Common bean extract as a dietary supplement has received increased attention globally owing to its α-amylase inhibitory activity. The objective of this study was to evaluate the toxicity of a white kidney bean (Phaseolus vulgaris) extract by a repeated-dose 90-day subchronic oral toxicity study in Sprague-Dawley rats. In the subchronic toxicity study, 80 rats were orally administrated with white kidney bean extract at doses of 4, 2, and 1 g/kg body weight daily for 90 days. The results showed that...
09:05
It has been reported that 18F-FDG uptake is higher in hypoxic cancer cells than in well-oxygenated cells. We demonstrated that 18F-FDG uptake in lung cancer would be affected by high concentration oxygen breathing. Methods. Overnight fasted non-small-cell lung cancer A549 subcutaneous (s.c.) xenografts bearing mice (n = 10) underwent 18F-FDG micro-PET scans, animals breathed room air on day 1, and same animals breathed carbogen (95% O2 + 5% CO2) on the subsequent day. In separated studies, autoradiography...
08:05
Exercise programs have been introduced to improve cognitive function, whereas studies showed inconsistent results regarding the effectiveness of exercise programs on patients with dementia. This study aimed to summarize randomized controlled trials (RCTs) to assess the effect of exercise programs on cognition, activities of daily living (ADL), and depression in elderly with dementia. We systematically screened PubMed, Embase, and the Cochrane library for relevant studies throughout November 21, 2018....
08:05
Background. Cardiovascular disease (CVD) contributes to be one of the leading causes of death in the population worldwide. Carotid arterial stiffness and local hemodynamics are associated with the occurrence and development of CVD. Therefore, understanding the alterations of human carotid arterial stiffness and hemodynamics is of great clinical value in the prevention and treatment of CVD. Objective. In this study, we aimed to investigate the acute effect of high-intensity interval cycling (HIIC)...
06:05
Although gut dysbiosis appears in 20%–75% of cirrhotic patients, there are limited data on microbiota profiles in viral hepatitis cirrhotics and its role in progression to cirrhosis. Further understanding on the relationship between gut dysbiosis and cirrhosis presents a unique opportunity in not only predicting the development of cirrhosis but also discovering new therapies. Recent advances have been made on identifying unique microbiota in viral hepatitis cirrhotics and adopting the microbiota...
05:05
Cutaneous squamous cell carcinoma (SCC) is a common cancer that significantly decreases the quality of life. It is known that external stimulus such as ultraviolet (UV) radiation induces cutaneous SCC via provoking oxidative stress. NAD(P)H dehydrogenase 1 (NQO1) is a ubiquitous flavoenzyme that functions as a guardian against oxidative stress. However, the effect of NQO1 on cutaneous SCC is not clearly elucidated. In this study, we investigated the effect of NQO1 on cutaneous SCC cells using the...
05:05
Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. A 62-year-old man was initially diagnosed with carcinoma that arose in a sebaceous lymphadenoma in the...
04:05
Aim. The aim of the present study was to evaluate the relationship between iron deficiency anemia and small for gestational age (SGA) in early third trimester pregnancies. Methods. A total of 4800 pregnant women who met the inclusion criteria were analyzed retrospectively. We included pregnant women who had iron deficiency anemia between 26+0 and 30+0 weeks of gestation and delivered singletons between 37+0 and 41+6 weeks of gestation. Patients were divided into four groups according to anemia level:...
04:05
Tenascin-C (TNC) is an extracellular matrix glycoprotein expressed in response to inflammation and tissue damage. The role of TNC in patients with inflammatory bowel disease (IBD) is not well understood. In this study, we analyzed the expression of TNC in the inflamed mucosa of patients with ulcerative colitis (UC) and Crohn’s disease (CD). Serum TNC levels were determined by the enzyme-linked immunosorbent assay (ELISA), and the levels of TNC in patients with different disease activities were compared....
04:05
PENTAX Medical is releasing its DEC HD duodenoscope, a high-definition device that uses disposable distal caps and elevator levers, in the United States. The capability to simply throw away the components that tend to harbor bacteria, associated with the transmission of disease and even death, helps to guarantee that there’s little chance of passing pathogens between patients. The duodenoscope, already introduced in many other countries two years ago, allows for high fidelity imaging during...
Thu Nov 21, 2019 21:38
Siemens Healthineers won FDA clearance and is releasing its brand new SOMATOM X.cite premium single-source CT scanner. The device, along with a high-end X-ray tube and other enhancements, features the company’s new myExam Companion technology that can intelligently adapt each scan to optimize a number of variables. The system asks a number of relevant questions of the technician about the patient and the exam, and, based on previously learned knowledge, suggests a routine that improves...
Thu Nov 21, 2019 19:00
Many people with Parkinson’s disease tend to talk more quietly and less clearly than before the disease struck them. Speech therapy can help in many cases, but a device recently developed at Purdue University automatically activates an internal mechanism in users that to spurs them to speak louder and more intelligibly. The SpeechVive device, an invention of Jessica Huber, a professor at Purdue’s Department of Speech, Language, and Hearing Sciences, looks like a hearing aid. Unlike a hearing...
Thu Nov 21, 2019 16:56
Publication date: Available online 21 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Rainer J. Klement, Nicolaus Andratschke, Matthias Guckenberger
Thu Nov 21, 2019 14:00
Bringing FLASH to the clinic: treatment planning considerations for ultrahigh dose-rate proton beams
Publication date: Available online 20 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): P. van Marlen, M. Dahele, M. Folkerts, E. Abel, B.J. Slotman, W.F.A.R. VerbakelAbstractBackgroundPre-clinical research into ultrahigh dose-rate (e.g. ≥40Gy/s) “FLASH”-radiotherapy suggests a decrease in side-effects compared to conventional irradiation, while maintaining tumor control. When FLASH is delivered using a scanning proton beam, tissue becomes subject to a spatially...
Thu Nov 21, 2019 14:00
Publication date: Available online 20 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Sara Thörnqvist, Bonny Abal, Kaja S. Øvrelid, Grete May Engeseth, Kristian S. Ytre-Hauge., Liv B. HysingAbstractPurposeIntensity modulated proton therapy (IMPT) of locally advanced prostate cancer can spare the bowel considerably compared to modern photon therapy, but simultaneous treatment of the prostate (p), seminal vesicles (sv) and lymph nodes is challenging due to...
Thu Nov 21, 2019 14:00
Publication date: Available online 20 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Homan Mohammadi, Austin Prince, Nicholas B. Figura, Jeffrey S. Peacock, Daniel C. Fernandez, Michael E. Montejo, Hye Sook Chon, Robert M. Wenham, Steven A. Eschrich, Javier F. Torres-Roca, Kamran A. AhmedAbstractBackgroundVariability exists in the adjuvant treatment for endometrial cancer (EC) based on surgical pathology and institutional preference. The radiosensitivity...
Thu Nov 21, 2019 14:00
Publication date: Available online 20 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): A. Popovtzer, E. Rosenfeld, A. Mizrachi, S.R. Bellia, R. Ben-Hur, G. Feliciani, A. Sarnelli, L. Arazi, L. Deutsch, I. Kelson, Y. KeisariAbstractPurposeTo report the feasibility and safety of Diffusing Alpha-emitter Radiation Therapy (DaRT), which entails the interstitial implantation of a novel alpha-emitting brachytherapy source, for the treatment of locally advanced and...
Thu Nov 21, 2019 14:00
Publication date: Available online 20 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Debarshi Banerjee, Sunjay M. Barton, Peter W. Grabham, Ariela L. Rumeld, Shunpei Okochi, Cherease Street, Angela Kadenhe-Chiweshe, Shuobo Boboila, Darrell J. Yamashiro, Eileen P. ConnollyAbstract:PurposeThe aim of this study is to characterize the effects of high-dose radiation therapy (HDRT) on Notch signaling components of the tumor vasculature.Methods and MaterialsHuman...
Thu Nov 21, 2019 14:00
Background Charcot-Marie-Tooth (CMT) disease is the most common neuromuscular disorder in humans affecting 40 out of 100,000 individuals. In 2008, we described the clinical, electrophysiological and pathological findings of a demyelinating motor and sensory neuropathy in Miniature Schnauzer dogs, with a suspected autosomal recessive mode of inheritance based on pedigree analysis. The discovery of additional cases has followed this work and led to a genome-wide association mapping...
Thu Nov 21, 2019 02:00
Objective A growing body of research has investigated the human microbiota and pregnancy outcomes, especially preterm birth. Most studies of the prenatal microbiota have focused on the vagina, with fewer investigating other body sites during pregnancy. Although pregnancy involves profound hormonal, immunological and metabolic changes, few studies have investigated either shifts in microbiota composition across pregnancy at different body sites or variation in composition at any site...
Thu Nov 21, 2019 02:00
Objective To investigate the correlation between the single nucleotide polymorphisms (SNPs) in the toll-like receptor 4 (TLR4) gene and the susceptibility to chronic periodontitis. Design 241 Chinese subjects from the cohort of Beijing Shijingshan Community were recruited. Buccal swab samples, the whole unstimulated saliva and periodontal clinical parameters were collected. Human DNA extracted from buccal swab samples...
Thu Nov 21, 2019 02:00
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