication date: Available online 9 November 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Kelly O. Thielbar, Kristen M. Triandafilou, Alexander J. Barry, Ning Yuan, Arthur Nishimoto, Joelle Johnson, Mary Ellen Stoykov, Daria Tsoupikova, Derek G. KamperAbstractObjectiveTo compare participation and subjective experience of participants in both home-based multi-user VR therapy and home-based single-user VR therapy.DesignCrossover, randomized trialSettingInitial training and...
Sun Nov 10, 2019 13:36
New Findings •What is the central question of this study? The effect of lower leg hot water immersion on vascular I/R injury induced in the arm of young healthy humans has not been previously explored. •What is the main finding and its importance? Our findings demonstrate that lower leg hot water immersion successfully protects against vascular I/R injury in humans. This finding raises the possibility that targeted heating of the lower legs may be an alternative therapeutic approach...
Sun Nov 10, 2019 11:34
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