Viruses, Vol. 11, Pages 1009: The C4 Protein from Tomato Yellow Leaf Curl Virus Can Broadly Interact with Plant Receptor-Like Kinases Viruses doi: 10.3390/v11111009 Authors: Borja Garnelo Gómez Dan Zhang Tábata Rosas-Díaz Yali Wei Alberto P. Macho Rosa Lozano-Durán Plant receptor-like kinases (RLKs) exert an essential function in the transduction of signals from the cell exterior to the cell interior, acting as important regulators of plant development and responses to...
Thu Oct 31, 2019 02:00
Viruses, Vol. 11, Pages 1008: Spatiotemporal Dynamics of Hantavirus Cardiopulmonary Syndrome Transmission Risk in Brazil Viruses doi: 10.3390/v11111008 Authors: Renata L. Muylaert Gilberto Sabino-Santos Paula R. Prist Júlia E. F. Oshima Bernardo Brandão Niebuhr Thadeu Sobral-Souza Stefan Vilges de Oliveira Ricardo Siqueira Bovendorp Jonathan C. Marshall David T. S. Hayman Milton Cezar Ribeiro Background: Hantavirus disease in humans is rare but frequently...
Thu Oct 31, 2019 02:00
Biomolecules, Vol. 9, Pages 675: The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance Biomolecules doi: 10.3390/biom9110675 Authors: Eliska Ruzickova Nikola Skoupa Petr Dolezel Dennis A. Smith Petr Mlejnek The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors...
Thu Oct 31, 2019 02:00
Entropy, Vol. 21, Pages 1069: Performance Assessment of Non-Gaussian Control Systems Based on Mixture Correntropy Entropy doi: 10.3390/e21111069 Authors: Jinfang Zhang Di Wu The performance assessment of any control system plays a key role in industrial control systems. To meet the real-time requirements of modern control systems, a quick and accurate evaluation of the performance of a system is necessary. In this paper, a performance assessment method of a non-Gaussian control system...
Thu Oct 31, 2019 02:00
Minerals, Vol. 9, Pages 670: Characterization of Diatomaceous Earth and Halloysite Resources of Poland Minerals doi: 10.3390/min9110670 Authors: Marcin Lutyński Piotr Sakiewicz Sylwia Lutyńska The mining industry of Poland is based mostly on coal and copper ores. Strict carbon emissions and the depletion of deposits will slowly phase out coal. Therefore, metallic ores and other mineral raw materials will dominate the extractive industry of Poland. Current measured resources of...
Thu Oct 31, 2019 02:00
Agronomy, Vol. 9, Pages 704: Domestication in Real Time: The Curious Case of a Trigenomic Sunflower Population Agronomy doi: 10.3390/agronomy9110704 Authors: Jill M. Ekar Kevin J. Betts Adam C. Herman Robert M. Stupar Donald L. Wyse Yaniv Brandvain Michael B. Kantar This study chronicles the ongoing process to domesticate an interspecific trigenomic tetraploid hybrid sunflower derived from a series of interspecific crosses between Helianthus annuus and Helianthus tuberosus....
Thu Oct 31, 2019 02:00
Cancers, Vol. 11, Pages 1694: Improved Anti-Tumour Adaptive Immunity Can Overcome the Melanoma Immunosuppressive Tumour Microenvironment Cancers doi: 10.3390/cancers11111694 Authors: Nana Dang Mark Waer Ben Sprangers Yuan Lin Clinical benefits obtained from checkpoint blockade regimens demonstrate the importance of overcoming the immunosuppressive tumour microenvironment (TME) in cancer immunotherapy. Intravenous (i.v.) injection of B16 melanoma cells (H-2Kb) leads to lethal...
Thu Oct 31, 2019 02:00
Applied Sciences, Vol. 9, Pages 4635: An Internal Folded Hardware-Efficient Architecture for Lifting-Based Multi-Level 2-D 9/7 DWT Applied Sciences doi: 10.3390/app9214635 Authors: Wei Zhang Changkun Wu Pan Zhang Yanyan Liu In this paper, a novel internal folded hardware-efficient architecture of multi-level 2-D 9/7 discrete wavelet transform (DWT) is proposed. For multi-level DWT, the unfolded structure is more extensively used compared with the folded structure, because of...
Thu Oct 31, 2019 02:00
IJMS, Vol. 20, Pages 5435: Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms20215435 Authors: Chiara Rizzo Lidia La Barbera Marianna Lo Pizzo Francesco Ciccia Guido Sireci Giuliana Guggino Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems...
Thu Oct 31, 2019 02:00
Microorganisms, Vol. 7, Pages 515: Functional Characterization and Structural Analysis of NADH Oxidase Mutants from Thermus Thermophilus HB27: Role of Residues 166, 174, and 194 in the Catalytic Properties and Thermostability Microorganisms doi: 10.3390/microorganisms7110515 Authors: Javier Rocha-Martin Pedro A. Sánchez-Murcia Fernando López-Gallego Aurelio Hidalgo José Berenguer José M. Guisan The Thermus thermophilus strain HB27 NADH-oxidase (Tt27-NOX) catalyzes the...
Thu Oct 31, 2019 02:00
Energies, Vol. 12, Pages 4165: Thermoeconomic Optimization with PSO Algorithm of Waste Heat Recovery Systems Based on Organic Rankine Cycle System for a Natural Gas Engine Energies doi: 10.3390/en12214165 Authors: Guillermo Valencia Ochoa Carlos Acevedo Peñaloza Jorge Duarte Forero To contribute to the economic viability of waste heat recovery systems application based on the organic Rankine cycle (ORC) under real operation condition of natural gas engines, this article presents...
Thu Oct 31, 2019 02:00
IJERPH, Vol. 16, Pages 4230: The Human Ecological Perspective and Biopsychosocial Medicine International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214230 Authors: Felix Tretter Henriette Löffler-Stastka With regard to philosophical anthropology, a human ecological framework for the human–environment relationship as an “ecology of the person” is outlined, which focuses on the term “relationship” and aims...
Thu Oct 31, 2019 02:00
Cells, Vol. 8, Pages 1361: MicroRNAs Contribute to Breast Cancer Invasiveness Cells doi: 10.3390/cells8111361 Authors: Ivana Fridrichova Iveta Zmetakova Cancer statistics in 2018 highlight an 8.6 million incidence in female cancers, and 4.2 million cancer deaths globally. Moreover, breast cancer is the most frequent malignancy in females and twenty percent of these develop metastasis. This provides only a small chance for successful therapy, and identification of new molecular markers...
Thu Oct 31, 2019 02:00
Genes, Vol. 10, Pages 874: Semidwarf Gene d60 Affected by Ubiquitous Gamete Lethal Gene gal Produced Rare Double Dwarf with d30 via Recombination Breaking Repulsion-Phase Linkage on Rice Chromosome 2 Genes doi: 10.3390/genes10110874 Authors: Motonori Tomita Jun Tanaka The genotype of gal and d60 were investigated in 33 rice varieties chosen from representative semidwarf and dwarf rice varieties. These were crossed with three tester lines, the d60Gal line (genotype d60d60GalGal), the...
Thu Oct 31, 2019 02:00
Infrastructures, Vol. 4, Pages 68: Ventilation Induced in an Isolated Subsurface Structure by Natural Forces: Method Development and Application Infrastructures doi: 10.3390/infrastructures4040068 Authors: Thomas Neil McManus Assed Haddad It is believed that isolated subsurface structures of an infrastructure do not ventilate through opening(s) in manhole covers. The literature has almost no information on this topic. This study reports on considerations involved in the development...
Thu Oct 31, 2019 02:00
Molecules, Vol. 24, Pages 3939: Synthesis, Characterization of Liposomes Modified with Biosurfactant MEL-A Loading Betulinic Acid and Its Anticancer Effect in HepG2 Cell Molecules doi: 10.3390/molecules24213939 Authors: Qin Shu Jianan Wu Qihe Chen As a novel natural compound delivery system, liposomes are capable of incorporating lipophilic bioactive compounds with enhanced compound solubility, stability and bioavailability, and have been successfully translated into real-time...
Thu Oct 31, 2019 02:00
Healthcare, Vol. 7, Pages 125: Help-Seeking Experiences of Hepatitis B Patients in Transnational Medical Care: The Solution to Health Inequality Is Social Mobility Healthcare doi: 10.3390/healthcare7040125 Authors: Chiao-Wen Cheng Cheng-Min Feng Chian Sem Chua This paper tracked hepatitis B patients from Medan, Indonesia to Penang, Malaysia under transnational medical care and has an understanding of their medical history and socioeconomic status. The condition of these patients...
Thu Oct 31, 2019 02:00
Water, Vol. 11, Pages 2283: Multifractal Analysis of River Networks in an Urban Catchment on the Taihu Plain, China Water doi: 10.3390/w11112283 Authors: Jie Xiang Youpeng Xu Jia Yuan Qiang Wang Jie Wang Xiaojun Deng Multifractal analysis was successfully used to investigate the structure of river networks. In this paper, we performed a multifractal analysis of river networks in an urban catchment that is located on the Taihu Plain in the lower part of the Yangtze River...
Thu Oct 31, 2019 02:00
Sci, Vol. 1, Pages 62: Static and Dynamic Evaluation of an UWB Localization System for Industrial Applications Sci doi: 10.3390/sci1030062 Authors: Mickael Delamare Remi Boutteau Xavier Savatier Nicolas Iriart Many applications in the context of Industry 4.0 require precise localization. However, indoor localization remains an open problem, especially in complex environments such as industrial environments. In recent years, we have seen the emergence of Ultra WideBand (UWB)...
Thu Oct 31, 2019 02:00
Mathematics, Vol. 7, Pages 1026: Development of Preform for Simulation of Cold Forging Process of A V8 Engine Camshaft Free from Flash & Under-Filling Mathematics doi: 10.3390/math7111026 Authors: A.N. Saquib H.M.T. Khaleed Irfan Anjum Badruddin Ali Algahtani M.F. Addas A.B. Abdullah Abdulgaphur Athani Sarfaraz Kamangar T.M. Yunus Khan Finite Element Method based techniques apply to a wide spectrum of engineering applications including manufacturing. The flexibility...
Thu Oct 31, 2019 02:00
Materials, Vol. 12, Pages 3588: Unusual Response of Thin LiTaO3 Films to Intense Microwave Pulses Materials doi: 10.3390/ma12213588 Authors: Haojia Chen Qiong Gao Baoliang Qian Lishan Zhao Fundamentally different responses of a LiTaO 3 thin film detector are observed when it is subjected to short microwave pulses as the pulse intensity is altered over a wide range. We start from weak microwave pulses which lead to only trivial pyroelectric peak response. However, when...
Thu Oct 31, 2019 02:00
Viruses, Vol. 11, Pages 1006: Rabies Surveillance Identifies Potential Risk Corridors and Enables Management Evaluation Viruses doi: 10.3390/v11111006 Authors: Amy J. Davis Kathleen M. Nelson Jordona D. Kirby Ryan Wallace Xiaoyue Ma Kim M. Pepin Richard B. Chipman Amy T. Gilbert Intensive efforts are being made to eliminate the raccoon variant of rabies virus (RABV) from the eastern United States and Canada. The United States Department of Agriculture (USDA) Wildlife...
Thu Oct 31, 2019 02:00
Brain Sciences, Vol. 9, Pages 303: Electrical Stimulation of C6 Glia-Precursor Cells In Vitro Differentially Modulates Gene Expression Related to Chronic Pain Pathways Brain Sciences doi: 10.3390/brainsci9110303 Authors: Ricardo Vallejo David C. Platt Jonathan A. Rink Marjorie A. Jones Courtney A. Kelley Ashim Gupta Cynthia L. Cass Kirk Eichenberg Alejandro Vallejo William J. Smith Ramsin Benyamin David L. Cedeño Glial cells comprise the majority of cells...
Thu Oct 31, 2019 02:00
Applied Sciences, Vol. 9, Pages 4633: A Feature Analysis Based Identifying Scheme Using GBDT for DDoS with Multiple Attack Vectors Applied Sciences doi: 10.3390/app9214633 Authors: Jian Zhang Qidi Liang Rui Jiang Xi Li In recent years, distributed denial of service (DDoS) attacks have increasingly shown the trend of multiattack vector composites, which has significantly improved the concealment and success rate of DDoS attacks. Therefore, improving the ubiquitous detection capability...
Thu Oct 31, 2019 02:00
IJMS, Vol. 20, Pages 5434: Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing International Journal of Molecular Sciences doi: 10.3390/ijms20215434 Authors: Craig S. McIntosh May Thandar Aung-Htut Sue Fletcher Steve D. Wilton Spinocerebellar ataxia type 3 (SCA3) is a devastating neurodegenerative disease for which there is currently no cure, nor effective treatment strategy. One of nine polyglutamine disorders known to date, SCA3 is clinically...
Thu Oct 31, 2019 02:00
Cancers, Vol. 11, Pages 1693: How Do Synchronous Lung Metastases Influence the Surgical Management of Children with Hepatoblastoma? An Update and Systematic Review of the Literature Cancers doi: 10.3390/cancers11111693 Authors: Roberta Angelico Chiara Grimaldi Carlo Gazia Maria Cristina Saffioti Tommaso Maria Manzia Aurora Castellano Marco Spada Approximately 20% of children with hepatoblastoma (HB) have metastatic disease at diagnosis, most frequently in the lungs....
Thu Oct 31, 2019 02:00
Electronics, Vol. 8, Pages 1250: Melody Extraction and Encoding Method for Generating Healthcare Music Automatically Electronics doi: 10.3390/electronics8111250 Authors: Shuyu Li Sejun Jang Yunsick Sung The strong relationship between music and health has helped prove that soft and peaceful classical music can significantly reduce people’s stress; however, it is difficult to identify and collect examples of such music to build a library. Therefore, a system is required...
Thu Oct 31, 2019 02:00
Viruses, Vol. 11, Pages 1005: The Rescue and Characterization of Recombinant, Microcephaly-Associated Zika Viruses as Single-Round Infectious Particles Viruses doi: 10.3390/v11111005 Authors: Chien-Yi Lu Chen-Sheng Lin Hsueh-Chou Lai Ya-Wen Yu Chih-Yi Liao Wen-Chi Su Bo-Han Ko Young-Sheng Chang Su-Hua Huang Cheng-Wen Lin Zika virus (ZIKV) is transmitted by Aedes mosquitoes and exhibits genetic variation with African and Asian lineages. ZIKV Natal RGN strain,...
Thu Oct 31, 2019 02:00
Philosophies, Vol. 4, Pages 56: It’s about Time: Film, Video Games, and the Advancement of an Artform Philosophies doi: 10.3390/philosophies4040056 Authors: Steven Gimbel Joseph Roman Jon Robson and Aaron Meskin have argued that the insights obtained through the philosophical analysis of video games is not specific to video games, but to a larger class of artistic creations they term Self-Involving Interactive Fictions, or SIIFs. But there is at least one aspect of SIIF video games...
Thu Oct 31, 2019 02:00
IJMS, Vol. 20, Pages 5433: A Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies—In Vitro and In Vivo Treatments to Boost Cellular Engraftment International Journal of Molecular Sciences doi: 10.3390/ijms20215433 Authors: Daniela Gois Beghini Samuel Iwao Horita Liana Monteiro da Fonseca Cardoso Luiz Anastacio Alves Kanneboyina Nagaraju Andrea Henriques-Pons Muscular dystrophies (MD) are a group of genetic diseases that lead to skeletal muscle wasting...
Thu Oct 31, 2019 02:00
Aerospace, Vol. 6, Pages 118: MeznSat—A 3U CubeSat for Monitoring Greenhouse Gases Using Short Wave Infra-Red Spectrometry: Mission Concept and Analysis Aerospace doi: 10.3390/aerospace6110118 Authors: Abdul-Halim Jallad Prashanth Marpu Zulkifli Abdul Aziz Abdulla Al Marar Mohammed Awad Climate change and global warming are attributed to the increased levels of greenhouse Gases in the atmosphere. Miniature low-cost, lightweight instruments on-board low-cost nanosatellite...
Thu Oct 31, 2019 02:00
Sustainability, Vol. 11, Pages 6055: A Memetic Algorithm for the Green Vehicle Routing Problem Sustainability doi: 10.3390/su11216055 Authors: Bo Peng Yuan Zhang Yuvraj Gajpal Xiding Chen The green vehicle routing problem is a variation of the classic vehicle routing problem in which the transportation fleet is composed of electric vehicles with limited autonomy in need of recharge during their duties. As an NP-hard problem, this problem is very difficult to solve. In this paper,...
Thu Oct 31, 2019 02:00
Micromachines, Vol. 10, Pages 743: A Novel Capacitance-Based In-Situ Pressure Sensor for Wearable Compression Garments Micromachines doi: 10.3390/mi10110743 Authors: Steven Lao Hamza Edher Utkarsh Saini Jeffrey Sixt Armaghan Salehian This paper pertains to the development & evaluation of a dielectric electroactive polymer-based tactile pressure sensor and its circuitry. The evaluations conceived target the sensor’s use case as an in-situ measurement device...
Thu Oct 31, 2019 02:00
Water, Vol. 11, Pages 2282: A Modified k – ε Turbulence Model for a Wave Breaking Simulation Water doi: 10.3390/w11112282 Authors: Giovanni Cannata Federica Palleschi Benedetta Iele Francesco Gallerano We propose a two-equation turbulence model based on modification of the k − ε standard model, for simulation of a breaking wave. The proposed model is able to adequately simulate the energy dissipation due to the wave breaking and does not require...
Thu Oct 31, 2019 02:00
Polymers, Vol. 11, Pages 1784: Preparation and Characterization of Flame-Retarded Poly(butylene terephthalate)/Poly(ethylene terephthalate) Blends: Effect of Content and Type of Flame Retardant Polymers doi: 10.3390/polym11111784 Authors: Weizhou Zhang Cheng Zheng Yuhui Zhang Weihong Guo A flame retardant named TAD was synthesized by the reaction of 9,10-Dihydro-9-oxa-10-phosphaphenanthrene-10-oxide and triallyl isocyanurate at first. Then, novel flameretarded materials based...
Thu Oct 31, 2019 02:00
IJMS, Vol. 20, Pages 5429: Dp71 Expression in Human Glioblastoma International Journal of Molecular Sciences doi: 10.3390/ijms20215429 Authors: Simona Ruggieri Michelina De Giorgis Tiziana Annese Roberto Tamma Angelo Notarangelo Andrea Marzullo Rebecca Senetta Paola Cassoni Michela Notarangelo Domenico Ribatti Beatrice Nico Background: Dp71 is the most abundant dystrophin (DMD) gene product in the nervous system. Mutation in the Dp71 coding region is associated...
Thu Oct 31, 2019 02:00
Toxins, Vol. 11, Pages 633: Efficacy of a Yeast Cell Wall Extract to Mitigate the Effect of Naturally Co-Occurring Mycotoxins Contaminating Feed Ingredients Fed to Young Pigs: Impact on Gut Health, Microbiome, and Growth Toxins doi: 10.3390/toxins11110633 Authors: Sung Woo Kim Débora Muratori Holanda Xin Gao Inkyung Park Alexandros Yiannikouris Mycotoxins are produced by fungi and are potentially toxic to pigs. Yeast cell wall extract (YCWE) is known to adsorb mycotoxins...
Thu Oct 31, 2019 02:00
IJMS, Vol. 20, Pages 5430: Dasatinib Inhibits Procoagulant and Clot Retracting Activities of Human Platelets International Journal of Molecular Sciences doi: 10.3390/ijms20215430 Authors: Ildikó Beke Debreceni Gabriella Mezei Péter Batár Árpád Illés János Kappelmayer Tyrosine kinase inhibitors (TKI) such as the BCR-ABL inhibitor dasatinib and nilotinib are highly effective therapies for chronic myeloid leukemia (CML). However, several lines of evidence suggest that dasatinib...
Thu Oct 31, 2019 02:00
Technologies, Vol. 7, Pages 77: An Improved Calculation Model for the Prediction of the Wear of Coated Electrical Contacts Technologies doi: 10.3390/technologies7040077 Authors: Haomiao Yuan Jian Song To connect terminals in a cyber–physical system, large quantities of electrical contacts are used. In order to guarantee a high reliability of the system, the lifetime of the electrical contacts should be very long. Thus, it is of great importance to understand the failure...
Thu Oct 31, 2019 02:00
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